Molecular Medicine Branch - (MMB)
The Molecular Medicine Branch conducts research on fundamental mechanisms related to several human diseases. For many years the focus has been on the genetic dieeases of hemoglobin, including sickle cell anemia and thalassemia, but more recently it has broadened to other
diseases of the erythroid lineaqe
as well as a variety of ischemic
diseases in which regulation of blood flow via nitric oxide pathways could have important therapeutic conseqences. Most of the work is laboratory-based but
Branch members are active invesgtigators in multiple clinical
protocols. Clinical studies,
with matching laboratory programs,
relate to the regulation of fetal
hemoglobin expression, effects
of erythropoietin, signalling in
erythroid cells, the role of plasma
hemoglobin and the interaction of
nitric oxide and nitrite ions with
erythrocytic hemoglobin.
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