U.S. Department of Health and Human Services

NIDDK Workshop: Imaging the Pancreatic Beta Cell

4/15/2013 7:00 AM
4/16/2013 7:00 AM
Yes
No
For questions concerning program content, contact:
Maren R. Laughlin, Ph.D.
Senior Advisor for Integrative Metabolism
National Institute for Diabetes and Digestive and Kidney Diseases
Telephone: (301) 594-8802
Email:   maren.laughlin@nih.gov  

For questions concerning logistical information or registration, contact:  
Michelle Watson
The Scientific Consulting Group, Inc.
Telephone: (301) 670-4990
Email:    mwatson@scgcorp.com  
Bethesda
 

Event Details

Meeting Objective:

This workshop is part of an ongoing program focused on in vivo imaging of islet mass, function, and disease pathogenesis that has been sponsored by the National Institutes of Health (NIH), Juvenile Diabetes Research Foundation (JDRF), and the European Union for more than a decade. The workshop will emphasize very cutting-edge beta cell biology that could inform the effort to visualize the beta cell, with an effort to highlight new data, reagents and ideas, new technologies that would be useful, lessons and reagents from neuroscience, and important imaging advances and recent work in islet/beta cell imaging.

Potential Topics:

  • What is a beta cell? Transdifferentiation, plasticity, and regeneration; new approaches to locating specific targets and targeting reagents
  • The neuroscience of the islet: neurotransmitter receptors and pathways in the islet, catecholamines, neuroimaging reporters, and beta cell imaging
  • Targeted functional biomarkers and targeted drug therapy
  • Imaging cellular therapies to treat diabetes
  • Imaging islet inflammation and beta cell stress: What causes diabetes? What keeps us from curing it?
  • Imaging beta cell function and mass

Chairs:

  • Alejandro Caicedo (University of Miami)
  • Markus Grompe (Oregon Health and Science University)
  • Olle Korsgren (Uppsala University)
  • Dean Sherry (University of Texas, Dallas and The University of Texas Southwestern Medical Center)

Organization Committee:

  • Olivier Blondel (NIDDK, NIH)
  • Maren Laughlin (NIDDK, NIH)
  • Antonio Sastre (NIBIB, NIH)
  • Adrianne Wong (JDRF)

Program Committee:

  • Gary Cline (Yale University)
  • Martin Gotthardt (Radboud University Nijmegen Medical Centre, the Netherlands)
  • Paul Harris (Columbia University Medical College)
  • Anna Moore (Massachusetts General Hospital)

Sponsors

  • National Institute of Diabetes and Digestive and Kidney Diseases
  • National Institute of Biomedical Imaging and Bioengineering
  • Juvenile Diabetes Research Foundation

Agenda

Please plan to arrive 20 minutes before the first session to get through security and walk over to the Natcher Conference Center.

Monday, April 15, 2013

8:00 a.m. Welcome
Griffin Rodgers, M.D., M.A.C.P., Director, National Institute of Diabetes and Digestive and Kidney Diseases
8:10 a.m. Keynote Address: Beta Cell Dedifferentiation and Plasticity in Diabetes
Domenico Accili

Session I: Inter-islet Communication: Nerves, Neurotransmitters, Vasculature, and Cell-cell Interactions

