U.S. Department of Health and Human Services

Quantitative Morphology in Kidney Research

2/13/2012 7:00 AM
2/14/2012 7:00 AM
Yes
No

NIDDK Workshop Contact:
Jeffrey Kopp, M.D.
National Institute of Diabetes and Digestive and Kidney Diseases
jeffreyk@intra.niddk.nih.gov

Workshop Logistics Coordinator:
John Hare, M.S., CMP
The Scientific Consulting Group, Inc. (SCG)
jhare@scgcorp.com
North Bethesda
 

Event Details

Goals

  1. Review the principles of stereological analysis, including design-based and model-based methods, and their application to kidney research using animal and human tissue, with a focus on accurate determination of glomerular number and podocyte number.
  2. Review the range of valid histomorphometric methods that can be used to generate estimates of these parameters, with varying degrees of precision and accuracy.
  3. Discuss what preclinical and clinical studies will be required prior to any kidney morphology parameter being accepted as a surrogate marker to facilitate drug development.
  4. Review novel approaches using in vivo imaging techniques to assess kidney tissue structure.
  5. Consider additional quantitative kidney tissue measurements (e.g., capillary density).

Steering Committee

John Bertram, Monash University, Australia
Agnes Fogo, Vanderbilt University
Kevin Lemley, University of Southern California Co-Chair
Michael Mauer, University of Minnesota
Roger Wiggins, University of Michigan 

NIH

Jeffrey Kopp, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Co-Chair
Paul Kimmel, NIDDK
Marva Moxey-Mims, NIDDKK
Robert Nelson, NIDDK
Steve Hewitt, National Cancer Institute

Agenda

Monday, February 13, 2012

3:00 - 3:30 p.m. Registration and Light Refreshments
3:30 - 3:35 p.m. Introduction and Goals
Robert Star, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Jeffrey Kopp, NIDDK
3:35 - 4:20 p.m. Overview: Principles of Stereology and Applications to Research Settings
John Bertram, Monash University, Australia
4:20 - 4:40 p.m. Discussion
4:40 - 5:10 p.m. Glomerular Numbers: Population Differences and Clinical Outcomes
Wendy Hoy, The University of Queensland, Australia
5:10 - 5:30 p.m. Discussion
5:30 - 6:30 p.m. Panel Discussion: Challenges and Unresolved Issues in Determining Glomerular Number in Autopsy and Biopsy Studies
John Bertram (Chair), Monash University, Australia
Bryan Myers, Stanford University
Julie Ingelfinger, Harvard University
Michael Mauer, University of Minnesota
Kathryn White, Newcastle University, United Kingdom
6:30 p.m. Adjourn for the Day

Tuesday, February 14, 2012

7:30 - 8:00 a.m.

Continental Breakfast

8:00 - 8:45 a.m. Podocyte Number: Methods to Estimate Podocyte Number
Kevin Lemley, University of Southern California
8:45 - 9:00 a.m. Discussion
9:00 - 9:30 a.m. Genetic Variation in Podocyte Number: Lessons From Mice
Erwin Bottinger, Mount Sinai Hospital School of Medicine
9:30 - 9:45 a.m. Discussion
9:45 - 10:15 a.m. Correlations Between Podocyte Number, Podocyte Volume, and Podocyte Loss
Roger Wiggins, University of Michigan
10:15 - 10:30 a.m. Discussion
10:30 - 10:45 a.m. Break
10:45 - 11:30 a.m. Panel Discussion: Is it Possible to Accurately Measure Podocyte Number in Clinical Biopsy Material?
Kevin Lemley (Chair), University of Southern California
Behzad Najafian, University of Washington
John Basgen, Charles R. Drew University of Medicine and Science
Jennifer Weil, NIDDK
Susanne Nicholas, University of California, Los Angeles
11:30 a.m. - 12:15 p.m. Quantitative Morphology to Generate Surrogate Outcomes: Morphologic Changes as Surrogate Outcomes - How Are These Defined and Validated? FDA Perspective.
Aliza Thompson and Lynne Yao, U.S. Food and Drug Administration (FDA)
12:15 - 12:45 p.m. Discussion
12:45 - 1:45 p.m. Lunch
1:45 - 2:15 p.m. Frontiers: Imaging Approaches to Cortical Volume and Glomerular Number
Kevin Bennett, Arizona State University
2:15 - 2:45 p.m. Panel Discussion
Norbert Gretz, University of Heidelberg, Germany
Takamune Takahashi, Vanderbilt University
2:45 - 3:45 p.m. Breakout Sessions
  • Glomerular Area and Volume
    John Bertram, Monash University, Australia
    Wendy Hoy, The University of Queensland, Australia
  • Interstitial Capillaries
    Michael Mauer, University of Minnesota
    Agnes Fogo, Vanderbilt University
  • Interstitial Fibrosis
    Kevin Lemley, University of Southern California
    Cindy Nast, Cedars-Sinai
  • Digital Pathology
    Stephen Hewitt, National Cancer Institute
    Laura Barisoni, New York University Langone Medical Center
3:45 - 4:15 p.m. Break
4:15 - 4:45 p.m. Breakout Reports and Summary
Kevin Lemley, University of Southern California
4:45 p.m. Adjournment
​​​

