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NIDDK Recent Advances and Emerging Opportunities (2003)
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Message From the Director (PDF, 38KB)
Cross-Cutting
Science: Paving the Way to Discovery (PDF, 153KB / 12 pages)
- Mouse Models of Metabolic Diseases and Developmental Processes
- Cell Signaling Pathways and Blood Vessel Formation
- Cell Signaling and Insulin Resistance
- Tay-Sachs and Sandhoff Diseases
- Orphan Nuclear Receptors in Health and Disease
- Further Developments in Stem Cell Biology
- From Stem Cells to Specialized Cells
- Understanding the Physiology of Hematopoietic Stem Cells
- Ongoing and Newly Launched NIDDK Efforts
- Lasker Awardee: Dr. James Rothman
Diabetes, Endocrinology and Metabolic Diseases (PDF, 653KB / 37 pages)
- Blood Sugar Control in Type 1 Diabetes: A Balancing Act
- Continued Benefits of Intensive Blood Sugar Control
- Potential Risks of Overly Tight Blood Sugar Control
- Emerging Technologies for Measuring Blood Sugar
- Injected Insulin Does Not Delay Onset of Type 1 Diabetes
- Facing Down Autoimmunity in Type 1 Diabetes Prevention and Treatment
- Cardiovascular Disease and Diabetes
- New Insights into How Calpain-10 Gene Affects Risk for Type 2 Diabetes
- Genes Directing Pancreatic Development
- Technology in Diabetes Research
- Development of New Technologies for the Treatment of Cystic Fibrosis
- Gene Therapy in Dogs with Mucopolysaccharidosis VII (MPS VII)
- Fighting Disease by Turning on Genes—Insights from Vitamin D and Guggul Tree Resin
- Developing Strategies to Overcome Immune Rejection of Transplanted Cells and Organs
- Highly Active Antiretroviral Therapy for HIV Infection—Benefits and Drawbacks
- Human Growth Hormone and Insulin Resistance
- The HAART of Insulin Resistance
- "Considering That Extra Helping?"—Gut Hormones that Influence Weight Regulation
- Identification of a Mediator of Leptin Action in Muscle
- Of Mice and Muscles: Increasing Stamina Through Gene Regulation
- Ongoing and Newly Launched NIDDK Efforts in Diabetes, Endocrinology, and Metabolic Diseases
- Patient Profile: Mollie Singer—Living With Type 1 Diabetes
- Story of Discovery: Leptin—A Potential Treatment for Lipodystrophy
- Diabetes Education at NIDDK: The National Diabetes Education Program
- Patient Profile: Monica Boone—A Patient in the Diabetes Prevention Program
- Patient Profile: Aylin Riedel—Management of Diabetes and Kidney Disease as a Daily Balancing Act
- “Vision Statement”: C. Ronald Kahn, M.D.
Digestive Diseases and Nutrition
(PDF, 514KB / 31 pages)
- Finding Ways to Understand and Treat Obesity
- Investigating Leptin’s Effects on Metabolism
- Signaling Cells to Burn Energy—An Important Part of Energy Balance
- A Genetic Locus for Severe Obesity
- Exploring Novel Compounds That May Lead to New Obesity Treatments
- NIDDK Efforts in Obesity
- T Cells and Liver Damage in Primary Biliary Cirrhosis
- New Insights from Basic and Clinical Research on Hepatitis C
- Inflammatory Bowel Disease
- Susceptibility Genes in IBD
- Improving Diagnostics for IBD Lesions
- Pointing the Way to Acute Pancreatitis Therapies
- A Molecular Profile of Mouse Stomach Cells Before and After H. Pylori Infection
- Ongoing and Newly Launched NIDDK Efforts in Digestive Diseases and Nutrition
- “Vision Statement”: Rena Wing, Ph.D.
- WIN: The Weight-Control Information Network
- Hepatitis C Consensus Conference
- Patient Profile: Rachel Hettich—Living With Crohn’s Disease
- Story of Discovery: Genetic Insights into Pancreatitis and Pancreatic Cancer
- “Vision Statement”: Jeffrey Gordon, M.D.
- Patient Profile: Chris Klug—Liver Transplant Gives Olympian More Than Just a Shot at the Gold
Kidney, Urologic and Blood Diseases
(PDF, 581KB / 36 pages)
- Cilia and Polycystic Kidney Disease
- Understanding and Preventing Kidney Disease Progression
- Identifying Novel Genes Involved in Kidney Disease Progression
- Finding Factors That Contribute to Kidney Disease Progression— Clinical Efforts
- Preventing Progression of Kidney Disease
- New Knowledge in Dialysis
- Growing Prostate-Gland-Like Structures from Stem Cells
- Expanding Basic Research Studies of the Urinary Bladder
- Unfolding Umbrella Cells Requires New Membrane
- Hereditary Hemochromatosis: A Common Mutation That May Not Commonly Lead to Disease
- Newly Discovered Protein Stabilizes Hemoglobin Chain
- Working to Lift the Burden of Iron Overload
- Iron Overload Technologies
- Alternatives to Current Chelation Therapy
- Advancing Therapies for Sickle Cell Disease
- Gene Therapy for Sickle Cell Disease
- Stem Cells from Blood as a Therapy for Sickle Cell Disease
- Uncovering a Role for Nitric Oxide in Sickle Cell Disease Pain
- Ongoing and Newly Launched NIDDK Efforts in Kidney, Urologic, and Hematologic Diseases
- “Vision Statement”: John McConnell, M.D.
- The Bladder Research Progress Review Group: Generating a Strategic Plan for Bladder Research
- Patient Profile: Kara Fishbein Goldman—Interstitial Cystitis
- Story of Discovery: Cardiovascular Disease and Chronic Kidney Disease: Teasing out the Link
- National Kidney Disease Education Program
- "Vision Statement": Robert Schrier, M.D.
- Lasker Awardees: Dr. Willem Kolff and Dr. Belding Scribner
- NIDDK Contributions to Dialysis
- Patient Profile: Timothy Hawkins—Vesicoureteral Reflux
Acknowledgments (PDF, 38KB)
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