8:40 a.m. Keynote: Role of Nerves in the Islet
Alejandro Caicedo
9:10 a.m. Discussion (with leader)
9:20 a.m. Invited Talk: Autocrine and Paracrine Regulation of Islet Cell Function
Patrik Rorsman
9:50 a.m. Discussion (with leader)
10:00 a.m. Break
10:20 a.m. Invited Talk: Cell-cell and Vascular-cell Interactions in the Islet
Eckhard Lammert
10:50 a.m. Discussion (with leader)
11:00 a.m. Submitted Talk: CT Perfusion Monitoring of the Pancreas in Streptozotocin-induced Diabetic Rats
Joo Ho Tai
11:15 a.m. Submitted Talk: Gadolinium-enhanced MRI of the Pancreatic Extracellular Volume to Detect Immune Infiltration Preceding Development of Type 1 Diabetes Mellitus in Mice
Patrick F. Antkowiak
11:30 a.m. Submitted Talk: Quantification of Pancreatic VMAT2 Binding Using (18F)FP-(+)-DTBZ in Human PET Studies: Optimization of Methods
Mika Naganawa
11:45 a.m. Submitted Talk: Functional Role of Dopamine Type 2 Receptors (D2R) and Vesicular Monoamine Transporter Type 2 (VMAT2) in Glucose Stimulated Insulin Secretion (GSIS) by Human Islets
Paul Harris
12:05 p.m. European Efforts, European Association for the Study of Diabetes Metabolic Imaging Study Group
Martin Gotthardt
12:15 p.m. Lunch (on your own) and Poster Session
There will be two informal, open discussions starting at 2:15 p.m., which will be held among the posters.
  1. DTBZ Ligands and the VMAT2 Target
  2. GLP-1 Receptor Targeting

Session II: Imaging Islet Function and Mass

3:00 p.m. Chair's Introduction: Zn imaging of Insulin Secretion
Dean Sherry
3:20 p.m. Keynote: Challenges and Opportunities in Beta Cell Imaging
Al Powers
3:50 p.m. Discussion (with leader)
4:00 p.m. Invited Talk
Guy Rutter
4:20 p.m. Discussion (with leader)
4:30 p.m. Break
4:50 p.m. Invited Talk: Manganese-enhanced Magnetic Resonance Imaging (MEMRI) of Pancreatic Islets, and Multivalent Targeting of Beta Cells
Paolo Meda
5:20 p.m. Discussion (with leader)
5:30 p.m. Submitted Talk: Quantitative Pathophysiological Analyses of the Whole Human Pancreas
Manami Hara
5:45 p.m. Submitted Talk: Introducing a Novel FRET Biosensor for Glycolytic Activity: Islet Beta Cell Glycolytic and Mitochondial Function Measured Simultaneously and in Real Time
Matthew J. Merrins
6:00 p.m. Submitted Talk: Application of a Novel GLP-1 Analogue for GLP-1R Targeted Imaging in Ossabaw Mini Pigs: Initial Result
William Silvers
6:15 p.m. Submitted Talk: A Heterobivalent Ligand Comprised of GLP-1 and Yohimbine Specifically Targets Pancreatic β-Cells In Vivo
Sean W. Limesand
6:30 p.m. Adjournment

Tuesday, April 16, 2013

8:00 a.m. Industry Perspective: Imaging Biomarker Needs for Preclinical Development and Clinical Trials in Diabetes
Melissa Thomas, Lily Pharmaceuticals

Session III: Beta Cell Markers and Search for Targeting Agents

8:20 a.m. Chair's Introduction
Markus Grompe
8:30 a.m. Keynote: Clinical and Practical Applications of Beta-cell Imaging
David Harlan
9:00 a.m. Discussion (with leader)
9:10 a.m. Invited Talk: Toward Islet Cell Specific Reagents
Phil Streeter
9:40 a.m. Discussion (with leader)
9:50 a.m. Break
10:10 a.m. Invited Talk: Radiopharmaceutical Development
Mark Mintun, Avid Radiopharmaceuticals
10:30 a.m. Discussion (with leader)
10:40 a.m. Submitted Talk: Exendin-4 Loaded Magnetic Iron Nanoparticles for Pancreatic Islet Imaging
Ping Wang
10:55 a.m. Submitted Talk: Non-invasive Determination of the Beta Cell Mass by SPECT With 111In-DTPA-exendin-3 in a Rat Model for Spontaneous Type 1 Diabetes
Maarten Brom
11:10 a.m. Submitted Talk: Preparation of Beta-cell Targeted Magnetic Nanoparticle With Sphingomyelin Specificity
Amol Kavishwar
11:25 a.m. Submitted Talk: Imaging With Aptamers
Giacomo Lanzoni
1:40 a.m. EC Perspective
Nathalie Vercruysse
11:50 a.m. Lunch and Poster Session

