U.S. Department of Health and Human Services

Host-Microbiota Interactions: How Host Physiology and Disease Pathophysiology Are Affected by the Gut Microbiota

9/9/2014 8:00 AM
9/10/2014 5:00 PM
No
No
Program Contact:
Michael J. Grey, PhD
Division of Digestive Diseases and Nutrition
NIDDK
Phone: 301-640-0121

Logistics Contact:
Lauren Meskill
Division of Digestive Diseases and Nutrition
NIDDK
Phone: 301-402-7503
Bethesda
 
Natcher Conference Center

Event Details

Meeting Objective​​

Advance our understanding of how host physiology and disease pathophysiology are affected by the gut microbiota; define research needs and opportunities for interrogating host-microbiota interactions and their role in modulating disease processes within NIDDK’s mission.

Meeting Format​

Retreat-style format designed to (1) highlight the clinical perspective of how diseases are affected by the gut microbiota; (2) provide case studies for studying host-microbiota interactions in the context of inflammation and epithelial barrier function, nutrient metabolism and energy balance, and communication with distant organs; and (3) introduce novel frameworks for understanding the factors that regulate host-microbiota interactions and stasis.  Sessions will have facilitated panel discussions to address the major scientific questions that will advance our understanding of host-microbiota interactions and how physiology and disease pathophysiology are affected by the gut microbiota.

Plan​ning Committee:
Eugene Chang, MD (University of Chicago)
Michael Fischbach, PhD (University of California San Francisco)
Marguerite Hatch, PhD (University of Florida)
Dan Littman, MD PhD (New York University)
Kristin Abraham, PhD (NIDDK, Division of Diabetes, Endocrinology, and Metabolic Diseases)
Michael J. Grey, PhD (NIDDK, Division of Digestive Diseases and Nutrition)
Chris Ketchum, PhD (NIDDK, Division of Kidney, Urologic, and Hematologic Diseases)
Rebekah Rasooly, PhD (NIDDK, Division of Kidney, Urologic, and Hematologic Diseases)​​​​​​​​​​​​​​​​​​​​​

​​​

Agenda

​Day 1 – September 9, ​2014

8:00 am                Welcome and Opening Remarks

 

                         Gregory Germino (Deputy Director, NIDDK)
                                     The Gut Microbiota and the NIDDK Mission

 

                                     Stephen James (Director, Division of Digestive Diseases and Nutrition, NIDDK)
                                     Understanding How Host Physiology is affected by the Gut Microbiota                 

Session 1:  How Are Disease Processes Affected by the Gut Microbiota – A Clinical Perspective

State-of-the-art Talks – What is known about how disease onset, progression, or treatment is affected by the gut microbiota?   What clinical considerations need to be taken into account when designing studies to understand the mechanisms by which disease pathophysiology is affected by the microbiota?  What are the most pressing clinical aspects for research to understand how the host and diseases respond to the microbiota and microbial functions?  Presentations will be 20 minutes followed by 5 min Q&A.

Moderator: Eugene Chang (University of Chicago)

8:30 – 8:50 am              Ramnik Xavier (Massachusetts General Hospital/Broad Institute)
                                    Inflammatory Bowel Diseases

8:50 – 9:10 am              Mark Atkinson (University of Florida)
                                     Type 1 Diabetes

9:10 – 9:30 am              Lee Kaplan (Massachusetts General Hospital)
                                     Obesity

9:30 – 9:50 am              John Lieske (Mayo Clinic)
                                     Primary Hyperoxaluria

9:50 – 10:10 am            Gary Wu (University of Pennsylvania)
                                    Diet and the Gut Microbiata

10:10 – 10:30 am          Panel Discussion

10:30 – 11:00 am          Break

 

Session 2:  Interrogating Host-Microbial Interactions in Host Physiology and Disease Pathophysiology

Case Studies – targeted case studies illustrating recent examples and state-of-the-art approaches for interrogating host-microbial interactions in thematic areas.  Presenters will integrate considerations for relevant clinical questions, host genetics, informatics advances, and assay platforms and models.  The moderator will facilitate a panel discussion to address key scientific questions that will advance our understanding of how host physiology and disease pathophysiology are affected by the gut microbiota.

