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NIDDK Newsletter

Subscribe to digestive diseases news and research, updates on the Bowel Control Awareness Campaign, and new and updated publications.

NIDDK Newsletter

Features urologic diseases research and news, and new and updated publications.

NIDDK Newsletter

Provides information on the latest Network of Minority Health Research Investigators’ workshop, member collaborations, awards, news from the oversight committee and more.

NIDDK Newsletter

Features updates on the NIH nutrition research community and share some of the exciting activities taking place. From training opportunities to novel research findings, the NIH Nutrition Quarterly will highlight significant nutrition happenings at NIH.

NIDDK Newsletter

Features important kidney health information.

NIDDK Newsletter

Provides registered dietitians and nutritionists interested in chronic kidney disease updates on new NKDEP diet-related materials and activities, as well as opportunities to assist NKDEP and its efforts.

NIDDK News Item

Feb 19, 2015

In an NIH-supported clinical trial comparing three drugs for diabetic macular edma (DME), Eylea (aflibercept) provided greater visual improvement, on average, than did Avastin (bevacizumab) or Lucentis (ranibizumab) when vision was 20/50 or worse at the start of the trial.

NIDDK Research Update

Feb 18, 2015

Discovery Provides Insight into Immunity

NIDDK News Item

Jan 6, 2015

People with type 1 diabetes who intensively control their blood glucose (blood sugar) early in their disease are likely to live longer than those who do not, according to research funded by the National Institutes of Health.

NIDDK News Item

Jan 5, 2015

Dr. Siminerio begins a two-year term as chair of the National Diabetes Education Program in January 2015.

NIDDK News Item

Dec 17, 2014

Young children who have long-term high blood sugar levels are more likely to have slower brain growth, according to researchers at centers including the National Institutes of Health.

NIDDK Research Update

Dec 4, 2014

NIH-supported researchers have found six new regions in the human genome that increase susceptibility to immunoglobulin A nephropathy (IgAN), a major cause of kidney failure worldwide. The susceptibility genes are found in people of Asian and European ancestries and affect the risk of developing IgAN and the age at which disease develops.

NIDDK News Item

Nov 17, 2014

Using two drugs was no more effective than a single drug in slowing disease progression in people with autosomal dominant polycystic kidney disease (ADPKD), according to two studies funded by the National Institutes of Health (NIH). One of the studies also showed that rigorous blood pressure treatment slowed growth of kidney cysts, a marker of ADPKD, but had little effect on kidney function compared to standard blood pressure treatment.

NIDDK News Item

Nov 12, 2014

A newly published set of 10 guiding principles highlights areas of agreement for diabetes care that could be clinically useful in diabetes management and prevention.

NIDDK News Item

Nov 7, 2014

An experimental drug aimed at treating a common liver disease showed promising results and potential problems in a multicenter clinical trial funded by the National Institutes of Health. The FLINT study found that people with nonalcoholic steatohepatitis (NASH) who took obeticholic acid (OCA) had improved liver health during that period, including decreased inflammation and fat in the liver and decreased body weight versus people receiving a placebo. OCA was also associated with increases in itching and total cholesterol.

NIDDK News Item

Nov 3, 2014

More than 29 million Americans have diabetes, and about 86 million more are on the verge of the disease. People with diabetes are nearly two times more likely than people without diabetes to die from heart disease, and are also at greater risk for kidney, eye and nerve diseases, among other painful and costly complications.

NIDDK News Item

Oct 9, 2014

Wide-ranging National Institutes of Health grants announced today will develop new strategies to analyze and leverage the explosion of increasingly complex biomedical data sets, often referred to as Big Data. These NIH multi-institute awards constitute an initial investment of nearly $32 million in fiscal year 2014 by NIH's Big Data to Knowledge (BD2K) initiative.

NIDDK News Item

Oct 8, 2014

Physician scientists at 22 consortia will collaborate with representatives of 98 patient advocacy groups to advance clinical research and investigate new treatments for patients with rare diseases. The collaborations are made possible through awards by the National Institutes of Health — totaling about $29 million in fiscal year 2014 funding — to expand the Rare Diseases Clinical Research Network (RDCRN), which is led by NIH’s National Center for Advancing Translational Sciences (NCATS).

NIDDK News Item

Sep 9, 2014

People who are obese may be more susceptible to environmental food cues than their lean counterparts due to differences in brain chemistry that make eating more habitual and less rewarding, according to a National Institutes of Health study published in Molecular Psychiatry.

NIDDK Grantee News

Aug 1, 2014

The HMG-CoA reductase inhibitors (statins) are widely prescribed for patients with hyperlipidemia and are generally well tolerated. Mild elevations in serum aminotransferases arise in up to 3% of treated patients, but clinically apparent drug-induced liver injury is rare. The aim of this study is to report the presenting features and outcomes of 22 patients with clinically apparent liver injury due to statins.

NIDDK News Item

Jul 31, 2014

NIH leaders have announced a new collaborative initiative to improve human health by exploring poorly understood genes that have the potential to be modified by medicines.

NIDDK News Item

Jul 8, 2014

Adults with extreme obesity have increased risks of dying at a young age from cancer and many other causes including heart disease, stroke, diabetes, and kidney and liver diseases, according to results of an analysis of data pooled from 20 large studies of people from three countries. The study, led by researchers from the National Cancer Institute (NCI), part of the National Institutes of Health, found that people with class III (or extreme) obesity had a dramatic reduction in life expectancy compared with people of normal weight. The findings appeared July 8, 2014, in PLOS Medicine.