Session IV: Transplantation and Immunology, Including Cell Therapies

1:30 p.m. Chair's Introduction
Olle Korsgren
1:40 p.m. Keynote: Imaging Beta Cell Mass
Olof Eriksson
2:10 p.m. Discussion (with leader)
2:20 p.m. Invited Talk: Imaging the T1D Pancreas: Anatomy, Beta Cell Mass, and Inflammation
Jason Gaglia
2:50 p.m. Discussion (with leader)
3:00 p.m. Break
3:20 p.m. Invited Talk: Insulitis and Islet Volume in the Non-obese Diabetic (NOD) Mouse
Dan Holmberg
3:50 p.m. Discussion (with leader)
4:00 p.m. Submitted Talk: High-resolution In Vivo Imaging of Transplanted Pancreatic Islets Reveals Complex Behavior of Innate Immune Cells in Engraftment
Gustaf Christoffersson
4:15 p.m. Submitted Talk: Dynamic Contrast Enhanced-MRI (DCE-MRI) Functional Assessment of Vascular Events Occurring During the Intra-hepatic Engraftment of Pancreatic Islets May Predict Long-term Outcome of Islets Transplantation
Anna Palmisano
4:30 p.m. Submitted Talk: Effect of Mesenchymal Stem Cells on the Vascularization of the Artificial Cavity Used as a Site for Islet Transplantation
Daniel Jirak
4:45 p.m. Summation and Discussion
Chairs
5:00 p.m. Adjournment
​​

Directions/Travel

HOTEL LODGING

Hyatt Regency Bethesda Hotel
One Bethesda Metro Center
7400 Wisconsin Avenue
Bethesda, MD 20814
Telephone: (301) 657-1234

Hotel Accommodations

A block of sleeping rooms has been reserved at the Hyatt Regency Bethesda, Bethesda, MD, for arrival on Sunday, April 14, 2013, and departing on Tuesday, April 16, 2013. The room rate is $224 plus tax per night.
 
Please contact the Hyatt Regency Bethesda by Thursday, March 14, 2013, at (402) 592-6464 or 1 (888) 421-1442 , and reference the NIDDK's Workshop: Imaging the Pancreatic Beta Cell when making your sleeping room reservations. For online registrations, please use the meeting code NITP at the following link: https://resweb.passkey.com/go/NITP . Please be certain that the hotel provides you with a confirmation number and retain this number for future reference. After March 14, 2013, the hotel will accept reservations on a space-available basis at the prevailing hotel rate.
 
When making a reservation, please provide your room and bedding preferences. The hotel will assign specific room types at check-in, based on availability. Please be advised that requests are not guaranteed. Check-in time is at 3:00 p.m., and check-out time is 12:00 noon. If for any reason you need to cancel your hotel reservation, please do so 48 hours in advance of your check-in date.

Additional Information

The Scientific Consulting Group, Inc. (SCG) is providing the logistical support for this meeting. The above information should help you with your planning. If you have any questions, please contact Michelle Watson of SCG by telephone at 301-670-4990 or by email at mwatson@scgcorp.com.

Directions

From Points North
From I-95: Take I-95 South to I-495 (Capital Beltway) West toward Silver Spring. Take Exit 34 (Wisconsin Avenue/Route 355). Follow Route 355 South for approximately 3 miles and the Hyatt Regency Bethesda will be on the right, on the corner of Wisconsin Avenue and Old Georgetown Road.
 
From I-270: Take I-270 South to I-495 (Capital Beltway) East toward Washington, DC. Stay in one of the three left lanes. Follow signs for 355 South, a left-lane exit, onto Wisconsin Avenue. Follow Route 355 South for approximately 3 miles and the Hyatt Regency Bethesda will be on the right, on the corner of Wisconsin Avenue and Old Georgetown Road.
 
