U.S. Department of Health and Human Services

Exploring the Role of Brown Fat in Humans

2/25/2014 8:00 AM
2/26/2014 5:00 PM
 
No
For questions concerning Program Content:
Carol Haft, Ph.D.
Adipocyte Biology Program Director, NIDDK, NIH
Phone: (301) 594-7689

Maren Laughlin, Ph.D.
Metabolism Program Director, NIDDK, NIH
Phone: (301) 594-8802

For questions concerning Logistical Information or Registration: 
Michelle Watson
The Scientific Consulting Group, Inc.
Phone: (301) 670-4990
Bethesda
 
Lister Hall Auditorium

Event Details

Meeting Obj​ective:
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) announces a workshop focused on elucidating the roles of recently described brown and beige/brite fat in people. Speakers will describe state-of-the-art technology for monitoring human brown adipose tissue (hBAT) mass and function, and present recent basic and clinical data. Plenary talks, selected “hot topic” presentations, and a poster session will provide a forum for interactions among basic scientists and clinical researchers.

Scientific Focus:

  • ​Physiological Functions and Clinical Relevance of hBAT: The 2013 Perspective
  • Classical and Inducible Brown, Beige, Brite, B/B Fat in Humans
  • Measuring hBAT Activity: Pushing the Limits of Position Emission Tomography/Computed Tomography (PET/CT)
  • hBAT as a Therapeutic Target: Investigations in Different Populations
  • Measuring hBAT Mass and Activity: Emerging Approaches
  • Novel Roles of hBAT: Thinking Outside the Box

Planning​ Committee:

  • A​aron Cypess (Joslin Diabetes Center, Harvard University)
  • Carol Haft (NIDDK, NIH, HSS)
  • Houchun Harry Hu (Children’s Hospital Los Angeles)
  • Maren Laughlin (NIDDK, NIH, HHS)
​​​​​​​​​​​​

Agenda

Agenda available for download

Day 1​ — Tuesday, February 25, 2014​

7:30 a.m. Registration (Lister Hill Auditorium, NIH Campus)
8:15 a.m. ​Opening Remarks
Griffin Rodgers, NIDDK, NIH

Meeting Overview
Carol Haft and Maren Laughlin, NIDDK, NIH
Aaron Cypess, Joslin Diabetes Center, Harvard University
Houchun Harry H​u, Childre​n’s Hospital, Los Angeles
   

Session I: Physiological Functions and Clinical Relevance of Human BAT: The 2013 Perspective

Kong Chen (Moderator)
8:30 a.m. Six Years with Adult Human Brown Adipose Tissue and Many More to Come
Jan Nedergaard, Stockholm University, Sweden
9:00 a.m. Treating Metabolic Disease Through Pharmacological Activation of Human BAT
Aaron Cypess, Joslin Diabetes Center, Harvard University
9:30 a.m. Fat Depots and Bone: the Role of Human BAT
Miriam Bredella, Massachusetts General Hospital
10:00 a.m. Brown and Beige Fat: Basic Biology and Novel Therapeutic Opportunities
Bruce Spiegelman, Dana Farber Cancer Institute, Harvard Medical School
10:30–11:00 a.m. Break
   

Session II: Measuring Human BAT Activity: Pushing the Limits of PET/CT

Richard Wahl (Moderator)
11:00 a.m. Does Cold-Activated Brown Fat Contribute Significantly to Daily Energy Expenditure?
Otto Muzik, Wayne State University School of Medicine
11:15 a.m. Novel Approaches for Investigating Fatty Acid Metabolism in Human BAT
Kirsi Virtanen, University of Turku and Turku University Hospital, Finland
11:30 a.m. The Norepinephrine Transporter: A Novel Target for Imaging Brown Adipose Tissue
Yu-Shin Ding, New York University School of Medicine
11:45 a.m. Insight into the Functional Organization of Human BAT
Igal Madar, Johns Hopkins University School of Medicine
12:00 p.m. Imaging of Brown Fat Metabolism using Hyperpolarized Carbon-13 MRI
Lanette Friesen-Waldner, University of Western Ontario, London
12:15–2:00 p.m. Poster Session and Lunch Buffet in Atrium
   

