U.S. Department of Health and Human Services
Sunita Agarwal

 Contact Info

Tel: 301-402-7834
Email: sunitaa@mail.nih.gov

 Select Experience

  • Staff ScientistNIDDK, NIH1999-2008
  • Postdoctoral FellowNIDDK, NIH1995-1999
  • Postdoctoral FellowUniversity of Delaware1992-1995
  • Visiting FellowUniversity of Delaware1991-1992
  • Ph.D.Bombay University1991
  • M.Sc.Bombay University1985

 Related Links


Sunita K. Agarwal, Ph.D.

Chief, Metabolic Diseases BranchGene Regulation Unit
  • Cancer Biology


A selection of recent and significant publications can be viewed below.

Modali SD, Parekh VI, Kebebew E, Agarwal SK. Epigenetic Regulation of the lncRNA MEG3 and Its Target c-MET in Pancreatic Neuroendocrine Tumors. Mol Endocrinol. 2015 Jan 7; 29 (2015 Jan 7; 2; 29):224-237. [Full Text/Abstract]
Desai SS, Modali SD, Parekh VI, Kebebew E, Agarwal SK. GSK-3β protein phosphorylates and stabilizes HLXB9 protein in insulinoma cells to form a targetable mechanism of controlling insulinoma cell proliferation. J Biol Chem. 2014 Feb 28; 289 (2014 Feb 28; 289; 9):5386-98. [Full Text/Abstract]
Agarwal SK. Exploring the tumors of multiple endocrine neoplasia type 1 in mouse models for basic and preclinical studies. Int J Endocr Oncol. 2014; 1 (2; 2014; 1):153-161. [Full Text/Abstract]
Costa-Guda J, Soong CP, Parekh VI, Agarwal SK, Arnold A. Germline and Somatic Mutations in Cyclin-Dependent Kinase Inhibitor Genes CDKN1A, CDKN2B, and CDKN2C in Sporadic Parathyroid Adenomas. Horm Cancer. 2013 Oct; 4 (2013 Oct; 4; 5):301-7. [Full Text/Abstract]
Shi K, Parekh VI, Roy S, Desai SS, Agarwal SK. The embryonic transcription factor Hlxb9 is a menin interacting partner that controls pancreatic β-cell proliferation and the expression of insulin regulators. Endocr Relat Cancer. 2013 Feb; 20 (20; 2013 Feb; 1):111-22. [Full Text/Abstract]
Agarwal SK. Multiple endocrine neoplasia type 1. Front Horm Res. 2013; 41 (41; 2013):1-15. [Full Text/Abstract]
Agarwal SK, Jothi R. Genome-wide characterization of menin-dependent H3K4me3 reveals a specific role for menin in the regulation of genes implicated in MEN1-like tumors. PLoS One. 2012; 7 (2012; 7; 5):e37952. [Full Text/Abstract]
Wang Y, Ozawa A, Zaman S, Prasad NB, Chandrasekharappa SC, Agarwal SK, Marx SJ. The tumor suppressor protein menin inhibits AKT activation by regulating its cellular localization. Cancer Res. 2011 Jan 15; 71 (71; 2; 2011 Jan 15):371-82. [Full Text/Abstract]
Agarwal SK, Mateo CM, Marx SJ. Rare germline mutations in cyclin-dependent kinase inhibitor genes in multiple endocrine neoplasia type 1 and related states. J Clin Endocrinol Metab. 2009 May; 94 (94; 5; 2009 May):1826-34. [Full Text/Abstract]
Agarwal SK, Ozawa A, Mateo CM, Marx SJ. The MEN1 gene and pituitary tumours. Horm Res. 2009 Apr; 71 Suppl 2 (2009 Apr; 71 Suppl 2):131-8. [Full Text/Abstract]
Shen HC, Rosen JE, Yang LM, Savage SA, Burns AL, Mateo CM, Agarwal SK, Chandrasekharappa SC, Spiegel AM, Collins FS, Marx SJ, Libutti SK. Parathyroid tumor development involves deregulation of homeobox genes. Endocr Relat Cancer. 2008 Mar; 15 (2008 Mar; 15; 1):267-75. [Full Text/Abstract]