From Points South
Take I-95 North to I-495 (Capital Beltway) toward Tysons Corner/Rockville. Follow I-495 for 20 miles. At the I-495/I-270 split, stay to the right on I-495. Take Exit 34 (Wisconsin Avenue/Route 355). Follow Route 355 South for approximately 3 miles and the Hyatt Regency Bethesda will be on the right, on the corner of Wisconsin Avenue and Old Georgetown Road.
 
From Baltimore/Washington International Thurgood Marshall Airport (BWI)
Take Route 195 West to Exit 4 (I-95 South). From I-95 take I-495 (Capital Beltway) West toward Silver Spring. Take Exit 34 (Wisconsin Avenue/Route 355). Follow Route 355 South for approximately 3 miles and the Hyatt Regency Bethesda will be on the right, on the corner of Wisconsin Avenue and Old Georgetown Road.
 
From Washington Dulles International Airport
Take the Dulles Access Road for approximately 13 miles to Exit 18. Move to the right on the Dulles Toll Road (Route 267); get off at Exit 18. Stay to the left on the ramp for Bethesda/Baltimore and proceed toward Bethesda on I-495 (Capital Beltway) for approximately 9 miles. At the I-495/I-270 split, stay to the right on I-495. Take Exit 34 (Wisconsin Avenue/Route 355 South). Follow Route 355 South for approximately 3 miles and the Hyatt Regency Bethesda will be on the right, on the corner of Wisconsin Avenue and Old Georgetown Road.
 
From Ronald Reagan National Airport
Take the George Washington Parkway North to I-495 (Capital Beltway) and follow the signs to Maryland. At the I-495/I-270 split, stay to the right on I-495. Take Exit 34 (Wisconsin Avenue/Route 355). Follow Route 355 South for approximately 3 miles and the Hyatt Regency Bethesda will be on the right, on the corner of Wisconsin Avenue and Old Georgetown Road.

METRO INFORMATION

The Metro System is clean, reliable, and safe. It operates from 5:30 a.m. to 12:00 midnight Monday through Thursday; 5:00 a.m. to 2:00 a.m. on Fridays; 8:00 a.m. to 2:00 a.m. on Saturdays; and 8:00 a.m. to 12:00 midnight on Sundays. Each passenger must buy a farecard to travel in the system. Guides for purchasing farecards are posted on the vending machines in each station. Each Metro car features a complete color-coded map. Station attendants on duty at each station can provide additional information on request.
 
From Union Station or downtown Washington (main Metro Lines into the city converge at Metro Center Station and Gallery Place Station), take the Metro Red Line toward Shady Grove or Grosvenor. Exit at the Bethesda Metro Station. The Hyatt is directly above the Bethesda Metro Station.

SHUTTLES

SuperShuttle offers service to most hotels from Ronald Reagan National Airport, Washington Dulles International Airport, and Baltimore/Washington International Thurgood Marshall Airport. The shuttle leaves on an as-needed basis between the hours of 5:30 a.m. and 11:00 p.m. During other times, arrange for a shuttle by calling 800-258-3826 from the airport.

TAXIS

The taxi fare is approximately $45-$55 from Ronald Reagan Washington National Airport, approximately $55-$65 from Washington Dulles International Airport, and approximately $65-$75 from Baltimore/Washington International Thurgood Marshall Airport. Fares may differ during peak travel hours.

MARC TRAINS

From BWI Airport, take the MARC train on the Penn Line to Union Station. Take the Metro Red Line toward Grosvenor or Shady Grove and exit at the Bethesda Metro Station. The hotel is directly above the Bethesda Metro Station.

PARKING INFORMATION

Self-parking at the hotel is $15 per day/overnight. Valet parking is $20 per day/overnight.

MEETING LOCATION

Natcher Conference Center
National Institute of Health, Building 45
Bethesda, MD 20892
 
The meeting will be held at the Natcher Conference Center (Building 45) on the National Institutes of Health (NIH) Campus in Bethesda, Maryland. For a map, general information, and directions to and around the NIH Campus, visit: http://parking.nih.gov/visitor_access_map.htm .

