U.S. Department of Health and Human Services
Paul Kovac
 

 Contact Info

 
Tel: 301-496-3569
Email: kovac@mail.nih.gov
 

 Select Experience

 
  • Senior InvestigatorLaboratory of Bioorganic Chemistry, NIDDK, NIH1983-present
  • Group LeaderBachem, Inc.1981-1982
  • Senior ScientistInstitute of Chemistry, Slovak Academy of Sciences1969-1981
  • Post-docPurdue University, Department of Biochemistry1967-1968
  • Ph.D.Institute of Chemistry, Slovak Academy of Sciences1967
  • M.S.Slovak Technical University1962
 

 Related Links

 
Specialties
  • Chemistry/Chemical Biology

​Publications

A selection of recent and significant publications can be viewed below.

Publications
Charles RC, Hilaire IJ, Mayo-Smith LM, Teng JE, Jerome JG, Franke MF, Saha A, Yu Y, Kováč P, Calderwood SB, Ryan ET, Larocque RC, Almazor CP, Qadri F, Ivers LC, Harris JB. Immunogenicity of a Killed Bivalent (O1 and O139) Whole Cell Oral Cholera Vaccine, Shanchol, in Haiti. PLoS Negl Trop Dis. 2014 May; 8 (5):e2828. [Full Text/Abstract]
Uddin T, Aktar A, Xu P, Johnson RA, Rahman MA, Leung DT, Afrin S, Akter A, Alam MM, Rahman A, Chowdhury F, Khan AI, Bhuiyan TR, Bufano MK, Rashu R, Yu Y, Wu-Freeman Y, Harris JB, Larocque RC, Charles RC, Kovač P, Calderwood SB, Ryan ET, Qadri F. Immune Responses to O-Specific Polysaccharide and Lipopolysaccharide of Vibrio cholerae O1 Ogawa in Adult Bangladeshi Recipients of an Oral Killed Cholera Vaccine and Comparison to Responses in Patients with Cholera. Am J Trop Med Hyg. 2014 May; 90 (5):873-81. [Full Text/Abstract]
Alam MM, Bufano MK, Xu P, Kalsy A, Yu Y, Freeman YW, Sultana T, Rashu MR, Desai I, Eckhoff G, Leung DT, Charles RC, LaRocque RC, Harris JB, Clements JD, Calderwood SB, Qadri F, Vann WF, Kováč P, Ryan ET. Evaluation in mice of a conjugate vaccine for cholera made from Vibrio cholerae O1 (Ogawa) O-specific polysaccharide. PLoS Negl Trop Dis. 2014 Feb; 8 (2):e2683. [Full Text/Abstract]
Soliman, S. E.; Kovac, P. Practical Synthesis of Building Blocks for Oligosaccharides Containing the β-D-Galp-(1→3)-β-D-GlcpNAc Motif. Synthesis. 2014; 46 :748-751. [Full Text/Abstract]
Jahouh F, Xu P, Vann WF, Kováč P, Banoub JH. Mapping the glycation sites in the neoglycoconjugate from hexasaccharide antigen of Vibrio cholerae, serotype Ogawa and the recombinant tetanus toxin C-fragment carrier. J Mass Spectrom. 2013 Oct; 48 (10):1083-90. [Full Text/Abstract]
Leung DT, Uddin T, Xu P, Aktar A, Johnson RA, Rahman MA, Alam MM, Bufano MK, Eckhoff G, Wu-Freeman Y, Yu Y, Sultana T, Khanam F, Saha A, Chowdhury F, Khan AI, Charles RC, Larocque RC, Harris JB, Calderwood SB, Kovác P, Qadri F, Ryan ET. Immune responses to the O-specific polysaccharide antigen in children who received a killed oral cholera vaccine compared to responses following natural cholera infection in Bangladesh. Clin Vaccine Immunol. 2013 Jun; 20 (6):780-8. [Full Text/Abstract]
Lu, X.; Sail, D.; Kovac, P. 6-O-Benzylidene and 4,6-O-methoxybenzylidene a,b-cellobiose and their hexa-O-benzoyl derivatives. Synthesis. 2013; 45 :1946-1949. [Full Text/Abstract]
