U.S. Department of Health and Human Services

Targeting Fibrosis in Kidney, Bone Marrow, and Urological Diseases

10/31/2013 8:00 AM
11/1/2013 8:00 PM
 
No

For questions concerning program content, contact:
Michael F. Flessner, M.D., Ph.D.
Director of Inflammatory Renal Diseases
Division of Kidney, Urologic, and Hematologic Diseases
National Institute of Diabetes and Digestive and Kidney Diseases
National Institutes of Health
Two Democracy Plaza, Room 641
6707 Democracy Boulevard, MSC 5458
Bethesda, MD  20892-5458
Telephone: (301) 451-4901
Email: flessnermf@niddk.nih.gov

For questions concerning meeting logistics, contact:
John Hare, M.S., CMP, CGMP
The Scientific Consulting Group, Inc.
656 Quince Orchard Road, Suite 210
Gaithersburg, MD  20878
Telephone: (301) 670-4990
Fax: (301) 670-3815
Email: jhare@scgcorp.com

Bethesda
 
Natcher Conference Center

Event Details

Meeting Objectives

Discuss Means of Detecting and Measuring Pathologic Fibrosis in Humans

Questions to be answered:

Can we differentiate between pathologic fibrosis and that of normal aging?
Does fibrosis correlate with organ dysfunction?
Does imaging of fibrosis correlate with organ dysfunction, recovery, and regression?
What novel biomarkers or technologies should be pursued to detect and measure pathologic fibrosis?

Steering Committee:

NIDDK Members: Tamara Bavendam, Terry Bishop, Ed Doo, Deborah Hoshizaki, Chris Ketchum,
Ziya Kirkali, Maren Laughlin, Tracy Rankin, and Krystyna Rys-Sikora

NIBIB Member: Christina Liu
​​​​

Agenda

Day 1:

7:30 a.m. Registration
8:30 a.m. Opening Remarks and Objectives
Dr. Robert Star and Dr. Michael Flessner
8:45 a.m. State-of-the-Art Lectures (20 min. each followed by 10 min. discussion)

Moderator:  TBD
Mechanisms of Fibrosis – Dr. Thomas Wynn
JAK2 Story in Myelofibrosis – Dr. Kenneth Kaushansky
Advances in Liver Fibrosis Research – Dr. Scott Friedman
10:15 a.m. Break
10:45 a.m. Detection (Imaging) of Pathologic Fibrosis (20 min. + 10 min. for questions)

Moderator: TBD
Molecular Imaging – Dr. Bryan Fuchs
Imaging Kidney Fibrosis With Labeled Macrophages – Dr. Rafael Kramann
Fibrosis and Prostate Disease – Dr. Chad Vezina
12:15 p.m.
Lunch (on your own)
1:15 p.m. Pathologic Fibrosis and Organ Dysfunction (20 min. + 10 min. for questions)

Moderator: TBD
Urinary Obstruction and Fibrosis – Dr. Jill Macoska
Myofibroblasts and Kidney Fibrosis – Dr. Raghu Kalluri
Hematologic Fibrosis: Monitoring Dysfunction and Recovery – Dr. Joachim Deeg
2:45 p.m. Break
3:15 p.m. Breakout Sessions:
  1. Differentiation of Pathologic Fibrosis From That of “Normal Aging”
  2. Organ Dysfunction: Does it Correlate With Degree of Fibrosis?
  3. Can Imaging Detect and Measure Fibrosis?
  4. Novel Biomarkers or Technology for Detection of Fibrosis
5:00 p.m. Preliminary Reports From the Breakout Sessions and General Discussion
6:00 p.m.
Adjourn for the day

Day 2:

7:00 – 8:00 a.m. Registration
8:00 – 9:30 a.m. FDA Procedures for Qualification (20 min. each + 10 min. for questions)
Moderator: TBD
  1. Biomarker Qualification – FDA Speaker
  2. Device Qualification – FDA Speaker
  3. Molecular Probe Qualification – Dr. Libero (Louis) Marzella (invited)
9:30 a.m. Break
9:45 a.m.
Breakouts Reconvene
11:15 a.m. Final Breakout Reports
12:15 p.m. Summary – Dr. Robert Star and Dr. Michael Flessner
1:00 p.m. Adjournment

Directions/Travel

Travel Arrangements

Participants are responsible for making their own travel arrangements. If you decide to extend your stay to take advantage of lower fares, DC-area attractions are only a short stop away from the suggested hotel.
 
Hotel and travel information are listed below.

Hotel Reservations 

The following hotels provide lodging in relatively close proximity that is accessible by taxi.
 
