U.S. Department of Health and Human Services
Peggy Hsieh

 Contact Info

Tel: +1-301-496-0306
Email: peggyh@niddk.nih.gov

 Select Experience

  • Ph.D.Massachusetts Institute of Technology1983
  • B.A.Princeton University1979

 Related Links


    • Cancer Biology
    • Chromosome Biology/Epigenetics
    • Molecular Biology/Biochemistry


    A selection of recent and significant publications can be viewed below.

    Hsieh PW, Wen CJ, Yu HP, Aljuffali IA, Huang YH, Fang JY. Nanostructured lipid carriers containing a high percentage of a Pluronic copolymer increase the biodistribution of novel PDE4 inhibitors for the treatment of traumatic hemorrhage. J Biomed Nanotechnol. 10 (8; 10):1520-35. [Full Text/Abstract]
    Hsieh PL, Chen ML, Huang CM, Chen WC, Li CH, Chang LC. Physical activity, body mass index, and cardiorespiratory fitness among school children in Taiwan: a cross-sectional study. Int J Environ Res Public Health. 11 (7; 11):7275-7285. [Full Text/Abstract]
    Lin TL, Hsieh PF, Huang YT, Lee WC, Tsai YT, Su PA, Pan YJ, Hsu CR, Wu MC, Wang JT. Isolation of a bacteriophage and its depolymerase specific for K1 capsule of Klebsiella pneumoniae: implication in typing and treatment. J Infect Dis. [Full Text/Abstract]
    Chuang HW, Liao JB, Chang HC, Wang JS, Lin SL, Hsieh PP. Ciliated muconodular papillary tumor of the lung: A newly defined peripheral pulmonary tumor with conspicuous mucin pool mimicking colloid adenocarcinoma: A case report and review of literature. Pathol Int. 64 (7; 64):352-7. [Full Text/Abstract]
    Chiang JM, Hsieh PS, Chen JS, Tang R, You JF, Yeh CY. Rectal cancer level significantly affects rates and patterns of distant metastases among rectal cancer patients post curative-intent surgery without neoadjuvant therapy. World J Surg Oncol. 12 (12; 1):197. [Full Text/Abstract]
    Tiong KL, Chang KC, Yeh KT, Liu TY, Wu JH, Hsieh PH, Lin SH, Lai WY, Hsu YC, Chen JY, Chang JG, Shieh GS. CSNK1E/CTNNB1 Are Synthetic Lethal To TP53 in Colorectal Cancer and Are Markers for Prognosis. Neoplasia. [Full Text/Abstract]
    Molina CA, Ames CP, Chou D, Rhines LD, Hsieh PC, Zadnik PL, Wolinsky JP, Gokaslan ZL, Sciubba DM. Outcomes following attempted en bloc resection of cervical chordomas in the C-1 and C-2 region versus the subaxial region: a multiinstitutional experience. J Neurosurg Spine. 1-9. [Full Text/Abstract]
    Acosta FL Jr, Ames C, Hsieh PC, McCarthy IM. Introduction: Costs and benefits of modern-day spine care. Neurosurg Focus. 36 (6; 36):Introduction. [Full Text/Abstract]
    Wang HH, Chung UL, Tsay SL, Hsieh PC, Su HF, Lin KC. Development and preliminary testing of an instrument to measure healthiness of lifestyle among breast cancer survivors. Int J Nurs Pract. [Full Text/Abstract]
    Ting YC, Ko HH, Wang HC, Peng CF, Chang HS, Hsieh PC, Chen IS. Biological evaluation of secondary metabolites from the roots of Myrica adenophora. Phytochemistry. [Full Text/Abstract]
    Tuchman A, Hsieh PC. Editorial: Comparing minimally invasive, hybrid, and open surgical techniques for adult spinal deformity. Neurosurg Focus. 36 (36; 5):E16. [Full Text/Abstract]
