U.S. Department of Health and Human Services
Rebecca Brown

 Contact Info

Tel: 301-594-0609
Email: brownrebecca@mail.nih.gov

 Select Experience

  • Assistant Clinical InvestigatorNIDDK, NIH2012–present
  • Senior FellowNIDDK, NIH2008–2012
  • FellowNICHD, NIH2005–2008
  • ResidentRainbow Babies and Children’s Hospital2002–2005
  • M.H.Sc.Duke University2011
  • M.D.Mayo Medical School2002

 Related Links


Rebecca J. Brown, M.D., M.H.Sc., Lasker Tenure Track Investigator

Assistant Clinical Investigator, Clinical and Cellular Biology SectionDiabetes, Endocrinology, and Obesity Branch
  • Clinical Research


A selection of recent and significant publications can be viewed below.

Irving WL, Rupp D, McClure CP, Than LM, Titman A, Ball JK, Steinmann E, Bartenschlager R, Pietschmann T, Brown RJ. Development of a high-throughput pyrosequencing assay for monitoring temporal evolution and resistance associated variant emergence in the Hepatitis C virus protease coding-region. Antiviral Res. 2014 Jul 22; 110 (110; 2014 Jul 22):52-9. [Full Text/Abstract]
Rahman MM, Kim KH, Brown RJ, Bae IS, Park CG. PCDD and PCDF concentrations in a traffic tunnel environment. Sci Total Environ. 2014 Sep 15; 493 (493; 2014 Sep 15):773-80. [Full Text/Abstract]
Joseph J, Shamburek RD, Cochran EK, Gorden P, Brown RJ. Lipid Regulation in Lipodystrophy Versus the Obesity-Associated Metabolic Syndrome: The Dissociation of HDL-C and Triglycerides. J Clin Endocrinol Metab. 2014 Jun 13; 99 (99; 2014 Jun 13; 9):E1676-80. [Full Text/Abstract]
Karunasena HC, Senadeera W, Brown RJ, Gu YT. A particle based model to simulate microscale morphological changes of plant tissues during drying. Soft Matter. 2014 Aug 7; 10 (2014 Aug 7; 10; 29):5249-68. [Full Text/Abstract]
Quétel CR, Zampella M, Brown RJ, Ent H, Horvat M, Paredes E, Tunc M. International system of units traceable results of Hg mass concentration at saturation in air from a newly developed measurement procedure. Anal Chem. 2014 Aug 5; 86 (86; 2014 Aug 5; 15):7819-27. [Full Text/Abstract]
Doerrbecker J, Friesland M, Riebesehl N, Ginkel C, Behrendt P, Brown RJ, Ciesek S, Wedemeyer H, Sarrazin C, Kaderali L, Pietschmann T, Steinmann E. Incorporation of primary patient-derived glycoproteins into authentic infectious hepatitis C virus particles. Hepatology. 2014 Aug; 60 (2; 2014 Aug; 60):508-20. [Full Text/Abstract]
Brown RJ, Harris PM, Cox MG. Assessing the performance of standard methods to predict the standard uncertainty of air quality data having incomplete time coverage. Environ Sci Process Impacts. 2014 Jul; 16 (16; 7; 2014 Jul):1700-4. [Full Text/Abstract]
Payne F, Lim K, Girousse A, Brown RJ, Kory N, Robbins A, Xue Y, Sleigh A, Cochran E, Adams C, Dev Borman A, Russel-Jones D, Gorden P, Semple RK, Saudek V, O'Rahilly S, Walther TC, Barroso I, Savage DB. Mutations disrupting the Kennedy phosphatidylcholine pathway in humans with congenital lipodystrophy and fatty liver disease. Proc Natl Acad Sci U S A. 2014 Jun 17; 111 (111; 2014 Jun 17; 24):8901-6. [Full Text/Abstract]
Kim YH, Kim KH, Szulejko JE, Bae MS, Brown RJ. Experimental validation of an effective carbon number-based approach for the gas chromatography-mass spectrometry quantification of 'compounds lacking authentic standards or surrogates. Anal Chim Acta. 2014 Jun 9; 830C (830C; 2014 Jun 9):32-41. [Full Text/Abstract]
Yang Y, Kuwano T, Lagor WR, Albert CJ, Brenton S, Rader DJ, Ford DA, Brown RJ. Lipidomic Analyses of Female Mice Lacking Hepatic Lipase and Endothelial Lipase Indicate Selective Modulation of Plasma Lipid Species. Lipids. 2014 Jun; 49 (6; 49; 2014 Jun):505-15. [Full Text/Abstract]