DoubleTree Hotel
8120 Wisconsin Avenue 
Bethesda, MD  20814
Phone: 301-652-2000 or 1-800-222-TREE
 
Hyatt Regency Bethesda
One Bethesda Metro Center 
Bethesda, MD  20814 
Phone: 301-657-1234 or 1-800-633-7313 
 
American Inn of Bethesda 
8130 Wisconsin Avenue 
Bethesda, MD  20814 
Phone: 301-656-9300 or 1-800-232-7081 
 
Hilton Garden Inn
7301 Waverly Street
Bethesda, MD  20814
Phone: 301-654-8111
 
Residence Inn 
7335 Wisconsin Avenue 
Bethesda, MD  20814
Phone: 301-718-0200 or 1-800-228-9290
 
Bethesda Marriott Hotel
5151 Pooks Hill Road 
Bethesda, MD  20814 
Phone: 301-897-9400 or 1-800-228-9290
 
Bethesda North Marriott Hotel & Conference Center 
5701 Marinelli Road 
North Bethesda, MD  20852 
Phone: 301-822-9200 or 1-800-228-9290 
 
Hilton Executive Conference Center
1750 Rockville Pike 
Rockville, MD  20852 
Phone: 301-468-1100 or 1-800-HILTONS
 
Taxi Service to Area Hotels
From Baltimore/Washington International Thurgood Marshall Airport (BWI):
Approximate hotel distance and direction: 35 miles S.W.
Estimated Taxi Fare: $60
 
From Washington Dulles International Airport (IAD):
Approximate hotel distance and direction: 25 miles N.E.
Estimated Taxi Fare: $50
 
From Ronald Reagan Washington National Airport (DCA):
Approximate hotel distance and direction: 21 miles N.E.
Estimated Taxi Fare: $45
 
Fares may differ during peak travel hours.

Metro to the Hotel

The Metro system is clean and reliable. It operates from 5:00 a.m. to 12:00 midnight Monday through Thursday; 5:00 a.m. to 3:00 a.m. on Fridays; 7:00 a.m. to 3:00 a.m. on Saturdays; and 7:00 a.m. to 12:00 midnight on Sundays. Each passenger must purchase a farecard to travel in the system. Instructions for purchasing farecards are posted on the vending machines in each station. Each Metro car features a complete color-coded map of the system. Station attendants on duty at each station can provide additional information on request. From Ronald Reagan Washington National Airport, a cost-effective way to travel to the meeting is by using the Metrorail system. A map of the system is available at: http://www.wmata.com/rail/maps/map.cfm Exit Disclaimer .
 
From the Ronald Reagan Washington National Airport station, take the Yellow Line toward Mt. Vernon Square or Fort Totten. At the Gallery/Chinatown stop, transfer to the Red Line toward Shady Grove or Grosvenor-Strathmore. Please see the following list of hotels and respective Metro stations.
 
Bethesda Station – Hyatt Regency, Residence Inn, Hilton Garden Inn
Medical Center Station – American Inn, DoubleTree, Bethesda Marriott (call for hotel shuttle)
White Flint Station – Bethesda Marriott North Hotel and Conference Center
Twinbrook – Hilton Executive Conference Center

SuperShuttle

SuperShuttle offers service to most hotels from Ronald Reagan Washington National Airport, Washington Dulles International Airport, and Baltimore/Washington International Thurgood Marshall Airport. The shuttle leaves on an as-needed basis between the hours of 5:30 a.m. and 11:00 p.m. During other times, arrangements for a shuttle can be made by calling 1-800-258-3826 from the airport, or visit their website at http://supershuttle.com Exit Disclaimer .

NIH Visitor Information

The Natcher Conference Center is located on the NIH Campus in Building 45. For a map, general information, and directions to and around the NIH Campus, visit http://www.ors.od.nih.gov/maps/Pages/NIH-Visitor-Map.aspx.

NIH Security

The NIH, like all federal government facilities, has instituted security measures to ensure the safety of NIH employees, patients, and visitors. The national threat advisory level, determined by the Department of Homeland Security (http://www.whitehouse.gov/homeland/), currently is yellow (elevated).

Perimeter Security

All visitor vehicles, including taxicabs, hotel and airport shuttles, delivery trucks, and vans will be inspected before being allowed on campus. Visitors will be asked to show one (1) form of identification (a government-issued photo ID: driver’s license, passport, green card, etc.) and to state the purpose of their visit. Be sure to allow at least 15-20 minutes for this vehicle inspection procedure.

Building Security

Due to the checking of IDs at the perimeter, employees and visitors will not be required to show their ID again to gain access to the majority of buildings on the NIH Campus during the normal business day.
 
Employees and visitors should continue to wear their identification prominently at all times while on campus.
 
