U.S. Department of Health and Human Services
Paul Kovac

 Contact Info

Tel: 301-496-3569
Email: kovac@mail.nih.gov

 Select Experience

  • Senior InvestigatorLaboratory of Bioorganic Chemistry, NIDDK, NIH1983-present
  • Group LeaderBachem, Inc.1981-1982
  • Senior ScientistInstitute of Chemistry, Slovak Academy of Sciences1969-1981
  • Post-docPurdue University, Department of Biochemistry1967-1968
  • Ph.D.Institute of Chemistry, Slovak Academy of Sciences1967
  • M.S.Slovak Technical University1962

 Related Links


Paul Kovac, Ph.D.

Senior Investigator, Laboratory of Bioorganic ChemistryCarbohydrates Section
  • Chemistry/Chemical Biology


A selection of recent and significant publications can be viewed below.

Jahouh F, Saksena R, Kováč P, Banoub J. Revealing the glycation sites in synthetic neoglycoconjugates formed by conjugation of the antigenic monosaccharide hapten of Vibrio cholerae O1, serotype Ogawa with the BSA protein carrier using LC-ESI-QqTOF-MS/MS. J Mass Spectrom. 2012 Jul; 47:890-900. [Full Text/Abstract]
Tarique AA, Kalsy A, Arifuzzaman M, Rollins SM, Charles RC, Leung DT, Harris JB, Larocque RC, Sheikh A, Bhuiyan MS, Saksena R, Clements JD, Calderwood SB, Qadri F, Kovác P, Ryan ET. Transcutaneous immunization with a Vibrio cholerae O1 Ogawa synthetic hexasaccharide conjugate following oral whole-cell cholera vaccination boosts vibriocidal responses and induces protective immunity in mice. Clin Vaccine Immunol. 2012 Apr; 19:594-602. [Full Text/Abstract]
Xu P, Alam MM, Kalsy A, Charles RC, Calderwood SB, Qadri F, Ryan ET, Kováč P. Simple, direct conjugation of bacterial O-SP-core antigens to proteins: development of cholera conjugate vaccines. Bioconjug Chem. 2011 Oct 19; 22:2179-85. [Full Text/Abstract]
Jahouh F, Hou SJ, Kováč P, Banoub JH. Determination of the glycation sites of Bacillus anthracis neoglycoconjugate vaccine by MALDI-TOF/TOF-CID-MS/MS and LC-ESI-QqTOF-tandem mass spectrometry. J Mass Spectrom. 2011 Oct; 46:993-1003. [Full Text/Abstract]
Bongat AF, Saksena R, Adamo R, Fujimoto Y, Shiokawa Z, Peterson DC, Fukase K, Vann WF, Kovác P. Multimeric bivalent immunogens from recombinant tetanus toxin HC fragment, synthetic hexasaccharides, and a glycopeptide adjuvant. Glycoconj J. 2010 Jan; 27:69-77. [Full Text/Abstract]
Rollenhagen JE, Kalsy A, Saksena R, Sheikh A, Alam MM, Qadri F, Calderwood SB, Kovác P, Ryan ET. Transcutaneous immunization with a synthetic hexasaccharide-protein conjugate induces anti-Vibrio cholerae lipopolysaccharide responses in mice. Vaccine. 2009 Aug 6; 27:4917-22. [Full Text/Abstract]
Hou SJ, Saksena R, Kovác P. Preparation of glycoconjugates by dialkyl squarate chemistry revisited. Carbohydr Res. 2008 Feb 4; 343:196-210. [Full Text/Abstract]
Saksena R, Adamo R, Kovác P. Immunogens related to the synthetic tetrasaccharide side chain of the Bacillus anthracis exosporium. Bioorg Med Chem. 2007 Jun 15; 15:4283-310. [Full Text/Abstract]
Wang D, Carroll GT, Turro NJ, Koberstein JT, Kovác P, Saksena R, Adamo R, Herzenberg LA, Herzenberg LA, Steinman L. Photogenerated glycan arrays identify immunogenic sugar moieties of Bacillus anthracis exosporium. Proteomics. 2007 Jan; 7:180-4. [Full Text/Abstract]
Ruttens B, Kovác P. Synthesis of spacer-equipped phosphorylated di-, tri- and tetrasaccharide fragments of the O-specific polysaccharide of Vibrio cholerae O139. Carbohydr Res. 2006 Jul 3; 341:1077-80. [Full Text/Abstract]
Saksena R, Ma X, Wade TK, Kovác P, Wade WF. Length of the linker and the interval between immunizations influences the efficacy of Vibrio cholerae O1, Ogawa hexasaccharide neoglycoconjugates. FEMS Immunol Med Microbiol. 2006 Jun; 47:116-28. [Full Text/Abstract]
Meeks MD, Saksena R, Ma X, Wade TK, Taylor RK, Kovác P, Wade WF. Synthetic fragments of Vibrio cholerae O1 Inaba O-specific polysaccharide bound to a protein carrier are immunogenic in mice but do not induce protective antibodies. Infect Immun. 2004 Jul; 72:4090-101. [Full Text/Abstract]
Taylor RK, Kirn TJ, Bose N, Stonehouse E, Tripathi SA, Kovác P, Wade WF. Progress towards development of a cholera subunit vaccine. Chem Biodivers. 2004 Jul; 1:1036-57. [Full Text/Abstract]
Ma X, Saksena R, Chernyak A, Kovác P. Neoglycoconjugates from synthetic tetra- and hexasaccharides that mimic the terminus of the O-PS of Vibrio cholerae O:1, serotype Inaba. Org Biomol Chem. 2003 Mar 7; 1:775-84. [Full Text/Abstract]
Chernyak A, Kondo S, Wade TK, Meeks MD, Alzari PM, Fournier JM, Taylor RK, Kovác P, Wade WF. Induction of protective immunity by synthetic Vibrio cholerae hexasaccharide derived from V. cholerae O1 Ogawa lipopolysaccharide bound to a protein carrier. J Infect Dis. 2002 Apr 1; 185:950-62. [Full Text/Abstract]
Provenzano D, Kovác P, Wade WF. The ABCs (Antibody, B cells, and Carbohydrate epitopes) of cholera immunity: considerations for an improved vaccine. Microbiol Immunol. 2006; 50:899-927. [Full Text/Abstract]