U.S. Department of Health and Human Services
Reed Wickner

 Contact Info

Tel: 301-496-3452
Email: wickner@helix.nih.gov

 Select Experience

  • M.D.Georgetown University1966
  • B.A.Cornell University1962

 Related Links



    • Biomedical Engineering/Biophysics/Physics
    • Genetics/Genomics
    • Microbiology/Infectious diseases (non-viral)
    • Molecular Biology/Biochemistry
    • Prions


    A selection of recent and significant publications can be viewed below.

    Kelly AC, Shewmaker FP, Kryndushkin D, Wickner RB. Sex, prions, and plasmids in yeast. Proc. Natl. Acad. Sci. U.S.A. 2012 Oct 2; 109:E2683-90. [Full Text/Abstract]
    Bateman DA, Wickner RB. [PSI+] Prion transmission barriers protect Saccharomyces cerevisiae from infection: intraspecies 'species barriers'. Genetics. 2012 Feb; 190:569-79. [Full Text/Abstract]
    McGlinchey RP, Kryndushkin D, Wickner RB. Suicidal [PSI+] is a lethal yeast prion. Proc. Natl. Acad. Sci. U.S.A. 2011 Mar 29; 108:5337-41. [Full Text/Abstract]
    Edskes HK, McCann LM, Hebert AM, Wickner RB. Prion variants and species barriers among Saccharomyces Ure2 proteins. Genetics. 2009 Mar; 181:1159-67. [Full Text/Abstract]
    Kryndushkin DS, Shewmaker F, Wickner RB. Curing of the [URE3] prion by Btn2p, a Batten disease-related protein. EMBO J. 2008 Oct 22; 27:2725-35. [Full Text/Abstract]
    Wickner RB, Shewmaker F, Kryndushkin D, Edskes HK. Protein inheritance (prions) based on parallel in-register beta-sheet amyloid structures. Bioessays. 2008 Oct; 30:955-64. [Full Text/Abstract]
    Shewmaker F, Ross ED, Tycko R, Wickner RB. Amyloids of shuffled prion domains that form prions have a parallel in-register beta-sheet structure. Biochemistry. 2008 Apr 1; 47:4000-7. [Full Text/Abstract]
    Wickner RB, Dyda F, Tycko R. Amyloid of Rnq1p, the basis of the [PIN+] prion, has a parallel in-register beta-sheet structure. Proc. Natl. Acad. Sci. U.S.A. 2008 Feb 19; 105:2403-8. [Full Text/Abstract]
    Baxa U, Wickner RB, Steven AC, Anderson DE, Marekov LN, Yau WM, Tycko R. Characterization of beta-sheet structure in Ure2p1-89 yeast prion fibrils by solid-state nuclear magnetic resonance. Biochemistry. 2007 Nov 13; 46:13149-62. [Full Text/Abstract]
    Ross ED, Minton A, Wickner RB. Prion domains: sequences, structures and interactions. Nat. Cell Biol. 2005 Nov; 7:1039-44. [Full Text/Abstract]
    Brachmann A, Baxa U, Wickner RB. Prion generation in vitro: amyloid of Ure2p is infectious. EMBO J. 2005 Sep 7; 24:3082-92. [Full Text/Abstract]
    Ross ED, Edskes HK, Terry MJ, Wickner RB. Primary sequence independence for prion formation. Proc. Natl. Acad. Sci. U.S.A. 2005 Sep 6; 102:12825-30. [Full Text/Abstract]
    Nakayashiki T, Kurtzman CP, Edskes HK, Wickner RB. Yeast prions [URE3] and [PSI+] are diseases. Proc. Natl. Acad. Sci. U.S.A. 2005 Jul 26; 102:10575-80. [Full Text/Abstract]
    Pierce MM, Baxa U, Steven AC, Bax A, Wickner RB. Is the prion domain of soluble Ure2p unstructured? Biochemistry. 2005 Jan 11; 44:321-8. [Full Text/Abstract]
    Wickner RB, Edskes HK, Ross ED, Pierce MM, Baxa U, Brachmann A, Shewmaker F. Prion genetics: new rules for a new kind of gene. Annu. Rev. Genet. 2004; 38:681-707. [Full Text/Abstract]
    Baxa U, Taylor KL, Steven AC, Wickner RB. Prions of Saccharomyces and Podospora. Contrib Microbiol. 2004; 11:50-71. [Full Text/Abstract]