U.S. Department of Health and Human Services

Cystic Fibrosis Related Diabetes Meeting

5/25/2011 7:00 AM
5/26/2011 7:00 AM
 
No
For scientific questions, contact:
Saul Malozowski, M.D., Ph.D.
Senior Advisor on Endocrine Physiology
Division Diabetes, Endocrinology, and Metabolic Diseases
National Institute of Diabetes and Digestive and Kidney Diseases
Democracy 2, Room 607
6707 Democracy Boulevard
Bethesda, MD  20892
Telephone:  (301) 451-4683
Fax:  (301) 480-3503
Email:  malozowskis@mail.nih.gov

Catherine McKeon, Ph.D.
Senior Advisor for Genetic Research
National Institute of Diabetes and Digestive and Kidney Diseases
Democracy 2, Room 6103
6707 Democracy Boulevard, MSC 5460
Bethesda, MD  20892-5460
Telephone:  (301) 594-8810
Fax:  (301) 480-3503
Email:  mckeonc@mail.nih.gov

For logistical information, contact:
Denise Hoffman, CMP
Deputy Director of Conferencing
The Scientific Consulting Group, Inc.
656 Quince Orchard Road, Suite 210
Gaithersburg, MD  20878-1409
Telephone:  (301) 670-4990 x232
Fax:  (301) 670-3815
Email:  dhoffman@scgcorp.com
Bethesda
 
Lister Hill Auditorium

Event Details

Meeting Objective:

Advancements in the management of patients with Cystic Fibrosis have substantially extended their life expectancy. As CF patients age, there is an increased incidence of diabetes mellitus. This form of diabetes has features of both type 1 and type 2 diabetes and is called Cystic Fibrosis Related Diabetes or CFRD. CFRD occurs in 35% of young adults ages 20 to 29 and 43% of adults over 30 years of age. In addition, many CF patients with CFRD experience weight loss and have a steeper decline in lung function. In contrast to other types of diabetes, CFRD presents unique diagnostic and therapeutic challenges that necessitate more rigorous answers. The goal of this workshop is to better understand the causes and consequences of CFRD as well as discuss emerging strategies to better control this metabolic complication. During the two panel discussions, participants will identify gaps and develop research questions that need to be addressed to more fully understand the causes, consequences, and management of CFRD.​​

Agenda

Wednesday, May 25, 2011

8:30 a.m. - 8:45 a.m. Welcome
Gregory G. Germino, Deputy Director, NIDDK
8:45 a.m. - 9:30 a.m.

Keynote:
CFRD: Overview of Our Current Understanding, and Where Do We Go From Here?
Toni Moran, M.D., University of Minnesota

Session 1

Causes and Consequences

Chair: Larry Phillips, M.D., Emory University

9:30 a.m. - 10:00 a.m.

Insulin Secretion and Cystic Fibrosis (CF)
Remi Rabasa-Lhoret, M.D., University of Montreal

10:00 a.m. - 10:30 a.m.

Islet Amyloid in Cystic Fibrosis:Blood or Bullet?
Peter Butler, M.D., University of California at Los Angeles

10:30 a.m. - 10:45 a.m. Break
10:45 a.m. - 11:15 a.m.

Hypoxia and Glucose Tolerance
Andrea Kelly, M.D., The Children's Hospital of Philadelphia

11:15 a.m. - 11:45 a.m.

Inflammation and Lung Disease in Cystic Fibrosis Related Diabetes
James Chmiel, M.D., Case Western Reserve University School of Medicine

11:45 a.m. - 12:15 p.m.

The Role of Redox Imbalance and Oxidative Stress in the Development of CFRD
Arlene Stecenko, M.D., Emory University

12:15 p.m. - 12:45 p.m.

Exocrine Pancreatic Disease in CF and Risk of CFRD
Steven Freedman, M.D., Ph.D., Deaconess Hospital

12:45 p.m. - 1:45 p.m. Lunch
1:45 p.m. - 2:15 p.m. A Structural Perspective of CFTR Function and Dysfunction
Philip Thomas, Ph.D., University of Texas Southwestern Medical Center
2:15 p.m. - 2:45 p.m.

Genetic Modifiers of Cystic Fibrosis Related Diabetes
Scott Blackman, M.D., Ph.D., The Johns Hopkins University

2:45 p.m. - 3:15 p.m. Lung Disease and Early Glycemic Instability in the Cystic Fibrosis Ferret Model
Andrew Norris, M.D., Ph.D., University of Iowa
3:15 p.m. - 3:45 p.m.

