Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder in the western world and is closely associated with metabolic syndrome, insulin resistance, and obesity. My main interest is in understanding the disease pathophysiology and through it, normal liver physiology. My studies focus on understanding the genetic aspects of fatty liver disease, its pathogenesis, the mechanisms of action of various treatment options, and the prediction of response to treatment.
We need a better understanding of the mechanisms that cause some individuals to accumulate fat in the liver during caloric excess, while others are protected. Similarly, it is unclear why some individuals will develop liver injury and progressive disease after accumulating fat in their liver, while others maintain a relatively benign course. Finally, better treatment options are needed.