U.S. Department of Health and Human Services
William Simonds

 Contact Info

Tel: 301-496-9299
Email: wfs@helix.nih.gov

 Select Experience

  • M.D.University of Pittsburgh School of Medicine1981
  • B.S.University of Pittsburgh College of Arts and Sciences1975

 Related Links


    • Cancer Biology
    • Cell Biology/Cell Signaling
    • Endocrinology


    A selection of recent and significant publications can be viewed below.

    Simonds WF, Varghese S, Marx SJ, Nieman LK. Cushing's syndrome in multiple endocrine neoplasia type 1. Clin Endocrinol (Oxf). 2012 Mar; 76 (76; 2012 Mar; 3):379-86. [Full Text/Abstract]
    Zhang JH, Pandey M, Seigneur EM, Panicker LM, Koo L, Schwartz OM, Chen W, Chen CK, Simonds WF. Knockout of G protein β5 impairs brain development and causes multiple neurologic abnormalities in mice. J Neurochem. 2011 Nov; 119 (2011 Nov; 119; 3):544-54. [Full Text/Abstract]
    Sharretts JM, Kebebew E, Simonds WF. Parathyroid cancer. Semin Oncol. 2010 Dec; 37 (6; 2010 Dec; 37):580-90. [Full Text/Abstract]
    Sharretts JM, Simonds WF. Clinical and molecular genetics of parathyroid neoplasms. Best Pract Res Clin Endocrinol Metab. 2010 Jun; 24 (2010 Jun; 3; 24):491-502. [Full Text/Abstract]
    Panicker LM, Zhang JH, Posokhova E, Gastinger MJ, Martemyanov KA, Simonds WF. Nuclear localization of the G protein beta 5/R7-regulator of G protein signaling protein complex is dependent on R7 binding protein. J Neurochem. 2010 Jun; 113 (113; 2010 Jun; 5):1101-12. [Full Text/Abstract]
    Panicker LM, Zhang JH, Dagur PK, Gastinger MJ, Simonds WF. Defective nucleolar localization and dominant interfering properties of a parafibromin L95P missense mutant causing the hyperparathyroidism-jaw tumor syndrome. Endocr Relat Cancer. 2010 Jun; 17 (2010 Jun; 2; 17):513-24. [Full Text/Abstract]
    Lin L, Zhang JH, Panicker LM, Simonds WF. The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene. Proc Natl Acad Sci U S A. 2008 Nov 11; 105 (105; 2008 Nov 11; 45):17420-5. [Full Text/Abstract]
    Marx SJ, Simonds WF. Hereditary hormone excess: genes, molecular pathways, and syndromes. Endocr Rev. 2005 Aug; 26 (5; 26; 2005 Aug):615-61. [Full Text/Abstract]
    Simonds WF, Woodard GE, Zhang JH. Assays of nuclear localization of R7/Gbeta5 complexes. Methods Enzymol. 2004; 390 (390; 2004):210-23. [Full Text/Abstract]
    Simonds WF, Robbins CM, Agarwal SK, Hendy GN, Carpten JD, Marx SJ. Familial isolated hyperparathyroidism is rarely caused by germline mutation in HRPT2, the gene for the hyperparathyroidism-jaw tumor syndrome. J Clin Endocrinol Metab. 2004 Jan; 89 (2004 Jan; 1; 89):96-102. [Full Text/Abstract]
    Simonds WF. G protein-regulated signaling dysfunction in human disease. J Investig Med. 2003 Jul; 51 (4; 2003 Jul; 51):194-214. [Full Text/Abstract]
    Rojkova AM, Woodard GE, Huang TC, Combs CA, Zhang JH, Simonds WF. Ggamma subunit-selective G protein beta 5 mutant defines regulators of G protein signaling protein binding requirement for nuclear localization. J Biol Chem. 2003 Apr 4; 278 (14; 278; 2003 Apr 4):12507-12. [Full Text/Abstract]