U.S. Department of Health and Human Services
Theo Heller

 Contact Info

Tel: 301-402-7147
Email: theoh@intra.niddk.nih.gov

 Select Experience

  • Hepatology FellowshipLDB, NIDDK, NIH2003
  • Gastroenterology and Hepatology FellowshipUniversity of Maryland Medical Systems2000
  • Postdoctoral FellowshipHepatitis Viruses Section, NIAID1997
  • Internal Medicine ResidencyGeorgetown University Hospital1993
  • M.D.University of the Witwatersrand1989
  • B.S.University of Cape Town1983

 Related Links


Theo Heller, M.D.

Investigator, Liver Diseases BranchTranslational Hepatology Unit
  • Clinical Research
  • Translational Research


A selection of recent and significant publications can be viewed below.

Alimchandani M, Lai JP, Aung PP, Khangura S, Kamal N, Gallin JI, Holland SM, Malech HL, Heller T, Miettinen M, Quezado MM. Gastrointestinal Histopathology in Chronic Granulomatous Disease: A Study of 87 Patients. Am. J. Surg. Pathol. 2013 Jul 24. [Full Text/Abstract]
Koh C, Turner T, Zhao X, Minniti CP, Feld JJ, Simpson J, Demino M, Conrey AK, Jackson MJ, Seamon C, Kleiner DE, Kato GJ, Heller T. Liver stiffness increases acutely during sickle cell vaso-occlusive crisis. Am. J. Hematol. 2013 Jul 5. [Full Text/Abstract]
Safar Zadeh E, Lungu AO, Cochran EK, Brown RJ, Ghany MG, Heller T, Kleiner DE, Gorden P. The liver diseases of lipodystrophy: the long-term effect of leptin treatment. J. Hepatol. 2013 Jul; 59:131-7. [Full Text/Abstract]
Heller T, Werner JM, Rahman F, Mizukoshi E, Sobao Y, Gordon AM, Sheets A, Sherker AH, Kessler E, Bean KS, Herrine SK, Stevens M, Schmitt J, Rehermann B. Occupational Exposure to Hepatitis C Virus: Early T-Cell Responses in the Absence of Seroconversion in a Longitudinal Cohort Study. J. Infect. Dis. 2013 Jun 28. [Full Text/Abstract]
Hsu AP, Sowerwine KJ, Lawrence MG, Davis J, Henderson CJ, Zarember KA, Garofalo M, Gallin JI, Kuhns DB, Heller T, Milner JD, Puck JM, Freeman AF, Holland SM. Intermediate phenotypes in patients with autosomal dominant hyper-IgE syndrome caused by somatic mosaicism. J. Allergy Clin. Immunol. 2013 Jun; 131:1586-93. [Full Text/Abstract]
Alvarez-Downing MM, Kamal N, Inchauste SM, Khangura SK, Malech HL, Holland SM, Hughes MS, Heller T, Sherry RM. The role of surgery in the management of patients with refractory chronic granulomatous disease colitis. Dis. Colon Rectum. 2013 May; 56:609-14. [Full Text/Abstract]
Hara K, Rivera MM, Koh C, Sakiani S, Hoofnagle JH, Heller T. Important factors in reliable determination of hepatitis C virus genotype by use of the 5' untranslated region. J. Clin. Microbiol. 2013 May; 51:1485-9. [Full Text/Abstract]
Fuss IJ, Friend J, Yang Z, He JP, Hooda L, Boyer J, Xi L, Raffeld M, Kleiner DE, Heller T, Strober W. Nodular regenerative hyperplasia in common variable immunodeficiency. J. Clin. Immunol. 2013 May; 33:748-58. [Full Text/Abstract]
Langan RC, Sherry RM, Avital I, Heller T, Henderson C, Holland SM, Freeman AF, Rudloff U. Safety of major abdominal surgical procedures in patients with hyperimmunoglobulinemia E (Job's syndrome): a changing paradigm? J. Gastrointest. Surg. 2013 May; 17:1009-14. [Full Text/Abstract]
Kamal N, Chen C, Ling A, O'Donnell T, Heller T. Goodness gracious great balls of fire. BMJ Case Rep. 2013 Mar 15; 2013. [Full Text/Abstract]
Werner JM, Heller T, Gordon AM, Sheets A, Sherker AH, Kessler E, Bean KS, Stevens M, Schmitt J, Rehermann B. Innate immune responses in hepatitis C virus exposed healthcare workers who do not develop acute infection. Hepatology. 2013 Mar 5. [Full Text/Abstract]
Tana MM, Heller T. Autoantibodies in hepatitis C: red flag or bystander effect? J. Pediatr. Gastroenterol. Nutr. 2013 Mar; 56:243. [Full Text/Abstract]
Rotman Y, Noureddin M, Feld JJ, Guedj J, Witthaus M, Han H, Park YJ, Park SH, Heller T, Ghany MG, Doo E, Koh C, Abdalla A, Gara N, Sarkar S, Thomas E, Ahlenstiel G, Edlich B, Titerence R, Hogdal L, Rehermann B, Dahari H, Perelson AS, Hoofnagle JH, Liang TJ. Effect of ribavirin on viral kinetics and liver gene expression in chronic hepatitis C. Gut. 2013 Feb 8. [Full Text/Abstract]
Oppenheimer AP, Koh C, McLaughlin M, Williamson JC, Norton TD, Laudadio J, Heller T, Kleiner DE, High KP, Morse CG. Vanishing bile duct syndrome in human immunodeficiency virus infected adults: a report of two cases. World J. Gastroenterol. 2013 Jan 7; 19:115-21. [Full Text/Abstract]