NIH Security

The NIH, like all federal government facilities, has instituted security measures to ensure the safety of NIH employees, patients, and visitors. The national threat advisory level, determined by the Department of Homeland Security ( http://www.whitehouse.gov/homeland/ ), currently is yellow (elevated).

Perimeter Security

All visitor vehicles, including taxicabs, hotel and airport shuttles, delivery trucks, and vans will be inspected before being allowed on campus. Visitors will be asked to show one (1) form of identification (a government-issued photo ID: driver's license, passport, green card, etc.) and to state the purpose of their visit. Be sure to allow at least 15-20 minutes for this vehicle inspection procedure.

Building Security

Due to the checking of IDs at the perimeter, employees and visitors will not be required to show their ID again to gain access to the majority of buildings on the NIH Campus during the normal business day.
 
Employees and visitors should continue to wear their identification prominently at all times while on campus.
 
Guards will remain at certain buildings to address specific program requirements, such as sensitive research and safety concerns. At building entrances where guards are posted:
  • Employees must show a DHHS-issued photo ID (for example, your NIH-issued ID badge).
  • Visitors may be required to log-in, wear a visitor's pass, and be escorted by an employee through the building.
  • Visitors may be required to pass through a metal detector and have bags, backpacks, or purses inspected or x-rayed as they enter buildings.
  • Security staff will confiscate any suspicious or potentially dangerous materials. U.S. code prohibits bringing any dangerous weapons onto federal property, including anything with a blade longer than 2½ inches. Meeting participants may want to leave extra bags or personal materials at their hotel to minimize the time needed for inspection.

Weekday Campus Access

Visitors, including meeting attendees, patients, contractors, vendors, and delivery persons: All visitors must use the following entrances (see the Visitor Map at http://parking.nih.gov/visitor_access_map.htm ):
  • Rockville Pike at South Drive (Metro): Regular weekday schedule: Open 24 hours for inbound and outbound traffic.
  • Old Georgetown Road at Center Drive: This entrance is primarily for commercial vehicles and visitors.
Regular weekday schedule:
5:00 a.m. to 2:00 p.m. - Inbound traffic only
2:00 p.m. to 7:00 p.m. - Inbound and outbound traffic
7:00 p.m. to 5:00 a.m. - Closed to all traffic

Taking the Metrorail to the NIH Campus

The Metro System is clean and reliable. It operates from 5:00 a.m. to 12:00 midnight, Monday through Thursday; 5:00 a.m. to 3:00 a.m. on Fridays; 7:00 a.m. to 3:00 a.m. on Saturdays; and 7:00 a.m. to 12:00 midnight on Sundays. Each passenger must buy a farecard to travel in the system. Guides for purchasing farecards are posted on the vending machines in each station. Each Metro car features a complete color-coded map. Station attendants on duty at each station can provide additional information on request. Metro Web Site: http://www.wmata.com
 
The Natcher Conference Center is a 5-minute walk from the Medical Center station on the Red Line. The Natcher Building is located on Center Drive directly behind the Medical Center Stop. The station's escalators come out on the NIH campus; upon exiting the escalator, proceed right, following the detour signs to Center Drive.

Driving Directions to NIH

From Points North and East:
Take I-95 South to I-495 West (Capital Beltway) toward Silver Spring. Follow I-495 West for 9 miles to Exit 34 (Bethesda/Wisconsin Avenue). Follow signs for Route 355 South and stay in the right lane. Travel approximately 1 mile and turn right at the light onto South Drive. Pass through NIH security and follow the signs to Building 45.
 
From Points North and West:
Take I-270 South to I-495 East (Capital Beltway) toward Washington, DC. Stay in one of the three left lanes. Follow signs for Route 355 South, a left-lane exit, onto Wisconsin Avenue. Travel approximately 1 mile and turn right at the light onto South Drive. Pass through NIH security and follow the signs to Building 45.
 
