Contextualizing Cellular Physiology Workshop

Event Details

Purpose

This hybrid workshop seeks to provide a forum for in-depth discussions on imaging, spatial mapping and analysis methods, examining strengths, limitations, and their applicability in the practical realm of identifying tissue function or dysfunction. The workshop is structured to promote the cross-pollination of ideas from computational and optical scientists, biologists, pathologists, disease domain experts, and machine learning experts, focusing on developing practical knowledge for the community.

Meeting Objectives

1. Perspectives on Advanced Techniques for Identifying Cells from Image Data
2. Examine Approaches to Segmentation 
3. Discuss Classification of Cells Across Health States
4. Omics Data Integration
5. Promote Cross-Disciplinary Collaboration
6. Showcase Cutting-Edge Machine Learning Applications
7. Identify Future Research Directions

By addressing these objectives, the workshop aims to advance knowledge, foster collaboration, and promote the innovative use of technology in the study of healthy and disease conditions.

Background

Biological research is experiencing exponential growth, amassing vast quantities of data from pathological images, various molecular datasets, and advanced imaging techniques. The complexity of this data presents significant challenges for researchers endeavoring to integrate these high-dimensional data sets and identify key biological mechanisms.  This workshop will address challenges in the field associated with integration of imaging data and various molecular approaches.  Specifically, this workshop will tackle the obstacles associated with cell identification from imaging data, the identification of biological processes informed by omics data alongside imaging-derived features, and how to leverage AI/ML for enhanced imaging and data analytics.   This workshop will discuss the prevalent challenges faced in the analysis and integration of imaging data, discuss relevant standards and benchmarks, and showcase strategies beneficial to the scientific community.

Registration Deadline

Organizing Committee

External Members

Rohit Bhargava, Ph.D., University of Illinois
Beth Cimini, Ph.D., Massachusetts Institute of Technology/Broad Institute
Michael Eadon, M.D., Indiana University–Purdue University Indianapolis
Agnes Fogo, M.D., Vanderbilt University
Elizabeth Hillman, Ph.D., Columbia University
Richard Levenson, M.D., University of California, Davis
Mingyao Li, Ph.D., University of Pennsylvania

Internal Members

Robert Star, M.D., National Institute of Diabetes and Digestive and Kidney Diseases, (NIDDK), National Institutes of Health (NIH)
Eric Brunskill, Ph.D., NIDDK, NIH
Richard Conroy, Ph.D., M.B.A., Office of the Director (OD), NIH
Stephen Hewitt, M.D., Ph.D., National Cancer Institute (NCI), NIH
Stephen Lockett, Ph.D., NCI, NIH
Ajay Pillay, Ph.D., National Human Genome Research Institute, NIH
Belinda Seto, Ph.D., OD, NIH

Registration Deadline

June 4, 2024

Agenda

Day One—June 11

8:00 a.m. – 8:15 a.m.

Welcome and Introductions
Robert Star, M.D., National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH)

8:15 a.m. – 9:15 a.m.

Session 1: Unveiling Tissue Secrets: Identifying Cells from Image Data
Keynote Speaker – Peter Boor, M.D., University Aachen

9:15 a.m. – 10:00 a.m.

Short Talks
Juan Caicedo, Ph.D., Broad Institute
Janis Taube, M.D., Johns Hopkins University
Ahmet Coskun, Ph.D., Georgia Institute of Technology

10:00 a.m. – 11:00 a.m.

Breakout Discussion: Challenges and Approaches to Segmentation

11:00 a.m. – 11:15 a.m.

Coffee Break and Prepare Reports for Group Discussion

11:15 a.m. – 12:00 p.m.

Reconvene Breakout Groups for Larger Discussion

12:00 p.m. – 1:30 p.m.

Lunch

1:30 p.m. – 2:15 p.m.

Session 2: Cellular Alchemy: Classifying Cells Across Health States
Keynote Speaker – Mingyao Li, Ph.D., University of Pennsylvania

2:15 p.m. – 2:45 p.m.

