Our goal is to find the causes and identify new and effective treatments to slow the progression or prevent the development of diabetic kidney disease.
Our lab has worked with the Pima Indians in Arizona since 1986, focusing primarily on the kidney complications of type 2 diabetes mellitus. Current activities include identifying biomarkers for diabetic kidney disease and characterizing the structural and functional changes within the kidneys that occur with the development and progression of diabetic kidney disease. Gene expression in kidney tissue and epigenetic modification of gene expression is also a major focus of our work.
Applying our Research
Diabetes is the leading cause of kidney disease worldwide and is a major cause of death and disability. New therapeutic options may reduce the frequency of this disease.
Need for Further Study
More studies are needed to understand the causes of diabetic kidney disease and to find more effective treatments.