U.S. Department of Health and Human Services
Stephen Marx

 Contact Info

Tel: +1 301 496 5051
Email: marxs@mail.nih.gov

 Training and Experience

M.D., Johns Hopkins University, 1968

B.A., Yale University, 1964

 Related Links



    Stephen J. Marx, M.D.

    Senior Investigator, Metabolic Diseases BranchGenetics and Endocrinology Section
    Specialties: Genetics/Genomics, Endocrinology

    Research Summary

    Current Research​

    The Genetics and Endocrinology Section studies the genetic bases of primary hyperparathyroidism and its relations to other neoplastic disorders. We have cloned the gene for multiple endocrine neoplasia type 1 and found that it is implicated in many nonhereditary tumors. This tumor suppressor gene encodes a novel protein, menin. We are studying the actions of menin protein by yeast two-hybrid, microarray, knockout, and other approaches. We have identified an important interaction of menin with junD, a nuclear transcription factor.