U.S. Department of Health and Human Services


Cardiovascular Disease and Type 1 Diabetes

10/8/2014 8:00 AM
10/9/2014 5:00 PM
Yes
No
Michael Schultz

Project Manager
The Scientific Consulting Group, Inc.
656 Quince Orchard Road, Suite 210
Gaithersburg, MD  20878
301-670-4990
Fax: 301-670-3815

Email:
mschultz@scgcorp.com​​​

Bethesda
 
Lister Hill Auditorium

Event Details

​​Purpose of the Workshop

Cardiovascular disease remains the leading cause of death for people with type 1 diabetes, despite improvements in the control of glucose, blood pressure, and lipid levels. The pathophysiology, risk factors, and clinical course of cardiovascular disease in type 1 diabetes have features that are different from those for cardiovascular disease in people with type 2 diabetes or without diabetes, yet most of the clinical recommendations for people with type 1 diabetes are based on studies of these other populations.  The goals of the workshop are the following:
  • Review the pathophysiology of atherosclerosis and myocardial infarction in people with type 1 diabetes.
  • Compare and contrast risk factors for cardiovascular disease that are general, diabetes-specific, and type 1 diabetes-specific.
  • Review the clinical presentation and course for acute coronary syndrome and stroke in type 1 diabetes.
  • Discuss and prioritize research questions for cardiovascular disease and type 1 diabetes. 
  • Review and discuss the approaches and resources needed to address the high-priority research questions. 

Workshop Organizing Committee
Robert H. Eckel, M.D., University of Colorado (Co-chair)
David M. Nathan, M.D., Massachusetts General Hospital (Co-chair)
Judith E. Fradkin, M.D., NIDDK
Larissa Aviles-Santa, M.D., M.P.H., NHLBI
Denise Bonds, M.D., M.P.H., NHLBI
Teresa L.Z. Jones, M.D., NIDDK
Barbara Linder, M.D., Ph.D., NIDDK
Peter J. Savage, M.D., NIDDK

​​​​

Agenda

 

DAY 1: What do we know and don't we know about cardiovascular disease and type 1 diabetes?

8:00 a.m.

Welcoming Remarks
Dr. Griffin P. Rodgers – Director, NIDDK
Dr. Gary H. Gibbons – Director, NHLBI
Dr. Robert H. Eckel and Dr. David M. Nathan – Workshop Co-chairs

8:10 a.m.

(30 min talk; 20 min discussion)

Cardiovascular Results from the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study (DCCT/EDIC) – Dr. Nathan (moderator)
Analysis of Risk Factors for Cardiovascular Disease – Dr. John Lachin

Discussion: How do these results compare to other type 1 diabetes cohorts and type 2 diabetes populations? How well did the surrogate end-points predict cardiovascular events?

9:00 a.m.

(12 min per talk; 35 min discussion; 15 min break)

 

The Pathophysiology of Atherosclerosis and Myocardial Infarction in Type 1 Diabetes – Dr. Eckel (moderator)
Post-mortem Studies – Dr. Renu Virmani
Magnetic Resonance Imaging and Intravascular Ultrasound Findings – Dr.  Anne Sofie Astrup
Vascular Calcification – Dr. Janet Snell-Bergeon
Inflammation and Macrophages – Dr. Karin Bornfeldt
Leukocytosis – Dr. Edward Fisher
Glyoxylase and Oxidative Metabolism – Dr. Michael Brownlee
Protective Factors – Dr. George King
Autoimmunity and Myocardial Infarction – Dr. Myra Lipes

Discussion: What mechanisms are unique or prevalent in type 1 diabetes? How is the development of atherosclerotic plaques similar and different among type 1 and type 2 diabetes and non-diabetes? What are promising targets for biomarker and therapy development?

11:30 a.m.

(60 min per group; 30 min general discussion; 60 min lunch)

Risk Factors – General, Diabetes-specific and Type 1 Diabetes-specific – Dr. Eckel (moderator)

Traditional Risk Factors (hypertension, tobacco use, exercise, obesity, gender) – Dr. Helen Colhoun
Dyslipidemia – Dr. John Brunzell
Thrombosis – Dr. Guenther Boden

Hyperglycemia – Dr. David Maahs
Insulin Resistance – Dr. Marian Rewers
Hypoglycemia – Dr. Mikhail Kosiborod

Chronic Kidney Disease – Dr. Daniel Gordin
Cardiac Autonomic Neuropathy – Dr. Rodica Pop-Busuiv Haptoglobin and Other Genetic Factors (hand-out) – Dr. Trevor Orchard
Heavy Metal Exposure (Trial to Assess Chelation Therapy) – Dr. Ana Navas-Acien and Dr. Gervasio Lamas

Discussion: Are we ready to build a risk calculator for type 1 diabetes? What would be the components? How might it differ from the clinical situation without diabetes or with type 2 diabetes? Are we missing important components? How good are the biomarkers to assess risk for individual patients and for stratification for clinical trials?

4:00 p.m.

