U.S. Department of Health and Human Services

Diabetic Wound Healing-Translation and Clinical Opportunities

10/9/2013 8:00 AM
10/9/2013 8:00 AM
Yes
No
Michael Schultz
Project Manager
The Scientific Consulting Group, Inc.
656 Quince Orchard Road, Suite 210
Gaithersburg, MD 20878
Email: mschultz@scgcorp.com
Phone: (301) 670-4990
Rockville
 
The NIH Neuroscience Center

Event Details

​Meeting Objectives

The goal of this workshop, sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and held in conjunction with the Diabetes Limb Salvage Conference sponsored by MedStar Georgetown University Hospital, is to explore scientific opportunities and challenges in translating and testing new therapeutic interventions for diabetic wound healing.​​

Agenda

8:00 a.m. Welcoming Remarks From the NIDDK Director
Griffin Rodgers, M.D., MACP

Pre-clinical Research

Moderator: Marjana Tomic-Canic, Ph.D.

8:10 a.m. What is the current state of progenitor cell research for wound healing? What are the barriers for moving this research to clinical testing?
Geoffrey G. Gurtner, M.D.
8:25 a.m. Of the many molecular and cellular changes from diabetes that impact the many steps in wound healing, which ones play a central role in the pathology of diabetic foot ulcers? What are the most promising drug targets and biomarkers?
Marjana Tomic-Canic, Ph.D.
8:40 a.m. Do we have the right animal models for pre-clinical testing? Which ones are the most predictive?
Matthew J. Hardman, Ph.D.
8:55 a.m. Panel Discussion
Jeffrey M. Davidson, Ph.D.; Song Hong, Ph.D.; Julie M. Jameson, Ph.D.; Aristidis Veves, M.D., D.Sc.
9:25 a.m. Keynote Speech
Current successes and failures in the prevention and treatment of diabetic foot ulcers in the clinic and in clinical trials. How can we improve?
Andrew J. M. Boulton, M.D., D.Sc., FRCP
9:55 a.m. Break
   

Local Interventions 

Moderator: Andrew J. M. Boulton, M.D., D.Sc., FRCP

10:10 a.m. What are the NICE recommendations for dressings? Which areas need more evidence-based research and how should this research be translated to the clinic? 
William Jeffcoate, M.B., MRCP
10:25 a.m. Is hyperbaric oxygen therapy effective compared to other therapies? What is the state of clinical research in this area?
Stephen R. Thom, M.D., Ph.D.
10:40 a.m. What is the role of drug-releasing matrices and nanostructures in diabetic wound healing? What properties of the structures are important? What therapie would benefit from application through a drug-release matrix?
Aristidis Veves, M.D., D.Sc.
10:55 a.m. What advantage does gene therapy offer for diabetic wound healing? What is the current state of the methodologies?
Jeffrey M. Davidson, Ph.D.
11:10 a.m. How does the FDA handle treatments at the interface between drugs and devices? In what areas would the FDA like more evidence-based research?
Speaker From the FDA
11:25 a.m. Panel Discussion  
David M. Armstrong, D.P.M., M.D., Ph.D.; Michael Edmonds, M.D.; Robert G. Frykberg, M.P.H., D.P.M.; Benjamin A. Lipsky, M.D.; Dane K. Wukich, M.D.
11:55 a.m. Lunch
   

Population Studies and Databases

Moderator: David J. Margolis, M.D., Ph.D.

12:45 p.m. What database resources on diabetic wound healing are available? What data on patient characteristics, treatment and outcome are essential for a database?
Joseph L. Mills, Sr., M.D.
1:00 p.m. What are the highest priority epidemiology questions for directing future clinical research, evaluating access and differences in care, and assessing cost-effectiveness?
Harold Brem, M.D.
1:15 p.m. Can we test interventions through population studies? Can alternative study designs compensate for the lack of randomization?
David J. Margolis, M.D., Ph.D.
1:30 p.m. Panel Discussion
Harold Brem, M.D.; William Jeffcoate, M.B., MRCP ; David J. Margolis, M.D., Ph.D.; Joseph L. Mills, Sr., M.D.
2:00 p.m. Break
   

Clinical Issues

Moderator: Lawrence A. Lavery, M.P.H., D.P.M.