Panel Discussion to Identify Research Needs I
Discussion Leaders: Catherine McKeon, Ph.D., NIDDK and Saul Malozowski, M.D., Ph.D., MBA, NIDDK

3:45 p.m. - 4:00 p.m. Break

Session 2

Clinical Trials and Patient Management

Chair: Toni Moran, M.D., University of Minnesota

4:00 p.m. - 4:30 p.m.

Clinical Care Guidelines for Cystic Fibrosis Related Diabetes
Bonnie Slovis, M.D., Vanderbilt University

4:30 p.m. - 5:00 p.m. Nationwide Implementation of CFRD Screening and Treatment
Sam Casella, M.D., Dartmouth College
5:00 p.m. - 5:30 p.m.

CFRD: Predicting, Screening, and Monitoring
Larry Phillips, M.D., Emory University

Thursday, May 26, 2011

8:30 a.m. - 9:00 a.m. Nutrition and Cystic Fibrosis: Can We Make a Difference?
Daniel Peckham, M.D., University of Leeds, United Kingdom
9:00 a.m. - 9:30 a.m.

Insulin Versus Other Diabetes Agents
Gary Onady, M.D., Wright State University

9:30 a.m. - 10:00 a.m.

Patient Adherence and Cystic Fibrosis Related Diabetes: Much to Learn and Then to Apply
Scott Powers, Ph.D., ABPP, Cincinnati Children's Hospital

10:00 a.m. - 10:30 a.m.

Panel Discussion to Identify Research Needs II
Discussion Leader: John Buse, M.D., Ph.D., University of North Carolina at Chapel Hill

10:30 a.m. Adjournment
​​​

Directions/Travel

MEETING LOCATION
Lister Hill Auditorium
National Institutes of Health
Building 38A
Bethesda, MD 20892

NOTE: Due to security reasons allocation of time to pass through security should be given.

NIH Campus
Click here to download a printable version of this page

NIH Campus Map 

NIH Gateway Center Map 
Click here to download a printable version of this page [PDF, 67kb]

NIH Gateway Center Map
Main Visitor Entrance: 

NIH Gateway Drive 


Gateway Center - Building 66
 (for pedestrians entering campus)
  • Open 24 hours, 7 days a week

Gateway Inspection Station - Building 66A (for vehicles entering campus)

  • Monday-Friday:
    5am - 10pm

    Weekends and After Hours:
    Closed

    After 10pm on weekdays, all day weekends and holidays, visitors in vehicles should enter campus via the Commercial Vehicle Inspection Facility (CVIF) - Building 67 (on Rockville Pike between North Drive and Wilson Drive)
  • After inspection, vehicles enter campus at Center Drive
  • Roadway at Center Drive is for entering campus only; visitors exiting campus may exit from other open locations. To see a list of exits, please visit the employee map.
  • All vehicles and their contents will be inspected upon entering the campus.

Multi-Level Parking Garage 11 - MLP-11 (for parking outside of campus)

  • Monday - Friday:
    6am - 9pm (entrance)
    6am - 11pm (exit) 
  • Weekends: Closed
  • When MLP-11 is closed, visitors can park in lots on the NIH Campus
  • Visitors parking in this garage should proceed to the Gateway Center (Bldg. 66) to get a visitor badge
  • All visitors traveling in a vehicle are highly encouraged to park in MLP-11 as there is limited visitor parking on the main campus
  • No vehicle inspection required to park in MLP-11
  • Vehicles left in the MLP-11 parking garage after 11pm on weekdays or during any weekends are subject to ticketing and towing
  • Cost: $2 per hour for the first three hours, $12 maximum for the entire day

Directions to NIH Gateway Drive from Rockville Pike/Wisconsin Avenue
Southbound:

  1. Continue on Rockville Pike past South Drive
  2. Turn right at NIH Gateway Drive

Northbound - Option 1:

  1. Continue on Rockville Pike past South Drive
  2. Make a u-turn from the left turn lane at Wilson Drive
  3. Continue southbound on Rockville Pike past South Drive
  4. Turn right at NIH Gateway Drive

Northbound - Option 2:

  1. Continue on Rockville Pike
  2. Turn left at Battery Lane
  3. Turn right on Old Georgetown Road
  4. Turn right on Cedar Lane
  5. Turn right on Rockville Pike
  6. Continue southbound on Rockville Pike past South Drive
  7. Turn right at NIH Gateway Drive

Northbound - Option 3:

  1. Continue on Rockville Pike to South Drive
  2. Make a u-turn from the left turn lane at South Drive
  3. Continue southbound on Rockville Pike
  4. Turn right at NIH Gateway Drive

Security Procedures for Entering the NIH Campus:
All visitors-please be aware:  Federal law prohibits the following items on Federal property:  firearms, explosives, archery equipment, dangerous weapons, knives with blades over 21/2 inches, alcoholic beverages and open containers of alcohol.
 
