U.S. Department of Health and Human Services

Translation Approaches for Pharmacotherapy Development for Acute Diarrhea Workshop

9/25/2011 7:00 AM
9/27/2011 7:00 AM
Yes
No
NIDDK Staff Organizers and Contacts for Program Information:
Jill Carrington
carringj@mail.nih.gov
Michael Grey
greymj@mail.nih.gov
Stephen James

For questions concerning logistical information or registration, contact:
Angela Meadows
ameadows@scgcorp.com
Bethesda
 

Event Details

Meeting Objective:

The NIDDK workshop on Translation Approaches for Pharmacotherapy Development for Acute Diarrhea is being held to identify new translational research opportunitie​s for the development of new pharmacologic agents to treat acute diarrhea in adults and in children. The workshop will bring together investigators to discuss the current understanding and challenges of acute diarrhea treatment, the pathogenesis of acute diarrhea and the pathophysiologic mechanisms involved. The workshop will also encompass translational approaches now being used and prospective approaches that may be developed to target common pathophysiologic mechanisms.

Extramural Organizers

  • David Alpers, Washington University
  • Henry J. Binder, Yale University
  • Thomas Brewer, The Bill and Melinda Gates Foundation
  • Mark Donowitz, Johns Hopkins University​

Agenda

Sunday, September 25, 2011

5:45 p.m. - 6:00 p.m. Welcome and NIDDK Priorities
Griffin Rodgers
Director, National Institute of Diabetes and Digestive and Kidney Diseases
6:00 p.m. - 6:10 p.m. Welcome and Review of Meeting Objectives and Agenda
Stephen James
6:10 p.m. - 7:30 p.m.
Session I:   Acute Diarrhea:  Current Understanding and Challenges         
Moderator:  James Nataro
Epidemiology, Risk Factors, Clinical Manifestations, and Outcomes
Sean Moore
Current Pharmacology and Unmet Medical Needs
Henry J. Binder
Therapeutic Challenges and Translational Approaches to Diarrhea Prevention and Treatment in Under-Developed Nations
Olivier Fontaine
Primary Discussant
David A. Sack
Panel Discussion

Monday, September 26, 2011

8:30 a.m. - 10:35 a.m.
Session II:  Pathogenesis
Moderator:  Gail Hecht
Common Pathways in Pathogenesis:  Clues for Potential Targets
Kim Barrett
Inflammatory Bacterial Diarrhea:  Inflammatory and Immune Mediators and Epithelial Damage
Gail Hecht
Toxin-Mediated Bacterial Diarrheas
Wayne Lencer
Viral Diarrheal Diseases
Mary K. Estes
Host Response to Acute Diarrhea Due to Parasites
William A. Petri
Impact of Intestinal Microbiota on Pathogen Susceptibility  
James Versalovic  
Primary Discussant:  Novel Approaches to Oral Rehydration and Nutrition Therapy (ORNT)
Richard Guerrant
Panel Discussion
10:35 a.m. - 11:00 a.m.  BREAK
11:00 a.m. - 5:45 p.m.
Session III:  Pathophysiologic Mechanisms
11:00 a.m. - 12:45 p.m. 
Session III A:  Transporters and Channels
Moderator:  James Anderson
Overview of Pathophysiologic Mechanisms
Mark Donowitz
Preclinical Models:  From Cultured Cells and Organoids to Animal Models and Biopsies
Hugo de Jonge
Overview of the Role of Cl channels
Nadia Ameen
Role of CFTR vs Calcium-Activated Chloride Channels in Intestinal Cl Secretion
Alan Verkman  
Role of Trafficking in the Regulation of CFTR Function
Raymond Frizzell
Role of CFTR and Its Interacting Partners in Cholera Toxin-Induced Diarrhea  
Anjaparavanda Naren
KCNMA1 K Channels Mediate K-Dependent Intestinal Fluid Ssecretion:  A Potential Anti-Secretory Target
Vazhaikkurichi Rajendran
12:45 p.m. - 1:45 p.m. Working Lunch and Poster Session
1:45 p.m. - 3:15 p.m.
Session III A:  PATHOPHYSIOLOGIC MECHANISMS   (Continued)
Regulation of Intestinal Na Absorption:  NHE3
Mark Donowitz
Regulation of Intestinal Chloride Absorption:  SLC26 Transporters  
Pradeep Dudeja
Pathways of Intestinal Epithelial Water Transport and Molecular Mechanisms of Its Regulation
Olga Kovbasnjuk  
Calcium Sensing Receptor (CaSR) Regulation of Intestinal Ion Transporters
John Geibel
Primary Discussant
Fayez Ghishan
Panel Discussion
3:15 p.m. - 3:30 p.m. BREAK
3:30 p.m. - 5:30 p.m.
Session III B:  Paracellular Transport and Motility
Moderator:  Jerrold Turner
Inflammatory Diarrhea:  New Approaches to Drugging the Junction
Jerrold Turner
Mechanisms of Epithelial Barrier Disturbance in Inflammatory Bowel Disease
Joerg-Dieter Schulzke
Primary Discussant
James Anderson
Panel Discussion
Neuromuscular/Nerve-Gut, EC cells, Motility
Terez Shea-Donohue
Review of Enteroendocrine and Neuromuscular Mechanisms in the Pathophysiology of Acute Diarrhea
Michael Camilleri
Panel Discussion
5:30 p.m. - 7:00 p.m.
Session IV:   Breakout Groups for Sessions I, II, IIIA, IIIB, and IV
Tuesday,  September 27, 2011
8:30 a.m. - 8:40 a.m.
Summary of Days 1 and 2
James Nataro and James Anderson
8:40 a.m. - 10:00 a.m. 
Session V: Translation of Current Understanding of Pathophysiological Mechanisms into Potential Treatment Options
David Alpers
Developmental Strategy for Approaching Druggable Targets
Alan Verkman
Challenges of Drug Development for Diarrhea
David Brown
Development of a CFTR Inhibitor as a Potential Treatment for Acute Secretory Diarrhea
Tue Nguyen