Fricker Z, Levy E, Kleiner D, Taylor JG 6th, Koh C, Holland SM, Heller T. Case series: biliary leak after transjugular liver biopsy. Am. J. Gastroenterol. 2013 Jan; 108:145-7. [Full Text/Abstract]
Gunay-Aygun M, Font-Montgomery E, Lukose L, Tuchman Gerstein M, Piwnica-Worms K, Choyke P, Daryanani KT, Turkbey B, Fischer R, Bernardini I, Sincan M, Zhao X, Sandler NG, Roque A, Douek DC, Graf J, Huizing M, Bryant JC, Mohan P, Gahl WA, Heller T. Characteristics of congenital hepatic fibrosis in a large cohort of patients with autosomal recessive polycystic kidney disease. Gastroenterology. 2013 Jan; 144:112-121.e2. [Full Text/Abstract]
Eccleston JL, Koh C, Markello TC, Gahl WA, Heller T. An apparent homozygous deletion in maltase-glucoamylase, a lesson in the evolution of SNP arrays. Mol. Genet. Metab. 2012 Dec; 107:674-8. [Full Text/Abstract]
Fan X, Upadhyaya B, Wu L, Koh C, Santín-Durán M, Pittaluga S, Uzel G, Kleiner D, Williams E, Ma CA, Bodansky A, Oliveira JB, Edmonds P, Hornung R, Wong DW, Fayer R, Fleisher T, Heller T, Prussin C, Jain A. CD40 agonist antibody mediated improvement of chronic Cryptosporidium infection in patients with X-linked hyper IgM syndrome. Clin. Immunol. 2012 May; 143:152-61. [Full Text/Abstract]
Leiding JW, Freeman AF, Marciano BE, Anderson VL, Uzel G, Malech HL, DeRavin S, Wilks D, Venkatesan AM, Zerbe CS, Heller T, Holland SM. Corticosteroid therapy for liver abscess in chronic granulomatous disease. Clin. Infect. Dis. 2012 Mar 1; 54:694-700. [Full Text/Abstract]
Kandiah E, Watts NR, Cheng N, Cardone G, Stahl SJ, Heller T, Liang TJ, Wingfield PT, Steven AC. Cryo-EM study of Hepatitis B virus core antigen capsids decorated with antibodies from a human patient. J. Struct. Biol. 2012 Jan; 177:145-51. [Full Text/Abstract]
O'Brien K, Font-Montgomery E, Lukose L, Bryant J, Piwnica-Worms K, Edwards H, Riney L, Garcia A, Daryanani K, Choyke P, Mohan P, Heller T, Gahl WA, Gunay-Aygun M. Congenital hepatic fibrosis and portal hypertension in autosomal dominant polycystic kidney disease. J. Pediatr. Gastroenterol. Nutr. 2012 Jan; 54:83-9. [Full Text/Abstract]
Gunay-Aygun M, Turkbey BI, Bryant J, Daryanani KT, Gerstein MT, Piwnica-Worms K, Choyke P, Heller T, Gahl WA. Hepatorenal findings in obligate heterozygotes for autosomal recessive polycystic kidney disease. Mol. Genet. Metab. 2011 Dec; 104:677-81. [Full Text/Abstract]
Sandler NG, Koh C, Roque A, Eccleston JL, Siegel RB, Demino M, Kleiner DE, Deeks SG, Liang TJ, Heller T, Douek DC. Host response to translocated microbial products predicts outcomes of patients with HBV or HCV infection. Gastroenterology. 2011 Oct; 141:1220-30, 1230.e1-3. [Full Text/Abstract]
Noureddin M, Kleiner DE, Gharib AM, Bratslavsky G, Heller T. To resect or not to resect? That is the question. Telangiectatic adenoma. Gut. 2011 Sep; 60:1177, 1235. [Full Text/Abstract]
Arora M, Uzel G, Shea YR, Kleiner DE, Holland SM, Heller T. GI involvement in disseminated Mycobacterium genavense: endoscopy and histology. Gastrointest. Endosc. 2011 Sep; 74:688-90. [Full Text/Abstract]
Shin EC, Park SH, Demino M, Nascimbeni M, Mihalik K, Major M, Veerapu NS, Heller T, Feinstone SM, Rice CM, Rehermann B. Delayed induction, not impaired recruitment, of specific CD8⁺ T cells causes the late onset of acute hepatitis C. Gastroenterology. 2011 Aug; 141:686-95, 695.e1. [Full Text/Abstract]
Weinstein DH, Childs R, Heller T. Giant duodenal ectasia. Clin. Gastroenterol. Hepatol. 2011 Jun; 9:A24. [Full Text/Abstract]
Feld JJ, Modi AA, El-Diwany R, Rotman Y, Thomas E, Ahlenstiel G, Titerence R, Koh C, Cherepanov V, Heller T, Ghany MG, Park Y, Hoofnagle JH, Liang TJ. S-adenosyl methionine improves early viral responses and interferon-stimulated gene induction in hepatitis C nonresponders. Gastroenterology. 2011 Mar; 140:830-9. [Full Text/Abstract]
Veerapu NS, Raghuraman S, Liang TJ, Heller T, Rehermann B. Sporadic reappearance of minute amounts of hepatitis C virus RNA after successful therapy stimulates cellular immune responses. Gastroenterology. 2011 Feb; 140:676-685.e1. [Full Text/Abstract]
Kuhns DB, Alvord WG, Heller T, Feld JJ, Pike KM, Marciano BE, Uzel G, DeRavin SS, Priel DA, Soule BP, Zarember KA, Malech HL, Holland SM, Gallin JI. Residual NADPH oxidase and survival in chronic granulomatous disease. N. Engl. J. Med. 2010 Dec 30; 363:2600-10. [Full Text/Abstract]