U.S. Department of Health and Human Services

Bile Acid-Mediated Integration of Metabolism and Liver Disease: A Research Workshop

6/8/2012 7:00 AM
6/8/2012 7:00 AM
 
No
For questions concerning meeting logistics, please contact:
Denise Hoffman, BIT, CMP
The Scientific Consulting Group, Inc.
Telephone: (301) 670-4990 
Email: dhoffman@scgcorp.com
Bethesda
 
Lister Hill Auditorium

Event Details

Meeting Objective:

Bile acids are arguably the perfect nutritional/metabolic integrator amphipathic cholesterol-derived molecules that solubilize diet-derived lipids in the intestine and signal through membrane and nuclear receptors to regulate whole body energy metabolism, intracellular signaling, and nuclear function. In various disease states, circulating bile acids drive normal and pathological processes in multiple organs both within and without enterohepatic tissues. This Workshop is designed to explore opportunities to define how drugs based on bile acid structure and activity can be utilized best to promote health. Disease targets include cholestasis, viral and autoimmune hepatitis, obesity/NASH, diabetes, and metabolism.

Planning Committee:

  • Saul Karpen
  • James Boyer
  • Keith Lindor
  • David Moore
  • Fred Suchy
  • Edward Doo
  • Jay Hoofnagle

Agenda

​Friday, ​June 8, 2012

8:00 - 8:05 a.m.​ Welcome and Introduction
Saul Karpen and Edward Doo
8:05 - 8:30 a.m. Keynote Talk
Bile Acids: Lessons for Therapeutic Intent
Alan Hofmann

Session 1: Bile Acid Chemistry and Molecular Targets

James Boyer​ (Moderator)

8:30 - 8:50 a.m. Bile Acids Linking Intestinal and Liver Physiology
Steve Kliewer
8:50 - 9:10 a.m. Molecular Targets for Therapeutic Bile Acids
Ulrich Beuers
9:10 - 9:30 a.m. TGR5
Kristina Schoonjans
9:30 - 9:50 a.m. Inactivation of Basolateral Transporter Ostα-Ostβ Alters Bile Acid Homeostasis via the FXR-FGF15 Pathway
Tian Lan
9:50 - 10:10 a.m. Discussion
10:10 - 10:30 a.m. Break and Poster Viewing

Session 2: Liver Biology and Toxicity

Fred Suchy (Moderator)

10:30 - 10:50 a.m. Bile Acid-mediated Toxicity and Multi-organ Adaptation to Cholestasis
Jim Boyer
10:50 - 11:10 a.m. Co-regulator Regulation of Bile Acid Homeostasis in Health and Disease
Fred Suchy
11:10 - 11:30 a.m. Intracellular Signaling Affected by Bile Acids
Sawket Anwer
11:30 - 11:50 a.m. Bile Acids in Hepatocyte Signaling and Polarity
Irwin Arias
11:50 a.m. - 12:10 p.m. Discussion
12:10 - 1:10 p.m. Lunch and Poster Viewing

Session 3: Disease Models

Kristina Schoonjans (Moderator)

1:10 - 1:30 p.m. Bile Acids and Liver Cancer
David Moore
1:30 - 1:50 p.m. Sleeve Gastrectomy in Obese Mice Raises Serum Bile Acid Levels and Modulates the FXR-SREBP-1c Pathway to Reduce Hepatic Triglyceride Levels
Andriy Myronovych
1:50 - 2:10 p.m. Serum MicroRNA: Novel Biomarkers for Prognosis of Ursodeoxycholic Acid Treatment in Primary Sclerosing Cholangitis
Yu Li
2:10 - 2:30 p.m. Crosstalk Between Inflammation and Bile Acid Regulated Pathways in Liver
Saul Karpen
2:30 - 2:50 p.m. Break and Poster Viewing

Session 4: Human Trials and Targets

Keith Lindor (Moderator)

2:50 - 3:10 p.m. Ursodeoxycholic Acid (UDCA) and 6α Ethyl Chenodeoxycholic Acid (6αECDCA) for Cholangiopathies
Keith Lindor
3:10 - 3:30 p.m. NorUDCA
Michael Trauner
3:30 - 3:50 p.m. ECDCA for Nonalcoholic Steatohepatitis (NASH)
Arun Sanyal
3:50 - 4:10 p.m TGR5: Genomics and Therapeutics
Verena Keitel
4:10 - 4:30 p.m. Cholic Acid: From Discovery to Clinical Practice
Kenneth Setchell

Session 5: Interactive Discussion : Setting the Agenda

Edward Doo and Jay Hoofnagle (Moderators)

4:30 - 5:00 p.m Edward Doo, Jay Hoofnagle, Saul Karpen, Kristina Schoonjans, Jim Boyer, Arun Sanyal, Keith Lindor, Fred Suchy, Michael Trauner
5:00 p.m. Adjournment
​​​​

Directions/Travel

Travel Arrangements:

Participants are responsible for making their own travel arrangements. Should you decide to extend your stay to take advantage of lower fares, DC-area attractions are only a short stop away from the suggested hotels.

Hotel and travel information are listed below.