2:15 p.m. Recruitment and retention strategies and inclusion/exclusion criteria.
Lawrence A. Lavery, M.P.H., D.P.M.
2:30 p.m. Standard of care for clinical trial protocols:  off-loading, debridement, dressings, diagnosis and treatment of infections.
Robert S. Kirsner, M.D., Ph.D.
2:45 p.m. Outcome measures and surrogate end-points: the value of complete epithelialization as a principal endpoint.
David J. Margolis, M.D., Ph.D.
3:15 p.m. The incorporation of psychological and behavioral factors in trial design.
Loretta Vileikyte, M.D., Ph.D.
3:30 p.m. Panel Discussion on the highest priority research questions for prevention and treatment:  weighing public health impact and cost, feasibility and scientific opportunity. Examples include:  recurrence prevention; prevention and treatment in dialysis patients; osteomyelitis treatment; hyperbaric oxygen efficacy; prevention of infections in diabetic foot ulcers; and acellular dermal matrix products
David G. Armstrong, D.P.M., M.D., Ph.D.; Christopher E. Attinger, M.D.;
Paul J. Kim, D.P.M., FACAS; Benjamin A. Lipsky, M.D.;
Stephen R. Thom, M.D., Ph.D.
4:15 p.m. Summary Discussion
Moderators: Christopher E. Attinger, M.D.; Andrew J. M. Boulton, M.D., D.Sc., FRCP; Marjana Tomic-Canic, Ph.D.
5:00 p.m. ADJOURNMENT

Directions/Travel

LOCATION

Workshop
The NIH Neuroscience Center
Conference Room C/D
6001 Executive Boulevard
Rockville, MD  20852   
Local Hotel
Bethesda North Marriott
5701 Marinelli Road
North Bethesda, MD 20852
Tel: 1-301-822-9200
Fax: 1-301-822-9201
Toll-free: 1-800-859-8003
Web: http://www.marriott.com/hotels/travel/wasbn-bethesda-north-marriott-hotel-and-conference-center

TRAVEL TO THE WORKSHOP

 
NSC BuildingThe NIH Neuroscience Center (6001 Executive Boulevard) is about a 0.5-mile, 5-10 minute walk from the Bethesda Marriott North and the White Flint Metro station on the Red Line. There will not be shuttle service available from the hotel to the meeting site.
 
WALKING DIRECTIONS: Exiting the hotel or the Metro station, turn right to walk west on Marinelli Road. Turn right onto Executive Boulevard. Follow Executive Boulevard through the Old Georgetown Road intersection, and the NIH Neuroscience Center will be on your right.
 
If driving or taking a taxi to the Neuroscience Center, please use the SECOND driveway past the Old Georgetown Road intersection, as the first is restricted-access to employees only. Paid visitor parking is available. The first 30 minutes are free, the first hour is $2, and all-day parking is $7.
 
Please allow an extra 10-15 minutes to allow for the security screening process at the NIH Neuroscience Center. Upon your arrival, visitors must show a government-issued, valid photo ID. Visitors should be prepared for a security search of their belongings. Visitors will be asked to sign in, will be issued a visitor’s pass, and will receive a temporary property pass for laptops or other electronic equipment they have brought with them.  

TRAVEL TO THE BETHESDA NORTH MARRIOTT

There are several options for transportation from the major airports and Union Station to the hotel.

METRORAIL (SUBWAY)

The Bethesda North Marriott is steps from the White Flint Metro station on the Red Line, and the NIH Neuroscience Center is an easy 0.5-mile walk further. The Washington, D.C. Metro system is clean, reliable, and safe. It opens at 5:00 a.m. on weekdays and 7:00 a.m. on weekends and closes at midnight Sunday-Thursday and 3:00 a.m. Friday-Saturday. Each Metro station and car features a complete color-coded map of the system. Station attendants on duty at each station can provide additional information on request. For fares, schedules, and to plan your trip on the Metrorail or Metrobus system, please visit http://www.wmata.com.
 
Each passenger must purchase a reusable SmartTrip card or a paper farecard to travel in the system. Guides for purchasing fares are posted on vending machines in each station. SmartTrip and farecards also are available for purchase online. Please note: If you use a paper farecard you need to add $1 extra to the stated fare for each leg of your trip.
  • From Union Station or Downtown Washington – Union Station is served by Amtrak, MARC, and Virginia Railway Express. Once you disembark, follow the signs to the Metrorail station. Take the Red Line in the direction of Shady Grove and exit at the White Flint station. Upon exiting the White Flint station, turn right and cross Rockville Pike. Follow Marinelli Road a half a block to the Bethesda North Marriott.
  • From Ronald Reagan Washington National Airport – Follow the airport signs through the covered walkways and into the Metro station. Board a Yellow Line train heading to Greenbelt or Fort Totten and transfer to the Red Line at Gallery Place/Chinatown. Take the Red Line in the direction of Shady Grove and exit at the White Flint station. Upon exiting the White Flint station, turn right and cross Rockville Pike. Follow Marinelli Road a half a block to the Bethesda North Marriott.