Overview of NIH Molecular Libraries Program
Ronald Margolis
Primary Discussant
Henry J. Binder
Panel Discussion
10:00 a.m. - 10:25 a.m. BREAK
10:25 a.m. - 11:15 a.m. 
Session VI: Breakout Reports
Moderator:    Mark Donowitz and Session Moderators
11:15 a.m. - 12:15 p.m. 
Session VII:  Final Discussion:  Knowledge Gaps, Opportunities and Priorities
David Alpers
12:15 p.m. - 12:30 p.m. 
Closing Remarks/Adjournment
Stephen James

Directions/Travel

​MEETING FACILITY AND HOTEL ACCOMMODATIONS

Bethesda Marriott Hotel  
5151 Pooks Hill Road
Bethesda, MD  20814 
Telephone:   (301) 897-9400
Toll Free:   (800) 228-9290      
(More hotel information can be obtained from this website.)  
 
The workshop will be held at the Bethesda Marriott Hotel. You may make reservations by calling the hotel directly at (301) 897-9400 .  Please note that reservations must be cancelled no later than 24 hours prior to the scheduled arrival date or 1 night's room and tax will be charged.  Check-in time is 4:00 p.m., and check-out time is 12:00 p.m.  
GROUND TRANSPORTATION

METRO

Each passenger must buy a farecard to travel in the system.  Guides for purchasing farecards are posted on the vending machines in each station.  Each Metro car features a complete color-coded map.  Station attendants on duty at each station can provide additional information on request.  The hotel is 3 miles from the Medical Center Station and offers a shuttle to and from this Metro station.  The shuttle runs daily on the hour between 6:00 a.m. and 10:00 a.m. and between 5:00 p.m. and 9:00 p.m. (the shuttle can be requested during other hours by calling the hotel at (301) 897-9400).
 
From Ronald Reagan National Airport:
Board the Metro Yellow Line to Gallery Place, and transfer to the Red Line toward Shady Grove or Grosvenor.  Exit at the Medical Center Station and take the escalator to the street level. On weekdays, the Marriott Shuttle departs from the Medical Center Station "Kiss & Ride Area" every half-hour between 6:30 a.m. and 10:30 a.m., and between 3:30 p.m. and 8:30 p.m.  Weekend and holiday hours for the Marriott Shuttle are 8:00 a.m. to 12:00 p.m. and 3:30 p.m. to 10:00 p.m.  Total travel time is approximately 45 minutes.
 
From Washington Dulles International Airport (IAD):
Take a Washington Flyer van from the airport to the West Falls Church Metro Station.  Board the Metro Orange Line toward New Carrolton and transfer at Metro Center to the Red Line toward Shady Grove or Grosvenor.  Exit at the Medical Center Station and take the escalator to the street level.  The Marriott Shuttle departs from the Medical Center Station "Kiss & Ride Area" every half-hour between 6:30 a.m. and 10:30 a.m., and between 3:30 p.m. and 8:30 p.m. weekdays.  Weekend and holiday hours for the Marriott Shuttle are 8:00 a.m. to 12:00 p.m. and 3:30 p.m. to 10:00 p.m.  Total travel time is approximately 1 hour.
 
