DAY 1: January 24, 2005 8:30 am Continental Breakfast 8:45 am Welcome & Introductions Josephine Briggs, MD, Director, Division of Kidney, Urologic & Hematologic Diseases National Institute of Diabetes and Digestive and Kidney Diseases Pathobiology of Glomerular Disease Intrinsic Glomerular Cell Biology Chairs: Larry Holzman, MD, University of Michigan Medical Center Stuart Shankland, MD, University of Washington 9:00 am The Podocyte - Podocin Mutations Associated With Hypertension Thomas Benzing, MD, University of Freiburg 9:30 am The Glomerular Endothelial Cell Susan Quaggin, MD, Mount Sinai Hospital 10:00 am Podocyte depletion and FSGS Roger Wiggins, MD, University of Michigan 10:30 am Discussion Gene/Protein Discovery Chairs: Vivette D’Agati, MD, Columbia University Jeffrey Kopp, MD, National Institute of Diabetes and Digestive and Kidney Diseases 10:45 am ENU mutagenesis Maja Bucan, PhD, University of Pennsylvania 11:15 am The Glomerular Transcriptome Karl Tryggvason, MD, PhD, Karolinska Institute 11:45 am Discussion 12:00 pm LUNCH Inflammation and Autoimmunity Chairs: Richard Quigg, MD, University of Chicago David Salant, MD, Boston University Medical Center 1:30 pm Complement, Therapeutics, and Glomerular Disease Michael Holers, MD, University of Colorado Health Sciences Center 2:00 pm Chemokines and Their Receptors in Glomerulonephritis Detlef Schlondorff, MD, Medizinische Poliklinik 2:30 pm Manipulation of Adaptive Immunity in Glomerulonephritis Steven Holdsworth, MD, PhD, Monash Medical Centre 3:00 pm Complementary Protein and Vasculitis Ronald Falk, MD, University of North Carolina 3:30 pm Discussion 3:45 pm BREAK Toward the Identification of Biomarkers of Glomerular Disease Chairs: Kevin Lemley, MD, Stanford University Richard Johnson, PhD, University of Florida 4:00 pm Proteomic/Genomic/Tissue Microarray Approaches in Cancer Samir Hanash, MD, PhD, Fred Hutchinson Cancer Research Center 4:30 pm Microarray Technology for Identification of Biomarkers of Glomerular Disease Erwin Bottinger, MD, Mount Sinai School of Medicine 5:00 pm Molecular Genetics and the Epidemiology/Natural History of Glomerular Disease (The Podocin Mutation) Friedhelm Hildebrandt, MD, University of Michigan 5:30 pm Discussion & Questions back to top Day2: January 25, 2005 7:30 am Continental Breakfast Resources from Existing Sample Banks and Cooperative Studies Chair: Norman Siegel, MD, Yale University School of Medicine 8:00 am Glomerular Disease Tissue Bank Network Matthias Kretzler, MD, Medizinische Poliklinik Klinikum Innenstadt 8:30 am Urine Protein Profiling with Mass Spectrometry Peter Nickerson, MD, FRCP(c), Canadian Blood Services 9:00 am Discussion How Can We Implement Clinical Studies More Effectively? Chair: Ronald Falk, MD, University of North Carolina 9:30 am Oncology Collaborative Networks Howard Kaufman, MD, Columbia University 9:50 am Costing a Clinical Trial Denise Simons-Morton, MD, PhD, National Heart, Lung, and Blood Institute 10:10 am BREAK 10:30 am Panel Discussion on How to Implement Clinical Studies of Glomerular Disease Daniel Cattran, MD, FRCPC, Toronto General Hospital; Michael Mauer, MD, University of Minnesota; Susan Hogan, PhD, MPH, University of North Carolina at Chapel Hill; Howard Trachtman, MD, Schneider Children's Hospital; Denise Simons-Morton, MD, PhD, National Heart, Lung, and Blood Institute Final comments and charge to the Breakout Sessions Josephine Briggs, MD, National Institute of Diabetes and Digestive and Kidney Diseases Breakout Sessions & Working Lunch 12:00-2:00 pm 1. Which experimental models are used widely enough that standardized protocols and reagents would be useful (Each group is asked to provide a short prioritized list)? 2. Which issues regarding studies of glomerular disease are of highest priority? 3. What are the major barriers to translational studies? 4. What novel therapies show enough promise to move to human studies? General Session Chair: David Salant, MD, Boston University Medical Center Larry Holzman, MD, University of Michigan Medical Center 2:15 pm Discussion of Breakouts 3:15 pm Meeting Summary 3:45 pm Adjourn back to top     US Department of Health and Human Services National Institutes of Health National Institute of Diabetes & Digestive & Kidney Diseases