    Wang WC, Liu SF, Chang WT, Shiue YL, Hsieh PF, Hung TJ, Hung CY, Hung YJ, Chen MF, Yang YL. The effects of diosgenin in the Regulation of renal proximal tubular fibrosis. Exp Cell Res. 323 (323; 2):255-62. [Full Text/Abstract]
    Chen YW, Tzeng JI, Lin MF, Hung CH, Hsieh PL, Wang JJ. High-Frequency Transcutaneous Electrical Nerve Stimulation Attenuates Postsurgical Pain and Inhibits Excess Substance P in Rat Dorsal Root Ganglion. Reg Anesth Pain Med. [Full Text/Abstract]
    Hsieh PH, Xu Y, Keire DA, Liu J. Chemoenzymatic synthesis and structural characterization of 2-O-sulfated glucuronic acid containing heparan sulfate hexasaccharides. Glycobiology. [Full Text/Abstract]
    Kuo CT, Chiang RH, Wang CY, Hsieh PH, Lin YT, Lin CH, Huang CY. Electrically switchable cholesteric gratings based on slit electrodes. Opt Express. 22 (8; 22):9759-9763. [Full Text/Abstract]
    Hsu SC, Lai YC, Hsieh PH, Cheng PJ, Wong SS, Hung CH. Successful enrichment of a rarely found Candidatus Anammoxoglobus propionicus from leachate sludge. J Microbiol Biotechnol. [Full Text/Abstract]
    Xu Y, Cai C, Chandarajoti K, Hsieh PH, Li L, Pham TQ, Sparkenbaugh EM, Sheng J, Key NS, Pawlinski R, Harris EN, Linhardt RJ, Liu J. Homogeneous low-molecular-weight heparins with reversible anticoagulant activity. Nat Chem Biol. 10 (4; 10):248-50. [Full Text/Abstract]
    Chen CH, Chang MY, Wang SS, Hsieh PC. Injection of autologous bone marrow cells in hyaluronan hydrogel improves cardiac performance after infarction in pigs. Am J Physiol Heart Circ Physiol. 306 (7; 306):H1078-86. [Full Text/Abstract]
    Hsueh YC, Wu JM, Yu CK, Wu KK, Hsieh PC. Prostaglandin E2 promotes post-infarction cardiomyocyte replenishment by endogenous stem cells. EMBO Mol Med. 6 (6; 4):496-503. [Full Text/Abstract]
    Liu C, Sheng J, Krahn JM, Perera L, Xu Y, Hsieh PH, Dou W, Liu J, Pedersen LC. Molecular mechanism of substrate specificity for heparan sulfate 2-O-sulfotransferase. J Biol Chem. [Full Text/Abstract]
    Jang WL, Lu YM, Chen CL, Lu YR, Dong CL, Hsieh PH, Hwang WS, Chen JL, Chen JM, Chan TS, Lee JF, Chou WC. Local geometric and electronic structures of gasochromic VO(x) films. Phys Chem Chem Phys. 16 (16; 10):4699-708. [Full Text/Abstract]
    Hsieh IC, Kuan TS, Hsieh PC, Chen SM, Yen WJ, Chang WC, Lin IL, Lin YC. Detection of Early Cognitive Impairment Using AD8 in a Young Patient With Stroke With Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Syndrome: A Case Report. Am J Alzheimers Dis Other Demen. 29 (2; 29):133-7. [Full Text/Abstract]
    Liu KS, Hsieh PW, Aljuffali IA, Lin YK, Chang SH, Wang JJ, Fang JY. Impact of ester promoieties on transdermal delivery of ketorolac. J Pharm Sci. 103 (3; 103):974-86. [Full Text/Abstract]
    Hsieh PC, Lee ST, Chen JF. Lower thoracic degenerative spondylithesis with concomitant lumbar spondylosis. Clin Neurol Neurosurg. 118 (118):21-5. [Full Text/Abstract]
    Tsai MT, Wu HY, Roan JN, Tsai YS, Hsieh PC, Yang YJ, Luo CY. Effect of false lumen partial thrombosis on repaired acute type A aortic dissection. J Thorac Cardiovasc Surg. [Full Text/Abstract]
    Lai CY, Wu PJ, Roffler SR, Lee ST, Hwang SM, Wang SS, Wang K, Hsieh PC. Clearance kinetics of biomaterials affects stem cell retention and therapeutic efficacy. Biomacromolecules. 15 (2; 15):564-73. [Full Text/Abstract]