* The NIH has implemented security measures to help ensure the safety of our patients, employees, guests and facilities. All visitors must enter through the NIH Gateway Center at Metro or the West Gateway Center. You will be asked to submit to a vehicle or personal inspection.

* Visitors over 15 years of age must provide a form of government-issued ID such as a driver's license or passport. Visitors under 16 years of age must be accompanied by an adult.

Vehicle Inspections - All vehicles and their contents will be inspected upon entering the campus. Additionally, all vehicles entering certain parking areas will be inspected, regardless of any prior inspection. Drivers will be required to present their driver's license and may be asked to open the trunk and hood. If you are physically unable to perform this function, please inform the inspector and they will assist you.

Vehicle inspection may consist of any combination of the following:  Detection Dogs Teams (K-9), Electronic Detection Devices and Manual Inspection.

After inspection, you will be issued a vehicle inspection pass. It must be displayed on your vehicle's dashboard while you are on campus. The inspection pass is not a "parking permit." It only grants your vehicle access to enter the campus. You can only park in designated parking areas.

Personal Inspections - All visitors should be prepared to submit to a personal inspection prior to entering the campus. These inspections may be conducted with a handheld monitoring device, a metal detector and by visible inspection. Additionally, your personal belongings may be inspected and passed through an x-ray machine.

Visitor passes must be prominently displayed at all times while on the NIH campus.

ACCOMMODATIONS

HOTEL RESERVATIONS
Bethesda Marriott Hotel
5151 Pooks Hill Road  
Bethesda, MD  20814  
Telephone:  or (800) 228-9290
Fax:  (301) 897-0192

Website:  http://www.bethesdamarriott.com 
(More hotel information can be obtained from this website.)

limited number of sleeping rooms for workshop participants have been reserved at the Bethesda Marriott Hotel.  The rate is the prevailing government rate of $211 per night for single and double occupancy plus tax (13%). To reserve a hotel room, call reservations at the above-listed number and be sure to identify yourself as a member of the CFRD Workshop to receive the group rate.  The room block will be in effect at the government rate only until Friday, April 22, 2011, or until full, whichever comes first.  Any room reservations received after that date will be accepted on a space- and rate-availability basis.  Reservations should be made for arrival on May 24 with departure on May 26. If you require alternate dates, please send an email to Denise Hoffman at dhoffman@scgcorp.com. Any alternate date requests will need to be approved by NIDDK.

Please be certain that the hotel provides you with a confirmation number for your reservation. After April 22, 2011, the official room block will be released, and the hotel may charge significantly higher rates and may be sold out. When making a reservation, please provide your room and bedding preferences. The hotel will assign specific room types at check-in, based on availability. Please be advised that requests are not guaranteed. Check-in time is 4:00 p.m., and check-out time is 12:00 p.m. If you need to cancel your reservation, please do so by 4:00 p.m. the day prior to arrival or you will be charged a no-show fee for one night on your credit card.  
  
DRIVING DIRECTIONS

From Points North and East:
Take I-95 South to I-495 West (Capital Beltway) toward Silver Spring. Follow I-495 West for 9 miles to Exit 34 (Bethesda/Wisconsin Avenue). Follow signs for Route 355 South and stay in the right lane. Turn right at the light onto Pooks Hill Road. The hotel is on the right.

From Points North and West: 
Take I-270 South to I-495 East (Capital Beltway) toward Washington, DC. Stay in one of the three left lanes. Follow signs for Route 355 South, a left-lane exit, onto Wisconsin Avenue. Follow signs for Route 355 South and stay in the right lane. Turn right at the light onto Pooks Hill Road. The hotel is on the right.

From Points South:
Take I-95 North to I-495 (Capital Beltway) toward Tyson's Corner/Rockville. Follow I-495 for 20 miles. Take Exit 34 (Bethesda/Wisconsin Avenue). Follow signs for Route 355 South and stay in the right lane. Turn right at the light onto Pooks Hill Road. The hotel is on the right.