Borresen EC, Gundlach KA, Wdowik M, Rao S, Brown RJ, Ryan EP. Feasibility of Increased Navy Bean Powder Consumption for Primary and Secondary Colorectal Cancer Prevention. Curr Nutr Food Sci. 2014 May; 10 (2; 2014 May; 10):112-119. [Full Text/Abstract]
Brown RJ, Mustoe CL. Demonstration of a standard dilution technique for standard addition calibration. Talanta. 2014 May; 122 (122; 2014 May):97-100. [Full Text/Abstract]
Brown RJ, Webb WR, Goddard SL. Observation of a physical matrix effect during cold vapour generation measurement of mercury in emissions samples. Anal Chim Acta. 2014 May 1; 823 (2014 May 1; 823):20-4. [Full Text/Abstract]
Basch E, Snyder C, McNiff K, Brown R, Maddux S, Smith ML, Atkinson TM, Howell D, Chiang A, Wood W, Levitan N, Wu AW, Krzyzanowska M. Patient-Reported Outcome Performance Measures in Oncology. J Oncol Pract. 2014 May; 10 (2014 May; 10; 3):209-11. [Full Text/Abstract]
Brown RJ, Yanovski JA. Estimation of insulin sensitivity in children: methods, measures and controversies. Pediatr Diabetes. 2014 May; 15 (2014 May; 15; 3):151-61. [Full Text/Abstract]
Muniyappa R, Brown RJ, Mari A, Joseph J, Warren MA, Cochran EK, Skarulis MC, Gorden P. Effects of Leptin Replacement Therapy on Pancreatic β-Cell Function in Patients With Lipodystrophy. Diabetes Care. 2014 Apr; 37 (37; 4; 2014 Apr):1101-7. [Full Text/Abstract]
Fox M, Ohlauson C, Sharpe AD, Brown RJ. The use of a Corophium volutator chronic sediment study to support the risk assessment of medetomidine for marine environments. Environ Toxicol Chem. 2014 Apr; 33 (33; 4; 2014 Apr):937-42. [Full Text/Abstract]
Sarkar G, Alattar M, Brown RJ, Quon MJ, Harlan DM, Rother KI. Exenatide treatment for 6 months improves insulin sensitivity in adults with type 1 diabetes. Diabetes Care. 2014 Mar; 37 (2014 Mar; 37; 3):666-70. [Full Text/Abstract]
Nguyen TT, Jayadeva V, Cizza G, Brown RJ, Nandagopal R, Rodriguez LM, Rother KI. Challenging recruitment of youth with type 2 diabetes into clinical trials. J Adolesc Health. 2014 Mar; 54 (2014 Mar; 3; 54):247-54. [Full Text/Abstract]
Demian WL, Jahouh FM, Stansbury D, Randell E, Brown RJ, Banoub JH. Characterizing changes in snow crab (Chionoecetes opilio) cryptocyanin protein during molting using matrix-assisted laser desorption/ionization mass spectrometry and tandem mass spectrometry. Rapid Commun Mass Spectrom. 2014 Feb 28; 28 (2014 Feb 28; 28; 4):355-69. [Full Text/Abstract]
Brewer PJ, Brown RJ, Miller MN, Miñarro MD, Murugan A, Milton MJ, Rhoderick GC. Preparation and validation of fully synthetic standard gas mixtures with atmospheric isotopic composition for global CO2 and CH4 monitoring. Anal Chem. 2014 Feb 4; 86 (86; 3; 2014 Feb 4):1887-93. [Full Text/Abstract]
Fairclough G, Fox J, Mercer G, Reuber M, Brown RJ. Understanding the perceived treatment needs of patients with psychogenic nonepileptic seizures. Epilepsy Behav. 2014 Feb; 31 (2014 Feb; 31):295-303. [Full Text/Abstract]
Brown RJ, Koutsoudakis G, Urbanowicz RA, Mirza D, Ginkel C, Riebesehl N, Calland N, Albecka A, Price L, Hudson N, Descamps V, Backx M, McClure CP, Duverlie G, Pecheur EI, Dubuisson J, Perez-del-Pulgar S, Forns X, Steinmann E, Tarr AW, Pietschmann T, Ball JK. Analysis of serine codon conservation reveals diverse phenotypic constraints on hepatitis C virus glycoprotein evolution. J Virol. 2014 Jan; 88 (2014 Jan; 1; 88):667-78. [Full Text/Abstract]
Lankford KL, Brown RJ, Sasaki M, Kocsis JD. Olfactory ensheathing cells, but not Schwann cells, proliferate and migrate extensively within moderately X-irradiated juvenile rat brain. Glia. 2014 Jan; 62 (2014 Jan; 62; 1):52-63. [Full Text/Abstract]
Kim YH, Kim KH, Ma CJ, Shon ZH, Park CG, Song SK, Ro CU, Brown RJ. An investigation into the relationship between the major chemical components of particulate matter in urban air. Chemosphere. 2014 Jan; 95 (95; 2014 Jan):387-94. [Full Text/Abstract]
