U.S. Department of Health and Human Services

Hepatitis E in the United States: An NIH Research Workshop

3/26/2012 7:00 AM
3/26/2012 7:00 AM
Yes
No
For questions concerning program content, contact:
Averell H. Sherker, M.D., FRCP(C)
National Institute of Diabetes and Digestive and Kidney Diseases
Telephone:  (301) 451-6207
Email:  averell.sherker@nih.gov
 
Jay H. Hoofnagle, M.D.
National Institute of Diabetes and Digestive and Kidney Diseases
Telephone:  (301) 496-1333
Email:  hoofnaglej@extra.niddk.nih.gov
 
For questions concerning meeting logistics, contact:
Denise Hoffman, BIT, CMP
The Scientific Consulting Group, Inc.
Telephone:  (301) 670-4990
Email:  dhoffman@scgcorp.com​
Bethesda
 
Lister Hill Auditorium

Event Details

Meeting Objective:

The purpose of the meeting is to assess the status of hepatitis E virus (HEV) infection in the United States, with particular focus on its distinct epidemiology, clinical features, serology, and burden of disease in the general population as well as in high-risk groups. The meeting will address the issues of the peculiar epidemiology and clinical course of the sporadic, non-travel-associated hepatitis E that occurs in the United States and other developed countries that usually is due to genotype 3 HEV infection, a strain that is considered a zoonosis and is common among domestic swine and wild game animals. The meeting will address the reliability of diagnostic tests to identify hepatitis E, the possible role of treatment in chronic infection, and approaches to prevention, including public health measures, particularly in immunosuppressed or immunodeficient patients.



Speakers from the Hepatitis E in the Unites States - An NIH Research Workshop
Pictured: Top: Chenyu Xu, John Ward, Scott Holmberg, James Wai Kuo Shih, Norah Terrault, Jay H. Hoofnagle, Caryn Morse, Xiang-Jin Meng, Robert Fontana, Philippe Colson, Sally Hojvat

Bottom: Averell H. Sherker, Rajen Koshy, Nassim Kamar, Kenrad Nelson, Alain Labrique, Harry Dalton, Robert H. Purcell, Sue Emerson.

Organizers:


Kenrad Nelson, Johns Hopkins University
Robert H. Purcell, NIAID, NIH
Rajen Koshy, NIAID, NIH
Averell H. Sherker, NIDDK, NIH
Jay H. Hoofnagle, NIDDK, NIH

Agenda

Monday, March 26, 2012

7:30 - 8:30 a.m. Registration
8:30 - 8:40 a.m.

Welcome and Aims
Jay H. Hoofnagle, M.D., National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

​Session 1: The Hepatitis E Virus (HEV)​​​​

Moderators:     Rajen Koshy, Ph.D., National Institute of Allergy and Infectious Diseases (NIAID)
Robert H. Purcell, M.D., NIAID
8:40 - 9:00 a.m.

Molecular Virology of HEV
Sue Emerson, Ph.D., NIAID

9:00 - 9:20 a.m.

Diagnostic Assays for HEV
Harry Dalton, MBBS, DPhil, Royal Cornwall Hospital Trust and Peninsula College of Medicine and Dentistry (United Kingdom)

9:20 - 9:40 a.m.

HEV as a Zoonosis
Xiang-Jin Meng, M.D., Ph.D., Virginia Polytechnic Institute and State University

9:40 - 10:10 a.m.

Discussion
Moderators and Speakers

10:10 - 10:30 a.m. Break

​Session 2: Epidemiology of Hepatitis E

Moderators: Jay H. Hoofnagle, M.D., NIDDK 
Harry Dalton, MBBS, DPhil, Royal Cornwall Hospital Trust and Peninsula College of Medicine and Dentistry
10:30 - 10:50 a.m.

Epidemiology in Asia
Alain Labrique, Ph.D., M.H.S., Johns Hopkins University

10:50 - 11:10 a.m.

Epidemiology in Europe
Philippe Colson, M.D., Centre Hospitalo-Universitaire Timone (France)

11:10 - 11:30 a.m.

Epidemiology in the United States
Kenrad Nelson, M.D., Johns Hopkins University

11:30 - 11:50 a.m.

Hepatitis E in the United States
Scott Holmberg, M.D., Centers for Disease Control and Prevention (CDC)

11:50 a.m. - 12:20 p.m.

Discussion
Moderators and Speakers

12:20 - 1:30 p.m. Lunch and Posters

​Session 3: ​Special Populations​ ​

Moderators: ​​Kenrad Nelson, M.D., Johns Hopkins University 
Averell H. Sherker, M.D., FRCP(C), NIDDK
1:30 - 1:50 p.m.

