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Enlaces a nuestra información en español sobre la diabetes, enfermedades digestivas, enfermedades renales, control de peso, enfermedades urológicas, enfermedades endocrinas y metabólicas, y enfermedades hematológicas
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Patents, materials, and other research resources appear below. Some resources may be available for use through Material Transfer Agreements (MTAs) or licensing agreements.
A Sphingosine-1-phosphate Receptor-1 (S1pr1) knockout mouse
Sphingosine-1-phosphate (S1P) is a potent bioactive lipid that activates a family of G-protein coupled receptors, S1P1, S1P2, S1P3, S1P4 and S1P5. The S1P1 receptor is widely expressed and…
A Spingosine-1-phosphate Receptor-2 (S1pr2) knockout mouse.
Sphingosine-1-phosphate (S1P), a sphingolipid metabolite, activates cell signaling by interacting with a family of G-protein-coupled cell-surface S1P receptors that activate different and…
A Spingosine-1-phosphate Receptor-3 (S1pr3) knockout mouse.
A Sphingosine kinase 1 (Sphk1) knockout mouse.
Sphingosine kinase 1 and 2 are enzymes that produce sphingosine-1-phosphate (S1P), a potent bioactive compound that activates a family of G-protein coupled receptors known as S1P receptors. Triggering…
A conditional knockout mouse for S1pr1
Sphingosine-1-phosphate (S1P) is a potent bioactive lipid that activates a family of G-protein coupled receptors, S1P1, S1P2, S1P3, S1P4 and S1P5. The S1P1 receptor is widely expressed and has critical functions…
Gba-444 knock-in mice carrying the milder L444P Gaucher disease mutation (Gba-L444P mice) and the severe Gaucher disease mutation (Gba-L444P A456P mice).
Gba-L444P and Gba-L444P A456P mice, respectively, carry common gene mutations for milder or…
A knockout mouse for Sphingosine kinase 2 (Sphk2).
Sphingosine kinase 1 and 2 are enzymes that produce sphingosine-1-phosphate (S1P), a potent bioactive compound that activates a family of G-protein coupled receptors known as S1P receptors…
Open studies conducted by NIDDK Principal Investigators appear below that are currently recruiting, not yet recruiting, or available for expanded access.