U.S. Department of Health and Human Services
Wei Yang

 Contact Info

Tel: +1 301 402 4645
Email: weiy@mail.nih.gov

 Training and Experience

Ph.D., Columbia University, 1991

M.A., Columbia University, 1985

B.A., State University of New York at Stony Brook, 1985

B.A., State University of New York at Stony Brook, 1983

 Related Links

Specialties: Cancer Biology, Molecular Biology/Biochemistry, Chromosome Biology/Epigenetics, Structural Biology


A selection of recent and significant publications can be viewed below.

Lapkouski M, Tian L, Miller JT, Le Grice SF, Yang W. Complexes of HIV-1 RT, NNRTI and RNA/DNA hybrid reveal a structure compatible with RNA degradation. Nat. Struct. Mol. Biol. 2013 Feb; 20 (20; 2; 2013 Feb):230-6. [Full Text/Abstract]
Nakamura T, Zhao Y, Yamagata Y, Hua YJ, Yang W. Watching DNA polymerase η make a phosphodiester bond. Nature. 2012 Jul 11; 487 (7406; 2012 Jul 11; 487):196-201. [Full Text/Abstract]
Zhao Y, Biertümpfel C, Gregory MT, Hua YJ, Hanaoka F, Yang W. Structural basis of human DNA polymerase η-mediated chemoresistance to cisplatin. Proc. Natl. Acad. Sci. U.S.A. 2012 May 8; 109 (109; 19; 2012 May 8):7269-74. [Full Text/Abstract]
Gupta S, Gellert M, Yang W. Mechanism of mismatch recognition revealed by human MutSβ bound to unpaired DNA loops. Nat. Struct. Mol. Biol. 2011 Dec 18; 19 (2011 Dec 18; 19; 1):72-8. [Full Text/Abstract]
Yang W. Nucleases: diversity of structure, function and mechanism. Q. Rev. Biophys. 2011 Feb; 44 (2011 Feb; 44; 1):1-93. [Full Text/Abstract]
Yang W. Topoisomerases and site-specific recombinases: similarities in structure and mechanism. Crit. Rev. Biochem. Mol. Biol. 2010 Dec; 45 (6; 2010 Dec; 45):520-34. [Full Text/Abstract]
Biertümpfel C, Zhao Y, Kondo Y, Ramón-Maiques S, Gregory M, Lee JY, Masutani C, Lehmann AR, Hanaoka F, Yang W. Structure and mechanism of human DNA polymerase eta. Nature. 2010 Jun 24; 465 (7301; 465; 2010 Jun 24):1044-8. [Full Text/Abstract]
Wang F, Yang W. Structural insight into translesion synthesis by DNA Pol II. Cell. 2009 Dec 24; 139 (7; 139; 2009 Dec 24):1279-89. [Full Text/Abstract]
Grundy GJ, Ramón-Maiques S, Dimitriadis EK, Kotova S, Biertümpfel C, Heymann JB, Steven AC, Gellert M, Yang W. Initial stages of V(D)J recombination: the organization of RAG1/2 and RSS DNA in the postcleavage complex. Mol. Cell. 2009 Jul 31; 35 (2009 Jul 31; 35; 2):217-27. [Full Text/Abstract]
Yang W. An equivalent metal ion in one- and two-metal-ion catalysis. Nat. Struct. Mol. Biol. 2008 Nov; 15 (15; 2008 Nov; 11):1228-31. [Full Text/Abstract]
Nowotny M, Cerritelli SM, Ghirlando R, Gaidamakov SA, Crouch RJ, Yang W. Specific recognition of RNA/DNA hybrid and enhancement of human RNase H1 activity by HBD. EMBO J. 2008 Apr 9; 27 (2008 Apr 9; 7; 27):1172-81. [Full Text/Abstract]
Yang W. Structure and mechanism for DNA lesion recognition. Cell Res. 2008 Jan; 18 (2008 Jan; 1; 18):184-97. [Full Text/Abstract]