NIDDK's Health Information News
NIDDK's Health Information News is an e-newsletter that provides subscribers with information from all of the NIDDK's health communications programs, including the National Diabetes Education Program; the National Kidney Disease Education Program; the Weight-control Information Network; the clearinghouses for diabetes, digestive diseases, and kidney and urologic diseases; and the information services for blood diseases and endocrine and metabolic diseases.
Apr 18, 2016
Islet transplantation restores blood sugar awareness and control in type 1 diabetes
New clinical trial results show that transplantation of pancreatic islets — cell clusters that contain insulin-producing cells—prevents severe, potentially life-threatening drops in blood sugar in people with type 1 diabetes. Researchers found that the treatment was effective for people who experienced episodes of severe hypoglycemia — low blood sugar levels that can lead to seizures, loss of consciousness and death — despite receiving expert care.
Apr 1, 2016
First in human clinical trial of ultrasonic propulsion of kidney stones.
[University of Washington; Indiana University] Ultrasonic propulsion is a new technology using focused ultrasound energy applied transcutaneously to reposition kidney stones. We report what are to our knowledge the findings from the first human investigational trial of ultrasonic propulsion toward the applications of expelling small stones and dislodging large obstructing stones.
Mar 29, 2016
Children with Cushing syndrome may have higher suicide risk
Children with Cushing syndrome may be at higher risk for suicide as well as for depression, anxiety and other mental health conditions long after their disease has been successfully treated, according to a study by researchers at the National Institutes of Health.
NIDDK Director’s Update
Features updates on NIH and NIDDK activities, events, NIDDK-specific plans, and trans-NIH issues.
Mar 10, 2016
This National Kidney Month, help your children adopt healthy habits
During National Kidney Month — and World Kidney Day — the National Institutes of Health encourages you to think about how to protect your children’s kidneys, for today and for a lifetime. While most children with kidney disease were born with urinary tract problems or inherited diseases that put them at risk, some develop kidney disease as they age due to growing problems of young people, such as type 2 diabetes and high blood pressure.
Mar 4, 2016
Nutrition Roadmap Aims to Advance Research to Provide More Individualized Advice
WASHINGTON, March 4, 2016 – Today, the Interagency Committee on Human Nutrition Research (ICHNR) released the first Nutrition Research Roadmap designed to guide federal nutrition research. The 2016-2021 National Nutrition Research Roadmap encourages an increased focus on research that can lead to more individualized advice for promoting health and preventing disease.
Mar 1, 2016
Christopher J. Lynch to direct Office of Nutrition Research
Christopher J. Lynch, Ph.D., has been named the new director of the Office of Nutrition Research (ONR) and chief of the Nutrition Research Branch within the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
Feb 19, 2016
Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children.
[Washington University] As we come to appreciate how our microbial communities (microbiota) assemble following birth, there is an opportunity to determine how this facet of our developmental biology relates to the healthy or impaired growth of infants and children. Childhood undernutrition is a devastating global health problem whose long-term sequelae, including stunting, neurodevelopmental abnormalities, and immune dysfunction, remain largely refractory to current therapeutic interventions.
Feb 1, 2016
Proton pump inhibitor use and the risk of chronic kidney disease.
[Johns Hopkins University; Yale University] Proton pump inhibitors (PPIs) are among the most commonly used drugs worldwide and have been linked to acute interstitial nephritis. Less is known about the association between PPI use and chronic kidney disease (CKD).
Jan 29, 2016
Airway acidification initiates host defense abnormalities in cystic fibrosis mice.
[University of Iowa] Cystic fibrosis (CF) is caused by mutations in the gene that encodes the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel. In humans and pigs, the loss of CFTR impairs respiratory host defenses, causing airway infection. But CF mice are spared. We found that in all three species, CFTR secreted bicarbonate into airway surface liquid.
Jan 25, 2016
Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice.