Acute Coronary Syndrome and Stroke

Panel discussion on the presentation, clinical course, and long-term outcomes from myocardial infarction and stroke in type 1 diabetes – Dr. Robert Califf, Dr. Mikhail Kosiborod, Dr. Darren McGuire and Dr. John Spertus

4:45 p.m.

Day 1 wrap-up – Dr. Eckel and Dr. Nathan (moderators)

Discussion: What areas need more basic mechanistic studies in animal models or humans? What areas need better epidemiologic data? What research questions are ready for pilot clinical trials? What research questions are ready for phase II or III clinical trials? In which area(s) could we make the biggest impact on patient health?

Consensus development on the top five research questions that will be the basis of discussion on Day 2.

5:30 p.m.

Adjournment Day 1

 

DAY 2: How do we proceed with the top five research questions?

8:00 a.m.

(30 min per panel; 15 min break)

 

Introduction – Dr. Nathan (moderator)

For the research questions that depend on preclinical and translational work, what resources or tools are needed? Panel – Dr. Karin Bornfeldt, Dr. Michael Brownlee, Dr. George King, and Dr. Ann Marie Schmidt  (30 min)

For these research questions, are there alternative ways to conduct clinical trials than the traditional randomized trial?  (60 min)
How could the Patient-Centered Outcomes Research Network (PCORnet) be applied to these research questions? – Dr. Robert Califf 

What are the appropriate outcome measures for the clinical research questions? Do we have adequate surrogate end-points for pilot clinical trials? Panel – Dr. Anne Sofie Astrup, Dr. Darren McGuire, Dr. Trevor Orchard, and Dr. John Spertus (30 min)

What recruitment strategies can be employed effectively for these research questions in type 1 diabetes adolescents and adults? How can we best involve the type 1 diabetes patient community?Panel – Dr. George King, Dr. David Maahs, Dr. John Petrie and Dr. Rodica Pop-Busui (30 min)

How could registries, cohorts and biorepositories be used to answer these research questions? The program book will include summaries of cohorts and registries. Panel – Dr. Helen Colhoun, Dr. Daniel Gordin, and Dr. Trevor Orchard

11:30 a.m.

Day 2 Wrap-up – Dr. Nathan and Dr. Eckel (moderators)

12:00 p.m.

Adjournment Day 2

Directions/Travel

​​

HOTEL ACCOMMODATIONS


DoubleTree by Hilton Hotel Bethesda – Washington DC

8120 Wisconsin Avenue

Bethesda, MD  20814

Phone:  (301) 652-2000 or (800) 955-7359

Hotel Website:  http://www.doubletreebethesda.com/             

Sleeping Room Rate:  $219 per night, plus tax (or prevailing government rate)

Check-In Time:  3:00 p.m.

Check-Out Time:  12:00 p.m.

Parking:  The current cost for daily parking in the hotel garage is $12.00 per day for the event or $23.00 for overnight guests.  These rates are subject to change.

Please make your room reservation by Friday, August 29, 2014, by calling the hotel at (301) 657-1234 or (800) 233-1234, or by reserving online at the following link: http://doubletree.hilton.com/en/dt/groups/personalized/W/WASBHDT-CV0-20141007/index.jhtml?WT.mc_id=POG. Please reference the CVD + T1D Workshop when making your sleeping room reservations, and be certain that the hotel provides you with a confirmation number. After August 29, 2014, the hotel will accept reservations on a space-available basis at the prevailing hotel rateWhen making a reservation, please provide your room and bedding preferences. The hotel will assign specific room types at check-in, based on availability. Please be advised that requests are not guaranteed. Check-in time is 3:00 p.m., and check-out time is 12:00 noon.

If you need to cancel your reservation, please do so at least 24 hours in advance or a no-show fee for 1 night will be charged on your credit card.

DRIVING DIRECTIONS


From Points North (Baltimore, Philadelphia, Wilmington, New York, and New Jersey):  Take I-95 South toward Washington, DC.  At I-495 (Capital Beltway), proceed west toward Silver Spring/Bethesda.  Take Exit 34 (Route 355 or Rockville Pike/Wisconsin Avenue) and proceed south toward Washington/Bethesda.  The hotel is approximately 2 miles ahead on the right.

From Points South (Richmond, Virginia Beach, and North and South Carolina):  Take I-95 North toward Washington, DC.  Take I-395 North via Exit 170A-B on the left.  Merge onto I-495 North/Capital Beltway via Exit 170B toward Tysons Corner.  Take Exit 34 (Route 355 or Wisconsin Avenue/Rockville Pike) and proceed south toward Washington/Bethesda.  The hotel is approximately 2 miles ahead on the right.

From Route 66 East (Northern Virginia, McLean, and Fairfax):  Take Route I-66 East to I-495 North/Capital Beltway Baltimore.  Take Exit 34 (Route 355 or Wisconsin Avenue/Rockville Pike) and proceed south toward Washington/Bethesda. The hotel is approximately 2 miles ahead on the right.

