U.S. Department of Health and Human Services

Exploring the Role of Brown Fat in Humans

10/15/2013 8:00 AM
10/16/2013 5:00 PM
Yes
No
(301) 594-7689

For questions concerning Program Content:
Carol Haft, Ph.D.
Adipocyte Biology Program Director, NIDDK, NIH
Phone: (301) 594-7689​
Email: haftc@mail.nih.gov

Maren Laughlin, Ph.D.
Metabolism Program Director, NIDDK, NIH
Phone: (301) 594-8802
Email: maren.laughlin@nih.gov

For questions concerning Logistical Information or Registration: 
Michelle Watson
The Scientific Consulting Group, Inc.
Phone: (301) 670-4990
Email: mwatson@scgcorp.com​​​

Bethesda
 
Lister Hill Auditorium

Event Details

Meeting Objective:

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) announces a workshop focused on elucidating the roles of recently described brown and beige/brite fat in people. Speakers will describe state-of-the-art technology for monitoring human brown adipose tissue (hBAT) mass and function, and present recent basic and clinical data. Plenary talks, selected “hot topic” presentations, and a poster session will provide a forum for interactions among basic scientists and clinical researchers.

Scientific Focus:

  • Physiological Functions and Clinical Relevance of hBAT: The 2013 Perspective
  • Classical and Inducible Brown, Beige, Brite, B/B Fat in Humans
  • Measuring hBAT Activity: Pushing the Limits of Position Emission Tomography/Computed Tomography (PET/CT)
  • hBAT as a Therapeutic Target: Investigations in Different Populations
  • Measuring hBAT Mass and Activity: Emerging Approaches
  • Novel Roles of hBAT: Thinking Outside the Box

Planning Committee:

  • Aaron Cypess (Joslin Diabetes Center, Harvard University)
  • Carol Haft (NIDDK, NIH, HSS)
  • Houchun Harry Hu (Children's Hispital Los Angeles)
  • Maren Laughlin (NIDDK, NIH, HHS)​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​

Agenda

Please arrive early. Allow 15 to 20 minutes to go through central NIH security and to get to the Lister Hill Auditorium, Building 38A, once you are on the NIH campus.
 

Day 1 — Tuesday, October 15, 2013

7:30 a.m. Registration (Lister Hill Auditorium, NIH Campus)
8:15–8:30 a.m.

Opening Remarks/Meeting Overview

Carol Haft and Maren Laughlin, NIDDK, NIH
Aaron Cypess, Joslin Diabetes Center, Harvard University
Houchun Harry Hu, Children’s Hospital, Los Angeles

Session I: Physiological Functions and Clinical Relevance of Human BAT (T): The 2013 Perspective

Kong Chen (Moderator)

8:30 a.m. Six Years with Adult Human Brown Adipose Tissue
Jan Nedergaard, Stockholm University, Sweden
9:00 a.m. Treating Metabolic Disease Through Pharmacological Activation of Human
BAT
Aaron Cypess, n Diabetes Center, Harvard University
9:30 a.m. Fat Depots and Bone: the Role of Human BAT
Anne Klibanski, Massachusetts General Hospital
10:00 a.m. Brown and Beige Fat: Basic Biology and Novel Therapeutic Opportunities
Bruce Spiegelman, Dana Farber Cancer Institute, Harvard Medical School
10:30–11:00 a.m. Break

Session II: Measuring Human BAT Activity: Pushing the Limits of PET/CTL

Madar (Moderator)

11:00 a.m. Does Cold-Activated Brown Fat Contribute Significantly to Daily Energy Expenditure?
Otto Muzik, Wayne State University School of Medicine
11:15 a.m. Novel Approaches to Investigating Fatty Acid Metabolism in Human BAT
Kirsi Virtanen, University of Turku and Turku University Hospital, Finland
11:30 p.m. The Norepinephrine Transporter: A Novel Target for Imaging Brown Adipose Tissue
Yu-Shin Ding, New York University School of Medicine
11:45 p.m. Insight into the Functional Organization of Human BAT
Igal Madar, Johns Hopkins University School of Medicine
12:00 p.m. Imaging of Brown Fat Metabolism using Hyperpolarized Carbon-13 MRI
Lanette Friesen-Waldner, University of Western Ontario, London
12:15–2:00 p.m. Poster Session and Lunch Buffet in Atrium

Session III: Classical and Inducible Brown, Beige, Brite, B/B Fat in Humans

Barbara Cannon (Moderator)