Hotel Reservations:

The following hotels provide lodging in close proximity that is accessible by taxi.

American Inn of Bethesda
8130 Wisconsin Avenue
Bethesda, MD 20814
P: (301) 656-9300 or 1-800-232-7081
F: (301) 656-2907

Bethesda Marriott Hotel
5151 Pooks Hill Road
Bethesda, MD 20814
P: (301) 897-9400 or 1-800-228-9290
F: (301) 897-0192

Bethesda North Marriott Hotel and Conference Center
5701 Marinelli Road
North Bethesda, MD 20852
P: (301) 822-9200 or 1-800-228-9290
F: (301) 822-9201

DoubleTree Hotel
8120 Wisconsin Avenue
Bethesda, MD 20814
P: (301) 652-2000 or 1-800-222-TREE
F: (301) 652-4525

Hilton Executive Conference Center
1750 Rockville Pike
Rockville, MD 20852
P: (301) 468-1100 or 1-800-HILTONS
F: (301) 468-0308

Hilton Garden Inn
7301 Waverly Street
Bethesda, MD 20814
P: (301) 654-8111

Hyatt Regency Bethesda
One Bethesda Metro Center
Bethesda, MD 20814
P: (301) 657-1234 or 1-800-633-7313
F: (301) 657-6453

Residence Inn
7335 Wisconsin Avenue
Bethesda, MD 20814
P: (301) 718-0200 or 1-800-228-9290
F: (301) 718-0679

The Legacy Hotel
1775 Rockville Pike
Rockville, MD 20852
P: (301) 231-8800
F: (301) 881-9047

Taxi Service to Area Hotels:

From Baltimore/Washington International Thurgood Marshall Airport (BWI):
Approximate hotel distance and direction: 35 miles S.W.
Estimated Taxi Fare: $60

From Washington Dulles International Airport (IAD):
Approximate hotel distance and direction: 25 miles N.E.
Estimated Taxi Fare: $50

From Ronald Reagan Washington National Airport (DCA):
Approximate hotel distance and direction: 21 miles N.E.
Estimated Taxi Fare: $45

Fares may differ during peak travel hours.

Metro to the Hotel:

The Metrorail system is clean and reliable. It operates from 5:00 a.m. to 12:00 midnight Monday through Thursday; 5:00 a.m. to 3:00 a.m. on Fridays; 7:00 a.m. to 3:00 a.m. on Saturdays; and 7:00 a.m. to 12:00 midnight on Sundays. Each passenger must purchase a farecard to travel in the system. Instructions for purchasing farecards are posted on the vending machines at each station. Each Metrorail car features a complete color-coded map of the system. Station attendants on duty at each station can provide additional information on request.

From Ronald Reagan Washington National Airport, a cost-effective way to travel to the meeting is by using the Metrorail system. A map of the system is available at: http://www.wmata.com/rail/maps/map.cfm .  From the Ronald Reagan Washington National Airport station, take the Yellow Line toward Mt. Vernon Square or Fort Totten. At the Gallery/Chinatown stop, transfer to the Red Line toward Shady Grove or Grosvenor-Strathmore. Please see the following list of hotels and respective Metrorail stations. 

Bethesda Station - Hyatt Regency, Residence Inn, Hilton Garden Inn
Medical Center Station - American Inn, DoubleTree, Bethesda Marriott (call for hotel shuttle)
White Flint Station - Bethesda Marriott North Hotel and Conference Center
Twinbrook - Hilton and Legacy

SuperShuttle:

SuperShuttle offers service to most hotels from Ronald Reagan Washington National Airport, Washington Dulles International Airport, and Baltimore/Washington International Thurgood Marshall Airport. The shuttle leaves on an as-needed basis between the hours of 5:30 a.m. and 11:00 p.m. During other times, arrangements for a shuttle can be made by calling 1-800-258-3826 from the airport, or by visiting their website at http://supershuttle.com .

NIH Visitor Information:

The Lister Hill Auditorium is located on the NIH Campus in Building 38A. For a map, general information, and directions to and around the NIH Campus, visit http://parking.nih.gov/visitor_access_map.htm .

NIH Security:

The NIH, like all federal government facilities, has instituted security measures to ensure the safety of NIH employees, patients, and visitors. The national threat advisory level, determined by the Department of Homeland Security ( http://www.whitehouse.gov/homeland /), currently is yellow (elevated).

Perimeter Security:

All visitor vehicles, including taxicabs, hotel and airport shuttles, delivery trucks, and vans will be inspected before being allowed on campus. Visitors will be asked to show one (1) form of identification (a government-issued photo ID: driver's license, passport, green card, etc.) and to state the purpose of their visit. Please allow at least 15 to 20 minutes for this vehicle inspection procedure.

Building Security:

Due to the checking of IDs at the perimeter, employees and visitors will not be required to show their ID again to gain access to the majority of the buildings on the NIH Campus during the normal business day.

Employees and visitors should continue to wear their identification prominently at all times while on campus.