Directions/Travel

LOCATION

Bethesda North Marriott Hotel & Conference Center
5701 Marinelli Road
North Bethesda, MD 20852
Telephone: (301) 822-9200 or (800) 859-8003
Fax: (301) 822-9201
(More hotel information can be obtained from this Website.)
 

AIR TRAVEL

Travel arrangements are your own responsibility, but you should know that three airports serve the Washington, DC, metropolitan area. Please make your own reservations obtaining the lowest possible coach fare.
 
Should you decide to extend your stay at your own expense, DC area attractions are only a short distance away from the suggested hotel.
 
Hotel and travel information is listed below.

ACCOMMODATIONS

A block of sleeping rooms for meeting participants has been reserved for the NIDDK Quantitative Morphology in Kidney Research Workshop at the Bethesda North Marriott Hotel & Conference Center. The rate is the prevailing government rate of $183 per night for single occupancy, plus tax (currently 13%). Reservations will be for arrival on Monday, February 13, 2012, with a departure of Tuesday,
February 14, 2012. If you require alternate dates, please send an email to John Hare of The Scientific Consulting Group, Inc. at jhare@scgcorp.com . Participants may make reservations by calling the hotel directly (numbers below) or online at https://resweb.passkey.com/Resweb.do?mode=welcome_ei_new&eventID=8285684&utm_source=2644099&utm_medium=email&utm_campaign=10818177 . Make sure you identify yourself as a member of the NIDDK Morphology group to receive the group rate. THE ROOM BLOCK WILL BE IN EFFECT AT THE GOVERNMENT RATE UNTIL FRIDAY, FEBRUARY 3, 2012, ONLY OR UNTIL FULL, WHICH EVER COMES FIRST. ANY ROOM RESERVATIONS RECEIVED AFTER THAT DATE WILL BE ACCEPTED ON A SPACE AND RATE AVAILABILITY BASIS. Check-in time is 4:00 p.m., and check-out time is 12:00 p.m. Any reservation cancellations must be made prior to 4:00 p.m. the day before to the scheduled arrival date, or charges will apply. If you plan to cancel your attendance, please alert the hotel as well as John Hare at jhare@scgcorp.com . The hotel information is as follows:

DRIVING DIRECTIONS

From points North and East
Take I-95 South toward Washington to I-495 West (Exit 27-Capital Beltway) toward Silver Spring. Follow I-495 West for 9 miles to Exit 34 (Bethesda/Wisconsin Avenue) toward Rockville. Continue on Route 355 North (Rockville Pike) for 3 miles. Turn left at the light onto Marinelli Road. The hotel is on the right.
 
From points North and West
Take I-270 South. After Exit 8 (Shady Grove Road), merge right into the local lanes. Take Exit 4A (Montrose Road East) onto Montrose Road. Turn right onto Rockville Pike/MD-355 South. Turn right at the light onto Marinelli Road. The hotel is on the right.
 