SUPERSHUTTLE

The Bethesda North Marriott does not offer an airport shuttle. However, SuperShuttle offers service to most hotels from Ronald Reagan Washington National Airport ($29 + $10/additional person), Washington Dulles International Airport ($30 + $10/additional person), and Baltimore/Washington International Thurgood Marshall Airport ($42 + $12/additional person). Please contact SuperShuttle directly to arrange for a shuttle by calling 1-800-258-3826 or visiting http://www.supershuttle.com. Please note:  SuperShuttle is a shared van service; therefore, there are likely to be additional stops to and from the airport.

TAXI

Taxi fare to the Bethesda North Marriott or the NIH Neuroscience Center is ~$45-$55 from Ronald Reagan National Airport, approximately $55-$65 from Dulles International Airport, and approximately $65-$75 from Baltimore/Washington International Thurgood Marshall Airport. Fares may differ during peak travel hours.

DRIVING DIRECTIONS

Parking is available at the Marriott at a rate of $5/hr or $15/day.
  • From Ronald Reagan Washington National Airport (DCA) – Take George Washington Parkway to I-495N. Merge onto I-270 and take Exit 1 (Democracy Boulevard East) to Democracy Boulevard. Turn left on MD-187/Old Georgetown Road. Turn right on Executive Boulevard. Turn left on Marinelli Road.
  • From Dulles International Airport (IAD) – Take Dulles Airport Access Road. Merge onto VA-267E via Exit 18-19 (toward I-495). Merge onto I-495N via Exit 18 (Baltimore/Bethesda). Merge onto I-270 Spur N via Exit 38 (Rockville/Frederick). Take Exit 1 (Democracy Boulevard East) to Democracy Boulevard. Turn left on MD-187/Old Georgetown Road. Turn right on Executive Boulevard. Turn left on Marinelli Road.
  • From Baltimore-Washington International Thurgood Marshall Airport (BWI) – Take I-195W to Exit 4B and merge with I-95S. Merge onto I-495W at Exit 27 (Silver Spring). Take Exit 34 (Rockville/Bethesda/Wisconsin Avenue) to Rockville Pike/MD-355. Travel about 2 miles and turn left onto Marinelli Road.
  • From Points North (NY, Philadelphia, Baltimore) – Take I-95S, following signs for Washington, D.C. Merge onto I-495W at Exit 27 (Silver Spring). Take Exit 34 (Rockville/Bethesda/Wisconsin Avenue) to Rockville Pike/MD-355. Travel about 2 miles and turn left onto Marinelli Road.
  • From Points South (Fredericksburg, Richmond, Alexandria) – Take I-95N, following signs for Washington, D.C. Merge onto the I-95N Connector and take Exit 170B (Tysons Corner) to merge onto I-495N. Merge onto I-495W. Merge onto I-270N and take Exit 1 (Democracy Boulevard East). Turn left on MD-187/Old Georgetown Road. Turn right on Executive Boulevard. Turn left on Marinelli Road.
  • From Points East (Annapolis, Eastern Shore) – Follow US-50W to Exit 7B to merge onto I-95N/I-495N. Take Exit 34 (Rockville/Bethesda/Wisconsin Avenue) to Rockville Pike/MD-355. Travel about 2 miles and turn left onto Marinelli Road.
  • From Points Northwest (Frederick, Germantown, Gaithersburg) – Take
    I-270S to Exit 4A (Montrose Road East). Follow Montrose Road (or Montrose Parkway) and turn right onto E. Jefferson Street/Executive Boulevard. Turn left onto Marinelli Road.

Minutes

​Minutes are currently unavailable.

Attendees

​​Attendees are currently unavailable.

Abstracts

​​Abstracts are currently unavailable.

Location

Line
  • Conference Room C/D6001 Executive Boulevard
  • MD 20852
Webinar

Contacts

Line
Michael Schultz
Project Manager
The Scientific Consulting Group, Inc.
656 Quince Orchard Road, Suite 210
Gaithersburg, MD 20878
Email: mschultz@scgcorp.com
Phone: (301) 670-4990