11:00 am – 12:00 pm     How are intestinal inflammation and epithelial barrier function modulated by the gut microbiota? (15 minutes per case study + 20 minutes for discussion)

 
                                    Moderator:  Dan Littman (New York University)
 
                                            Case Study 1:     Dan Littman (New York University)
                                                                      Microbiota, innate immunity, and inflammation

                                            Case Study 2:     Wendy Garrett (Harvard School of Public Health)
                                                                      Microbiota and Tregs

                                            Case Study 3:     Gunnar C. Hansson (University of Gothenburg)
                                                                      The impervious nature of the inner mucus layer is influenced by the                                                                                  luminal bacteria and the host immune system

                                           Case Study 4:     Thad Stappenbeck (Washington University St. Louis)
                                                                      Tools and technologies for studying microbe-epithelial-immune                                                                                       interactions

                                           Discussion

12:00 – 12:15 pm           Panel Discussion

 

12:15 - 1:30 pm             Lunch

 

1:30 – 2:30 pm              How are nutrient metabolism, transport, and energy balance modulated by the gut microbiota? (15 minutes per case study + 20 minutes for discussion)

Moderator:        Marguerite Hatch (University of Florida)

                                          Case Study 1:    Sandrine Claus (University of Pennsylvania)
                                                                   Understanding host-microbiata interplay: How can nutrimetabonomics help?

                                          Case Study 2:    Marguerite Hatch (University of Florida)
                                                                    Oxalate transport and metabolism

                                          Case Study 3:    John Rawls (Duke University)
                                                                    Microbial regulation of host lipid metabolism

                                          Case Study 4:    Aldons J. Lusis (UCLA)
                                                                    Microbiota-dependent metabolism of dietary components  and CVD risk

2:30 – 2:45 pm              Discussion

2:45 – 4:00 pm              Poster Session

4:00 – 5:15 pm              How are microbe-dependent factors and host-microbe interactions in the gut communicated to affect host physiology and disease pathophysiology at distant organ sites? (15 minutes per case study + 20 minutes for discussion)

  

Moderator:  Ron Kahn (Joslin Diabetes Center)

                                            Case Study 1:     Ron Kahn (Joslin Diabetes Center)
                                                                       Microbiota, insulin signaling, obesity and diabetes

                                            Case Study 2:     Frank Gonzalez (National Cancer Institute, NIH)
                                                                       Microbiota, nuclear receptors, and metabolism

                                            Case Study 3:     Jennifer Pluznick (Johns Hopkins University)
                                                                       Renal receptors for microbe-derived SCFAs and regulation of blood                                                                                pressure

                                            Case Study 4:     Patrick Tso (University of Cincinnati)
                                                                       Role of lymphatics in the transport of microbial-derived products
 
                                            Case Study 5:     Gilles Mithieux (INSERM)
                                                                       Microbiata-brain communication via short-chain fatty acids and intestinal
                                                                       gluconeogenesis.

5:15 – 5:30 pm               Discussion

5:30 pm                         Wrap-up and Adjourn Day 1

Day 2, September 10, 2014​

8:45 – 9:00 am                   Recap Day 1 and Introduction to Day 2

Session 3:  Novel Frameworks for Understanding and Modulating Host-Microbiota Dynamics

Concept Talks – What concepts regarding host-microbiota interactions should the community consider as we think about research to understand how host physiology and disease pathophysiology are affected by the gut microbiota?  Do these concepts offer a framework for interrogating host-microbial interactions in complex systems?  How can they be applied to research questions for understanding how to manipulate host-microbiota interactions to modulate host physiology or disease pathophysiology?

