U.S. Department of Health and Human Services
Robert Tycko
 

 Contact Info

 
Tel: 301-402-8272
Email: robertty@mail.nih.gov
 

 Select Experience

 
  • Senior InvestigatorLCP, NIDDK, NIH1994-present
  • Member of Technical Staff (Principal Investigator)Physical Chemistry Research Department, AT&T Bell Laboratories1986-1994
  • Postdoctoral ResearcherUniversity of Pennsylvania1984-1986
  • Ph.D.University of California at Berkeley1984
  • A.B.Princeton University1980
 

 Related Links

 

    Specialties
    • Biomedical Engineering/Biophysics/Physics

    ​Publications

    A selection of recent and significant publications can be viewed below.

    Publications
    Tycko R, Wickner RB. Molecular Structures of Amyloid and Prion Fibrils: Consensus versus Controversy. Acc. Chem. Res. 2013 Jul 16; 46:1487-96. [Full Text/Abstract]
    Thurber KR, Potapov A, Yau WM, Tycko R. Solid state nuclear magnetic resonance with magic-angle spinning and dynamic nuclear polarization below 25 K. J. Magn. Reson. 2013 Jan; 226:100-6. [Full Text/Abstract]
    Qiang W, Tycko R. Zero-quantum stochastic dipolar recoupling in solid state nuclear magnetic resonance. J Chem Phys. 2012 Sep 14; 137:104201. [Full Text/Abstract]
    Thurber KR, Tycko R. Theory for cross effect dynamic nuclear polarization under magic-angle spinning in solid state nuclear magnetic resonance: the importance of level crossings. J Chem Phys. 2012 Aug 28; 137:084508. [Full Text/Abstract]
    Qiang W, Yau WM, Luo Y, Mattson MP, Tycko R. Antiparallel β-sheet architecture in Iowa-mutant β-amyloid fibrils. Proc. Natl. Acad. Sci. U.S.A. 2012 Mar 20; 109:4443-8. [Full Text/Abstract]
    Chen B, Tycko R. Simulated self-assembly of the HIV-1 capsid: protein shape and native contacts are sufficient for two-dimensional lattice formation. Biophys. J. 2011 Jun 22; 100:3035-44. [Full Text/Abstract]
    Kryndushkin DS, Wickner RB, Tycko R. The core of Ure2p prion fibrils is formed by the N-terminal segment in a parallel cross-β structure: evidence from solid-state NMR. J. Mol. Biol. 2011 Jun 3; 409:263-77. [Full Text/Abstract]
    Qiang W, Yau WM, Tycko R. Structural evolution of Iowa mutant β-amyloid fibrils from polymorphic to homogeneous states under repeated seeded growth. J. Am. Chem. Soc. 2011 Mar 23; 133:4018-29. [Full Text/Abstract]
    Lu JX, Yau WM, Tycko R. Evidence from solid-state NMR for nonhelical conformations in the transmembrane domain of the amyloid precursor protein. Biophys. J. 2011 Feb 2; 100:711-9. [Full Text/Abstract]
    Tycko R, Savtchenko R, Ostapchenko VG, Makarava N, Baskakov IV. The α-helical C-terminal domain of full-length recombinant PrP converts to an in-register parallel β-sheet structure in PrP fibrils: evidence from solid state nuclear magnetic resonance. Biochemistry. 2010 Nov 9; 49:9488-97. [Full Text/Abstract]
    Lu JX, Sharpe S, Ghirlando R, Yau WM, Tycko R. Oligomerization state and supramolecular structure of the HIV-1 Vpu protein transmembrane segment in phospholipid bilayers. Protein Sci. 2010 Oct; 19:1877-96. [Full Text/Abstract]
    Thurber KR, Tycko R. Prospects for sub-micron solid state nuclear magnetic resonance imaging with low-temperature dynamic nuclear polarization. Phys Chem Chem Phys. 2010 Jun 14; 12:5779-85. [Full Text/Abstract]
    Chen B, Tycko R. Structural and dynamical characterization of tubular HIV-1 capsid protein assemblies by solid state nuclear magnetic resonance and electron microscopy. Protein Sci. 2010 Apr; 19:716-30. [Full Text/Abstract]
    Hu KN, Yau WM, Tycko R. Detection of a transient intermediate in a rapid protein folding process by solid-state nuclear magnetic resonance. J. Am. Chem. Soc. 2010 Jan 13; 132:24-5. [Full Text/Abstract]
    Hu KN, Havlin RH, Yau WM, Tycko R. Quantitative determination of site-specific conformational distributions in an unfolded protein by solid-state nuclear magnetic resonance. J. Mol. Biol. 2009 Oct 2; 392:1055-73. [Full Text/Abstract]
    Paravastu AK, Leapman RD, Yau WM, Tycko R. Molecular structural basis for polymorphism in Alzheimer's beta-amyloid fibrils. Proc. Natl. Acad. Sci. U.S.A. 2008 Nov 25; 105:18349-54. [Full Text/Abstract]
    Luca S, Yau WM, Leapman R, Tycko R. Peptide conformation and supramolecular organization in amylin fibrils: constraints from solid-state NMR. Biochemistry. 2007 Nov 27; 46:13505-22. [Full Text/Abstract]
    Tycko R. Symmetry-based constant-time homonuclear dipolar recoupling in solid state NMR. J Chem Phys. 2007 Feb 14; 126:064506. [Full Text/Abstract]
    Petkova AT, Leapman RD, Guo Z, Yau WM, Mattson MP, Tycko R. Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils. Science. 2005 Jan 14; 307:262-5. [Full Text/Abstract]