Guards will remain at certain buildings to address specific program requirements, such as sensitive research and safety concerns. At building entrances where guards are posted:

  • Employees must show a DHHS-issued photo ID (for example, your NIH-issued ID badge).
  • Visitors may be required to log-in, wear a visitor's pass, and be escorted by an employee through the building.
  • Visitors may be required to pass through a metal detector and have bags, backpacks, or purses inspected or X-rayed as they enter buildings.
  • Security staff will confiscate any suspicious or potentially dangerous materials. U.S. code prohibits bringing any dangerous weapons onto federal property, including anything with a blade longer than 2" inches. Meeting participants may want to leave extra bags or personal materials at their hotel to minimize the time needed for inspection.

Weekday Pedestrian Campus Access:

All visitors must enter through the NIH Gateway Center at the Medical Center Metro stop or the West Gateway Center (see the Visitor Map at http://parking.nih.gov/visitor_access_map.htm ).
  • Gateway Center

Wisconsin Avenue at Gateway Drive (near the Metro)
Open 24 hours, 7 days per week 

  • West Gateway Center

Near Old Georgetown Road and South Drive
Open 6 a.m. to 12 p.m., Monday through Friday

Driving Directions to NIH:

From Points North and East:

Take I-95 South to I-495 West (Capital Beltway) toward Silver Spring. Follow I-495 West for 9 miles to Exit 34 (Bethesda/Wisconsin Avenue). Follow signs for Route 355 South and stay in the right lane. Travel approximately 1 mile and turn right at the light onto South Drive. Pass through NIH security and follow the signs to Building 38A.

From Points North and West:

Take I-270 South to I-495 East (Capital Beltway) toward Washington, DC. Stay in one of the three left lanes. Follow signs for Route 355 South, a left-lane exit, onto Wisconsin Avenue. Travel approximately 1 mile and turn right at the light onto South Drive. Pass through NIH security and follow the signs to Building 38A.

From Points South:

Take I-95 North to I-495 (Capital Beltway) toward Tyson's Corner/Rockville. Follow I-495 for 20 miles. Take Exit 34 (Bethesda/Wisconsin Avenue). Travel approximately 1 mile and turn right at the light onto South Drive. Pass through NIH security and follow the signs to Building 38A.

From Baltimore/Washington International Thurgood Marshall Airport (BWI):  
Take the Route 195 connector to I-95 South. Take I-95 South to I-495 West (Capital Beltway) toward Silver Spring. Follow I-495 West for 9 miles to Exit 34 (Bethesda/Wisconsin Avenue). Follow signs for Route 355 South and stay in the right lane. Travel approximately 1 mile and turn right at the light onto South Drive. Pass through NIH security and follow the signs to Building 38A.

From Washington Dulles International Airport (IAD):
Take the Dulles Access Road for approximately 13 miles to Exit 18. Move to the right lane on the Dulles Toll Road (Route 267) and take Exit 18. Stay left on the ramp for Bethesda/Baltimore, and proceed toward Bethesda
(I-495). Continue approximately 9 miles on I-495. Stay on I-495 at the I-495/I-270 split (bear right). Take Exit 34 (Wisconsin Avenue South/Route 355) toward Bethesda. Travel approximately 1 mile and turn right at the light onto South Drive. Pass through NIH security and follow the signs to Building 38A.

From Ronald Reagan Washington National Airport (DCA): 
Take the George Washington Parkway North for 12 miles to I-495 (Capital Beltway) toward Maryland. Take Exit 34 (Bethesda/Wisconsin Avenue). Travel approximately 1 mile and turn right at the light onto South Drive. Pass through NIH security and follow the signs to Building 38A.

Parking:

Parking on the NIH campus is limited and costs $12 per day in the visitor lots. The closest visitor lot is the Gateway Parking Garage (MLP-11) located at the Gateway Drive entrance. From here, it is a 5 minute walk to the building. The NIH Campus shuttle is also an option, which runs every 15 minutes.

Minutes

​Minutes are currently unavailable

Attendees

​​Attendees are currently unavailable

Abstracts

Abstract Submission and Travel Awards

(Students, Postdoctoral Fellows/Junior Faculty Only)

Abstracts should be limited to one page. Include a title, all authors (presenting author should be clearly underlined), departmental affiliation, university, city, state/province, country, zip code/postal code, and email address, along with sufficient experimental detail to assess the relevance of the work. Please acknowledge appropriate funding sources for your research. Inclusion of figures is encouraged. In addition to sending us your abstract, please check the "I will be submitting an abstract" button when you register for the workshop. There is no fee for registration.
 
Students and postdoctoral fellows/Junior Faculty are encouraged to attend this workshop. Travel awards are available for a limited number of selected postdoctoral fellows/junior faculty and students. These will be chosen from among submitted abstracts on the basis of the quality and significance of the research. If you would like to apply for a travel award, please email your abstract to dhoffman@scgcorp.com by March 30, 2012. 

Location

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  • Building 38A, NIH Campus
  • MD 20892
Webinar

Contacts

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For questions concerning meeting logistics, please contact:
Denise Hoffman, BIT, CMP
The Scientific Consulting Group, Inc.
Telephone: (301) 670-4990 
Email: dhoffman@scgcorp.com