Oram RA, Jones AG, Besser RE, Knight BA, Shields BM, Brown RJ, Hattersley AT, McDonald TJ. The majority of patients with long-duration type 1 diabetes are insulin microsecretors and have functioning beta cells. Diabetologia. 2014 Jan; 57 (2014 Jan; 1; 57):187-91. [Full Text/Abstract]
Edwards VC, McClure CP, Brown RJ, Thompson E, Irving WL, Ball JK. Use of short tandem repeat fingerprinting to validate sample origins in hepatitis C virus molecular epidemiology studies. J Gen Virol. 2014 Jan; 95 (95; Pt 1; 2014 Jan):66-70. [Full Text/Abstract]
Frentzen A, Anggakusuma, Gürlevik E, Hueging K, Knocke S, Ginkel C, Brown RJ, Heim M, Dill MT, Kröger A, Kalinke U, Kaderali L, Kuehnel F, Pietschmann T. Cell entry, efficient RNA replication, and production of infectious hepatitis C virus progeny in mouse liver-derived cells. Hepatology. 2014 Jan; 59 (2014 Jan; 59; 1):78-88. [Full Text/Abstract]
Singh K, Brown RJ. Health-related internet habits and health anxiety in university students. Anxiety Stress Coping. 2014 Sep; 27 (27; 5; 2014 Sep):542-54. [Full Text/Abstract]
Hamed MR, Brown RJ, Zothner C, Urbanowicz RA, Mason CP, Krarup A, McClure CP, Irving WL, Ball JK, Harris M, Hickling TP, Tarr AW. Recombinant human L-ficolin directly neutralizes hepatitis C virus entry. J Innate Immun. 2014; 6 (6; 2014; 5):676-84. [Full Text/Abstract]
Gorden P, Zadeh ES, Cochran E, Brown RJ. Syndromic insulin resistance: models for the therapeutic basis of the metabolic syndrome and other targets of insulin resistance. Endocr Pract. 2012 Sep-Oct; 18 (2012 Sep-Oct; 5; 18):763-71. [Full Text/Abstract]
Sylvetsky AC, Welsh JA, Brown RJ, Vos MB. Low-calorie sweetener consumption is increasing in the United States. Am J Clin Nutr. 2012 Sep; 96 (2012 Sep; 3; 96):640-6. [Full Text/Abstract]
Brown RJ, Rother KI. Non-nutritive sweeteners and their role in the gastrointestinal tract. J Clin Endocrinol Metab. 2012 Aug; 97 (2012 Aug; 8; 97):2597-605. [Full Text/Abstract]
Foreyt J, Kleinman R, Brown RJ, Lindstrom R. The use of low-calorie sweeteners by children: implications for weight management. J Nutr. 2012 Jun; 142 (2012 Jun; 6; 142):1155S-62S. [Full Text/Abstract]
Brown RJ, Walter M, Rother KI. Effects of diet soda on gut hormones in youths with diabetes. Diabetes Care. 2012 May; 35 (2012 May; 35; 5):959-64. [Full Text/Abstract]
Sylvetsky A, Rother KI, Brown R. Artificial sweetener use among children: epidemiology, recommendations, metabolic outcomes, and future directions. Pediatr Clin North Am. 2011 Dec; 58 (6; 58; 2011 Dec):1467-80, xi. [Full Text/Abstract]
Brown RJ, Wijewickrama RC, Harlan DM, Rother KI. Uncoupling intensive insulin therapy from weight gain and hypoglycemia in type 1 diabetes. Diabetes Technol Ther. 2011 Apr; 13 (2011 Apr; 4; 13):457-60. [Full Text/Abstract]
Brown RJ, Walter M, Rother KI. Ingestion of diet soda before a glucose load augments glucagon-like peptide-1 secretion. Diabetes Care. 2009 Dec; 32 (32; 12; 2009 Dec):2184-6. [Full Text/Abstract]
Rother KI, Brown RJ, Morales MM, Wright E, Duan Z, Campbell C, Hardin DS, Popovic J, McEvoy RC, Harlan DM, Orlander PR, Brod SA. Effect of ingested interferon-alpha on beta-cell function in children with new-onset type 1 diabetes. Diabetes Care. 2009 Jul; 32 (32; 7; 2009 Jul):1250-5. [Full Text/Abstract]
Brown RJ, Rother KI, Artman H, Mercurio MG, Wang R, Looney RJ, Cowen EW. Minocycline-induced drug hypersensitivity syndrome followed by multiple autoimmune sequelae. Arch Dermatol. 2009 Jan; 145 (145; 2009 Jan; 1):63-6. [Full Text/Abstract]
Brown RJ, Sinaii N, Rother KI. Too much glucagon, too little insulin: time course of pancreatic islet dysfunction in new-onset type 1 diabetes. Diabetes Care. 2008 Jul; 31 (7; 2008 Jul; 31):1403-4. [Full Text/Abstract]