U.S. Department of Health and Human Services
Stoney Simons Jr

 Contact Info

Tel: 301-496-6796
Email: stoney.simons@nih.gov

 Select Experience

  • Postdoctoral FellowUniversity of California, San Francisco1972-1975
  • Ph.D.Harvard University1972
  • B.A.Princeton University1967

 Related Links



    • Cell Biology/Cell Signaling
    • Molecular Pharmacology/Toxicology


    A selection of recent and significant publications can be viewed below.

    Blackford JA Jr, Brimacombe KR, Dougherty EJ, Pradhan M, Shen M, Li Z, Auld DS, Chow CC, Austin CP, Simons SS Jr. Research Resource: Modulators of glucocorticoid receptor activity identified by a new high-throughput screening assay. Mol Endocrinol. 2014 Jul; 28 (7):me20141069. [Full Text/Abstract]
    Zhu R, Lu X, Pradhan M, Armstrong SP, Storchan GB, Chow CC, Simons SS Jr. A kinase-independent activity of cdk9 modulates glucocorticoid receptor-mediated gene induction. Biochemistry. 2014 Mar 25; 53 (11):1753-67. [Full Text/Abstract]
    Simons SS Jr, Edwards DP, Kumar R. Dynamic Structures of Nuclear Hormone Receptors: New Promises and Challenges. Mol Endocrinol. 2014 Feb; 28 (2):173-82. [Full Text/Abstract]
    Luo M, Lu X, Zhu R, Zhang Z, Chow CC, Li R, Simons SS Jr. A Conserved Protein Motif Is Required for Full Modulatory Activity of Negative Elongation Factor Subunits NELF-A and NELF-B in Modifying Glucocorticoid Receptor-regulated Gene Induction Properties. J Biol Chem. 2013 Nov 22; 288 (47):34055-72. [Full Text/Abstract]
    Simons SS Jr, Kumar R. Variable steroid receptor responses: Intrinsically disordered AF1 is the key. Mol Cell Endocrinol. 2013 Aug 25; 376 (1-2):81-4. [Full Text/Abstract]
    Lee GS, He Y, Dougherty EJ, Jimenez-Movilla M, Avella M, Grullon S, Sharlin DS, Guo C, Blackford JA Jr, Awasthi S, Zhang Z, Armstrong SP, London EC, Chen W, Dean J, Simons SS Jr. Disruption of Ttll5/stamp gene (tubulin tyrosine ligase-like protein 5/SRC-1 and TIF2-associated modulatory protein gene) in male mice causes sperm malformation and infertility. J Biol Chem. 2013 May 24; 288 (21):15167-80. [Full Text/Abstract]
    Zhang Z, Sun Y, Cho YW, Chow CC, Simons SS Jr. PA1 protein, a new competitive decelerator acting at more than one step to impede glucocorticoid receptor-mediated transactivation. J Biol Chem. 2013 Jan 4; 288 (1):42-58. [Full Text/Abstract]
    Khan SH, Awasthi S, Guo C, Goswami D, Ling J, Griffin PR, Simons SS Jr, Kumar R. Binding of the N-terminal region of coactivator TIF2 to the intrinsically disordered AF1 domain of the glucocorticoid receptor is accompanied by conformational reorganizations. J Biol Chem. 2012 Dec 28; 287 (53):44546-60. [Full Text/Abstract]
    Blackford JA Jr, Guo C, Zhu R, Dougherty EJ, Chow CC, Simons SS Jr. Identification of location and kinetically defined mechanism of cofactors and reporter genes in the cascade of steroid-regulated transactivation. J Biol Chem. 2012 Nov 30; 287 (49):40982-95. [Full Text/Abstract]
    Awasthi S, Simons SS Jr. Separate regions of glucocorticoid receptor, coactivator TIF2, and comodulator STAMP modify different parameters of glucocorticoid-mediated gene induction. Mol Cell Endocrinol. 2012 May 15; 355 (1):121-34. [Full Text/Abstract]
    Simons SS Jr, Chow CC. The road less traveled: new views of steroid receptor action from the path of dose-response curves. Mol Cell Endocrinol. 2012 Jan 30; 348 (2):373-82. [Full Text/Abstract]
    Dougherty EJ, Guo C, Simons SS Jr, Chow CC. Deducing the temporal order of cofactor function in ligand-regulated gene transcription: theory and experimental verification. PLoS One. 2012; 7 (1):e30225. [Full Text/Abstract]
    Lee GS, Simons SS Jr. Ligand binding domain mutations of the glucocorticoid receptor selectively modify the effects with, but not binding of, cofactors. Biochemistry. 2011 Jan 25; 50 (3):356-66. [Full Text/Abstract]