Session III: Classical and Inducible Brown, Beige, Brite, B/B Fat in Humans

Barbara Cannon (Moderator)
2:00 p.m. Deciphering Brown Adipogenesis from a Progenitor and Inductive Signaling Perspective
Yu-Hua Tseng, Joslin Diabetes Center, Harvard Medical School
2:30 p.m. Pharmacological Approaches to Induce Brown and Beige Fat Cell Development
Shingo Kajimura, University of California, San Francisco
3:00 p.m. The Role of FGF21 in Brown Fat
Alexei Kharitonenkov, Lilly Research Laboratories, Indianapolis
3:20 p.m. Brown Fat Dynamics: Elucidation of Molecular Drivers Based on the Innate Expertise of a Hibernator
Sandra L. Martin, U​niversity of Colorado School of Medicine, Aurora
3:40–4:00 p.m. Break
   

Sessio​n IV: Measuring Human BAT Mass and Activity: Emerging Approaches

Houchun Harry Hu (Moderator)
4:00 p.m. Brown Adipose Tissue Quantification Using Magnetic Resonance Imaging
E. Brian Welch, Vanderbilt University Medical Center
4:15 p.m. Brown Adipose Tissue Perfusion: From Mice to Men
Marielle Scherrer-Crosbie, Massachusetts General Hospital
4:30 p.m. Detecting BAT Mass and Thermogenic Activity by Using Nonlinear 1H MRI and Hyperpolarized 129Xe Gas MRI
Rosa Tamara Branca, University of North Carolina, Chapel Hill
4:45 p.m. Passive and Active Microwave Radiometry for Non-Invasive Detection of Human Brown Fat
Fred Sterzer, MMTC, Inc.
5:00 p.m. Peptide Probes for Targeted Brown Adipose Tissue Imaging
Mikhail G. Kolonin, University of Texas Health Science Center, Houston
5:15 p.m. Adjournment
   

Day 2 — Wednesday, February 26, 2014

7:30–8:00 a.m. Registration (Lister Hill Auditorium, NIH Campus)
7:55 a.m. Opening Remarks
   

Session V: Human BAT ​as a Therapeutic Target

Rebecca Brown (Moderator)
8:00 a.m. Effect of Ambient Temperature on Human Brown Fat Activity and Recruitment
Wouter van Marken Lichtenbelt, Maastricht University Medical Center, The Netherlands
8:30 a.m. Exploring the Roles of Brown Fat in Children
Vicente Gilsanz, Children’s Hospital Los Angeles
9:00 a.m. Signal Transduction Pathways Converging to Promote “Brown(ing)” Adipocytes
Sheila Collins, Sanford-Burnham Medical Research Institute
9:30 a.m. Brown Adipose Tissue Improves Glucose Metabolism and Whole Body Insulin Sensitivity in Humans
Maria Chondronikola, University of Texas Medical Branch, Galveston
9:50–10:15 a.m. Break
10:15 a.m. Acute Cold Exposure Elicits Increases in BAT Oxidative Metabolism in Individuals with Type 2 Diabetes
Denis Blondin, Université de Sherbrooke
10:35 a.m. Autologous Matrix Assisted Cell Transplantation as a Strategy for the Expansion of Human BAT
Andreas Stahl, UC Berkeley
 

Session VI: Human BAT Research: Future Directions

Houchun Harry Hu and Aaron Cypess (Moderators)
11:00 a.m. Open Floor Discussion of Research Gaps and Opportunities
  • What are the potential physiological roles for adults human BAT/beige/brite cells?

  • What technologies, in addition to imaging or temperature detection, are needed to assess the role(s) of adult human BAT?

  • Is there more to be learned from the mouse regarding the role(s) of adult human BAT?

  • Are epidemiologic studies of human BAT needed?
    • Impact of climate and environment
    • Impact of exercise and diet
    • Impact of age, gender, body composition, genetics
    • Unique populations
12:00–1:30 p.m. Poster Session and Lunch Buffet


