U.S. Department of Health and Human Services
 

 Contact Info

 
Tel: 301-496-4201
Email: robertj@bdg10.niddk.nih.gov
 

 Select Experience

 
  • M.D.University of Chicago1964
  • B.S.Washington State University1960
 

 Related Links

 

    Robert T. Jensen, M.D.

    Senior Investigator, Digestive Disease BranchGastrointestinal Cell Biology Section
    Specialties
    • Cell Biology/Cell Signaling
    • Clinical Research
    • Molecular Pharmacology/Toxicology

    ​Publications

    A selection of recent and significant publications can be viewed below.

    Publications
    Di Florio A, Sancho V, Moreno P, Delle Fave G, Jensen RT. Gastrointestinal hormones stimulate growth of Foregut Neuroendocrine Tumors by transactivating the EGF receptor. Biochim. Biophys. Acta. 2013 Mar; 1833:573-82. [Full Text/Abstract]
    Uehara H, Hocart SJ, González N, Mantey SA, Nakagawa T, Katsuno T, Coy DH, Jensen RT. The molecular basis for high affinity of a universal ligand for human bombesin receptor (BnR) family members. Biochem. Pharmacol. 2012 Oct 1; 84:936-48. [Full Text/Abstract]
    Norton JA, Fraker DL, Alexander HR, Jensen RT. Value of surgery in patients with negative imaging and sporadic Zollinger-Ellison syndrome. Ann. Surg. 2012 Sep; 256:509-17. [Full Text/Abstract]
    Moody TW, Osefo N, Nuche-Berenguer B, Ridnour L, Wink D, Jensen RT. Pituitary adenylate cyclase-activating polypeptide causes tyrosine phosphorylation of the epidermal growth factor receptor in lung cancer cells. J. Pharmacol. Exp. Ther. 2012 Jun; 341:873-81. [Full Text/Abstract]
    Kulke MH, Anthony LB, Bushnell DL, de Herder WW, Goldsmith SJ, Klimstra DS, Marx SJ, Pasieka JL, Pommier RF, Yao JC, Jensen RT, North American Neuroendocrine Tumor Society (NANETS). NANETS treatment guidelines: well-differentiated neuroendocrine tumors of the stomach and pancreas. Pancreas. 2010 Aug; 39:735-52. [Full Text/Abstract]
    González N, Nakagawa T, Mantey SA, Sancho V, Uehara H, Katsuno T, Jensen RT. Molecular basis for the selectivity of the mammalian bombesin peptide, neuromedin B, for its receptor. J. Pharmacol. Exp. Ther. 2009 Oct; 331:265-76. [Full Text/Abstract]
    Hoffmann KM, Tapia JA, Berna MJ, Thill M, Braunschweig T, Mantey SA, Moody TW, Jensen RT. Gastrointestinal hormones cause rapid c-Met receptor down-regulation by a novel mechanism involving clathrin-mediated endocytosis and a lysosome-dependent mechanism. J. Biol. Chem. 2006 Dec 8; 281:37705-19. [Full Text/Abstract]
    Norton JA, Fraker DL, Alexander HR, Gibril F, Liewehr DJ, Venzon DJ, Jensen RT. Surgery increases survival in patients with gastrinoma. Ann. Surg. 2006 Sep; 244:410-9. [Full Text/Abstract]
    Moody TW, Sun LC, Mantey SA, Pradhan T, Mackey LV, Gonzales N, Fuselier JA, Coy DH, Jensen RT. In vitro and in vivo antitumor effects of cytotoxic camptothecin-bombesin conjugates are mediated by specific interaction with cellular bombesin receptors. J. Pharmacol. Exp. Ther. 2006 Sep; 318:1265-72. [Full Text/Abstract]
    Mantey SA, Coy DH, Entsuah LK, Jensen RT. Development of bombesin analogs with conformationally restricted amino acid substitutions with enhanced selectivity for the orphan receptor human bombesin receptor subtype 3. J. Pharmacol. Exp. Ther. 2004 Sep; 310:1161-70. [Full Text/Abstract]
    Moody TW, Mantey SA, Pradhan TK, Schumann M, Nakagawa T, Martinez A, Fuselier J, Coy DH, Jensen RT. Development of high affinity camptothecin-bombesin conjugates that have targeted cytotoxicity for bombesin receptor-containing tumor cells. J. Biol. Chem. 2004 May 28; 279:23580-9. [Full Text/Abstract]
    Tapia JA, García-Marin LJ, Jensen RT. Cholecystokinin-stimulated protein kinase C-delta kinase activation, tyrosine phosphorylation, and translocation are mediated by Src tyrosine kinases in pancreatic acinar cells. J. Biol. Chem. 2003 Sep 12; 278:35220-30. [Full Text/Abstract]
    Abou-Saif A, Gibril F, Ojeaburu JV, Bashir S, Entsuah LK, Asgharian B, Jensen RT. Prospective study of the ability of serial measurements of serum chromogranin A and gastrin to detect changes in tumor burden in patients with gastrinomas. Cancer. 2003 Jul 15; 98:249-61. [Full Text/Abstract]
    Pace A, García-Marin LJ, Tapia JA, Bragado MJ, Jensen RT. Phosphospecific site tyrosine phosphorylation of p125FAK and proline-rich kinase 2 is differentially regulated by cholecystokinin receptor type A activation in pancreatic acini. J. Biol. Chem. 2003 May 23; 278:19008-16. [Full Text/Abstract]
    Peghini PL, Annibale B, Azzoni C, Milione M, Corleto VD, Gibril F, Venzon DJ, Delle Fave G, Bordi C, Jensen RT. Effect of chronic hypergastrinemia on human enterochromaffin-like cells: insights from patients with sporadic gastrinomas. Gastroenterology. 2002 Jul; 123:68-85. [Full Text/Abstract]
    Tokita K, Hocart SJ, Coy DH, Jensen RT. Molecular basis of the selectivity of gastrin-releasing peptide receptor for gastrin-releasing peptide. Mol. Pharmacol. 2002 Jun; 61:1435-43. [Full Text/Abstract]
    Shojamanesh H, Gibril F, Louie A, Ojeaburu JV, Bashir S, Abou-Saif A, Jensen RT. Prospective study of the antitumor efficacy of long-term octreotide treatment in patients with progressive metastatic gastrinoma. Cancer. 2002 Jan 15; 94:331-43. [Full Text/Abstract]
    Jensen RT, Cadiot G, Brandi ML, de Herder WW, Kaltsas G, Komminoth P, Scoazec JY, Salazar R, Sauvanet A, Kianmanesh R, Barcelona Consensus Conference participants. ENETS Consensus Guidelines for the management of patients with digestive neuroendocrine neoplasms: functional pancreatic endocrine tumor syndromes. Neuroendocrinology. 2012; 95:98-119. [Full Text/Abstract]