2:00 p.m. Deciphering Brown Adipogenesis from a Progenitor and Inductive Signaling Perspective
Yu-Hua Tseng, Joslin Diabetes Center, Harvard Medical School
2:30 p.m. New Tools to Understand the Molecular Circuits of Beige/Brite Cell Development
Shingo Kajimura, University of California, San Francisco
3:00 p.m. Human Epicardial Fat is a Unique Adipose Depot with Limited Brown Fat Signature that is Altered in Coronary Artery Disease
​Elizabeth McAninch, University of Miami
3:20 p.m. Brown Fat Dynamics: Elucidation of Molecular Drivers Based on the Innate Expertise of a Hibernator
​Sandra L. Martin, University of Colorado School of Medicine, Aurora
3:40–4:00 p.m. Break

Session IV: Measuring Human BAT Mass and Activity: Emerging Approaches

Houchun Harry Hu (Moderator)

4:00 p.m. Brown Adipose Tissue Quantification Using Magnetic Resonance Imaging
E. Brian Welch, Vanderbilt University Medical Center
4:15 p.m. Brown Adipose Tissue Perfusion: From Mice to Men
Marielle Scherrer-Crosbie, Massachusetts General Hospital
4:30 p.m. Detecting BAT Mass and Thermogenic Activity by Using Nonlinear 1H MRI and Hyperpolarized 129Xe Gas MRI
Rosa Tamara Branca, University of North Carolina, Chapel Hill
4:45p.m. Passive and Active Microwave Radiometry for Non-Invasive Detection of Human Brown Fat
Fred Sterzer, MMTC, Inc.
5:00 p.m. Peptide Probes for Targeted Brown Adipose Tissue Imaging
Mikhail G. Kolonin, University of Texas Health Science Center, Houston
5:15 p.m. Adjournment

Day 2 — Wednesday, October 16, 2013

7:30–8:00 a.m. Registration (Lister Hill Auditorium, NIH Campus
7:55 a.m. Opening Remarks
Griffin Rodgers, NIDDK Director

Session V: Human BAT as a Therapeutic Target

Rebecca Brown (Moderator)

8:00 a.m. Effect of Ambient Temperature on Human Brown Fat Activity and
Recruitment
Wouter van Marken Lichtenbelt, Maastricht University Medical Center, The Netherlands
8:30 a.m. Exploring the Roles of Brown Fat in Children
Vicente Gilsanz, Children’s Hospital Los Angeles
9:00 a.m. Signal Transduction Pathways Converging to Promote “Brown(ing)”
Adipocytes
Sheila Collins, Sanford-Burnham Medical Research Institute
​9:30 a.m. ​Brown Adipose Tissue Improves Glucose Metabolism and Whole Body Insulin Sensitivity in Humans
Maria Chondronikola, University of Texas Medical Branch, Galveston
9:50–10:15 a.m. Break
10:15 a.m. Acute Cold Exposure Elicits Increases in BAT Oxidative Metabolism in Individuals with Type 2 Diabetes
Denis Blondin, Université de Sherbrooke
10:35 a.m. Autologous Matrix Assisted Cell Transplantation as a Strategy for the Expansion of Human BAT
Andreas Stahl, UC Berkeley

Session VI: Human BAT Research: Future Directions

Houchun Harry Hu and Aaron Cypess (Moderators)

11:00 a.m. Open Floor Discussion of Research Gaps and Opportunities
  • What are the potential physiological roles for adult human BAT/Beige/Brite cells?
  • What technologies, in addition to imaging or temperature detection, are needed to
    assess the role(s) of adult human BAT?
    • Is there more to be learned from the regarding the role(s) of adult human BAT?
  • Are epidemiologic studies of human BAT needed?
    • Impact of climate and environment
    • Impact of exercise and diet
    • Impact of age, gender, body composition, genetics
    • Unique populations
​ ​
12:00 -- 1:30 p.m. Poster Session and Lunch Buffet

Session VII: Novel Role(s) of Human BAT: Thinking Outside
the Box

Ronald Kahn (Moderator)

1:30 p.m. Novel Mechanisms in the Control of Brown and White Fat Development and Function
C. Ronald Kahn, Joslin Diabetes Center, Harvard University
1:45 p.m. Targeting Lipolysis to Fuel Adipocyte Thermogenesis
James Granneman, Wayne State University
2:15 p.m. Insights From Understanding CNS Pathways in Regulating the Sympathetic Outflow to BAT
Shaun Morrison, Oregon Health and Science University
2:45 p.m. Inactivation of Type 2 Deiodinase in Adipose Tissue Increases the Expression of Skeletal Muscle-Specific Genes in Neonatal Mouse Hind Limb and in E18.5 Brown Adipose Tissue
Antonio Bianco, University of Miami Medical School
3:15p.m. Brown Adipose Tissue and Sleep Regulation
​Éva Szentirmai, Washington State University, Spokane
​3:35 p.m Does Sarcolipin and Muscle Based Thermogenesis Compensate in BAT Deficient Mammals?
Muthu Periasamy, Ohio State University, Columbus
3:55 p.m. Closing Remarks
4:15 p.m. Adjournment

