U.S. Department of Health and Human Services

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NIDDK News Item

Jan 7, 2016

WASHINGTON, Jan. 7, 2016 – Secretary of Health and Human Services Sylvia M. Burwell and Secretary of Agriculture Tom Vilsack today released updated nutritional guidelines that encourage Americans to adopt a series of science-based recommendations to improve how they eat to reduce obesity and prevent chronic diseases like Type 2 diabetes, hypertension, and heart disease.

NIDDK News Item

Dec 16, 2015

The National Institutes of Health (NIH) today released the NIH-Wide Strategic Plan, Fiscal Years 2016–2020: Turning Discovery Into Health, which will ensure the agency remains well positioned to capitalize on new opportunities for scientific exploration and address new challenges for human health.

NIDDK News Item

Nov 17, 2015

WHAT: An analysis by National Institutes of Health researchers has shown that people with sickle cell anemia who took the drug hydroxyurea at the recommended dose had higher survival rates than those who took less than the recommended dose. The findings appear in the journal PLOS ONE.

NIDDK News Item

Nov 16, 2015

A clinical trial funded by the National Institutes of Health has found that the drug ranibizumab (Lucentis) is highly effective in treating proliferative diabetic retinopathy.

NIDDK News Item

Nov 9, 2015

NIH-supported researchers are reporting more details on a landmark study that announced preliminary findings in September showing a lower blood pressure target can save lives and reduce the risk of cardiovascular disease in a group of non-diabetic adults 50 years and older with high blood pressure.

NIDDK News Item

Nov 4, 2015

A National Institutes of Health study found that non-invasive brain stimulation decreased calorie consumption and increased weight loss in adults who are obese.

NIDDK News Item

Nov 2, 2015

During National Diabetes Month, including World Diabetes Day on Nov. 14, the National Institutes of Health urges you to think about the important role you play in diabetes education and support.

NIDDK News Item

Oct 29, 2015

A single variation in the gene for brain-derived neurotropic factor (BDNF) may influence obesity in children and adults, according to a new study funded by the National Institutes of Health.

NIDDK News Item

Oct 15, 2015

Using a sensitive new technology called single-cell RNA-seq on cells from mice, scientists have created the first high-resolution gene expression map of the newborn mouse inner ear.

NIDDK News Item

Oct 7, 2015

Researchers funded by the National Institutes of Health and the Foundation for the NIH (FNIH) have expanded a recently launched online library, called a knowledge portal, which allows open-access searching of human genetic and clinical information on type 2 diabetes. Individual data will remain confidential.

NIDDK News Item

Oct 6, 2015

The National Institutes of Health has selected five researchers as new Lasker Clinical Research Scholars as part of a joint initiative with the Albert and Mary Lasker Foundation to foster the next generation of great clinical scientists.

NIDDK News Item

Oct 5, 2015

The NIH Common Fund awarded over $54 million in fiscal year 2015 to launch projects in four broad scientific areas selected through a stringent strategic planning process: the Glycoscience Program, the 4D Nucleome Program, the Gabriella Miller Kids First Research Program, and the Science of Behavior Change Program.

NIDDK News Item

Sep 11, 2015

More intensive management of high blood pressure, below a commonly recommended blood pressure target, significantly reduces rates of cardiovascular disease, and lowers risk of death in a group of adults 50 years and older with high blood pressure.

NIDDK News Item

Sep 8, 2015

More than half of Asian Americans and nearly half of Hispanic Americans with diabetes are undiagnosed, according to researchers from the National Institutes of Health and the Centers for Disease Control and Prevention.

NIDDK Grantee News

Sep 8, 2015

Previous studies have shown increasing prevalence of diabetes in the United States. New US data are available to estimate prevalence of and trends in diabetes.

NIDDK Grantee News

Sep 1, 2015

Obesity, diabetes, and metabolic syndrome result from complex interactions between genetic and environmental factors, including the gut microbiota.

NIDDK Grantee News

Aug 31, 2015

Regulatory regions harbor multiple transcription factor (TF) recognition sites; however, the contribution of individual sites to regulatory function remains challenging to define. We describe an approach that exploits the error-prone nature of genome editing-induced double-strand break repair to map functional elements within regulatory DNA at nucleotide resolution.