From Points South
Take I-95 North to I-495 (Capital Beltway West) toward Tysons Corner/Rockville. Follow I-495 for 20 miles. Take Exit 36 (MD-187) toward Bethesda/Rockville. Bear left to take the ramp toward Rockville. Turn left onto Old Georgetown Road. Turn right onto Executive Boulevard. Turn left at the light onto Marinelli Road. The hotel is on the left.
 
From Baltimore/Washington International Thurgood Marshall Airport (BWI)
Take I-195 to Exit 4B (Route I-95 South). Take I-95 South toward Washington (20 miles) to I-495 West (Exit 27-Capital Beltway) toward Silver Spring. Follow I-495 West for 9 miles to Exit 34 (Bethesda/Wisconsin Avenue) toward Rockville. Continue on Route 355 North (Rockville Pike) for 3 miles. Turn left at the light onto Marinelli Road. The hotel is on the right.
 
From Washington Dulles International Airport (IAD)
Take the Dulles Access Road to Exit 18 (I-495) to Maryland. Take Exit 36 (MD-187) toward Bethesda/Rockville. Bear left to take the ramp toward Rockville. Turn left onto Old Georgetown Road. Turn right onto Executive Boulevard. Turn left at the light onto Marinelli Road. The hotel is on the left.
 
From Ronald Reagan Washington National Airport (DCA)
Take the George Washington Parkway North for 12 miles to the Capital Beltway (I-495) toward Maryland. Take Exit 36 (MD-187) toward Bethesda/Rockville. Bear left to take the ramp toward Rockville. Turn left onto Old Georgetown Road. Turn right onto Executive Boulevard. Turn left at the light onto Marinelli Road. The hotel is on the left.

METRO INFORMATION

The Metro system is a clean and reliable mode of transportation. It operates from 5:00 a.m. to 12:00 midnight on Monday through Thursday; 5:00 a.m. to 3:00 a.m. on Fridays; 7:00 a.m. to 3:00 a.m. on Saturdays; and 7:00 a.m. to 12:00 midnight on Sundays. Each passenger must buy a farecard to travel in the system. Guides for purchasing farecards are posted on the vending machines in each station. Each Metro car features a complete color-coded map of the system. Station attendants on duty at each station can provide additional information on request. A map of the system is available at: http://www.wmata.com/rail/maps/map.cfm .
 
From Union Station or downtown Washington (main Metro Lines into the city converge at Metro Center Station and Gallery Place Station), take the Metro Red Line toward Shady Grove. Exit at the White Flint Station and cross the street to the hotel.

SHUTTLES

SuperShuttle offers service to most hotels from Ronald Reagan Washington National Airport, Washington Dulles International Airport, and Baltimore/Washington International Thurgood Marshall Airport. The shuttle leaves on an as-needed basis between the hours of 5:30 a.m. and 11:00 p.m. During other times, arrangements for a shuttle can be made by calling 1-800-258-3826 from the airport, or visit their Web site at http://supershuttle.com.

TAXIS

The taxi fare is approximately $55 from Ronald Reagan Washington National Airport, approximately $55 from Washington Dulles International Airport, and approximately $75 from Baltimore/Washington International Thurgood Marshall Airport.

PARKING INFORMATION

There is complimentary parking for meeting participants at the conference center. Passes will be available at the meeting registration desk.

Minutes

​Minutes are currently unavailable.

Attendees

​​Attendees are currently unavailable.

Abstracts

​​Abstracts are currently unavailable.

Location

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  • Bethesda North Marriott Hotel & Conference Center
  • 5701 Marinelli Road
  • MD
Webinar

Contacts

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NIDDK Workshop Contact:
Jeffrey Kopp, M.D.
National Institute of Diabetes and Digestive and Kidney Diseases
jeffreyk@intra.niddk.nih.gov

Workshop Logistics Coordinator:
John Hare, M.S., CMP
The Scientific Consulting Group, Inc. (SCG)
jhare@scgcorp.com