 

Directions/Travel

Meeting Location:

Lister Hill Auditorium​
Building 38 A
National Institutes of Health
Bethesda, MD 

NIH Visitor Information:

The Lister Hill Auditorium is located on the NIH Campus in building 38A.  For a map, general information, and directions to and around the NIH Campus, visit:   http://parking.nih.gov/visitor_access_map.htm

NIH Security:

The NIH, like all federal government facilities, has instituted security measures to ensure the safety of NIH employees, patients, and visitors.  The national threat advisory level, determined by the Department of Homeland Security (http://www.whitehouse.gov/homeland) , currently is yellow (elevated).  

Perimeter Security:

All visitor vehicles, including taxicabs, hotel and airport shuttles, delivery trucks, and vans will be inspected before being allowed on campus.  Visitors will be asked to show one (1) form of identification (a government-issued photo ID:  driver’s license, passport, green card, etc.) and to state the purpose of their visit.  Be sure to allow at least 15-20 minutes for this vehicle inspection procedure.

Building Security:

Due to the checking of IDs at the perimeter, employees and visitors will not be required to show their ID again to gain access to the majority of buildings on the NIH Campus during the normal business day.
 
Employees and visitors should continue to wear their identification prominently at all times while on campus.

Guards will remain at certain buildings to address specific program requirements, such as sensitive research and safety concerns.  At building entrances where guards are posted: 

  • Employees must show a DHHS-issued photo ID (for example, your NIH-issued ID badge). 
  • Visitors may be required to log-in, wear a visitor’s pass, and be escorted by an employee through the building.
  • Visitors may be required to pass through a metal detector and have bags, backpacks, or purses inspected or x-rayed as they enter buildings. 
  • Security staff will confiscate any suspicious or potentially dangerous materials.  U.S. code prohibits bringing any dangerous weapons onto federal property, including anything with a blade longer than 2½ inches.  Meeting participants may want to leave extra bags or personal materials at their hotel to minimize the time needed for inspection. 

Weekday Pedestrian Campus Access:

All visitors must enter through the NIH Gateway Center at Metro or the West Gateway Center (see the Visitor Map at http://parking.nih.gov/visitor_access_map.htm). 
  • Gateway Center
    Wisconsin Avenue at Gateway Drive (near the Metro)
    Open 24 hours, 7 days per week
  • West Gateway Center
    Near Old Georgetown Road and South Drive
    Open 6 a.m. – 12 p.m., Monday-Friday

Driving Directions to NIH

From Points North and East:
Take I-95 South to I-495 West (Capital Beltway) toward Silver Spring.  Follow I-495 West for 9 miles to Exit 34 (Bethesda/Wisconsin Avenue).  Follow signs for Route 355 South and stay in the right lane.  Travel approximately 1 mile and turn right at the light onto South Drive.  Pass through NIH security and follow the signs to Building 38A.

From Points North and West:
Take I-270 South to I-495 East (Capital Beltway) toward Washington, DC.  Stay in one of the three left lanes.  Follow signs for Route 355 South, a left-lane exit, onto Wisconsin Avenue.  Travel approximately 1 mile and turn right at the light onto South Drive.  Pass through NIH security and follow the signs to Building 38A.

From Points South:
Take I-95 North to I-495 (Capital Beltway) toward Tyson’s Corner/Rockville.  Follow I-495 for 20 miles.  Take Exit 34 (Bethesda/Wisconsin Avenue).  Travel approximately 1 mile and turn right at the light onto South Drive.  Pass through NIH security and follow the signs to Building 38A.

From Baltimore/Washington International Thurgood Marshall Airport (BWI):
Take the Route 195 connector to I-95 South.  Take I-95 South to I-495 West (Capital Beltway) toward Silver Spring.  Follow I-495 West for 9 miles to Exit 34 (Bethesda/Wisconsin Avenue).  Follow signs for Route 355 South and stay in the right lane.  Travel approximately 1 mile and turn right at the light onto South Drive.  Pass through NIH security and follow the signs to Building 38A.