[Massachusetts Institute of Technology; Harvard University] The transplantation of glucose-responsive, insulin-producing cells offers the potential for restoring glycemic control in individuals with diabetes. Pancreas transplantation and the infusion of cadaveric islets are currently implemented clinically, but these approaches are limited by the adverse effects of immunosuppressive therapy over the lifetime of the recipient and the limited supply of donor tissue.
Jan 25, 2016
Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates.
[Massachusetts Institute of Technology] The foreign body response is an immune-mediated reaction that can lead to the failure of implanted medical devices and discomfort for the recipient. There is a critical need for biomaterials that overcome this key challenge in the development of medical devices. Here we use a combinatorial approach for covalent chemical modification to generate a large library of variants of one of the most widely used hydrogel biomaterials, alginate.
Jan 14, 2016
Weight loss and health status 3 years after bariatric surgery in adolescents.
[University of Cincinnati; University of Pittsburgh; Baylor College of Medicine; University of Buffalo; University of Alabama] Severe obesity affects 4.4 million children and adolescents in the United States, and few effective treatments are available. Particular concern has centered on health problems among severely obese adolescents and possible treatment with bariatric surgery.
Jan 13, 2016
Diet-induced extinctions in the gut microbiota compound over generations.
[Stanford University; Harvard University] The gut is home to trillions of microorganisms that have fundamental roles in many aspects of human biology, including immune function and metabolism. The reduced diversity of the gut microbiota in Western populations compared to that in populations living traditional lifestyles presents the question of which factors have driven microbiota change during modernization.
Dec 29, 2015
Musclin is an activity-stimulated myokine that enhances physical endurance.
[University of Iowa] Exercise remains the most effective way to promote physical and metabolic wellbeing, but molecular mechanisms underlying exercise tolerance and its plasticity are only partially understood. In this study we identify musclin—a peptide with high homology to natriuretic peptides (NP)—as an exercise-responsive myokine that acts to enhance exercise capacity in mice.
Dec 16, 2015
NIH unveils FY2016–2020 Strategic Plan
The National Institutes of Health (NIH) today released the NIH-Wide Strategic Plan, Fiscal Years 2016–2020: Turning Discovery Into Health, which will ensure the agency remains well positioned to capitalize on new opportunities for scientific exploration and address new challenges for human health.
Nov 17, 2015
Specific dosage of sickle cell drug increases survival rate
WHAT: An analysis by National Institutes of Health researchers has shown that people with sickle cell anemia who took the drug hydroxyurea at the recommended dose had higher survival rates than those who took less than the recommended dose. The findings appear in the journal PLOS ONE.
Nov 11, 2015
Tissue-engineered microvasculature to reperfuse isolated renal glomeruli.
[Yale University] Kidney transplantation is often the most effective therapy for end-stage renal disease, but there are not enough donor organs to meet the rising demand. Tissue engineering of kidneys is a potential solution to this organ shortage. Achieving microvascular perfusion has been a major barrier to engineering tissues beyond thin muscularized sheets such as the bladder wall.
Nov 3, 2015
Altered brain responses in subjects with irritable bowel syndrome during cued and uncued pain expectation.
[University of California, Los Angeles] A majority of the subjects with irritable bowel syndrome (IBS) show increased behavioral and brain responses to expected and delivered aversive visceral stimuli during controlled rectal balloon distension, and during palpation of the sigmoid colon. We aimed to determine if altered brain responses to cued and uncued pain expectation are also seen in the context of a noxious somatic pain stimulus applied to the same dermatome as the sigmoid colon.
Nov 1, 2015
Matrix-assisted transplantation of functional beige adipose tissue.
[University of California, Berkeley; École Polytechnique Fédérale de Lausanne, Switzerland] Novel, clinically relevant, approaches to shift energy balance are urgently needed to combat metabolic disorders such as obesity and diabetes. One promising approach has been the expansion of brown adipose tissues that express uncoupling protein (UCP) 1 and thus can uncouple mitochondrial respiration from ATP synthesis.