U.S. Department of Health and Human Services
Ranganath Muniyappa
 

 Contact Info

 
Tel: +1 301 451 7702
Email: muniyapr@mail.nih.gov
 

 Training and Experience

 
Ph.D., Wayne State University, 1999

M.D., Bangalore Medical College, 1991

Fellowship, State University of New York (SUNY), 2001–2004

Residency, Wayne State University Program, 1998–2001
 

 Related Links

 

    Ranganath Muniyappa, M.D., Ph.D.

    Staff Clinician, Diabetes, Endocrinology, and Obesity BranchClinical Endocrinology Section
    Specialties: Cell Biology/Cell Signaling, Clinical Research, Health Disparities

    Research Summary

    Research Goal

    Our ultimate goal is to develop effective therapies that simultaneously target metabolic and vascular dysfunction in obesity and diabetes.​

    Current Research

    Our research focuses on studies of the metabolic and vascular actions of insulin and how these actions are impaired in insulin-resistant states such as obesity, diabetes, and cardiovascular disease.  Insulin-mediated microvascular recruitment plays an important role in glucose disposal and is frequently impaired in people with obesity and diabetes.  We perform clinical studies that seek to understand how therapeutic interventions modulate biological actions of insulin and the molecular mechanisms of insulin resistance that play a role in coupling metabolic and vascular dysfunction in obesity and diabetes. Our research is also directed toward understanding the physiologic basis for the higher prevalence of cardiovascular dysfunction and insulin resistance in ethnic minorities such as African-Americans, Hispanic/Latinos, and Asians.

    Applying our Research

    Cardiovascular disease is a major cause of mortality and morbidity in diabetes. Developing novel therapies that target cardiovascular risk in obesity and diabetes will greatly benefit our patients with diabetes and obesity.