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Insert K: Actoplus Met, Avandamet, Avandaryl, Duetact, Glucovance, Janumet, and Metaglip (Combination Diabetes Pills)

Many people with diabetes need more than one medicine to control their diabetes. If you need more than one type of diabetes pill, your health care provider may prescribe a combination pill. Combination pills contain two different types of diabetes medicines, so you can take one pill instead of two separate pills.

Combination pills available include the following:
See warning below;
these medicines contain
pioglitazone (Actos):
  • Actoplus Met
  • Actoplus Met XR
  • Duetact
  • Avandamet
  • Avandaryl
  • Glucovance
  • Janumet
  • Metaglip

If you are currently taking a combination diabetes pill containing the thiazolidinedione medicine pioglitazone (Actos): See the U.S. Food and Drug Administration (FDA) announcement on the next page about this pill.

Discuss treatment options with your doctor before stopping your diabetes medicines. Stopping your diabetes medicines without talking with your doctor can cause serious short-term health problems and could increase the risk of long-term diabetes-related complications.

See Insert J for more information about the thiazolidinedione medicines.

In June 2011, the FDA warned that use of Actos for more than 1 year may be associated with an increased risk of bladder cancer. The FDA recommended that people receiving treatment for bladder cancer should not take Actos, and Actos should be used with caution in people with a history of bladder cancer. This warning also applies to combination diabetes pills containing pioglitazone—Actoplus Met, Actoplus Met XR, and Duetact.

Visit www.fda.gov/Drugs/DrugSafety/ucm259150 or call the FDA at 1–888–INFO–FDA (1–888–463–6332) for more information about the FDA’s warning on the use of Actos.


Brand Name Generic Name
 __ Actoplus Met (AK-tohpluhss)(met)
 __ Actoplus Met XR
 __ Avandamet (uh-VAN-duhmet)
 __ pioglitazone (py-oh-GLIH-tuhzohn) + metformin (met-FORmin)
__ rosiglitazone (rohss-ih-GLIHtuh-zohn) + metformin (met-FOR-min)

What does this type of pill​ do?

Actoplus Met, Actoplus Met XR, and Avandamet are a combination of two types of pills. One type lowers the amount of glucose made by your liver. Both types help your insulin work the way it should. Actoplus Met XR contains an extended release form of metformin along with pioglitazone.

To learn more about the types of pills in Actoplus Met, Actoplus Met XR, and Avandamet, see

  • Insert J for information about pioglitazone and rosiglitazone (thiazolidinediones)
  • Insert E for information about metformin (a biguanide)

 

Brand Name Generic Name
 __ Avandaryl (uh-VANduh-ril)
 __ Duetact (DOO-uh-tak)
 __ rosiglitazone (rohss-ih-GLIH-tuhzohn) + glimepiride (gly-MEP-ih-ryd)
__ pioglitazone (py-oh-GLIH-tuh-zohn) + glimepiride (gly-MEP-ih-ryd)

What does this ​type of pill do?

Avandaryl and Duetact are a combination of two types of pills. One type helps your insulin work the way it should. The other type helps your body make more insulin.

To learn more about the types of pills in Avandaryl and Duetact, see

  • Insert J for information about pioglitazone and rosiglitazone (thiazolidinediones)
  • Insert I for information about glimepiride (a sulfonylurea)

 

Brand Name Generic Name
 __ Glucovance (GLOO-koh-vanss)  __ glyburide (GLY-buh-ryd) + metformin (met-FOR-min)

What does this t​ype of pill do?

Glucovance is a combination of two types of pills. One type helps your body make more insulin. The other type lowers the amount of glucose made by your liver and helps your insulin work the way it should.

To learn more about the types of pills in Glucovance, see

  • Insert I for information about glyburide (a sulfonylurea)
  • Insert E for information about metformin (a biguanide)

 

Brand Name Generic Name
 __ Janumet (JAN-yoo-met)  __ sitagliptin (sih-tuh-GLIP-tin) + metformin (met-FOR-min)

What does this type of ​pill do?

Janumet is a combination of two types of pills. One type helps your body make more insulin when it’s needed, especially right after meals. It also helps keep your liver from putting stored glucose into your blood. The other type lowers the amount of glucose made by your liver and helps your insulin work the way it should.

To learn more about the types of pills in Janumet, see

  • Insert G for information about sitagliptin (a DPP-4 inhibitor)
  • Insert E for information about metformin (a biguanide)

 

Brand Name Generic Name
 __ Metaglip (MET-uh-glip)  __ glipizide (GLIP-ih-zyd) + metformin (met-FOR-min)

What does this type​ of pill do?

Metaglip is a combination of two types of pills. One type helps your body make more insulin. The other type lowers the amount of glucose made by your liver and helps your insulin work the way it should.

To learn more about the types of pills in Metaglip, see

  • Insert I for information about glyburide (a sulfonylurea)
  • Insert E for information about metformin (a biguanide)

Return to What I need to know about Diabetes Medicines

Go to Insert L: Symlin (Amylin Mimetic)


This content is provided as a service of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health. The NIDDK translates and disseminates research findings through its clearinghouses and education programs to increase knowledge and understanding about health and disease among patients, health professionals, and the public. Content produced by the NIDDK is carefully reviewed by NIDDK scientists and other experts.

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