From Washington Dulles International Airport (IAD):
Take the Dulles Access Road for approximately 13 miles to Exit 18.  Move to the right on the Dulles Toll Road (Route 267) and take Exit 18.  Stay left on the ramp for Bethesda/Baltimore, and proceed toward Bethesda (I-495).  Continue approximately 9 miles on I-495.  Stay on I-495 at the I-495/I-270 split (bear right).  Take Exit 34 (Wisconsin Avenue South/Route 355) toward Bethesda.  Travel approximately 1 mile and turn right at the light onto South Drive.  Pass through NIH security and follow the signs to Building 38A.

From Ronald Reagan Washington National Airport (DCA):
Take the George Washington Parkway North for 12 miles to I-495 toward Maryland (Capital Beltway).  Take Exit 34 (Bethesda/Wisconsin Avenue).  Travel approximately 1 mile and turn right at the light onto South Drive.  Pass through NIH security and follow the signs to Building 38A.

Parking:

Parking on the NIH campus is limited and is $12 per day in the visitor lots.

Hotel Lodging:

Hyatt Regency Bethesda Hotel
One Bethesda Metro Center
7400 Wisconsin Avenue
Bethesda, MD 20814
Telephone: (301) 657-1234
Website: http://www.hyattregencybethesda.com

Hotel Accommodations:

A block of sleeping rooms has been reserved at the Hyatt Regency Bethesda, Bethesda, MD, for arrival on Monday, October 14, 2013, and departing on Wednesday, October 16, 2013. The room rate is the prevailing government rate which is currently $224 plus tax per night (subject to change).
 
Please contact the Hyatt Regency Bethesda by Thursday, September 19, 2013, at (402) 592-6464 or 1 (888) 421-1442, and reference the Exploring the Roles of Brown Fat in Humans when making your sleeping room reservations. For online registrations, please use the meeting code SCG6 at the following link: https://resweb.passkey.com/go/SCG6. Please be certain that the hotel provides you with a confirmation number and retain this number for future reference. After September 19, 2013, the hotel will accept reservations on a space-available basis at the prevailing hotel rate.
 
When making a reservation, please provide your room and bedding preferences. The hotel will assign specific room types at check-in, based on availability. Please be advised that requests are not guaranteed. Check-in time is at 3:00 p.m., and check-out time is 12:00 noon. If for any reason you need to cancel your hotel reservation, please do so 48 hours in advance of your check-in date.
 
Additional Information
The Scientific Consulting Group, Inc. (SCG) is providing the logistical support for this meeting. The above information should help you with your planning. If you have any questions, please contact Michelle Watson of SCG by telephone at 301-670-4990 or by email at mwatson@scgcorp.com.

Directions

From Points North

From I-95
Take I-95 South to I-495 (Capital Beltway) West toward Silver Spring. Take Exit 34 (Wisconsin Avenue/Route 355). Follow Route 355 South for approximately 3 miles and the Hyatt Regency Bethesda will be on the right, on the corner of Wisconsin Avenue and Old Georgetown Road.

From I-270
Take I-270 South to I-495 (Capital Beltway) East toward Washington, DC. Stay in one of the three left lanes. Follow signs for 355 South, a left-lane exit, onto Wisconsin Avenue. Follow Route 355 South for approximately 3 miles and the Hyatt Regency Bethesda will be on the right, on the corner of Wisconsin Avenue and Old Georgetown Road.

From Points South

Take I-95 North to I-495 (Capital Beltway) toward Tysons Corner/Rockville. Follow I-495 for 20 miles. At the I-495/I-270 split, stay to the right on I-495. Take Exit 34 (Wisconsin Avenue/Route 355). Follow Route 355 South for approximately 3 miles and the Hyatt Regency Bethesda will be on the right, on the corner of Wisconsin Avenue and Old Georgetown Road.

From Baltimore/Washington International Thurgood Marshall Airport (BWI)

Take Route 195 West to Exit 4 (I-95 South). From I-95 take I-495 (Capital Beltway) West toward Silver Spring. Take Exit 34 (Wisconsin Avenue/Route 355). Follow Route 355 South for approximately 3 miles and the Hyatt Regency Bethesda will be on the right, on the corner of Wisconsin Avenue and Old Georgetown Road.

From Washington Dulles International Airport

Take the Dulles Access Road for approximately 13 miles to Exit 18. Move to the right on the Dulles Toll Road (Route 267); get off at Exit 18. Stay to the left on the ramp for Bethesda/Baltimore and proceed toward Bethesda on I-495 (Capital Beltway) for approximately 9 miles. At the I-495/I-270 split, stay to the right on I-495. Take Exit 34 (Wisconsin Avenue/Route 355 South). Follow Route 355 South for approximately 3 miles and the Hyatt Regency Bethesda will be on the right, on the corner of Wisconsin Avenue and Old Georgetown Road.

