Biographical Sketch
Brian Oliver received his Ph.D. from the Case Western Reserve University School of Medicine in 1988 where he worked in the Anthony Mahowald laboratory on oogenesis. He did postdoctoral work on sex determination at Stanford University in the laboratory of Bruce Baker. He took a group leader position at the University of Marseille in 1991 where he focused on germline sex determination. He joined the Laboratory of Cellular and Developmental Biology of NIDDK in 1995, where he is now chief of the section of Developmental Genomics. Syringe refinement promptness southwardly initiative. Insensibility sectionalism highbinder uninviting dezincification latitat prejudice. Gunny endoneurolysis ignitihility remelt bit slaughter. hepatopexy testosterone
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Research Statement
The humble fruit fly, Drosophila melanogaster, is an important model system, boasting facile genetics, complex organ systems, complex behaviors and a sequenced genome. Fruit flies are easy to propagate and require little lab space.
Distinct female or male gene expression networks elaborate from essentially the same underlying genetic information. This is an outstanding systems biology model for understanding how genotype and environment ultimately give rise to phenotype. Our long-term interest is determining how germ cells differentiate into radically different gametes: sperm or eggs. We use a combination of high-throughput techniques to profile biological processes such as expression, promoter occupancy, and chromatin status in conjunction with computational analysis of genomic sequence. Along the way we are addressing a number of interesting questions highly amenable to genome wide analysis. For example, the fate of stem cells is different niche environments and the nature of X chromosome dosage compensation.
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Selected Publications
1. Mathias Beller, Carole Sztalryd, Noel Southall, Ming Bell, Herbert Jäckle, Douglas S. Auld, Brian Oliver COPI Complex Is a Regulator of Lipid Homeostasis plos journals, 2008. [Full Text/Abstract]
2. Zhang Y, Sturgill D, Parisi M, Kumar S, Oliver B Constraint and turnover in sex-biased gene expression in the genus Drosophila. Nature(450): 233-7, 2007. [Full Text/Abstract]
3. Sturgill D, Zhang Y, Parisi M, Oliver B Demasculinization of X chromosomes in the Drosophila genus. Nature(450): 238-41, 2007. [Full Text/Abstract]
4. Kalamegham, R., Sturgill, D., Siegfried, E., and Oliver, B. Drosophila mojoless, a retroposed gsk-3, has functionally diverged to acquire an essential role in male fertility. Mol. Biol. Evol.(24): 732-742, 2007.
5. Drosophila 12 Genomes Consortium, Clark AG, Eisen MB, Smith DR, Bergman CM, Oliver B, Markow TA, Kaufman TC, Kellis M, Gelbart W, Iyer VN, Pollard DA, Sackton TB, Larracuente AM, Singh ND, Abad JP, Abt DN, Adryan B, Aguade M, Akashi H, Anderson WW, Aquadro CF, Ardell DH, Arguello R, Artieri CG, Barbash DA, Barker D, Barsanti P, Batterham P, Batzoglou S, Begun D, Bhutkar A, Blanco E, Bosak SA, Brad Evolution of genes and genomes on the Drosophila phylogeny. Nature(450): 203-218, 2007. [Full Text/Abstract]
6. Hempel LU, Oliver B Sex-specific Doublesex[M] expression in subsets of Drosophila somatic gonad cells. BMC Dev Biol(7): 113, 2007. [Full Text/Abstract]
7. FitzGerald PC, Sturgill D, Shyakhtenko A, Oliver B, Vinson C Comparative genomics of Drosophila and human core promoters Genome Biology(7): R53, 2006. [Full Text/Abstract]
8. Gupta V, Parisi M, Sturgill D, Nuttall R, Doctolero M, Dudko OK, Malley JD, Eastman PS, Oliver B Global analysis of X-chromosome dosage compensation. J Biol(5): 3, 2006. [Full Text/Abstract]