From I-270 South:  From I-270 South, take the left spur toward I-495 East.  Just before the spur ends, take Exit 34/Route 355 (Wisconsin Avenue/Rockville Pike) on the left and proceed south toward Washington/Bethesda.  The hotel is approximately 2 miles ahead on the right.

From Ronald Reagan Washington National Airport (DCA):  Take the George Washington Parkway North to I-495 North toward Maryland.  From I-495, take Exit 34 (Route 355 or Wisconsin Avenue/Rockville Pike) and proceed south toward Washington/Bethesda.  The hotel is approximately 2 miles ahead on the right.

From Baltimore Washington International Thurgood Marshall Airport (BWI):  Take the Baltimore Washington Parkway South toward Washington, DC.  At I-495 (Capital Beltway) proceed west toward Silver Spring/Bethesda.  Take Exit 34 (Route 355 or Wisconsin Avenue/Rockville Pike) and proceed south toward Washington/Bethesda.  The hotel is approximately 2 miles ahead on the right.

From Washington Dulles International Airport (IAD):  Take the Dulles Access Road East to I-495 (Capital Beltway) heading North to Bethesda/Baltimore.  From I-495, take Exit 34 (Route 355 or Wisconsin Avenue/Rockville Pike) and proceed south toward Washington/Bethesda.  The hotel is approximately 2 miles ahead on the right.

GROUND TRANSPORTATION


METRO INFORMATION

The Metro system is clean, reliable, and safe. It operates from 5:00 a.m. to 12:00 midnight Monday through Thursday; 5:00 a.m. to 3:00 a.m. on Friday; 7:00 a.m. to 3:00 a.m. on Saturday; and 7:00 a.m. to 12:00 midnight on Sunday. Each passenger must purchase a farecard to travel in the system. Guides for purchasing farecards are posted on the vending machines in each station. Each Metro car features a complete color-coded map of the system. A map of the system is available at: http://www.wmata.com/rail/maps/map.cfm. The hotel is within walking distance from the Medical Center Metro Station. Station attendants on duty at each station can provide additional information on request.

From the Ronald Regan Washington National Airport station, take the Yellow Line toward Mt. Vernon Square or Fort Totten. At the Gallery/Chinatown stop, transfer to the Red Line toward Shady Grove or Grosvenor-Strathmore. The Doubletree Bethesda is located just south of the Medical Center Metro Station. Exit at the Medical Center station. After taking the escalator up, look for the hotel shuttle, which runs every half hour between 7:00 a.m. and 10:00 p.m. For further information on the shuttle, please call the hotel.

SHUTTLES

SuperShuttle offers service to most hotels from Ronald Reagan National Airport, Washington Dulles International Airport, and Baltimore/Washington International Thurgood Marshall Airport. The shuttle leaves on an as-needed basis between the hours of 5:30 a.m. and 11:00 p.m. During other times, arrange for a shuttle by calling 800-258-3826 from the airport.

TAXIS

The taxi fare is approximately $45-$55 from Ronald Reagan Washington National Airport, approximately $55-$65 from Washington Dulles International Airport, and approximately $65-$75 from Baltimore/Washington International Thurgood Marshall Airport.  Fares may differ during peak travel hours.

MARC TRAINS

From BWI Airport, take the MARC train on the Penn Line to Union Station. Take the Metro Red Line toward Grosvenor or Shady Grove and exit at the Bethesda Metro Station. The hotel is approximately 4 blocks from the Bethesda Metro Station.

NEARBY HOTELS

If the rooming block at the Doubletree is full, below are nearby hotels.  You are responsible for booking and paying for your own room.

Bethesda Marriott

5151 Pooks Hill Road

Bethesda, Maryland  20814

Telephone:  301-897-9400

URL:  http://www.marriott.com/marriott/WASBT

Hilton Garden Inn Washington DC/Bethesda

7301 Waverly Street

Bethesda, Maryland  20814

Telephone: 301-654-8111

URL:  http://hiltongardeninn3.hilton.com/en/hotels/maryland/hilton-garden-inn-washington-dc-bethesda-WASBTGI/index.html

Hyatt Regency Bethesda

One Bethesda Metro Center

Bethesda, Maryland  20814

Phone:  301-657-1234

URL:  http://www.bethesda.hyatt.com

Holiday Inn Bethesda

8120 Wisconsin Avenue

Bethesda, Maryland  20814

Telephone:  301-652-2000

URL:  http://www.sixcontinentshotels.com/holiday-inn?_franchisee=RKVMD

Residence Inn Bethesda by Marriott

7335 Wisconsin Avenue

Bethesda, Maryland  20814

Telephone:  301-718-0200

URL:  http://www.residenceinn.com/WASBR

Minutes

Attendees

Abstracts

Location

Line
  • 8600 Rockville Pike
  • NIH Building 38A
  • MD 20894
Webinar

Contacts

LineMichael Schultz

Project Manager
The Scientific Consulting Group, Inc.
656 Quince Orchard Road, Suite 210
Gaithersburg, MD  20878
301-670-4990
Fax: 301-670-3815

Email:
mschultz@scgcorp.com​​​