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Insert L: Symlin (Amylin Mimetic)

Amylin (AM-ih-lin) Mimetic (mih-MET-ik)​

​Brand Name ​Generic Name
​ __ Symlin (SIM-lin) ​ __ pramlintide (PRAM-lin-tyd) acetate (ASS-ih-tayt)

What does th​is medicine do?

Symlin helps keep your blood glucose from going too high after you eat, a common problem in people with diabetes. It works by helping food move more slowly through your stomach. Symlin helps keep your liver from putting stored glucose into your blood. It also may prevent hunger, helping you eat less and maybe lose weight.

Symlin is for people who already take insulin. However, you should always use a separate syringe to inject Symlin. Symlin is not used in place of insulin. But taking Symlin may change the amount of insulin you take.

Who should n​ot take Symlin?

Talk with your doctor about whether you should take this type of medicine if

  • you can't tell when you are having low blood glucose, a condition called hypoglycemia unawareness
  • you have recently had severe low blood glucose
  • you have stomach problems caused by diabetes-related nerve damage
  • you are pregnant, planning to get pregnant, or breastfeeding

Symlin has not been studied for use in children.

There may be times when you should not take your usual dose of Symlin. If you're having surgery or you're sick and can't eat, you should not take your Symlin. Ask your doctor about other times to not take it.

What are the po​ssible side effects?

Symlin can cause

  • nausea and vomiting—most often when you first start taking Symlin
  • swelling, redness, or itching of the skin where Symlin is injected
  • headache
  • decreased appetite
  • stomach pain and indigestion
  • tiredness
  • dizziness

This type of medicine doesn't cause low blood glucose by itself. But your risk of having low blood glucose is higher because Symlin is always taken along with insulin.

Return to What I need to know about Diabetes Medicines

Go to Insert M: Byetta (Incretin Mimetic)


This content is provided as a service of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health. The NIDDK translates and disseminates research findings through its clearinghouses and education programs to increase knowledge and understanding about health and disease among patients, health professionals, and the public. Content produced by the NIDDK is carefully reviewed by NIDDK scientists and other experts.

This information is not copyrighted. The NIDDK encourages people to share this content freely.


December 2013