NIDDK Grantee News

Jul 3, 2014

The presence of HLA haplotype DR3–DQ2 or DR4–DQ8 is associated with an increased risk of celiac disease. In addition, nearly all children with celiac disease have serum antibodies against tissue transglutaminase (tTG).

NIDDK News Item

Jul 3, 2014

Acute kidney injury (AKI) and chronic kidney disease (CKD) are closely intertwined, with each disease a risk factor for developing the other and sharing other risk factors in common, as well as sharing causes for the diseases to get worse, and outcomes, suggests a comprehensive analysis by scientists at the National Institutes of Health and George Washington University Medical Center, Washington, D.C. Findings were published July 3 in the New England Journal of Medicine.

NIDDK News Item

Jul 2, 2014

More than one quarter of children with two copies of a high-risk variant in a specific group of genes develop an early sign of celiac disease called celiac disease autoimmunity (CDA) by age 5. The findings are from The Environmental Determinants of Diabetes in Youth consortium, or TEDDY . The National Institutes of Health-funded study, published July 2 in the New England Journal of Medicine , also found that participants in Sweden had higher rates of celiac disease than participants in the United States, Finland and Germany, even with the same genetic risks.

NIDDK News Item

Jul 1, 2014

Half of patients in a trial have safely stopped immunosuppressant medication following a modified blood stem-cell transplant for severe sickle cell disease, according to a study in the July 1 issue of the Journal of the American Medical Association. The trial was conducted at the National Institutes of Health’s Clinical Center in Bethesda, Maryland, by researchers from NIH’s National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the National Heart, Lung, and Blood Institute.

NIDDK Grantee News

Jul 1, 2014

Microvillus inclusion disease (MVID) is a severe form of congenital diarrhea that arises from inactivating mutations in the gene encoding myosin Vb (MYO5B). We have examined the association of mutations in MYO5B and disruption of microvillar assembly and polarity in enterocytes. Stable MYO5B knockdown (MYO5B-KD) in CaCo2-BBE cells elicited loss of microvilli, alterations in junctional claudins, and disruption of apical and basolateral trafficking; however, no microvillus inclusions were observed in MYO5B-KD cells.

NIDDK Grantee News

Jul 1, 2014

miRNAs are important regulators of biological processes in many tissues, including the differentiation and function of brown and white adipocytes. The endoribonuclease dicer is a major component of the miRNA-processing pathway, and in adipose tissue, levels of dicer have been shown to decrease with age, increase with caloric restriction, and influence stress resistance.

NIDDK News Item

Jun 30, 2014

Researchers have developed a new supercooling technique to increase the amount of time human organs could remain viable outside the body. This study was conducted in rats, and if it succeeds in humans, it would enable a world-wide allocation of donor organs, saving more lives.

NIDDK Grantee News

Jun 19, 2014

Clec16a has been identified as a disease susceptibility gene for type 1 diabetes, multiple sclerosis, and adrenal dysfunction, but its function is unknown. Here we report that Clec16a is a membrane-associated endosomal protein that interacts with E3 ubiquitin ligase Nrdp1. Loss of Clec16a leads to an increase in the Nrdp1 target Parkin, a master regulator of mitophagy. Islets from mice with pancreas-specific deletion of Clec16a have abnormal mitochondria with reduced oxygen consumption and ATP concentration, both of which are required for normal β cell function.

NIDDK Grantee News

Jun 19, 2014

Therapeutic food interventions have reduced mortality in children with severe acute malnutrition (SAM), but incomplete restoration of healthy growth remains a major problem1, 2. The relationships between the type of nutritional intervention, the gut microbiota, and therapeutic responses are unclear. In the current study, bacterial species whose proportional representation define a healthy gut microbiota as it assembles during the first two postnatal years were identified by applying a machine-learning-based approach to 16S ribosomal RNA data sets generated from monthly faecal samples obtained from birth onwards in a cohort of children living in an urban slum of Dhaka, Bangladesh, who exhibited consistently healthy growth.

NIDDK Grantee News

Jun 17, 2014

α-Intercalated cells (A-ICs) within the collecting duct of the kidney are critical for acid-base homeostasis. Here, we have shown that A-ICs also serve as both sentinels and effectors in the defense against urinary infections. In a murine urinary tract infection model, A-ICs bound uropathogenic E. coli and responded by acidifying the urine and secreting the bacteriostatic protein lipocalin 2 (LCN2; also known as NGAL). A-IC-dependent LCN2 secretion required TLR4, as mice expressing an LPS-insensitive form of TLR4 expressed reduced levels of LCN2.

NIDDK Grantee News

Jun 15, 2014

The safety and effectiveness of automated glycemic management have not been tested in multiday studies under unrestricted outpatient conditions.

NIDDK News Item

Jun 15, 2014

People with type 1 diabetes who used a bionic pancreas instead of manually monitoring glucose using fingerstick tests and delivering insulin using a pump were more likely to have blood glucose levels consistently within the normal range, with fewer dangerous lows or highs. The full report of the findings, funded by the National Institutes of Health, can be found online June 15 in the New England Journal of Medicine.