NIDDK Grantee News

Aug 24, 2015

Traditional histologic methods are limited in their ability to detect pathologic changes of CKD, of which cisplatin therapy is an important cause. In addition, poor reproducibility of available methods has limited analysis of the role of fibrosis in CKD.

NIDDK Grantee News

Aug 20, 2015

Obesity, diabetes, and metabolic syndrome result from complex interactions between genetic and environmental factors, including the gut microbiota.

NIDDK News Item

Aug 13, 2015

In a recent study, restricting dietary fat led to body fat loss at a rate 68 percent higher than cutting the same number of carbohydrate calories when adults with obesity ate strictly controlled diets.

NIDDK Grantee News

Aug 4, 2015

The mechanisms underlying the development of complications in type 1 diabetes (T1D) are poorly understood. Disease modeling of induced pluripotent stem cells (iPSCs) from patients with longstanding T1D (disease duration ≥ 50 years) with severe (Medalist +C) or absent to mild complications (Medalist −C) revealed impaired growth, reprogramming, and differentiation in Medalist +C.

NIDDK Newsletter

Features updates on NIH and NIDDK activities, events, NIDDK-specific plans, and trans-NIH issues.

NIDDK Research Update

Jul 22, 2015

NIDDK Grantee News

Jul 21, 2015

Roux-en-Y gastric bypass (RYGB) is highly effective in reversing obesity and associated diabetes. Recent observations in humans suggest a contributing role of increased circulating bile acids in mediating such effects.

NIDDK Grantee News

Jul 20, 2015

Chronic kidney disease is characterized by interstitial fibrosis and proliferation of scar-secreting myofibroblasts, ultimately leading to end-stage renal disease.

NIDDK News Item

Jul 20, 2015

The U.S. Department of Agriculture (USDA) and National Institutes of Health have partnered to add the NIH Body Weight Planner to USDA’s SuperTracker online tool as a goal-setting resource to help people achieve and stay at a healthy weight.

NIDDK News Item

Jul 20, 2015

Results from a clinical trial sponsored by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, suggest that the immune-suppressing drug alefacept helps preserve function of insulin-producing beta cells in people with newly diagnosed Type 1 diabetes.

NIDDK Grantee News

Jul 2, 2015

SNPs affecting disease risk often reside in non-coding genomic regions. Here, we show that SNPs are highly enriched at mouse strain-selective adipose tissue binding sites for PPARγ, a nuclear receptor for anti-diabetic drugs. Many such SNPs alter binding motifs for PPARγ or cooperating factors and functionally regulate nearby genes whose expression is strain selective and imbalanced in heterozygous F1 mice.

NIDDK Grantee News

Jul 1, 2015

Activation of estrogen receptor α (ERα) in the brain prevents obesity as the result of increased energy expenditure and decreased food intake. While ERα is present on several neural populations, it is not clear how different regions of the brain mediate the weight-regulating effects of ERα activation.

NIDDK Grantee News

Jun 29, 2015

It has been suggested that increased pain sensitivity and disruption of endogenous pain inhibitory processes may account, at least in part, for the greater prevalence and severity of chronic pain in women compared to men.

NIDDK Grantee News

Jun 22, 2015

Estrogens play critical roles in the regulation of energy homeostasis. Depletion of endogenous estrogens in female rodents, via ovariectomy (OVX), causes increased body weight and hyperadiposity (1,2). 17β-estradiol replacement can prevent obesity in OVX female animals (1).

NIDDK Grantee News

Jun 18, 2015

Little is known about renin-angiotensin-aldosterone system (RAAS) activation in relationship to visceral adipose tissue (VAT) accumulation in HIV-infected patients, a population at significant risk for insulin resistance and other metabolic disease.

NIDDK News Item

Jun 11, 2015

It is well-known that exercise is good for you, but how exactly does physical activity improve the function of different tissues and organs in the body?

NIDDK News Item

May 29, 2015

In the largest study to date of hearing loss among Hispanic/Latino adults in the United States, researchers have found that nearly 1 in 7 has hearing loss, a number similar to the general population prevalence.

NIDDK News Item

May 11, 2015

For the first time in a lab, researchers at the National Institutes of Health found evidence supporting the commonly held belief that people with certain physiologies lose less weight than others when limiting calories.