From Union Station:
Take the Metro Red Line toward Shady Grove or Grosvenor.  Exit at the Medical Center Station and take the escalator to the street level.  The Marriott Shuttle departs from the Medical Center Station "Kiss & Ride Area" every half-hour between 6:30 a.m. and 10:30 a.m., and between 3:30 p.m. and 8:30 p.m. weekdays.  Weekend and holiday hours for the Marriott Shuttle are 8:00 a.m. to 12:00 p.m. and 3:30 p.m. to 10:00 p.m.  Total travel time is approximately 35 minutes.

AIRPORT SHUTTLES       

SuperShuttle offers service to most hotels from Ronald Reagan National Airport, Washington Dulles International Airport, and Baltimore-Washington International Thurgood Marshall Airport.  The shuttle leaves on an as-needed basis between the hours of 5:30 a.m. and 11:00 p.m.  During other times, please arrange for a shuttle by calling 800-258-3826 from the airport.

TAXIS

The taxi fare is approximately $60 one way from Ronald Reagan National Airport, approximately $70 from Washington Dulles International Airport, and approximately $90 from Baltimore-Washington International Thurgood Marshall Airport.

DRIVING DIRECTIONS TO THE HOTEL

From Ronald Reagan National Airport:
Take the George Washington Parkway North for 12 miles to I-495 toward Maryland (Capital Beltway).  Take Exit 34 (Wisconsin Avenue South/Route 355).  Turn right at the light onto Pooks Hill Road.  The hotel is on the right.
 
From Washington Dulles International Airport (IAD):
Take the Dulles Access Road for approximately 13 miles to Exit 18.  Move to the right on the Dulles Toll Road (Route 267) and take Exit 18.  Stay left on the ramp for Bethesda/Baltimore and proceed toward Bethesda (I-495).  Go approximately 9 miles on I-495.  Stay on I-495 at the I-495/I-270 split (bear right).  Take Exit 34 (Wisconsin Avenue South/Route 355) toward Bethesda.  Follow Wisconsin Avenue to the first traffic light and turn right onto Pooks Hill Road.  The hotel is on the right. 
 
From Baltimore-Washington International Thurgood Marshall Airport (BWI):
Take the Route 195 connector to I-95 South.  Take I-95 South to I-495 West (Capital Beltway) toward Silver Spring.  Follow I-495 West for 9 miles to Exit 34 (Bethesda/Wisconsin Avenue).  Follow signs for Route 355 South and stay in the right lane.  Turn right at the light onto Pooks Hill Road.  The hotel is on the right.

PARKING  

On-site parking is $4 hourly and $9 daily.

Minutes

Minutes are currently unavailable.

Attendees

​Attendees are currently unavailable.

Abstracts

Call for Poster Abstracts

Participants in the Translational Approaches for Pharmacotherapy Development for Acute Diarrhea Workshop are encouraged to submit abstracts for presentation of their research in poster format. There will be a formal poster session held during a working lunch on Monday, September 26, 2011. In addition, posters will be kept on display throughout the workshop with additional opportunities for networking and discussion during breaks. Please follow the instructions below to submit an abstract for a poster presentation:
All abstracts must be submitted electronically by 5:00 pm (Eastern Standard Time) on Friday, August 12, 2011, via email to Angela Meadows at ameadows@scgcorp.com. Please include "Poster Abstract for NIDDK Acute Diarrhea Workshop" in the subject line.

Please attach your abstract as a MS Word document to the email along with any comments.

The abstract should be no more than one, single-sided page.

The abstract should be single-spaced with sections on Background, Methods, Results, and Conclusions.

Please type the title of your abstract in Arial, 12 pt. bold font using Title Case Letters

List the names, degree(s), and institutional affiliation(s) of all authors in order of their contribution to the research.

Underline the name of the person presenting the abstract.

Poster Presentations

Posters will be displayed on 4-foot-high by 6-foot-wide poster boards. Pushpins and Velcro will be provided onsite. All presenters must register for the conference. ​

Location

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  • Bethesda Marriott Hotel
  • MD 20892
Webinar

Contacts

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NIDDK Staff Organizers and Contacts for Program Information:
Jill Carrington
carringj@mail.nih.gov
Michael Grey
greymj@mail.nih.gov
Stephen James

For questions concerning logistical information or registration, contact:
Angela Meadows
ameadows@scgcorp.com