    Chiu YW, Chen WP, Su CC, Lee YC, Hsieh PH, Ho YL. The arrhythmogenic effect of self-assembling nanopeptide hydrogel scaffolds on neonatal mouse cardiomyocytes. Nanomedicine. [Full Text/Abstract]
    Hsieh PC, Chen KC, Yeh TL, Lee IH, Chen PS, Yao WJ, Chiu NT, Chen CC, Liao MH, Yang YK. Lower availability of midbrain serotonin transporter between healthy subjects with and without a family history of major depressive disorder - a preliminary two-ligand SPECT study. Eur Psychiatry. [Full Text/Abstract]
    Chen DW, Hu CC, Chang YH, Lee MS, Chang CJ, Hsieh PH. Intra-Articular Bupivacaine Reduces Postoperative Pain and Meperidine Use After Total Hip Arthroplasty: A Randomized, Double-Blind Study. J Arthroplasty. [Full Text/Abstract]
    Geng H, Sakato M, DeRocco V, Yamane K, Du C, Erie DA, Hingorani M, Hsieh P. Biochemical analysis of the human mismatch repair proteins hMutSα MSH2(G674A)-MSH6 and MSH2-MSH6(T1219D). J Biol Chem. 2012 Mar 23; 287 (287; 13; 2012 Mar 23):9777-91. [Full Text/Abstract]
    Diouf B, Cheng Q, Krynetskaia NF, Yang W, Cheok M, Pei D, Fan Y, Cheng C, Krynetskiy EY, Geng H, Chen S, Thierfelder WE, Mullighan CG, Downing JR, Hsieh P, Pui CH, Relling MV, Evans WE. Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells. Nat Med. 2011 Sep 25; 17 (17; 2011 Sep 25; 10):1298-303. [Full Text/Abstract]
    Geng H, Du C, Chen S, Salerno V, Manfredi C, Hsieh P. In vitro studies of DNA mismatch repair proteins. Anal Biochem. 2011 Jun 15; 413 (2; 413; 2011 Jun 15):179-84. [Full Text/Abstract]
    Tessmer I, Yang Y, Zhai J, Du C, Hsieh P, Hingorani MM, Erie DA. Mechanism of MutS searching for DNA mismatches and signaling repair. J Biol Chem. 2008 Dec 26; 283 (2008 Dec 26; 283; 52):36646-54. [Full Text/Abstract]
    Liu A, Yoshioka K, Salerno V, Hsieh P. The mismatch repair-mediated cell cycle checkpoint response to fluorodeoxyuridine. J Cell Biochem. 2008 Sep 1; 105 (105; 1; 2008 Sep 1):245-54. [Full Text/Abstract]
    Hsieh P, Yamane K. DNA mismatch repair: molecular mechanism, cancer, and ageing. Mech Ageing Dev. 2008 Jul-Aug; 129 (2008 Jul-Aug; 129; 7-8):391-407. [Full Text/Abstract]
    Yoshioka K, Yoshioka Y, Hsieh P. ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. Mol Cell. 2006 May 19; 22 (2006 May 19; 4; 22):501-10. [Full Text/Abstract]
    Wang H, Yang Y, Schofield MJ, Du C, Fridman Y, Lee SD, Larson ED, Drummond JT, Alani E, Hsieh P, Erie DA. DNA bending and unbending by MutS govern mismatch recognition and specificity. Proc Natl Acad Sci U S A. 2003 Dec 9; 100 (25; 2003 Dec 9; 100):14822-7. [Full Text/Abstract]
    Obmolova G, Ban C, Hsieh P, Yang W. Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA. Nature. 2000 Oct 12; 407 (6805; 2000 Oct 12; 407):703-10. [Full Text/Abstract]
    Grigoriev M, Hsieh P. Migration of a Holliday junction through a nucleosome directed by the E. coli RuvAB motor protein. Mol Cell. 1998 Sep; 2 (2; 3; 1998 Sep):373-81. [Full Text/Abstract]
    Panyutin IG, Hsieh P. The kinetics of spontaneous DNA branch migration. Proc Natl Acad Sci U S A. 1994 Mar 15; 91 (1994 Mar 15; 6; 91):2021-5. [Full Text/Abstract]