Session VII: Novel Role(s) of Human BAT: Thinking Outside the Box

Eric Ravussin (Moderator)​
1:30 p.m. Hope for a Therapy Based on Thermogenic Drugs and BAT
Eric Ravussin, Pennington Biomedical Research Center, Louisiana State University System​
2:00 p.m. Does hBAT Play a Role in Non-Shivering Thermogenesis?
Kong Chen, NIDDK, NIH
2:30 p.m. Insights From Understanding CNS Pathways in Regulating the Sympathetic Outflow to BAT
Shaun Morrison, Oregon Health and Science University
3:00 p.m. Brown Adipose Tissue and Sleep Regulation
Éva Szentirmai, Washington State University, Spokane
3:20 p.m Does Sarcolipin and Muscle Based Thermogenesis Compensate in BAT Deficient Mammals?
Muthu Periasamy, Ohio State University, Columbus
3:40 p.m. Closing Remarks
4:00 p.m. Adjournment
​​

Directions/Travel

Meeting Location:

Lister Hill Auditorium
Building 38 A
National Institutes of Health
Bethesda, MD 

NIH Visitor Information:

The Lister Hill Auditorium is located on the NIH Campus in building 38A.  For a map, general information, and directions to and around the NIH Campus, visit: http://parking.nih.gov/visitor_access_map.htm.

NIH Secur​ity:
The NIH, like all federal government facilities, has instituted security measures to ensure the safety of NIH employees, patients, and visitors.  The national threat advisory level, determined by the Department of Homeland Security (http://www.whitehouse.gov/homeland), currently is yellow (elevated). 

Perime​ter Security:

All visitor vehicles, including taxicabs, hotel and airport shuttles, delivery trucks, and vans will be inspected before being allowed on campus.  Visitors will be asked to show one (1) form of identification (a government-issued photo ID:  driver’s license, passport, green card, etc.) and to state the purpose of their visit.  Be sure to allow at least 15-20 minutes for this vehicle inspection procedure.

Building Security:

Due to the checking of IDs at the perimeter, employees and visitors will not be required to show their ID again to gain access to the majority of buildings on the NIH Campus during the normal business day.
Employees and visitors should continue to wear their identification prominently at all times while on campus.
Guards will remain at certain buildings to address specific program requirements, such as sensitive research and safety concerns.  At building entrances where guards are posted: 

  • Employees must show a DHHS-issued photo ID (for example, your NIH-issued ID badge). 
  • Visitors may be required to log-in, wear a visitor’s pass, and be escorted by an employee through the building.
  • Visitors may be required to pass through a metal detector and have bags, backpacks, or purses inspected or x-rayed as they enter buildings. 
  • Security staff will confiscate any suspicious or potentially dangerous materials.  U.S. code prohibits bringing any dangerous weapons onto federal property, including anything with a blade longer than 2½ inches.  Meeting participants may want to leave extra bags or personal materials at their hotel to minimize the time needed for inspection. 

Weekday Pedestrian Campus Access:

All visitors must enter through the NIH Gateway Center at Metro or the West Gateway Center (see the Visitor Map at http://parking.nih.gov/visitor_access_map.htm).

  • Gateway Center
    Wisconsin Avenue at Gateway Drive (near the Metro)
    Open 24 hours, 7 days per week
  • West Gateway Center
    Near Old Georgetown Road and South Drive
    Open 6 a.m. – 12 p.m., Monday-Friday

Driving Directions ​to NIH

From Points North and East:

Take I-95 South to I-495 West (Capital Beltway) toward Silver Spring.  Follow I-495 West for 9 miles to Exit 34 (Bethesda/Wisconsin Avenue).  Follow signs for Route 355 South and stay in the right lane.  Travel approximately 1 mile and turn right at the light onto South Drive.  Pass through NIH security and follow the signs to Building 38A.

From Points North and West:

Take I-270 South to I-495 East (Capital Beltway) toward Washington, DC.  Stay in one of the three left lanes.  Follow signs for Route 355 South, a left-lane exit, onto Wisconsin Avenue.  Travel approximately 1 mile and turn right at the light onto South Drive.  Pass through NIH security and follow the signs to Building 38A.

From Points South:

Take I-95 North to I-495 (Capital Beltway) toward Tyson’s Corner/Rockville.  Follow I-495 for 20 miles.  Take Exit 34 (Bethesda/Wisconsin Avenue).  Travel approximately 1 mile and turn right at the light onto South Drive.  Pass through NIH security and follow the signs to Building 38A.