Johnson RA, Uddin T, Aktar A, Mohasin M, Alam MM, Chowdhury F, Harris JB, LaRocque RC, Bufano MK, Yu Y, Wu-Freeman Y, Leung DT, Sarracino D, Krastins B, Charles RC, Xu P, Kovác P, Calderwood SB, Qadri F, Ryan ET. Comparison of immune responses to the O-specific polysaccharide and lipopolysaccharide of Vibrio cholerae O1 in Bangladeshi adult patients with cholera. Clin Vaccine Immunol. 2012 Nov; 19 (11):1712-21. [Full Text/Abstract]
Jahouh F, Saksena R, Kováč P, Banoub J. Revealing the glycation sites in synthetic neoglycoconjugates formed by conjugation of the antigenic monosaccharide hapten of Vibrio cholerae O1, serotype Ogawa with the BSA protein carrier using LC-ESI-QqTOF-MS/MS. J Mass Spectrom. 2012 Jul; 47 (7):890-900. [Full Text/Abstract]
Jahouh F, Hou SJ, Kováč P, Banoub JH. Determination of glycation sites by tandem mass spectrometry in a synthetic lactose-bovine serum albumin conjugate, a vaccine model prepared by dialkyl squarate chemistry. Rapid Commun Mass Spectrom. 2012 Apr 15; 26 (7):749-58. [Full Text/Abstract]
Tarique AA, Kalsy A, Arifuzzaman M, Rollins SM, Charles RC, Leung DT, Harris JB, Larocque RC, Sheikh A, Bhuiyan MS, Saksena R, Clements JD, Calderwood SB, Qadri F, Kovác P, Ryan ET. Transcutaneous immunization with a Vibrio cholerae O1 Ogawa synthetic hexasaccharide conjugate following oral whole-cell cholera vaccination boosts vibriocidal responses and induces protective immunity in mice. Clin Vaccine Immunol. 2012 Apr; 19 (4):594-602. [Full Text/Abstract]
Xu P, Alam MM, Kalsy A, Charles RC, Calderwood SB, Qadri F, Ryan ET, Kováč P. Simple, direct conjugation of bacterial O-SP-core antigens to proteins: development of cholera conjugate vaccines. Bioconjug Chem. 2011 Oct 19; 22 (10):2179-85. [Full Text/Abstract]
Jahouh F, Hou SJ, Kováč P, Banoub JH. Determination of the glycation sites of Bacillus anthracis neoglycoconjugate vaccine by MALDI-TOF/TOF-CID-MS/MS and LC-ESI-QqTOF-tandem mass spectrometry. J Mass Spectrom. 2011 Oct; 46 (10):993-1003. [Full Text/Abstract]
Jahouh F, Saksena R, Aiello D, Napoli A, Sindona G, Kováč P, Banoub JH. Glycation sites in neoglycoglycoconjugates from the terminal monosaccharide antigen of the O-PS of Vibrio cholerae O1, serotype Ogawa, and BSA revealed by matrix-assisted laser desorption-ionization tandem mass spectrometry. J Mass Spectrom. 2010 Oct; 45 (10):1148-59. [Full Text/Abstract]
Hou SJ, Kovác P. Enhanced stereoselectivity of alpha-mannosylation under thermodynamic control using trichloroacetimidates. Carbohydr Res. 2010 May 27; 345 (8):999-1007. [Full Text/Abstract]
Bongat AF, Saksena R, Adamo R, Fujimoto Y, Shiokawa Z, Peterson DC, Fukase K, Vann WF, Kovác P. Multimeric bivalent immunogens from recombinant tetanus toxin HC fragment, synthetic hexasaccharides, and a glycopeptide adjuvant. Glycoconj J. 2010 Jan; 27 (1):69-77. [Full Text/Abstract]
Parameswar AR, Park IH, Saksena R, Kovác P, Nahm MH, Demchenko AV. Synthesis, conjugation, and immunological evaluation of the serogroup 6 pneumococcal oligosaccharides. Chembiochem. 2009 Dec 14; 10 (18):2893-9. [Full Text/Abstract]
Kuehn A, Kovác P, Saksena R, Bannert N, Klee SR, Ranisch H, Grunow R. Development of antibodies against anthrose tetrasaccharide for specific detection of Bacillus anthracis spores. Clin Vaccine Immunol. 2009 Dec; 16 (12):1728-37. [Full Text/Abstract]