Clinical Course and Complications
Jay H. Hoofnagle, M.D., NIDDK

1:50 - 2:10 p.m.

HEV and Acute Liver Failure
Robert Fontana, M.D., University of Michigan

2:10 - 2:30 p.m.

HEV After Organ Transplantation
Norah Terrault, M.D., M.P.H., University of California, San Francisco

2:30 - 2:50 p.m.

HEV and HIV Co-infection
Caryn Morse, M.D ., M.P.H., Warren G. Magnuson Clinical Center (CC), National Institutes of Health (NIH)

2:50 - 3:20 p.m.

Discussion
Moderators and Speakers

3:20 - 3:40 p.m. Break​

​​ ​Session 4: Treatment and Prevention​​

Moderators: Sally Hojvat, U.S. Food and Drug Administration (FDA) 
John Ward, M.D., CDC
3:40 - 4:00 p.m.

HEV Screening in Blood Donors
Chenyu Xu, Ph.D., CC, NIH

4:00 - 4:20 p.m.

HEV and Food Safety Issues
Julie Ann Kase, Ph.D., FDA

4:20 - 4:40 p.m.

HEV Vaccines
James Wai Kuo Shih, Ph.D., Xiamen University (China)

4:40 - 5:00 p.m.

Treatment of HEV
Nassim Kamar, M.D., Center Hospitalier Universitaire Rangueil (France)

5:00 - 5:30 p.m.

Discussion of Future Needs
Moderators and Speakers

5:30 p.m. Adjournment

Directions/Travel

Participants are responsible for making their own travel arrangements.  Should you decide to extend your stay to take advantage of lower fares, DC-area attractions are only a short stop away from the suggested hotels. 

Hotel and travel information are listed below. 

Hotel Reservations  

The following hotels provide lodging in close proximity that is accessible by taxi.  
 
American Inn of Bethesda  
8130 Wisconsin Avenue  
Bethesda, MD  20814  
P:  (301) 656-9300 or 1-800-232-7081  
F:  (301) 656-2907  
 
Bethesda Marriott Hotel
5151 Pooks Hill Road  
Bethesda, MD  20814  
P:  (301) 897-9400 or 1-800-228-9290
F:  (301) 897-0192  
 
Bethesda North Marriott Hotel and Conference Center  
5701 Marinelli Road  
North Bethesda, MD  20852  
P:  (301) 822-9200 or 1-800-228-9290  
F:  (301) 822-9201 

DoubleTree Hotel
8120 Wisconsin Avenue  
Bethesda, MD  20814 
P:  (301) 652-2000 or 1-800-222-TREE 
F:  (301) 652-4525  

Hilton Executive Conference Center
1750 Rockville Pike  
Rockville, MD  20852  
P:  (301) 468-1100 or  
F:  (301) 468-0308 

Hilton Garden Inn ​
7301 Waverly Street
Bethesda, MD  20814
P:  (301) 654-8111

Hyatt Regency Bethesda 
One Bethesda Metro Center  
Bethesda, MD  20814  
P:  (301) 657-1234 or 1-800-633-7313  
F:  (301) 657-6453  

Residence Inn  
7335 Wisconsin Avenue  
Bethesda, MD  20814 
P:  (301) 718-0200 or 1-800-228-9290
F:  (301) 718-0679  

The Legacy Hotel
1775 Rockville Pike  
Rockville, MD  20852 
P:  (301) 231-8800 
F:  (301) 881-9047

Taxi Service to Area Hotels

From Baltimore/Washington International Thurgood Marshall Airport (BWI):
Approximate hotel distance and direction:  35 miles S.W.
Estimated Taxi Fare:  $60

From Washington Dulles International Airport (IAD):
Approximate hotel distance and direction:  25 miles N.E.
Estimated Taxi Fare:  $50

From Ronald Reagan Washington National Airport (DCA):
Approximate hotel distance and direction:  21 miles N.E.
Estimated Taxi Fare:  $45

Fares may differ during peak travel hours.

Metro to the Hotel

The Metrorail system is clean and reliable.  It operates from 5:00 a.m. to 12:00 midnight Monday through Thursday; 5:00 a.m. to 3:00 a.m. on Fridays; 7:00 a.m. to 3:00 a.m. on Saturdays; and 7:00 a.m. to 12:00 midnight on Sundays.  Each passenger must purchase a farecard to travel in the system.  Instructions for purchasing farecards are posted on the vending machines at each station.  Each Metrorail car features a complete color-coded map of the system.  Station attendants on duty at each station can provide additional information on request.