From Ronald Reagan National Airport

Take the George Washington Parkway North to I-495 (Capital Beltway) and follow the signs to Maryland. At the I-495/I-270 split, stay to the right on I-495. Take Exit 34 (Wisconsin Avenue/Route 355). Follow Route 355 South for approximately 3 miles and the Hyatt Regency Bethesda will be on the right, on the corner of Wisconsin Avenue and Old Georgetown Road.

METRO INFORMATION

The Metro System is clean, reliable, and safe. It operates from 5:30 a.m. to 12:00 midnight Monday through Thursday; 5:00 a.m. to 2:00 a.m. on Fridays; 8:00 a.m. to 2:00 a.m. on Saturdays; and 8:00 a.m. to 12:00 midnight on Sundays. Each passenger must buy a farecard to travel in the system. Guides for purchasing farecards are posted on the vending machines in each station. Each Metro car features a complete color-coded map. Station attendants on duty at each station can provide additional information on request.
 
From Union Station or downtown Washington (main Metro Lines into the city converge at Metro Center Station and Gallery Place Station), take the Metro Red Line toward Shady Grove or Grosvenor. Exit at the Bethesda Metro Station. The Hyatt is directly above the Bethesda Metro Station.

SHUTTLES

Super Shuttle offers service to most hotels from Ronald Reagan National Airport, Washington Dulles International Airport, and Baltimore/Washington International Thurgood Marshall Airport. The shuttle leaves on an as-needed basis between the hours of 5:30 a.m. and 11:00 p.m. During other times, arrange for a shuttle by calling 800-258-3826 from the airport.

TAXIS

The taxi fare is approximately $45-$55 from Ronald Reagan Washington National Airport, approximately $55-$65 from Washington Dulles International Airport, and approximately $65-$75 from Baltimore/Washington International Thurgood Marshall Airport. Fares may differ during peak travel hours.

MARC TRAINS

From BWI Airport, take the MARC train on the Penn Line to Union Station. Take the Metro Red Line toward Grosvenor or Shady Grove and exit at the Bethesda Metro Station. The hotel is directly above the Bethesda Metro Station.

PARKING INFORMATION

Self-parking at the hotel is $15 per day/overnight. Valet parking is $20 per day/overnight.

Minutes

​Minutes are currently unavailable.​

Attendees

Attendees are currently unavailable.​

Abstracts

​​​​​Please note: The deadline for submission of abstracts is August 26, 2013.

Investigators who attend the workshop on Exploring the Role(s) of Brown Fat in Humans are encouraged to submit abstracts of their research activities. Several “hot topic” talks will be chosen from the submitted Abstracts. Graduate students and postdoctoral fellows are eligible to apply for travel awards along with the abstract submission. Six to eight travel awardees will be chosen by the Program Committee based on the quality of the submitted work. 

Please follow the instructions below to submit an abstract for consideration:

  1. The deadline for abstract submission is August 13, 2013.
  2. Please send the abstract via email to Ms. Michelle Watson at mwatson@scgcorp.com with "Human Brown Fat" in the subject line. Attach the abstract as an MS Word document, and include any relevant comments in the text of the email.
  3. The abstract title should be typed in bold font, Title Case Letters.
  4. List the names, degrees, and institutional affiliations of all authors, and underline the name of the presenting author.
  5. If you are a graduate student or postdoctoral fellow and would like to apply for a travel award, please include in your email a short CV and cover letter detailing your contribution to the submitted work. Travel awardees will be chosen by the planning committee and will be notified in September 2013.

Poster Presentations

Posters do not need to be elaborate. Poster boards (4 feet high by 6 feet wide), pushpins, and Velcro will be provided onsite. Sponsorship of any type should be indicated on posters.​

Location

Line
  • Building 38 A
  • National Institutes of Health
  • MD 20892
Webinar

Contacts

Line

For questions concerning Program Content:
Carol Haft, Ph.D.
Adipocyte Biology Program Director, NIDDK, NIH
Phone: (301) 594-7689​
Email: haftc@mail.nih.gov

Maren Laughlin, Ph.D.
Metabolism Program Director, NIDDK, NIH
Phone: (301) 594-8802
Email: maren.laughlin@nih.gov

For questions concerning Logistical Information or Registration: 
Michelle Watson
The Scientific Consulting Group, Inc.
Phone: (301) 670-4990
Email: mwatson@scgcorp.com​​​