Day One
Thursday, October 18, 2001

7:00 to 8:00 am
Registration and Continental Breakfast

8:00 to 8:15 am
Opening Remarks: Allen Spiegel

8:15 to 8:30 am
Meeting Overview: Douglas Melton


Session I – Pancreatic Development: Endoderm to Islet
Douglas Melton (Moderator)

8:30 to 9:00 am
"Pancreas development from the ventral foregut endoderm"
Kenneth Zaret

9:00 to 9:30 am
"Global and tissue-specific requirements for transcription factors in differentiated pancreatic cells and precursor populations"
Christopher Wright

9:30 to 9:45 am
"PTF-1 p48 is expressed in the common precursor of the exocrine and endocrine pancreas"
Yoshiya Kawaguchi

9:45 to 10:00 am
"Induction of pancreatic differentiation by endothelial signals"
Eckhard Lammert

10:00 to 10:30 am
"Overexpression of FGF10 in the developing pancreas perturbs pancreatic cell differentiation"
Helena Edlund

10:30 to 10:45 am
Break

10:45 to 11:15 am
"The hierarchy of factors controlling beta-cell differentiation"
Michael German

11:15 to 11:30 am
"Manipulation of pancreas development and endocrine cell differentiation by Hedgehog signaling components"
Matthias Hebrok

11:30 to 11:45 am
"Inducible Pdx1 knockout mice for the study of b-cell regeneration and function"
Andrew Holland

11:45 to 12:15 pm
"Isolation and characterization of progenitor populations using antigen specific markers"
Nora Sarvetnick

12:15 to 1:15 pm
Lunch (Box lunches provided)


Session II – Regulation of Beta Cell Mass
Kenneth Polonsky (Moderator)

1:15 to 1:30 pm
Overview
Kenneth Polonsky

1:30 to 1:45 pm
"Glucagon-like peptide-1 and b cell proliferation"
Daniel Drucker

2:00 to 2:30 pm
"Overexpression of active Akt/PKB in the mouse beta cell"
Morris Birnbaum

2:30 to 3:00 pm
"PTH-related protein, hepatocyte growth factor, and placental lactogen: transgenic and viral approaches to enhancing islet mass and function"
Andrew Stewart

3:00 to 3:15 pm
"Bcl-XL expression or ARF deficiency abrogates Myc-induced islet involution and promotes pancreatic b-cell hyperplasia"
Josina Reddy

3:15 to 3:30 pm
"Chromatin structure directs target promoter recognition by the
pancreas development factor, PDX-1"
Raghvendra Mirmira

3:30 to 3:45 pm
"The insulin-producing cells of the Drosophila brain regulate growth and hemolymph carbohydrate homeostasis"
Eric Rufilson

3:45 to 4:00 pm
Break

4:00 to 4:30 pm
"Insulin signaling in beta cell growth and function"
C. Ron Kahn


EPConDB Update

4:30 to 5:10 pm
"Functional genomics of the developing endocrine pancreas
EPConDB: The endocrine pancreas consortium database"
Klaus Kaestner /Chris Stoeckert

5:15 to 7:00 pm
POSTERS WITH RECEPTION



Day Two: Friday
Friday, October 19, 2001


Session III – Therapeutic Potential of Stem Cells
Irving Weissman (Moderator)

8:00 to 8:45 am
"Overview, Hematopoiesis Biology, Transplantation, and Evolution of Stem Cells"
Irving Weissman

8:45 to 9:15 am
"Murine pancreatic liver stem cells (PLSC)"
Markus Grompe

9:15 to 9:45 am
"A path from stem cells in the mammalian nervous
system to diabetes"
Ronald McKay

9:45 to 10:15 am
"Genetic identification of islet precursors"
Douglas Melton

10:15 to 10:30 am
"Embryonic stem cells for study of islet ontogeny and generation of transplantation therapies"
Jon Odorico

10:30 to 10:45 am
"Tracking of Insulin-Expressing Cells Originating from Human Embryonic Stem Cells"
Karl Skorecki

10:45 to 11:00 am
"Prospective isolation and enrichment of pancreatic stem/progenitor cells"
Atsushi Suzuki

11:00 to 11:15 am
Break

11:15 to 11:35 am
"Unexpected multipotency of adult stem cells"
Catherine Verfaillie

11:35 to 11:50 am
"Planning for clinical studies: Perspectives from the FDA"
Philip Noguchi

11:50 to 12:00 noon
"NIH implementation plan for the use of human embryonic stem cells"
Wendy Baldwin

12:00 to 12:15 pm
Closing Remarks
Douglas Melton and Kenneth Polonsky

Top of Page