U.S. Department of Health and Human Services
Rafael Daniel Camerini-Otero
 

 Contact Info

 
Tel: 301-496-2710
Email: rc10d@nih.gov
 

 Select Experience

 
  • M.D., Ph.D.New York University1973
  • B.S.Massachusetts Institute of Technology1966
 

 Related Links

 

    Rafael Daniel Camerini-Otero, M.D., Ph.D.

    Chief, Genetics and Biochemistry Branch
    Senior Investigator, Genetics and Biochemistry BranchGenetics and Biochemistry Section
    Specialties
    • Chromosome Biology/Epigenetics
    • Computational Biology/Bioinformatics/Biostatistics/Mathematics
    • Genetics/Genomics
    • Molecular Biology/Biochemistry
    • Systems Biology

    ​Publications

    A selection of recent and significant publications can be viewed below.

    Publications
    Broering TJ, Alavattam KG, Sadreyev RI, Ichijima Y, Kato Y, Hasegawa K, Camerini-Otero RD, Lee JT, Andreassen PR, Namekawa SH. BRCA1 establishes DNA damage signaling and pericentric heterochromatin of the X chromosome in male meiosis. J Cell Biol. ; 205:663-75. [Full Text/Abstract]
    Moktan H, Guiraldelli MF, Eyster CA, Zhao W, Lee CY, Mather T, Camerini-Otero RD, Sung P, Zhou DH, Pezza RJ. Solution Structure and DNA-binding Properties of the Winged Helix Domain of the Meiotic Recombination HOP2 Protein. J Biol Chem. 2014 Apr 6. [Full Text/Abstract]
    Pezza RJ, Voloshin ON, Volodin AA, Boateng KA, Bellani MA, Mazin AV, Camerini-Otero RD. The dual role of HOP2 in mammalian meiotic homologous recombination. Nucleic Acids Res. 2014 Feb; 42:2346-57. [Full Text/Abstract]
    Margolin G, Khil PP, Kim J, Bellani MA, Camerini-Otero RD. Integrated transcriptome analysis of mouse spermatogenesis. BMC Genomics. 2014 Jan 18; 15:39. [Full Text/Abstract]
    Zhao W, Saro D, Hammel M, Kwon Y, Xu Y, Rambo RP, Williams GJ, Chi P, Lu L, Pezza RJ, Camerini-Otero RD, Tainer JA, Wang HW, Sung P. Mechanistic insights into the role of Hop2-Mnd1 in meiotic homologous DNA pairing. Nucleic Acids Res. 2014 Jan; 42:906-17. [Full Text/Abstract]
    Naumova AK, Fayer S, Leung J, Boateng KA, Camerini-Otero RD, Taketo T. Dynamics of response to asynapsis and meiotic silencing in spermatocytes from Robertsonian translocation carriers. PLoS One. 2013; 8:e75970. [Full Text/Abstract]
    Smagulova F, Brick K, Pu Y, Sengupta U, Camerini-Otero RD, Petukhova GV. Suppression of genetic recombination in the pseudoautosomal region and at subtelomeres in mice with a hypomorphic Spo11 allele. BMC Genomics. 2013 Jul 22; 14:493. [Full Text/Abstract]
    Boateng KA, Bellani MA, Gregoretti IV, Pratto F, Camerini-Otero RD. Homologous pairing preceding SPO11-mediated double-strand breaks in mice. Dev Cell. 2013 Jan 28; 24:196-205. [Full Text/Abstract]
    Grant J, Mahadevaiah SK, Khil P, Sangrithi MN, Royo H, Duckworth J, McCarrey JR, VandeBerg JL, Renfree MB, Taylor W, Elgar G, Camerini-Otero RD, Gilchrist MJ, Turner JM. Rsx is a metatherian RNA with Xist-like properties in X-chromosome inactivation. Nature. 2012 Jul 12; 487:254-8. [Full Text/Abstract]
    Brick K, Smagulova F, Khil P, Camerini-Otero RD, Petukhova GV. Genetic recombination is directed away from functional genomic elements in mice. Nature. 2012 May 13; 485:642-5. [Full Text/Abstract]
    Khil PP, Smagulova F, Brick KM, Camerini-Otero RD, Petukhova GV. Sensitive mapping of recombination hotspots using sequencing-based detection of ssDNA. Genome Res. 2012 May; 22:957-65. [Full Text/Abstract]
    Gowher H, Brick K, Camerini-Otero RD, Felsenfeld G. Vezf1 protein binding sites genome-wide are associated with pausing of elongating RNA polymerase II. Proc Natl Acad Sci U S A. 2012 Feb 14; 109:2370-5. [Full Text/Abstract]
    Fukuda T, Pratto F, Schimenti JC, Turner JM, Camerini-Otero RD, Höög C. Phosphorylation of chromosome core components may serve as axis marks for the status of chromosomal events during mammalian meiosis. PLoS Genet. 2012 Feb; 8:e1002485. [Full Text/Abstract]