From Ronald Reagan Washington National Airport, a cost-effective way to travel to the meeting is by using the Metrorail system.  A map of the system is available. From the Ronald Reagan Washington National Airport station, take the Yellow Line toward Mt. Vernon Square or Fort Totten.  At the Gallery/Chinatown stop, transfer to the Red Line toward Shady Grove or Grosvenor-Strathmore.  Please see the following list of hotels and respective Metrorail stations.

Bethesda Station - Hyatt Regency, Residence Inn, Hilton Garden Inn
Medical Center Station - American Inn, DoubleTree, Bethesda Marriott (call for hotel shuttle)
White Flint Station - Bethesda Marriott North Hotel and Conference Center
Twinbrook - Hilton and Legacy

SuperShuttle

SuperShuttle offers service to most hotels from Ronald Reagan Washington National Airport, Washington Dulles International Airport, and Baltimore/Washington International Thurgood Marshall Airport.  The shuttle leaves on an as-needed basis between the hours of 5:30 a.m. and 11:00 p.m.  During other times, arrangements for a shuttle can be made by calling 1-800-258-3826 from the airport, or by visiting their website.

NIH Visitor Information 

The Lister Hill Auditorium is located on the NIH Campus in Building 38A.  For a map, general information, and directions to and around the NIH Campus, visit http://parking.nih.gov/visitor_access_map.htm

NIH Security

The NIH, like all federal government facilities, has instituted security measures to ensure the safety of NIH employees, patients, and visitors.  The national threat advisory level, determined by the Department of Homeland Security (http://www.whitehouse.gov/homeland/), currently is yellow (elevated). 

Perimeter Security

All visitor vehicles, including taxicabs, hotel and airport shuttles, delivery trucks, and vans will be inspected before being allowed on campus.  Visitors will be asked to show one (1) form of identification (a government-issued photo ID:  driver's license, passport, green card, etc.) and to state the purpose of their visit.  Please allow at least 15 to 20 minutes for this vehicle inspection procedure. 

Building Security

Due to the checking of IDs at the perimeter, employees and visitors will not be required to show their ID again to gain access to the majority of the buildings on the NIH Campus during the normal business day.

Employees and visitors should continue to wear their identification prominently at all times while on campus.

Guards will remain at certain buildings to address specific program requirements, such as sensitive research and safety concerns.  At building entrances where guards are posted: 

  • Employees must show a DHHS-issued photo ID (for example, your NIH-issued ID badge). 
  • Visitors may be required to log-in, wear a visitor's pass, and be escorted by an employee through the building.
  • Visitors may be required to pass through a metal detector and have bags, backpacks, or purses inspected or X-rayed as they enter buildings. 
  • Security staff will confiscate any suspicious or potentially dangerous materials.  U.S. code prohibits bringing any dangerous weapons onto federal property, including anything with a blade longer than 21/2 inches.  Meeting participants may want to leave extra bags or personal materials at their hotel to minimize the time needed for inspection. 

 

Weekday Pedestrian Campus Access

All visitors must enter through the NIH Gateway Center at the Medical Center Metro stop or the West Gateway Center (see the Visitor Map at http://parking.nih.gov/visitor_access_map.htm).
  • Gateway Center

Wisconsin Avenue at Gateway Drive (near the Metro)
Open 24 hours, 7 days per week

  • West Gateway Center

Near Old Georgetown Road and South Drive 
Open 6 a.m. to 12 p.m., Monday through Friday

Driving Directions to NIH

From Points North and East:
Take I-95 South to I-495 West (Capital Beltway) toward Silver Spring.  Follow I-495 West for 9 miles to Exit 34 (Bethesda/Wisconsin Avenue).  Follow signs for Route 355 South and stay in the right lane.  Travel approximately 1 mile and turn right at the light onto South Drive.  Pass through NIH security and follow the signs to Building 38A.

From Points North and West: 
Take I-270 South to I-495 East (Capital Beltway) toward Washington, DC.  Stay in one of the three left lanes.  Follow signs for Route 355 South, a left-lane exit, onto Wisconsin Avenue.  Travel approximately 1 mile and turn right at the light onto South Drive.  Pass through NIH security and follow the signs to Building 38A.

From Points South:
Take I-95 North to I-495 (Capital Beltway) toward Tyson's Corner/Rockville.  Follow I-495 for 20 miles.  Take Exit 34 (Bethesda/Wisconsin Avenue).  Travel approximately 1 mile and turn right at the light onto South Drive.  Pass through NIH security and follow the signs to Building 38A.

