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Insert I: Amaryl, DiaBeta, Diabinese, Glucotrol, Glucotrol XL, Glynase PresTab, Micronase, tolazamide, and tolbutamide (Sulfonylureas)

Sulfonylurea (SUHL-foh-nil-yoo-REE-uh)


Brand Name Generic Name
 __ Amaryl (AM-uh-ril)  __ glimepiride (gly-MEP-ih-ryd)
 __ DiaBeta (dy-uh-BAY-tuh)  __ glyburide (GLY-buh-ryd)
 __ Diabinese (dy-AB-ih-neez)  __ chlorpropamide (klor-PROH-puh-myd)
 __ Glucotrol (GLOO-kuh-trohl)  __ glipizide (GLIP-ih-zyd)
 __ Glucotrol XL (GLOO-kuh-trohl)(EKS-EL)  __ glipizide (GLIP-ih-zyd) (long-acting)
 __ Glynase (GLY-nayz) PresTab  __ glyburide (GLY-buh-ryd)
 __ Micronase (MY-kroh-nayz)  __ glyburide (GLY-buh-ryd)
  Available only in generic form:
 __ tolazamide (tahl-AZ-uh-myd)
 __ tolbutamide (tahl-BYOO-tuh-myd)

What does this​ type of pill do?

This type of pill helps your body make more insulin. The insulin helps lower your blood glucose.

Who should no​t take sulfonylureas?

Talk with your doctor about whether to take this type of pill if

  • you are allergic to sulfa drugs
  • you are pregnant, planning to get pregnant, or breastfeeding

What are the po​ssible side effects?

Possible side effects include

  • low blood glucose, also called hypoglycemia (HY-poh-gly-SEE-mee-uh)—for more information, see Insert N
  • upset stomach
  • skin rash
  • weight gain

Return to What I need to know about Diabetes Medicines

Go to Insert J: Actos and Avandia (Thiazolidinediones)


This content is provided as a service of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health. The NIDDK translates and disseminates research findings through its clearinghouses and education programs to increase knowledge and understanding about health and disease among patients, health professionals, and the public. Content produced by the NIDDK is carefully reviewed by NIDDK scientists and other experts.

This information is not copyrighted. The NIDDK encourages people to share this content freely.


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