Short-Talks
Beth Cimini, Ph.D., Broad Institute
Aaron Newman, Ph.D., Stanford University
Qing Nie, Ph.D., University of California, Irvine

2:45 p.m. – 3:45 p.m.

Breakout Discussion: Inferring Biology from Omics Data and Identified Features from Imaging

3:45 p.m. – 4:00 p.m.

Coffee Break and Prepare Reports for Group Discussion

4:00 a.m. – 4:45 p.m.

Reconvene Breakout Groups for Larger Discussion

4:45 p.m. – 5:00 p.m.

Recap of the day

5:00 p.m.

Day 1 Adjournment

Evening: Group Dinner (Location to be determined)

Day Two—June 12

8:00 a.m. - 8:15 a.m.

Welcome
Robert Star, M.D., NIDDK, NIH
Eric Brunskill, Ph.D., NIDDK, NIH

8:15 a.m. – 9:00 a.m.

Session 3: Histology Hubble: Zooming in on Cellular Features Using Machine Learning
Keynote Speaker – Richard Levenson, M.D., FACP, University of California, Davis

9:00 a.m. – 9:45 a.m.

Short-Talks
Pinaki Sarder, Ph.D., University of Florida
Madeleine Durkee (Torcasso), Ph.D., University of Chicago
Yuankai Huo, Ph.D., Vanderbilt University

9:45 a.m. – 10:45 a.m.

Breakout Discussion: From Pixels to Patterns: AI/ML in Imaging and Spatial Analysis

10:45 a.m. – 11:00 a.m.

Coffee Break and Prepare Reports for Group Discussion

11:00 a.m. – 11:45 a.m.

Reconvene Breakout Groups for Larger Discussion

11:45 a.m. – 1:00 p.m.

Lunch

1:00 p.m. – 1:45 p.m.

Session 4: Imaging Horizons: What Lies Ahead in Technology
Keynote Speaker – Hari Shroff, Ph.D., Howard Hughes Medical Institute

1:45 p.m. – 2:30 p.m.

Short-Talks
Seth Winfree, Ph.D., National Institute on Aging, National Institutes of Health
Rohit Bhargava, Ph.D., University of Illinois
Lingyan Shi, Ph.D., University of California, San Diego

2:30 p.m. – 3:30 p.m.

Breakout Discussion: Advanced Imaging Systems and Techniques

3:30 p.m. – 3:45 p.m.

Coffee Break and Prepare Reports for Group Discussion

3:45 p.m. – 4:30 p.m.

Reconvene Breakout Groups for Larger Discussion

4:30 p.m. – 4:45 p.m.

Closing Thoughts
Robert Star, M.D., NIDDK, NIH
Eric Brunskill, Ph.D., NIDDK, NIH

4:45 p.m.

Adjournment

Travel

Hotel Accommodations

Bethesda Marriott
5151 Pooks Hill Road
Bethesda, MD 20814
Telephone: (301) 897-9400
Reserve a Room

Government Room Rate

A limited block of sleeping rooms for meeting participants has been reserved at The Bethesda Marriott. The rate is the prevailing government rate of $258 per night for single occupancy, plus tax (13%). The room block will be in effect at the Government rate only until Monday, May 20, 2024, or until full, whichever comes first. Any room reservations received after this date will be accepted on a space- and rate-availability basis. Please be certain that the hotel provides you with a confirmation number for your reservation.

Reservation Dates

Book your arrival date as Monday, June 10, 2024, and departure as Wednesday, June 12, 2024. If you require alternate dates, please contact Mark Dennis of The Scientific Consulting Group, Inc. (SCG).

Check-in

When making a reservation, please provide your room and bedding preferences. The hotel will assign specific room types at check-in, based on availability. Please be advised that requests are not guaranteed. Check-in time is 4:00 p.m., and checkout time is 12:00 p.m.

Cancellations

If you need to cancel your reservation, please do so 48 hours prior to your arrival date, or you will be charged a no-show fee for 1 night on your credit card.