From Points South:
Take I-95 North to I-495 (Capital Beltway) toward Tyson's Corner/Rockville. Follow I-495 for 20 miles. Take Exit 34 (Bethesda/Wisconsin Avenue). Travel approximately 1 mile and turn right at the light onto South Drive. Pass through NIH security and follow the signs to Building 45.
 
From Baltimore/Washington International Thurgood Marshall Airport (BWI):
Take the Route 195 connector to I-95 South. Take I-95 South to I-495 West (Capital Beltway) toward Silver Spring. Follow I-495 West for 9 miles to Exit 34 (Bethesda/Wisconsin Avenue). Follow signs for Route 355 South and stay in the right lane. Travel approximately 1 mile and turn right at the light onto South Drive. Pass through NIH security and follow the signs to Building 45.
 
From Washington Dulles International Airport (IAD):
Take the Dulles Access Road for approximately 13 miles to Exit 18. Move to the right on the Dulles Toll Road (Route 267) and take Exit 18. Stay left on the ramp for Bethesda/Baltimore, and proceed toward Bethesda (I-495). Continue approximately 9 miles on I-495. Stay on I-495 at the I-495/I-270 split (bear right). Take Exit 34 (Wisconsin Avenue South/Route 355) toward Bethesda. Travel approximately 1 mile and turn right at the light onto South Drive. Pass through NIH security and follow the signs to Building 45.
 
From Ronald Reagan Washington National Airport (DCA):
Take the George Washington Parkway North for 12 miles to I-495 toward Maryland (Capital Beltway). Take Exit 34 (Bethesda/Wisconsin Avenue). Travel approximately 1 mile and turn right at the light onto South Drive. Pass through NIH security and follow the signs to Building 45.

Parking

Parking on the NIH campus is limited and is $12 per day in the visitor lots.

Minutes

​Minutes are currently unavailable.

Attendees

​Attendees are currently unavailable.

Abstracts

Please note: The deadline for submission of abstracts is   February 11, 2013 .  

Investigators who attend the   Imaging the Pancreatic Beta Cell   are encouraged to submit abstracts of their research activities. Graduate students and post-doctoral fellows are eligible to apply for a Travel Awards of up to $1000 along with the abstract submission.  10-12 Travel Awardees will be chosen by the program committee based on the quality of their submitted work.

Please follow the instructions below to submit an abstract for consideration:  
  1. The deadline for submission is   February 11, 2013 .
  2. Please send the abstract via email to Ms. Michelle Watson at mwatson@scgcorp.com with "Pancreatic Beta Cell" in the subject line. Attach the abstract as a MS Word document, and make any relevant comments in the text of the email.
  3. The abstract title should be typed in bold font, Title Case Letters.
  4. List the names, degrees and institutional affiliations of all authors, and italicize the name of the presenting author.
  5. The body of the abstract should completely and concisely describe the submitted work and should not exceed two pages, including figures. It should be divided into sections: Introduction and Objectives, Methods, Results, Conclusions.
  6. If you are a graduate student or post-doctoral fellow and would like to apply for a Travel Award, please include in your email a short CV and cover letter detailing your contribution to the submitted work and a dollar amount request of up to $1000 (should not exceed your estimated expense for the meeting). Travel awardees will be chosen by the program committee and will be notified in March.
Poster Presentations
Posters do not need to be elaborate. Poster boards, (4 feet high by 6 feet wide), pushpins and Velcro will be provided on site. Sponsorship of any type should be indicated on poster.

Location

Line
  • Natcher Conference Center, Building 45
  • National Institutes of Health
  • MD 20892
Webinar

Contacts

Line
For questions concerning program content, contact:
Maren R. Laughlin, Ph.D.
Senior Advisor for Integrative Metabolism
National Institute for Diabetes and Digestive and Kidney Diseases
Telephone: (301) 594-8802
Email:   maren.laughlin@nih.gov  

For questions concerning logistical information or registration, contact:  
Michelle Watson
The Scientific Consulting Group, Inc.
Telephone: (301) 670-4990
Email:    mwatson@scgcorp.com