From Baltimore/Washington International Thurgood Marshall Airport (BWI):

Take the Route 195 connector to I-95 South.  Take I-95 South to I-495 West (Capital Beltway) toward Silver Spring.  Follow I-495 West for 9 miles to Exit 34 (Bethesda/Wisconsin Avenue).  Follow signs for Route 355 South and stay in the right lane.  Travel approximately 1 mile and turn right at the light onto South Drive.  Pass through NIH security and follow the signs to Building 38A.

From Washington Dulles International Airport (IAD):

Take the Dulles Access Road for approximately 13 miles to Exit 18.  Move to the right on the Dulles Toll Road (Route 267) and take Exit 18.  Stay left on the ramp for Bethesda/Baltimore, and proceed toward Bethesda (I-495).  Continue approximately 9 miles on I-495.  Stay on I-495 at the I-495/I-270 split (bear right).  Take Exit 34 (Wisconsin Avenue South/Route 355) toward Bethesda.  Travel approximately 1 mile and turn right at the light onto South Drive.  Pass through NIH security and follow the signs to Building 38A.

From Ronald Reagan Washington National Airport (DCA):

Take the George Washington Parkway North for 12 miles to I-495 toward Maryland (Capital Beltway).  Take Exit 34 (Bethesda/Wisconsin Avenue).  Travel approximately 1 mile and turn right at the light onto South Drive.  Pass through NIH security and follow the signs to Building 38A.

Parking:

Parking on the NIH campus is limited and is $12 per day in the visitor lots.

HOTEL ACCOMMODATIONS:

Bethesda Marriott Hotel
5151 Pooks Hill Road
Bethesda, MD  20814
Telephone: (301) 897-9400 or (800) 228-9290
Fax: (301) 897-0192
http://www.marriott.com/hotels/travel/wasbt-bethesda-marriott/

An additional block of sleeping rooms has been reserved at the Bethesda Marriott (Pooks Hill), Bethesda, MD, for arrival on Monday, February 24, 2014, and departing on Wednesday, February 26, 2014. The room rate is $149 plus tax per night. You will be responsible for the room cost and your incidental charges upon checkout. 

Please contact the Bethesda Marriott by Monday, February 3, 2014, at (301) 897-9400 or 1 (877) 212-5752, and reference the “Exploring the Roles of Brown Fat in Humans” when making your sleeping room reservations. For online registrations, please use the following link: https://resweb.passkey.com/Resweb.do?mode=welcome_ei_new&eventID=10990245.
Please be certain that the hotel provides you with a confirmation number. After February 3, 2014, the hotel will accept reservations on a space-available basis at the prevailing hotel rate.

If for any reason you need to cancel your hotel reservation, please do so 48 hours in advance of your check-in date or you will be charged.

DIRECTIONS

From Points North
From points North and East: Take I-95 South to I-495 West (Capital Beltway) toward Silver Spring. Follow I-495 West for 9 miles to Exit 34 (Bethesda/Wisconsin Avenue). Follow signs for Route 355 South and stay in the right lane. Turn right at the light onto Pooks Hill Road. The hotel is on the right.
 
From Points North and West
Take I-270 South to I-495 East (Capital Beltway) toward Washington, DC. Stay in one of the three left lanes.  Follow signs for Route 355 South, a left-lane exit, onto Wisconsin Avenue. Turn right at the light onto Pooks Hill Road. The hotel is on the right.
 
From Points South
Take I-95 North to I-495 (Capital Beltway) toward Tysons Corner/Rockville. Follow I-495 for 20 miles. Take Exit 34 (Bethesda/Wisconsin Avenue). Turn right at the light onto Pooks Hill Road. The hotel is on the right.
 
From Baltimore/Washington International Airport (BWI)
Take the Route 195 connector to I-95 South.  Take I-95 South to I-495 West (Capital Beltway) toward Silver Spring. Follow I-495 West for 9 miles to Exit 34 (Bethesda/Wisconsin Avenue). Follow signs for Route 355 South and stay in the right lane. Turn right at the light onto Pooks Hill Road. The hotel is on the right.
 
From Washington Dulles International Airport
Take the Dulles Access Road for approximately 13 miles to Exit 18. Move to the right on the Dulles Toll Road (Route 267) and exit at Exit 18. Stay left on the ramp for Bethesda/Baltimore and proceed toward Bethesda (I-495). Go approximately 9 miles on I-495. Stay on I-495 at the I-495/I-270 split (bear right). Take Exit 34 (Wisconsin Avenue South/Route 355) toward Bethesda. Follow Wisconsin Avenue to the first traffic light and turn right onto Pooks Hill Road. The hotel is on the right.
 
