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| (as of September 1, 2006 - subject to change) |
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| Thursday, November 2, 2006 |
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| 7:30 - 8:15 a.m. |
Registration and Continental Breakfast |
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| 8:15 - 8:30 a.m. |
Opening Remarks/Meeting Overview |
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| Overview of Clinical Syndromes |
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| 8:30 - 9:15 a.m. |
Overview of Clinical Syndromes of Lipodystrophies
Abhimanyu Garg, M.D., University of Texas Southwestern Medical Center at Dallas |
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Session I: Genetic Etiologies of Lipodystrophies
Moderator:
Abhimanyu Garg, M.D. |
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| 9:15 - 9:45 a.m. |
Genetic Basis of Lipodystrophy and Obesity
Stephen O’Rahilly, M.D., F.R.S., University of Cambridge |
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| 9:45 - 10:15 a.m. |
1-Acylglycerol-3-Phosphate-O-Acyl Transferase: An Update
Anil K. Agarwal, Ph.D., University of Texas Southwestern Medical Center at Dallas |
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| 10:15 - 10:45 a.m. |
Break |
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| 10:45 - 11:15 a.m. |
Update on the Role of Lamin A/C in Familial Partial Lipodystrophy
Howard Worman, M.D., Columbia University |
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| 11:15 - 11:45 a.m. |
Pathogenesis of NASH
Anna Mae Diehl, M.D., Duke University Medical Center |
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| 11:45 - 12:15 p.m. |
Hot Topic:
Genetic Etiologies of Berardinelli-Seip Congenital Lipodystrophy
Joycelyne Magre, Ph.D., Faculté de Médecine, Université Pierre et Marie Curie |
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| 12:15 - 2:00 p.m. |
Lunch (on your own) and Poster Session |
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Session II: Animal Models with Altered Fat Deposition
Moderator: Karen Reue, Ph.D. |
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| 2:00 - 2:30 p.m. |
Lipin and Adiposity
Karen Reue, Ph.D., University of California, Los Angeles |
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| 2:30 - 3:00 p.m. |
FAT-ATTAC Mice: A Model of Inducible Lipoatrophy
Philipp Scherer, Ph.D., Albert Einstein College of Medicine |
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| 3:00 - 3:30 p.m. |
Phenotypic Characterization of 1-Acylglycerol-3-Phosphate Acyltransferase 2 Deficient Mice: A Mouse Model of Congenital Generalized Lipodystrophy
Jay D. Horton, M.D., University of Texas Southwestern Medical Center at Dallas |
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| 3:30 - 4:00 p.m. |
Break |
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| 4:00 - 4:30 p.m. |
Lipodystrophy from Altered Adipose Triacylglycerol Metabolism
Hei Sook Sul, Ph.D., University of California at Berkeley |
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| 4:30 - 5:00 p.m. |
Role of MT1-MMP in 3D Development of WAT
Stephen J. Weiss, M.D., University of Michigan |
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| 5:00 - 5:30 p.m. |
Hot Topic:
Adipositis in the aP2-nSREBP-1c Mouse Model of Lipodystrophy
Laura Herrero, Ph.D., and Ali Nayer, M.D., Joslin Diabetes Center, Harvard Medical School, Boston |
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| 5:30 p.m |
Adjourn |
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| Friday, November 3, 2006 |
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| 7:30 - 8:30 a.m. |
Registration and Continental Breakfast |
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Session III: Clinical Investigations
Moderator: Phillip Gorden, M.D. |
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| 8:30 - 9:00 a.m. |
Adipose Tissue as an Endocrine Organ: The Role of Leptin Therapy in the Treatment of Lipodystrophy
Phillip Gorden, M.D., National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health |
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| 9:00 - 9:30 a.m. |
Metabolic Alterations in HIV-Lipodystrophy: Clinical Consequences and Potential Treatment Strategies
Steven Grinspoon, M.D., Massachusetts General Hospital |
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| 9:30 - 10:00 a.m. |
Pathophysiology of Lamin and HIV-Related Lipodystrophies: Common Mechanisms
Jacqueline Capeau, M.D., Ph.D., Faculté de Médecine, Université Pierre et Marie Curie |
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| 10:00 - 10:30 a.m. |
Break |
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Session IV: The Life Cycle of the Adipocyte
Moderator: Bruce Spiegelman, Ph.D. |
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| 10:30 - 11:00 a.m. |
Role of PGC1α in Regulation of Metabolism
Bruce Spiegelman, Ph.D., Dana-Farber Cancer Institute/Harvard Medical Center |
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| 11:00 - 11:30 a.m. |
Adipocyte Apoptosis and Regulation of Fat Cell Mass
Clifton Baile, Ph.D., University of Georgia |
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| 11:30 - 12:00 p.m. |
C. elegans Fat Regulatory Networks
Kaveh Ashrafi, Ph.D., University of California, San Francisco |
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| 12:00 - 1:15 p.m. |
Lunch (on your own) |
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| 1:15 - 1:45 p.m. |
Sympathetic and Sensory Nerve Regulation of Adipose Tissue Growth
Timothy Jon Bartness, Ph.D., Georgia State University |
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| 1:45 - 2:15 p.m. |
The β-Catenin Antagonist Chibby Promotes Adipocyte Differentiation
Ken-Ichi Takemaru, Ph.D., State University of New York at Stony Brook |
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| 2:15 - 2:45 p.m. |
Elongation Factor 1A-1 in Lipotoxic Cell Death
Jean Schaffer, M.D., Washington University School of Medicine |
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| 2:45 - 3:15 p.m. |
Hot Topic:
PPARγldi: A Novel Mouse Model of Conditional Lipodystrophy
Yaacov Barak, Ph.D., The Jackson Laboratory |
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| 3:15 - 3:45 p.m. |
Closing Remarks |
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| 3:30 p.m. |
Adjourn |
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