From Baltimore/Washington International Thurgood Marshall Airport (BWI):
Take the Route 195 connector to I-95 South. Take I-95 South to I-495 West (Capital Beltway) toward Silver Spring. Follow I-495 West for 9 miles to Exit 34 (Bethesda/Wisconsin Avenue). Follow signs for Route 355 South and stay in the right lane. Turn right at the light onto Pooks Hill Road. The hotel is on the right.

From Washington Dulles International Airport (IAD):
Take the Dulles Airport Access Road for approximately 13 miles to Exit 18. Move to the right on the Dulles Toll Road (Route 267) and take Exit 18. Stay left on the ramp for Bethesda/Baltimore, and proceed toward Bethesda (I-495). Continue approximately 9 miles on I-495.  Stay on I-495 at the I-495/I-270 split (bear right). Take Exit 34 (Wisconsin Avenue South/Route 355) toward Bethesda. Follow Wisconsin Avenue to the first traffic light and turn right onto Pooks Hill Road. The hotel is on the right.

From Ronald Reagan Washington National Airport (DCA):
Take the George Washington Parkway North for 12 miles to I-495 (Capital Beltway) toward Maryland. Take Exit 34 (Bethesda/Wisconsin Avenue). Follow signs for Route 355 South and stay in the right lane. Turn right at the light onto Pooks Hill Road. The hotel is on the right.

METRORAIL
The Metro system is clean and reliable. It operates from 5:00 a.m. to 12:00 midnight on Monday through Thursday; 5:00 a.m. to 3:00 a.m. on Fridays; 7:00 a.m. to 3:00 a.m. on Saturdays; and 7:00 a.m. to 12:00 midnight on Sundays. Each passenger must buy a farecard to travel in the system. Guides for purchasing farecards are posted on the vending machines in each station. Each Metro car features a complete color-coded map of the system. Station attendants on duty at each station can provide additional information on request. A map of the system is available at: http://www.wmata.com/rail/maps/map.cfm exit disclaimer.

From Union Station or downtown Washington (the main Metro Lines into the city converge at Metro Center Station and Gallery Place Station), take the Metro Red Line toward Shady Grove. Exit at the Medical Center Station. The hotel has a shuttle that runs every half hour. Please notify hotel of the pick-up request at the hotel's number above.

SHUTTLES
SuperShuttle offers service to most hotels from Ronald Reagan Washington National Airport, Washington Dulles International Airport, and Baltimore/Washington International Thurgood Marshall Airport. The shuttle leaves on an as-needed basis between the hours of 5:30 a.m. and 11:00 p.m. During other times, arrangements for a shuttle can be made by calling (800) 258-3826 from the airport, or by visiting their website at http://supershuttle.com.

TAXIS
The taxi fare is approximately $45-$55 from Ronald Reagan Washington National Airport, approximately $55-$65 from Washington Dulles International Airport, and approximately $65-$75 from Baltimore/Washington International Thurgood Marshall Airport. Fares may differ during peak travel hours.

Minutes

​Minutes are currently unavailable.

Attendees

​​Attendees are currently unavailable.

Abstracts

​​Abstracts are currently unavailable.

Location

Line
  • Building 38A, NIH Campus
  • MD 20892
Webinar

Contacts

LineFor scientific questions, contact:
Saul Malozowski, M.D., Ph.D.
Senior Advisor on Endocrine Physiology
Division Diabetes, Endocrinology, and Metabolic Diseases
National Institute of Diabetes and Digestive and Kidney Diseases
Democracy 2, Room 607
6707 Democracy Boulevard
Bethesda, MD  20892
Telephone:  (301) 451-4683
Fax:  (301) 480-3503
Email:  malozowskis@mail.nih.gov

Catherine McKeon, Ph.D.
Senior Advisor for Genetic Research
National Institute of Diabetes and Digestive and Kidney Diseases
Democracy 2, Room 6103
6707 Democracy Boulevard, MSC 5460
Bethesda, MD  20892-5460
Telephone:  (301) 594-8810
Fax:  (301) 480-3503
Email:  mckeonc@mail.nih.gov

For logistical information, contact:
Denise Hoffman, CMP
Deputy Director of Conferencing
The Scientific Consulting Group, Inc.
656 Quince Orchard Road, Suite 210
Gaithersburg, MD  20878-1409
Telephone:  (301) 670-4990 x232
Fax:  (301) 670-3815
Email:  dhoffman@scgcorp.com