From Ronald Reagan National Airport
Take the George Washington Parkway North for 12 miles to I-495 toward Maryland (Capital Beltway). Take Exit 34 (Bethesda/Wisconsin Avenue). Turn right at the light onto Pooks Hill Road. The hotel is on the right.

ADDITIONAL HOTEL ACCOMMODATIONS:​

Hyatt Regency Bethesda Hotel
One Bethesda Metro Center
7400 Wisconsin Avenue
Bethesda, MD  20814 
Telephone:  (301) 657-1234
Website:  http://www.hyattregencybethesda.com

Hotel Accommodations

A block of sleeping rooms has been reserved at the Hyatt Regency Bethesda, Bethesda, MD, for arrival on Monday, February 24, 2014, and departing on Wednesday, February 26, 2014. The room rate is the prevailing government rate which is currently $184 plus tax per night (subject to change).

Please contact the Hyatt Regency Bethesda by Thursday, January 30, 2014, at (402) 592-6464 or 1 (888) 421-1442, and reference the Exploring the Roles of Beige and Brown Fat in Humans when making your sleeping room reservations. For online registrations, please use the meeting code SCG9 at the following link https://resweb.passkey.com/go/SCG9.   Please be certain that the hotel provides you with a confirmation number and retain this number for future reference. After January 30, 2014, the hotel will accept reservations on a space-available basis at the prevailing hotel rate.

When making a reservation, please provide your room and bedding preferences. The hotel will assign specific room types at check-in, based on availability. Please be advised that requests are not guaranteed.  Check-in time is at 3:00 p.m., and check-out time is 12:00 noon.  If for any reason you need to cancel your hotel reservation, please do so 48 hours in advance of your check-in date.

Additional Information​

The Scientific Consulting Group, Inc. (SCG) is providing the logistical support for this meeting. The above information should help you with your planning. If you have any questions, please contact Michelle Watson of SCG by telephone at 301-670-4990 or by email at mwatson@scgcorp.com.

Directions

From Points North

From I-95: Take I-95 South to I-495 (Capital Beltway) West toward Silver Spring. Take Exit 34 (Wisconsin Avenue/Route 355). Follow Route 355 South for approximately 3 miles and the Hyatt Regency Bethesda will be on the right, on the corner of Wisconsin Avenue and Old Georgetown Road.

From I-270: Take I-270 South to I-495 (Capital Beltway) East toward Washington, DC. Stay in one of the three left lanes. Follow signs for 355 South, a left-lane exit, onto Wisconsin Avenue. Follow Route 355 South for approximately 3 miles and the Hyatt Regency Bethesda will be on the right, on the corner of Wisconsin Avenue and Old Georgetown Road.

Fr​om Points South

Take I-95 North to I-495 (Capital Beltway) toward Tysons Corner/Rockville. Follow I-495 for 20 miles. At the I-495/I-270 split, stay to the right on I-495. Take Exit 34 (Wisconsin Avenue/Route 355). Follow Route 355 South for approximately 3 miles and the Hyatt Regency Bethesda will be on the right, on the corner of Wisconsin Avenue and Old Georgetown Road.

From Baltimore/Washington ​International Thurgood Marshall Airport (BWI)

Take Route 195 West to Exit 4 (I-95 South). From I-95 take I-495 (Capital Beltway) West toward Silver Spring. Take Exit 34 (Wisconsin Avenue/Route 355). Follow Route 355 South for approximately 3 miles and the Hyatt Regency Bethesda will be on the right, on the corner of Wisconsin Avenue and Old Georgetown Road.

From Washington Dulles International Airport

Take the Dulles Access Road for approximately 13 miles to Exit 18. Move to the right on the Dulles Toll Road (Route 267); get off at Exit 18. Stay to the left on the ramp for Bethesda/Baltimore and proceed toward Bethesda on I-495 (Capital Beltway) for approximately 9 miles. At the I-495/I-270 split, stay to the right on I-495. Take Exit 34 (Wisconsin Avenue/Route 355 South). Follow Route 355 South for approximately 3 miles and the Hyatt Regency Bethesda will be on the right, on the corner of Wisconsin Avenue and Old Georgetown Road.