    Ichijima Y, Ichijima M, Lou Z, Nussenzweig A, Camerini-Otero RD, Chen J, Andreassen PR, Namekawa SH. MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells. Genes Dev. 2011 May 1; 25:959-71. [Full Text/Abstract]
    Smagulova F, Gregoretti IV, Brick K, Khil P, Camerini-Otero RD, Petukhova GV. Genome-wide analysis reveals novel molecular features of mouse recombination hotspots. Nature. 2011 Apr 21; 472:375-8. [Full Text/Abstract]
    Bugreev DV, Pezza RJ, Mazina OM, Voloshin ON, Camerini-Otero RD, Mazin AV. The resistance of DMC1 D-loops to dissociation may account for the DMC1 requirement in meiosis. Nat Struct Mol Biol. 2011 Jan; 18:56-60. [Full Text/Abstract]
    Pezza RJ, Camerini-Otero RD, Bianco PR. Hop2-Mnd1 condenses DNA to stimulate the synapsis phase of DNA strand exchange. Biophys J. 2010 Dec 1; 99:3763-72. [Full Text/Abstract]
    Yao H, Brick K, Evrard Y, Xiao T, Camerini-Otero RD, Felsenfeld G. Mediation of CTCF transcriptional insulation by DEAD-box RNA-binding protein p68 and steroid receptor RNA activator SRA. Genes Dev. 2010 Nov 15; 24:2543-55. [Full Text/Abstract]
    Bellani MA, Boateng KA, McLeod D, Camerini-Otero RD. The expression profile of the major mouse SPO11 isoforms indicates that SPO11beta introduces double strand breaks and suggests that SPO11alpha has an additional role in prophase in both spermatocytes and oocytes. Mol Cell Biol. 2010 Sep; 30:4391-403. [Full Text/Abstract]
    Khil PP, Camerini-Otero RD. Genetic crossovers are predicted accurately by the computed human recombination map. PLoS Genet. 2010 Jan 29; 6:e1000831. [Full Text/Abstract]
    Kouznetsova A, Wang H, Bellani M, Camerini-Otero RD, Jessberger R, Höög C. BRCA1-mediated chromatin silencing is limited to oocytes with a small number of asynapsed chromosomes. J Cell Sci. 2009 Jul 15; 122:2446-52. [Full Text/Abstract]
    Suhasini AN, Sommers JA, Mason AC, Voloshin ON, Camerini-Otero RD, Wold MS, Brosh RM Jr. FANCJ helicase uniquely senses oxidative base damage in either strand of duplex DNA and is stimulated by replication protein A to unwind the damaged DNA substrate in a strand-specific manner. J Biol Chem. 2009 Jul 3; 284:18458-70. [Full Text/Abstract]
    Volodin AA, Bocharova TN, Smirnova EA, Camerini-Otero RD. Reversibility, equilibration, and fidelity of strand exchange reaction between short oligonucleotides promoted by RecA protein from escherichia coli and human Rad51 and Dmc1 proteins. J Biol Chem. 2009 Jan 16; 284:1495-504. [Full Text/Abstract]
    Usdin TB, Paciga M, Riordan T, Kuo J, Parmelee A, Petukova G, Camerini-Otero RD, Mezey E. Tuberoinfundibular Peptide of 39 residues is required for germ cell development. Endocrinology. 2008 Sep; 149:4292-300. [Full Text/Abstract]
    Shiao MS, Khil P, Camerini-Otero RD, Shiroishi T, Moriwaki K, Yu HT, Long M. Origins of new male germ-line functions from X-derived autosomal retrogenes in the mouse. Mol Biol Evol. 2007 Oct; 24:2242-53. [Full Text/Abstract]
    Pezza RJ, Voloshin ON, Vanevski F, Camerini-Otero RD. Hop2/Mnd1 acts on two critical steps in Dmc1-promoted homologous pairing. Genes Dev. 2007 Jul 15; 21:1758-66. [Full Text/Abstract]
    Voloshin ON, Camerini-Otero RD. The DinG protein from Escherichia coli is a structure-specific helicase. J Biol Chem. 2007 Jun 22; 282:18437-47. [Full Text/Abstract]
    Bannister LA, Pezza RJ, Donaldson JR, de Rooij DG, Schimenti KJ, Camerini-Otero RD, Schimenti JC. A dominant, recombination-defective allele of Dmc1 causing male-specific sterility. PLoS Biol. 2007 May; 5:e105. [Full Text/Abstract]
    Cotroneo MS, Haag JD, Zan Y, Lopez CC, Thuwajit P, Petukhova GV, Camerini-Otero RD, Gendron-Fitzpatrick A, Griep AE, Murphy CJ, Dubielzig RR, Gould MN. Characterizing a rat Brca2 knockout model. Oncogene. 2007 Mar 8; 26:1626-35. [Full Text/Abstract]
    Liebe B, Petukhova G, Barchi M, Bellani M, Braselmann H, Nakano T, Pandita TK, Jasin M, Fornace A, Meistrich ML, Baarends WM, Schimenti J, de Lange T, Keeney S, Camerini-Otero RD, Scherthan H. Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages. Exp Cell Res. 2006 Nov 15; 312:3768-81. [Full Text/Abstract]