U.S. Department of Health and Human Services
Richard Proia
 

 Contact Info

 
Tel: 301-496-4391
Email: proiar@mail.nih.gov
 

 Select Experience

 
  • Ph.D.University of Texas Southwestern Medical Center1980
  • B.S.Bates College1976
 

 Related Links

 

    Specialties
    • Cell Biology/Cell Signaling
    • Genetics/Genomics
    • Immunology
    • Molecular Biology/Biochemistry

    ​Research Images

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    TitleDescriptionImage
    S1P and the integrity of the skinPsoriasis and other skin diseases may be caused by disturbances in the balance between the growth and the differentiation of keratinocytes, the major cell type in the outer layer of skin. We have found that a lipid molecule called sphingosine-1-phosphate (S1P) plays a key role in controlling the differentiation of keratinocytes. Mice missing the gene controlling intracellular S1P concentrations suffered from stunted growth and thickened skin that was prone to peeling within the first few days of life (image to the right). Most of the mutant mice died, but the ones that survived had skin abnormalities—their keratinocytes had high concentrations of S1P, which enhanced keratinocyte differentiation. The findings suggest that manipulating S1P concentrations may be a way to alter the abnormal growth and differentiation of keratinocytes. This suggests that one possible treatment for psoriasis—a disorder in which there is a hyperproliferation of keratinocytes—might be to increase S1P concentrations. (M.L. Allende, L.M. Sipe, G. Tuymetova, K.L. Wilson-Henjum, W. Chen, and R.L. Proia; J Biol Chem 288:18381–18391, 2013)S1P and the integrity of the skinEnlarge