Ji Y, Prasad NB, Novotny EA, Kaur S, Elkahloun A, Chen Y, Zhang RZ, Chu ML, Agarwal SK, Marx SJ, Collins FS, Chandrasekharappa SC. Mouse embryo fibroblasts lacking the tumor suppressor menin show altered expression of extracellular matrix protein genes. Mol Cancer Res. 2007 Oct; 5 (2007 Oct; 10; 5):1041-51. [Full Text/Abstract]
Ozawa A, Agarwal SK, Mateo CM, Burns AL, Rice TS, Kennedy PA, Quigley CM, Simonds WF, Weinstein LS, Chandrasekharappa SC, Collins FS, Spiegel AM, Marx SJ. The parathyroid/pituitary variant of multiple endocrine neoplasia type 1 usually has causes other than p27Kip1 mutations. J Clin Endocrinol Metab. 2007 May; 92 (2007 May; 92; 5):1948-51. [Full Text/Abstract]
Agarwal SK, Impey S, McWeeney S, Scacheri PC, Collins FS, Goodman RH, Spiegel AM, Marx SJ. Distribution of menin-occupied regions in chromatin specifies a broad role of menin in transcriptional regulation. Neoplasia. 2007 Feb; 9 (2; 9; 2007 Feb):101-7. [Full Text/Abstract]
Scacheri PC, Davis S, Odom DT, Crawford GE, Perkins S, Halawi MJ, Agarwal SK, Marx SJ, Spiegel AM, Meltzer PS, Collins FS. Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis. PLoS Genet. 2006 Apr; 2 (2; 4; 2006 Apr):e51. [Full Text/Abstract]
Agarwal SK, Kennedy PA, Scacheri PC, Novotny EA, Hickman AB, Cerrato A, Rice TS, Moore JB, Rao S, Ji Y, Mateo C, Libutti SK, Oliver B, Chandrasekharappa SC, Burns AL, Collins FS, Spiegel AM, Marx SJ. Menin molecular interactions: insights into normal functions and tumorigenesis. Horm Metab Res. 2005 Jun; 37 (6; 2005 Jun; 37):369-74. [Full Text/Abstract]
Simonds WF, Robbins CM, Agarwal SK, Hendy GN, Carpten JD, Marx SJ. Familial isolated hyperparathyroidism is rarely caused by germline mutation in HRPT2, the gene for the hyperparathyroidism-jaw tumor syndrome. J Clin Endocrinol Metab. 2004 Jan; 89 (2004 Jan; 1; 89):96-102. [Full Text/Abstract]
Obungu VH, Lee Burns A, Agarwal SK, Chandrasekharapa SC, Adelstein RS, Marx SJ. Menin, a tumor suppressor, associates with nonmuscle myosin II-A heavy chain. Oncogene. 2003 Sep 25; 22 (2003 Sep 25; 41; 22):6347-58. [Full Text/Abstract]
Agarwal SK, Novotny EA, Crabtree JS, Weitzman JB, Yaniv M, Burns AL, Chandrasekharappa SC, Collins FS, Spiegel AM, Marx SJ. Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoter. Proc Natl Acad Sci U S A. 2003 Sep 16; 100 (100; 19; 2003 Sep 16):10770-5. [Full Text/Abstract]
Carpten JD, Robbins CM, Villablanca A, Forsberg L, Presciuttini S, Bailey-Wilson J, Simonds WF, Gillanders EM, Kennedy AM, Chen JD, Agarwal SK, Sood R, Jones MP, Moses TY, Haven C, Petillo D, Leotlela PD, Harding B, Cameron D, Pannett AA, Höög A, Heath H 3rd, James-Newton LA, Robinson B, Zarbo RJ, Cavaco BM, Wassif W, Perrier ND, Rosen IB, Kristoffersson U, Turnpenny PD, Farnebo LO, Besser GM, Jackson CE, Morreau H, Trent JM, Thakker RV, Marx SJ, Teh BT, Larsson C, Hobbs MR. HRPT2, encoding parafibromin, is mutated in hyperparathyroidism-jaw tumor syndrome. Nat Genet. 2002 Dec; 32 (32; 4; 2002 Dec):676-80. [Full Text/Abstract]