Guards will remain at certain buildings to address specific program requirements, such as sensitive research and safety concerns. At building entrances where guards are posted:
  • Employees must show a DHHS-issued photo ID (for example, your NIH-issued ID badge).
  • Visitors may be required to log-in, wear a visitor’s pass, and be escorted by an employee through the building.
  • Visitors may be required to pass through a metal detector and have bags, backpacks, or purses inspected or x-rayed as they enter buildings.
  • Security staff will confiscate any suspicious or potentially dangerous materials. U.S. code prohibits bringing any dangerous weapons onto federal property, including anything with a blade longer than 2½ inches. Meeting participants may want to leave extra bags or personal materials at their hotel to minimize the time needed for inspection.

Weekday Pedestrian Campus Access

All visitors must enter through the NIH Gateway Center at Metro or the West Gateway Center (see the Gatewayr Map at http://www.ors.od.nih.gov/maps/Pages/Gateway-Center-Map.aspx).
  • Gateway Center
    Wisconsin Avenue at Gateway Drive (near the Metro)
    Open 24 hours, 7 days per week
  • West Gateway Center
    Near Old Georgetown Road and South Drive
    Open 6:00 a.m. – 12:00 p.m., Monday-Friday

Driving Directions to NIH

From Points North and East:
Take I-95 South to I-495 West (Capital Beltway) toward Silver Spring. Follow I-495 West for 9 miles to Exit 34 (Bethesda/Wisconsin Avenue). Follow signs for Route 355 South and stay in the right lane. Travel approximately 1 mile and turn right at the light onto South Drive. Pass through NIH security and follow the signs to Building 45.
 
From Points North and West:
Take I-270 South to I-495 East (Capital Beltway) toward Washington, DC. Stay in one of the three left lanes. Follow signs for Route 355 South, a left-lane exit, onto Wisconsin Avenue. Travel approximately 1 mile and turn right at the light onto South Drive. Pass through NIH security and follow the signs to Building 45.
 
From Points South:
Take I-95 North to I-495 (Capital Beltway) toward Tyson’s Corner/Rockville. Follow I-495 for 20 miles. Take Exit 34 (Bethesda/Wisconsin Avenue). Travel approximately 1 mile and turn right at the light onto South Drive. Pass through NIH security and follow the signs to Building 45.
 
From Baltimore/Washington International Thurgood Marshall Airport (BWI):
Take the Route 195 connector to I-95 South. Take I-95 South to I-495 West (Capital Beltway) toward Silver Spring. Follow I-495 West for 9 miles to Exit 34 (Bethesda/Wisconsin Avenue). Follow signs for Route 355 South and stay in the right lane. Travel approximately 1 mile and turn right at the light onto South Drive. Pass through NIH security and follow the signs to Building 45.
 
From Washington Dulles International Airport (IAD):
Take the Dulles Access Road for approximately 13 miles to Exit 18. Move to the right on the Dulles Toll Road (Route 267) and take Exit 18. Stay left on the ramp for Bethesda/Baltimore, and proceed toward Bethesda (I-495). Continue approximately 9 miles on I-495. Stay on I-495 at the I-495/I-270 split (bear right). Take Exit 34 (Wisconsin Avenue South/Route 355) toward Bethesda. Travel approximately
1 mile and turn right at the light onto South Drive. Pass through NIH security and follow the signs to
Building 45.
 
From Ronald Reagan Washington National Airport (DCA):
Take the George Washington Parkway North for 12 miles to I-495 toward Maryland (Capital Beltway). Take Exit 34 (Bethesda/Wisconsin Avenue). Travel approximately 1 mile and turn right at the light onto South Drive. Pass through NIH security and follow the signs to Building 45.

Parking

Parking on the NIH campus is limited and is $12 per day in the visitor lots. Natcher Conference Center is located just behind the Gateway Center parking garage.

Minutes

​Minutes are currently unavailable.

Attendees

​​Attendees are currently unavailable.

Abstracts

​​Abstracts are currently unavailable.

Location

Line
  • National Institutes of Health, Building 45
  • MD 20892
Webinar

Contacts

Line

For questions concerning program content, contact:
Michael F. Flessner, M.D., Ph.D.
Director of Inflammatory Renal Diseases
Division of Kidney, Urologic, and Hematologic Diseases
National Institute of Diabetes and Digestive and Kidney Diseases
National Institutes of Health
Two Democracy Plaza, Room 641
6707 Democracy Boulevard, MSC 5458
Bethesda, MD  20892-5458
Telephone: (301) 451-4901
Email: flessnermf@niddk.nih.gov

For questions concerning meeting logistics, contact:
John Hare, M.S., CMP, CGMP
The Scientific Consulting Group, Inc.
656 Quince Orchard Road, Suite 210
Gaithersburg, MD  20878
Telephone: (301) 670-4990
Fax: (301) 670-3815
Email: jhare@scgcorp.com