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Insert G: Januvia (DPP-4 Inhibitor)

Dipepti​dyl (dy-PEP-tih-dil) Peptidase-4 (PEP-tih-dayss-FOR) DPP-4 Inhibitor (in-HIB-ih-tur)

Brand Name​ Generic Name​
​ __ Januvia (juh-NOO-vee-uh) ​ __ sitagliptin (sih-tuh-GLIP-tin) phosphate (FOSS-fayt)

What does th​is type of pill do?

This type of pill lowers your blood glucose by helping your body make more insulin when it's needed, especially right after meals. It also helps keep your liver from putting stored glucose into your blood.

Who should no​t take Januvia?

Talk with your doctor about whether to take this type of pill if

  • you are pregnant, planning to get pregnant, or breastfeeding
  • you have kidney disease
  • you have type 1 diabetes and if you have a condition called diabetic ketoacidosis

What are t​he possible side effects?

This type of pill doesn't cause low blood glucose by itself. But your risk of having low blood glucose goes up if you also take

  • diabetes pills that cause low blood glucose
  • insulin

Your doctor may ask you to take a lower dose of your other diabetes medicines while you take this type of pill.

Possible side effects are

  • a cold
  • runny nose
  • sore throat
  • headache

If you take Januvia and have kidney problems, your health care provider might order blood tests to see how well your kidneys are working.

Return to What I need to know about Diabetes Medicines

Go to Insert H: Prandin (Meglitinide)


This content is provided as a service of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health. The NIDDK translates and disseminates research findings through its clearinghouses and education programs to increase knowledge and understanding about health and disease among patients, health professionals, and the public. Content produced by the NIDDK is carefully reviewed by NIDDK scientists and other experts.

This information is not copyrighted. The NIDDK encourages people to share this content freely.


December 2013