From Ronald Reagan Natio​nal Airport

Take the George Washington Parkway North to I-495 (Capital Beltway) and follow the signs to Maryland. At the I-495/I-270 split, stay to the right on I-495. Take Exit 34 (Wisconsin Avenue/Route 355). Follow Route 355 South for approximately 3 miles and the Hyatt Regency Bethesda will be on the right, on the corner of Wisconsin Avenue and Old Georgetown Road.

MET​RO INFORMATION

The Metro System is clean, reliable, and safe. It operates from 5:30 a.m. to 12:00 midnight Monday t​hrough Thursday; 5:00 a.m. to 2:00 a.m. on Fridays; 8:00 a.m. to 2:00 a.m. on Saturdays; and 8:00 a.m. to 12:00 midni​ght on Sundays. Each passenger must buy a farecard to travel in the system. Guides for purchasing farecards are posted on the vending machines in each station. Each Metro car features a complete color-coded map. Station attendants on duty at each station can provide additional information on request.   From Union Station or downtown Washington (main Metro Lines into the city converge at Metro Center Station and Gallery Place Station), take the Metro Red Line toward Shady Grove or Grosvenor. Exit at the Bethesda Metro Station. The Hyatt is directly above the Bethesda Metro Station.

SHUTTLES

SuperShuttle offers service to most hotels from Ronald Reagan National Airport, Washington Dulles International Airport, and Baltimore/Washington International Thurgood Marshall Airport. The shuttle leaves on an as-needed basis between the hours of 5:30 a.m. and 11:00 p.m. During other times, arrange for a shuttle by calling 800-258-3826 from the airport.

TAXIS​

The taxi fare is approximately $45-$55 from Ronald Reagan Washington National Airport, approximately $55-$65 from Washington Dulles International Airport, and approximately $65-$75 from Baltimore/Washington International Thurgood Marshall Airport.  Fares may differ during peak travel hours.

MARC T​RAINS

From BWI Airport, take the MARC train on the Penn Line to Union Station. Take the Metro Red Line toward Grosvenor or Shady Grove and exit at the Bethesda Metro Station. The hotel is directly above the Bethesda Metro Station.

PARKING INFORMA​TION

Self-parking at the hotel is $15 per day/overnight. Valet parking is $20 per day/overnight.

Minutes

​Minutes are currently unavailable.

Attendees

The attendees list is available for download here. (508 compliant, 323kb)

Abstracts

Abstrac​ts

Abstracts from meeting participants that were previously selected to be presented as posters and/or hot topic presentations (when the workshop was set for Oct 15-16, 2013) do not need to resubmit abstracts unless the presenter has significant updates that he/she would like to make. If you plan to update your abstract, please provide the updated abstract at the time that you re-register for the meeting using the instructions shown below. 

If you are a new meeting participant and would like to have an abstract of your work considered for presentation as a poster, please submit your abstract when you register for the workshop. Your abstract will be considered for one of a small number of poster spots remaining. 

Please follow the instructions below to submit a new or revised abstract for consideration:
  1. Please send the abstract via email to Ms. Michelle Watson at mwatson@scgcorp.com with "Human Brown Fat" in the subject line. Attach the abstract as an MS Word document, and include any relevant comments in the text of the email. 
  2. The abstract title should be typed in bold font, Title Case Letters. 
  3. List the names, degrees, and institutional affiliations of all authors, and underline the name of the presenting author.
  4. New or updated abstracts will not be considered after Friday, February 7, 2014

Poster Presentati​ons

Posters do not need to be elaborate. Poster boards (4 feet high by 6 feet wide), pushpins, and Velcro will be provided onsite. Sponsorship of any type should be indicated on posters.

Downloads

Location

Line
  • Building 38 A National Institutes of Health
  • MD 20814
Webinar

Contacts

LineFor questions concerning Program Content:
Carol Haft, Ph.D.
Adipocyte Biology Program Director, NIDDK, NIH
Phone: (301) 594-7689

Maren Laughlin, Ph.D.
Metabolism Program Director, NIDDK, NIH
Phone: (301) 594-8802

For questions concerning Logistical Information or Registration: 
Michelle Watson
The Scientific Consulting Group, Inc.
Phone: (301) 670-4990