    Chow CC, Ong KM, Dougherty EJ, Simons SS Jr. Inferring mechanisms from dose-response curves. Methods Enzymol. 2011; 487 :465-83. [Full Text/Abstract]
    Simons SS Jr. Glucocorticoid receptor cofactors as therapeutic targets. Curr Opin Pharmacol. 2010 Dec; 10 (6):613-9. [Full Text/Abstract]
    Ong KM, Blackford JA Jr, Kagan BL, Simons SS Jr, Chow CC. A theoretical framework for gene induction and experimental comparisons. Proc Natl Acad Sci U S A. 2010 Apr 13; 107 (15):7107-12. [Full Text/Abstract]
    He Y, Blackford JA Jr, Kohn EC, Simons SS Jr. STAMP alters the growth of transformed and ovarian cancer cells. BMC Cancer. 2010 Apr 7; 10 :128. [Full Text/Abstract]
    Luo M, Simons SS Jr. Modulation of glucocorticoid receptor induction properties by cofactors in peripheral blood mononuclear cells. Hum Immunol. 2009 Oct; 70 (10):785-9. [Full Text/Abstract]
    Ronacher K, Hadley K, Avenant C, Stubsrud E, Simons SS Jr, Louw A, Hapgood JP. Ligand-selective transactivation and transrepression via the glucocorticoid receptor: role of cofactor interaction. Mol Cell Endocrinol. 2009 Feb 27; 299 (2):219-31. [Full Text/Abstract]
    Simons SS Jr. What goes on behind closed doors: physiological versus pharmacological steroid hormone actions. Bioessays. 2008 Aug; 30 (8):744-56. [Full Text/Abstract]
    Tao YG, Xu Y, Xu HE, Simons SS Jr. Mutations of glucocorticoid receptor differentially affect AF2 domain activity in a steroid-selective manner to alter the potency and efficacy of gene induction and repression. Biochemistry. 2008 Jul 22; 47 (29):7648-62. [Full Text/Abstract]
    Suino-Powell K, Xu Y, Zhang C, Tao YG, Tolbert WD, Simons SS Jr, Xu HE. Doubling the size of the glucocorticoid receptor ligand binding pocket by deacylcortivazol. Mol Cell Biol. 2008 Mar; 28 (6):1915-23. [Full Text/Abstract]
    Szapary D, Song LN, He Y, Simons SS Jr. Differential modulation of glucocorticoid and progesterone receptor transactivation. Mol Cell Endocrinol. 2008 Feb 13; 283 (1-2):114-26. [Full Text/Abstract]
    Wang D, Wang Q, Awasthi S, Simons SS Jr. Amino-terminal domain of TIF2 is involved in competing for corepressor binding to glucocorticoid and progesterone receptors. Biochemistry. 2007 Jul 10; 46 (27):8036-49. [Full Text/Abstract]
    He Y, Simons SS Jr. STAMP, a novel predicted factor assisting TIF2 actions in glucocorticoid receptor-mediated induction and repression. Mol Cell Biol. 2007 Feb; 27 (4):1467-85. [Full Text/Abstract]
    Kim Y, Sun Y, Chow C, Pommier YG, Simons SS Jr. Effects of acetylation, polymerase phosphorylation, and DNA unwinding in glucocorticoid receptor transactivation. J Steroid Biochem Mol Biol. 2006 Jul; 100 (1-3):3-17. [Full Text/Abstract]
    Simons SS Jr. How much is enough? Modulation of dose-response curve for steroid receptor-regulated gene expression by changing concentrations of transcription factor. Curr Top Med Chem. 2006; 6 (3):271-85. [Full Text/Abstract]
    Wang D, Simons SS Jr. Corepressor binding to progesterone and glucocorticoid receptors involves the activation function-1 domain and is inhibited by molybdate. Mol Endocrinol. 2005 Jun; 19 (6):1483-500. [Full Text/Abstract]
    Cho S, Blackford JA Jr, Simons SS Jr. Role of activation function domain-1, DNA binding, and coactivator GRIP1 in the expression of partial agonist activity of glucocorticoid receptor-antagonist complexes. Biochemistry. 2005 Mar 8; 44 (9):3547-61. [Full Text/Abstract]
    Cho S, Kagan BL, Blackford JA Jr, Szapary D, Simons SS Jr. Glucocorticoid receptor ligand binding domain is sufficient for the modulation of glucocorticoid induction properties by homologous receptors, coactivator transcription intermediary factor 2, and Ubc9. Mol Endocrinol. 2005 Feb; 19 (2):290-311. [Full Text/Abstract]