Moderator:  Michael Fischbach (University of California San Francisco)

9:00 – 9:25 am                  Eugene Chang (University of Chicago)
    Our microbial organ and its role in regulating host metabolism

9:25 – 9:50 am                  Frederic Bushman (University of Pennsylvania)
                                        Exploring the human virome and the role of virus-bacteria-host interactions in physiology and                                           disease pathophysiology​
9:50 – 10:15 am                Charles F. Burant (University of Michigan)
                                        Metabolomic technologies to discover mediators of host-microbiota interaction

10:15 – 10:45 am               Break
 

10:45 – 11:15 am               Michael Fischbach (University of California San Francisco)
                                        Small molecules from the human microbiota

11:15 – 11:40 am              Christopher Voigt (Massachusetts Institute of Technology)
   Synthetic biology and bacterial engineering to interrogate host-microbiota interactions

11:40 am – 12:05 pm        Alex Khoruts (University of Minnesota)
                                       From stool transplants to next-generation microbiota therapeutics
 

Session 4:  Future Directions and Opportunities for Research to Understand How Host Physiology and Disease Pathophysiology Are Affected by the Gut Microbiota

12:30 – 1:30 pm               Panel Discussion – Eugene Chang, Michael Fischbach, Marguerite Hatch, Dan Littman

1:30 pm ​                          Closing Remarks and Adjourn

Directions/Travel

Meeting L​ocation:

Natcher Conference Center​​
Building 45, Conference Room E1E2
National Institutes of Health
Bethesda, MD

NIH Visitor Informati​on:

The Natcher Conference Center is located on the NIH Campus in building 45.  For a map, general information, and directions to and around the NIH Campus, visit: http://parking.nih.gov/visitor_access_map.htm.

NIH Se​curity:

The NIH, like all federal government facilities, has instituted security measures to ensure the safety of NIH employees, patients, and visitors.  The national threat advisory level, determined by the Department of Homeland Security (http://www.whitehouse.gov/homelandExternal Link Disclaimer), currently is yellow (elevated).

Perimeter Secu​rity:

All visitor vehicles, including taxicabs, hotel and airport shuttles, delivery trucks, and vans will be inspected before being allowed on campus.  Visitors will be asked to show one (1) form of identification (a government-issued photo ID:  driver’s license, passport, green card, etc.) and to state the purpose of their visit.  Be sure to allow at least 15-20 minutes for this vehicle inspection procedure.

Building Se​curity:

Due to the checking of IDs at the perimeter, employees and visitors will not be required to show their ID again to gain access to the majority of buildings on the NIH Campus during the normal business day.

Employees and visitors should continue to wear their identification prominently at all times while on campus.

Guards will remain at certain buildings to address specific program requirements, such as sensitive research and safety concerns.  At building entrances where guards are posted:

 

  • Employees must show a DHHS-issued photo ID (for example, your NIH-issued ID badge).
  • Visitors may be required to log-in, wear a visitor’s pass, and be escorted by an employee through the building.
  • Visitors may be required to pass through a metal detector and have bags, backpacks, or purses inspected or x-rayed as they enter buildings.
  • Security staff will confiscate any suspicious or potentially dangerous materials.  U.S. code prohibits bringing any dangerous weapons onto federal property, including anything with a blade longer than 2½ inches.  Meeting participants may want to leave extra bags or personal materials at their hotel to minimize the time needed for inspection. 

 

Weekday Pede​strian Campus Access:

All visitors must enter through the NIH Gateway Center at Metro or the West Gateway Center (see the Visitor Map at http://parking.nih.gov/visitor_access_map.htm).

 

  • Gateway Center
    Wisconsin Avenue at Gateway Drive (near the Metro)
    Open 24 hours, 7 days per week

  • West Gateway Center
    Near Old Georgetown Road and South Drive
    Open 6 a.m. – 12 p.m., Monday-Friday

 

Driving Direct​ions ​to NIH

From Points North and East:

Take I-95 South to I-495 West (Capital Beltway) toward Silver Spring.  Follow I-495 West for 9 miles to Exit 34 (Bethesda/Wisconsin Avenue).  Follow signs for Route 355 South and stay in the right lane.  Travel approximately 1 mile and turn right at the light onto South Drive.  Pass through NIH security and follow the signs to Building 38A.

