U.S. Department of Health and Human Services
Reed Wickner

 Contact Info

Tel: 301-496-3452
Email: wickner@helix.nih.gov

 Select Experience

  • M.D.Georgetown University1966
  • B.A.Cornell University1962

 Related Links

  • Biophysics
  • Genetics/Genomics
  • Microbiology/Infectious diseases (non-viral)
  • Molecular Biology/Biochemistry
  • Prions


A selection of recent and significant publications can be viewed below.

Groveman BR, Dolan MA, Taubner LM, Kraus A, Wickner RB, Caughey B. Parallel In-register Intermolecular β-Sheet Architectures for Prion-seeded Prion Protein (PrP) Amyloids. J Biol Chem. 2014 Jul 15; 289 (35):24129-42. [Full Text/Abstract]
Edskes HK, Khamar HJ, Winchester CL, Greenler AJ, Zhou A, McGlinchey RP, Gorkovskiy A, Wickner RB. Sporadic Distribution of Prion-Forming Ability of Sup35p from Yeasts and Fungi. Genetics. 2014 Jul 31. [Full Text/Abstract]
Wickner RB, Bezsonov E, Bateman DA. Normal levels of the antiprion proteins Btn2 and Cur1 cure most newly formed [URE3] prion variants. Proc Natl Acad Sci U S A. 2014 Jul 1; 111 (26):E2711-20. [Full Text/Abstract]
Kelly AC, Busby B, Wickner RB. Effect of Domestication on the Spread of the [PIN+] Prion in Saccharomyces cerevisiae. Genetics. 2014 May 8; 197 (3):1007-1024. [Full Text/Abstract]
Kelly AC, Shewmaker FP, Kryndushkin D, Wickner RB. Sex, prions, and plasmids in yeast. Proc Natl Acad Sci U S A. 2012 Oct 2; 109 (40):E2683-90. [Full Text/Abstract]
Bateman DA, Wickner RB. [PSI+] Prion transmission barriers protect Saccharomyces cerevisiae from infection: intraspecies 'species barriers'. Genetics. 2012 Feb; 190 (2):569-79. [Full Text/Abstract]
McGlinchey RP, Kryndushkin D, Wickner RB. Suicidal [PSI+] is a lethal yeast prion. Proc Natl Acad Sci U S A. 2011 Mar 29; 108 (13):5337-41. [Full Text/Abstract]
Edskes HK, McCann LM, Hebert AM, Wickner RB. Prion variants and species barriers among Saccharomyces Ure2 proteins. Genetics. 2009 Mar; 181 (3):1159-67. [Full Text/Abstract]
Kryndushkin DS, Shewmaker F, Wickner RB. Curing of the [URE3] prion by Btn2p, a Batten disease-related protein. EMBO J. 2008 Oct 22; 27 (20):2725-35. [Full Text/Abstract]
Wickner RB, Shewmaker F, Kryndushkin D, Edskes HK. Protein inheritance (prions) based on parallel in-register beta-sheet amyloid structures. Bioessays. 2008 Oct; 30 (10):955-64. [Full Text/Abstract]
Shewmaker F, Ross ED, Tycko R, Wickner RB. Amyloids of shuffled prion domains that form prions have a parallel in-register beta-sheet structure. Biochemistry. 2008 Apr 1; 47 (13):4000-7. [Full Text/Abstract]
Wickner RB, Dyda F, Tycko R. Amyloid of Rnq1p, the basis of the [PIN+] prion, has a parallel in-register beta-sheet structure. Proc Natl Acad Sci U S A. 2008 Feb 19; 105 (7):2403-8. [Full Text/Abstract]
Baxa U, Wickner RB, Steven AC, Anderson DE, Marekov LN, Yau WM, Tycko R. Characterization of beta-sheet structure in Ure2p1-89 yeast prion fibrils by solid-state nuclear magnetic resonance. Biochemistry. 2007 Nov 13; 46 (45):13149-62. [Full Text/Abstract]
Ross ED, Minton A, Wickner RB. Prion domains: sequences, structures and interactions. Nat Cell Biol. 2005 Nov; 7 (11):1039-44. [Full Text/Abstract]
Brachmann A, Baxa U, Wickner RB. Prion generation in vitro: amyloid of Ure2p is infectious. EMBO J. 2005 Sep 7; 24 (17):3082-92. [Full Text/Abstract]
Ross ED, Edskes HK, Terry MJ, Wickner RB. Primary sequence independence for prion formation. Proc Natl Acad Sci U S A. 2005 Sep 6; 102 (36):12825-30. [Full Text/Abstract]
Nakayashiki T, Kurtzman CP, Edskes HK, Wickner RB. Yeast prions [URE3] and [PSI+] are diseases. Proc Natl Acad Sci U S A. 2005 Jul 26; 102 (30):10575-80. [Full Text/Abstract]
Pierce MM, Baxa U, Steven AC, Bax A, Wickner RB. Is the prion domain of soluble Ure2p unstructured?. Biochemistry. 2005 Jan 11; 44 (1):321-8. [Full Text/Abstract]
Wickner RB, Edskes HK, Ross ED, Pierce MM, Baxa U, Brachmann A, Shewmaker F. Prion genetics: new rules for a new kind of gene. Annu Rev Genet. 2004; 38 :681-707. [Full Text/Abstract]
Baxa U, Taylor KL, Steven AC, Wickner RB. Prions of Saccharomyces and Podospora. Contrib Microbiol. 2004; 11 :50-71. [Full Text/Abstract]