From Baltimore/Washington International Thurgood Marshall Airport (BWI):
Take the Route 195 connector to I-95 South.  Take I-95 South to I-495 West (Capital Beltway) toward Silver Spring.  Follow I-495 West for 9 miles to Exit 34 (Bethesda/Wisconsin Avenue).  Follow signs for Route 355 South and stay in the right lane.  Travel approximately 1 mile and turn right at the light onto South Drive.  Pass through NIH security and follow the signs to Building 38A.

From Washington Dulles International Airport (IAD):
Take the Dulles Access Road for approximately 13 miles to Exit 18.  Move to the right lane on the Dulles Toll Road (Route 267) and take Exit 18.  Stay left on the ramp for Bethesda/Baltimore, and proceed toward Bethesda 
(I-495).  Continue approximately 9 miles on I-495.  Stay on I-495 at the I-495/I-270 split (bear right).  Take Exit 34 (Wisconsin Avenue South/Route 355) toward Bethesda.  Travel approximately 1 mile and turn right at the light onto South Drive.  Pass through NIH security and follow the signs to Building 38A.

From Ronald Reagan Washington National Airport (DCA):
Take the George Washington Parkway North for 12 miles to I-495 (Capital Beltway) toward Maryland.  Take Exit 34 (Bethesda/Wisconsin Avenue).  Travel approximately 1 mile and turn right at the light onto South Drive.  Pass through NIH security and follow the signs to Building 38A.

Parking

Parking on the NIH campus is limited and costs $12 per day in the visitor lots. The closest visitor lot is the Gateway Parking Garage (MLP-11) located at the Gateway Drive entrance. From here, it is a 5 minute walk to the building. The NIH Campus shuttle is also an option, which runs every 15 minutes.​

Minutes

Minutes are curently unavailable.

Attendees

Attendees are curently unavailable.

Abstracts

CALL FOR ABSTRACTS

Submission Deadline:  Wednesday, February 1, 2012

Abstracts must be sent by email to Denise Hoffman at dhoffman@scgcorp.com as a Microsoft Word document by the deadline date listed above. Please put "Hepatitis E Poster Abstract" in the subject line.

  1. The abstract should be typed single-spaced to fit standard abstract measurements using type no smaller than 10 point (12 cpi). The abstract's title should be typed in CAPITAL LETTERS and should clearly represent the nature of the investigation. The title should be followed in lowercase letters by the author's first and last names, degree, affiliation (if applicable), city, state, and country. Underline the primary author's name (one primary author per abstract). Do not leave spaces between the title and the body of the abstract, or between paragraphs. Indent paragraphs three spaces. The abstract file should be saved as: primary author's last name_first word in the title (e.g., Zucker_Effects).
  2. Please ensure that your abstract is no more than one page in length. Set the margins to the following using Microsoft Word: Top 1"; Bottom 1"; Left 1"; Right 1".
  3. Use of standard abbreviations is desirable (e.g., RBC). Use kg, gm, mg, mL, L, and %. Place a special or unusual abbreviation in parentheses after the full word the first time that it appears. Use numerals to indicate numbers except to begin sentences. Do not use subtitles (e.g., Methods, Results).
  4. Simple tables or graphs may be included; however, they must fit within the designated abstract space.
  5. Please use a common font such as Helvetica, Times New Roman, or Arial.
  6. Your abstract must conform to the above guidelines, as incorrect formatting could result in disqualification.

Body of the Abstract

Organize the body of the abstract as follows:

  • Statement of the purpose of the study/program/project;
  • Statement of the methods used;
  • Summary of the results presented in sufficient detail to support the conclusion;
  • Statement of the conclusions reached.

Poster Presentations

Poster Presentations will be displayed on 4-foot-high by 6-foot-wide posterboards. Pushpins and velcro will be provided.

All presenters must register for the workshop.​

Location

Line
  • Building 38A, NIH Campus
  • MD 20892
Webinar

Contacts

Line
For questions concerning program content, contact:
Averell H. Sherker, M.D., FRCP(C)
National Institute of Diabetes and Digestive and Kidney Diseases
Telephone:  (301) 451-6207
Email:  averell.sherker@nih.gov
 
Jay H. Hoofnagle, M.D.
National Institute of Diabetes and Digestive and Kidney Diseases
Telephone:  (301) 496-1333
Email:  hoofnaglej@extra.niddk.nih.gov
 
For questions concerning meeting logistics, contact:
Denise Hoffman, BIT, CMP
The Scientific Consulting Group, Inc.
Telephone:  (301) 670-4990
Email:  dhoffman@scgcorp.com​