From Points Nor​th and West:

Take I-270 South to I-495 East (Capital Beltway) toward Washington, DC.  Stay in one of the three left lanes.  Follow signs for Route 355 South, a left-lane exit, onto Wisconsin Avenue.  Travel approximately 1 mile and turn right at the light onto South Drive.  Pass through NIH security and follow the signs to Building 38A.

From Points ​South:

Take I-95 North to I-495 (Capital Beltway) toward Tyson’s Corner/Rockville.  Follow I-495 for 20 miles.  Take Exit 34 (Bethesda/Wisconsin Avenue).  Travel approximately 1 mile and turn right at the light onto South Drive.  Pass through NIH security and follow the signs to Building 38A.

From Baltimore/Was​hington International Thurgood Marshall Airport (BWI):

Take the Route 195 connector to I-95 South.  Take I-95 South to I-495 West (Capital Beltway) toward Silver Spring.  Follow I-495 West for 9 miles to Exit 34 (Bethesda/Wisconsin Avenue).  Follow signs for Route 355 South and stay in the right lane.  Travel approximately 1 mile and turn right at the light onto South Drive.  Pass through NIH security and follow the signs to Building 38A.

From Washington Dulles ​International Airport (IAD):

Take the Dulles Access Road for approximately 13 miles to Exit 18.  Move to the right on the Dulles Toll Road (Route 267) and take Exit 18.  Stay left on the ramp for Bethesda/Baltimore, and proceed toward Bethesda (I-495).  Continue approximately 9 miles on I-495.  Stay on I-495 at the I-495/I-270 split (bear right).  Take Exit 34 (Wisconsin Avenue South/Route 355) toward Bethesda.  Travel approximately 1 mile and turn right at the light onto South Drive.  Pass through NIH security and follow the signs to Building 38A.

From Ronald Reagan Washin​gton National Airport (DCA):

Take the George Washington Parkway North for 12 miles to I-495 toward Maryland (Capital Beltway).  Take Exit 34 (Bethesda/Wisconsin Avenue).  Travel approximately 1 mile and turn right at the light onto South Drive.  Pass through NIH security and follow the signs to Building 38A.

Parking​:

Parking on the NIH campus is limited and is $12 per day in the visitor lots.

Local Are​a Hotels:

Doubletree Hotel Bethesda (4 blocks from NIH entrance/Medical Center Metro)
8120 Wisconsin Ave., Bethesda, MD
301.652.2000

Hyatt Regency Bethesda (directly above the Metro)
One Bethesda Metro Center, Bethesda, MD (7400 Wisconsin Ave)
Wisconsin Ave @ Old Georgetown Rd., Bethesda, MD
301.657.1234

Bethesda Marriott
5151 Pooks Hill Road, Bethesda, MD
301-897-9400
*complimentary shuttle to the NIH Clinical Center

​​

Minutes

The Planning Group will develop a workshop summary to highlight the research needs and opportunities identified by workshop participants.

 

Attendees

Attendee information is unavailable at this time.

 

 

Abstracts

If you would like to have an abstract of your work considered for a poster presentation, please submit your abstract when you register for the workshop.  All participants are encouraged to submit an abstract.  Particular emphasis will be given to “hot topics” and emerging advances, topics that complement the themes covered in the plenary sessions, and abstracts from junior investigators and trainees.  Abstracts will be reviewed by the planning committee and considered for poster presentations as space permits.

A limited number of travel awards will be made to support the presentation of posters by junior investigators and trainees. Abstracts for poster presentations must be submitted by August 22, 2014.

Please follow the instructions on the abstract submission page after you register for the meeting. For more information, please visit http://www.diacomp.org/shared/microbiota.aspx.

Poster Presentations​

Posters do not need to be elaborate. Poster boards (4 feet high by 6 feet wide), pushpins, and Velcro will be provided onsite. Sponsorship of any type should be indicated on posters.

Location

Line
  • Room E1E2, National Institutes of Health
  • MD
Webinar

Contacts

LineProgram Contact:
Michael J. Grey, PhD
Division of Digestive Diseases and Nutrition
NIDDK
Phone: 301-640-0121

Logistics Contact:
Lauren Meskill
Division of Digestive Diseases and Nutrition
NIDDK
Phone: 301-402-7503