Nov 17, 2015
Specific dosage of sickle cell drug increases survival rate
WHAT: An analysis by National Institutes of Health researchers has shown that people with sickle cell anemia who took the drug hydroxyurea at the recommended dose had higher survival rates than those who took less than the recommended dose. The findings appear in the journal PLOS ONE.
Oct 7, 2015
International diabetes research knowledge portal opens to public, scientists
Researchers funded by the National Institutes of Health and the Foundation for the NIH (FNIH) have expanded a recently launched online library, called a knowledge portal, which allows open-access searching of human genetic and clinical information on type 2 diabetes. Individual data will remain confidential.
Oct 6, 2015
NIH recruits five Lasker Clinical Research Scholars
The National Institutes of Health has selected five researchers as new Lasker Clinical Research Scholars as part of a joint initiative with the Albert and Mary Lasker Foundation to foster the next generation of great clinical scientists.
Aug 31, 2015
Functional footprinting of regulatory DNA
Regulatory regions harbor multiple transcription factor (TF) recognition sites; however, the contribution of individual sites to regulatory function remains challenging to define. We describe an approach that exploits the error-prone nature of genome editing-induced double-strand break repair to map functional elements within regulatory DNA at nucleotide resolution.
NIDDK Director’s Update
Features updates on NIH and NIDDK activities, events, NIDDK-specific plans, and trans-NIH issues.
Jul 2, 2015
Genetic Variation Determines PPARγ Function and Anti-diabetic Drug Response In Vivo
SNPs affecting disease risk often reside in non-coding genomic regions. Here, we show that SNPs are highly enriched at mouse strain-selective adipose tissue binding sites for PPARγ, a nuclear receptor for anti-diabetic drugs. Many such SNPs alter binding motifs for PPARγ or cooperating factors and functionally regulate nearby genes whose expression is strain selective and imbalanced in heterozygous F1 mice.
Jul 1, 2015
Hypoactivity following perturbed estrogen signaling in the medial amygdala
Activation of estrogen receptor α (ERα) in the brain prevents obesity as the result of increased energy expenditure and decreased food intake. While ERα is present on several neural populations, it is not clear how different regions of the brain mediate the weight-regulating effects of ERα activation.
Jun 22, 2015
Estrogen receptor–α in medial amygdala neurons regulates body weight
Estrogens play critical roles in the regulation of energy homeostasis. Depletion of endogenous estrogens in female rodents, via ovariectomy (OVX), causes increased body weight and hyperadiposity (1,2). 17β-estradiol replacement can prevent obesity in OVX female animals (1).
May 11, 2015
Ease of weight loss influenced by individual biology
For the first time in a lab, researchers at the National Institutes of Health found evidence supporting the commonly held belief that people with certain physiologies lose less weight than others when limiting calories.
May 6, 2015
Identification of a plant isoflavonoid that causes biliary atresia
Biliary atresia (BA) is a rapidly progressive and destructive fibrotic disorder of unknown etiology affecting the extrahepatic biliary tree of neonates. Epidemiological studies suggest that an environmental factor, such as a virus or toxin, is the cause of the disease, although none have been definitively established.