Rollenhagen JE, Kalsy A, Saksena R, Sheikh A, Alam MM, Qadri F, Calderwood SB, Kovác P, Ryan ET. Transcutaneous immunization with a synthetic hexasaccharide-protein conjugate induces anti-Vibrio cholerae lipopolysaccharide responses in mice. Vaccine. 2009 Aug 6; 27 (36):4917-22. [Full Text/Abstract]
Ko H, Das A, Carter RL, Fricks IP, Zhou Y, Ivanov AA, Melman A, Joshi BV, Kovác P, Hajduch J, Kirk KL, Harden TK, Jacobson KA. Molecular recognition in the P2Y(14) receptor: Probing the structurally permissive terminal sugar moiety of uridine-5'-diphosphoglucose. Bioorg Med Chem. 2009 Jul 15; 17 (14):5298-311. [Full Text/Abstract]
Saksena R, Chernyak A, Kovác P. Synthesis of spacer-equipped di-, tri-, and the tetrasaccharide fragments of the deacetylated O-PS1 of Citrobacter gillenii O9a,9b, and a related pentasaccharide. Carbohydr Res. 2008 Jul 21; 343 (10-11):1693-706. [Full Text/Abstract]
Hou SJ, Saksena R, Kovác P. Preparation of glycoconjugates by dialkyl squarate chemistry revisited. Carbohydr Res. 2008 Feb 4; 343 (2):196-210. [Full Text/Abstract]
Saksena R, Adamo R, Kovác P. Immunogens related to the synthetic tetrasaccharide side chain of the Bacillus anthracis exosporium. Bioorg Med Chem. 2007 Jun 15; 15 (12):4283-310. [Full Text/Abstract]
Wang D, Carroll GT, Turro NJ, Koberstein JT, Kovác P, Saksena R, Adamo R, Herzenberg LA, Herzenberg LA, Steinman L. Photogenerated glycan arrays identify immunogenic sugar moieties of Bacillus anthracis exosporium. Proteomics. 2007 Jan; 7 (2):180-4. [Full Text/Abstract]
Chmelík J, Rehulka P, Kovácik V, Pätoprstý V, Kovác P. Negative matrix-assisted laser desorption/ionization time-of-flight/time-of-flight tandem mass spectrometry fragmentation of synthetic analogs of the O-specific polysaccharide of Vibrio cholerae O:1 in the presence of anionic dopants. Eur J Mass Spectrom (Chichester, Eng). 2007; 13 (5):347-53. [Full Text/Abstract]
Wade TK, Saksena R, Shiloach J, Kovác P, Wade WF. Immunogenicity of synthetic saccharide fragments of Vibrio cholerae O1 (Ogawa and Inaba) bound to Exotoxin A. FEMS Immunol Med Microbiol. 2006 Nov; 48 (2):237-51. [Full Text/Abstract]
Ruttens B, Kovác P. Synthesis of spacer-equipped phosphorylated di-, tri- and tetrasaccharide fragments of the O-specific polysaccharide of Vibrio cholerae O139. Carbohydr Res. 2006 Jul 3; 341 (9):1077-80. [Full Text/Abstract]
Saksena R, Ma X, Wade TK, Kovác P, Wade WF. Length of the linker and the interval between immunizations influences the efficacy of Vibrio cholerae O1, Ogawa hexasaccharide neoglycoconjugates. FEMS Immunol Med Microbiol. 2006 Jun; 47 (1):116-28. [Full Text/Abstract]
Kovácik V, Bekesová S, Tvaroska I, Kovác P. Positive electrospray ion trap multistage mass spectrometric fragmentation of synthetic analogs of saccharide part of lipopolysaccharides of Vibrio cholerae O:1. J Am Soc Mass Spectrom. 2006 Jun; 17 (6):749-56. [Full Text/Abstract]
Saksena R, Adamo R, Kovác P. Synthesis of the tetrasaccharide side chain of the major glycoprotein of the Bacillus anthracis exosporium. Bioorg Med Chem Lett. 2006 Feb; 16 (3):615-7. [Full Text/Abstract]