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NIDDK News Item

Jul 31, 2014

NIH leaders have announced a new collaborative initiative to improve human health by exploring poorly understood genes that have the potential to be modified by medicines.

NIDDK News Item

Jul 8, 2014

Adults with extreme obesity have increased risks of dying at a young age from cancer and many other causes including heart disease, stroke, diabetes, and kidney and liver diseases, according to results of an analysis of data pooled from 20 large studies of people from three countries. The study, led by researchers from the National Cancer Institute (NCI), part of the National Institutes of Health, found that people with class III (or extreme) obesity had a dramatic reduction in life expectancy compared with people of normal weight. The findings appeared July 8, 2014, in PLOS Medicine.

NIDDK News Item

Jul 3, 2014

Acute kidney injury (AKI) and chronic kidney disease (CKD) are closely intertwined, with each disease a risk factor for developing the other and sharing other risk factors in common, as well as sharing causes for the diseases to get worse, and outcomes, suggests a comprehensive analysis by scientists at the National Institutes of Health and George Washington University Medical Center, Washington, D.C. Findings were published July 3 in the New England Journal of Medicine.

NIDDK News Item

Jul 2, 2014

More than one quarter of children with two copies of a high-risk variant in a specific group of genes develop an early sign of celiac disease called celiac disease autoimmunity (CDA) by age 5. The findings are from The Environmental Determinants of Diabetes in Youth consortium, or TEDDY . The National Institutes of Health-funded study, published July 2 in the New England Journal of Medicine , also found that participants in Sweden had higher rates of celiac disease than participants in the United States, Finland and Germany, even with the same genetic risks.

NIDDK News Item

Jul 1, 2014

Half of patients in a trial have safely stopped immunosuppressant medication following a modified blood stem-cell transplant for severe sickle cell disease, according to a study in the July 1 issue of the Journal of the American Medical Association. The trial was conducted at the National Institutes of Health’s Clinical Center in Bethesda, Maryland, by researchers from NIH’s National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the National Heart, Lung, and Blood Institute.

NIDDK News Item

Jun 30, 2014

Researchers have developed a new supercooling technique to increase the amount of time human organs could remain viable outside the body. This study was conducted in rats, and if it succeeds in humans, it would enable a world-wide allocation of donor organs, saving more lives.

NIDDK News Item

Jun 15, 2014

People with type 1 diabetes who used a bionic pancreas instead of manually monitoring glucose using fingerstick tests and delivering insulin using a pump were more likely to have blood glucose levels consistently within the normal range, with fewer dangerous lows or highs. The full report of the findings, funded by the National Institutes of Health, can be found online June 15 in the New England Journal of Medicine.

NIDDK News Item

Jun 10, 2014

More than 29 million people in the United States have diabetes, up from the previous estimate of 26 million in 2010, according to a report released today by the Centers for Disease Control and Prevention. One in four people with diabetes doesn’t know he or she has it.

NIDDK News Item

May 4, 2014

Long-term use of a drug combination reduces the risk of recurrent urinary tract infection by up to 80 percent in children with the urinary condition vesicoureteral compared to placebo, according to research funded by the National Institutes of Health. Results were published online May 4 in theNew England Journal of Medicine External Web Site Policy to coincide with presentation at the Pediatric Academic Societies Annual Meeting in Vancouver, British Columbia.

NIDDK News Item

May 3, 2014

Infants with biliary atresia — a rare liver disease — did not benefit from corticosteroid treatment after bile duct surgery and could face more harm, according to a study funded by the National Institutes of Health. Results were published online May 3 in the Journal of the American Medical Association to coincide with the Pediatric Academic Societies annual meeting.

NIDDK News Item

Mar 13, 2014

In recognition of World Kidney Day 2014 on March 13, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the National Institute on Aging (NIA) at the National Institutes of Health remind older Americans about the importance of protecting their kidneys and urge them to better understand the decline of kidney function as people age.

NIDDK News Item

Feb 4, 2014

The National Institutes of Health, 10 biopharmaceutical companies and several nonprofit organizations today launched an unprecedented partnership to transform the current model for identifying and validating the most promising biological targets of disease for new diagnostics and drug development.

NIDDK News Item

Dec 22, 2013

In a 1,300-word article on its front page, the New York Times (12/22, A1, O'Connor, Subscription Publication) reported that an analysis by the Drug-Induced Liver Injury Network, which was established by the National Institutes of Health, indicated that "dietary supplements account for nearly 20 percent of drug-related liver injuries that turn up in hospitals, up from 7 percent a decade ago." The findings "included only the most severe cases of liver damage referred to a representative group of hospitals around the country, and the investigators said they were undercounting the actual number of cases." Some of these patients ultimately need a liver transplant or will die due to liver failure. The article discusses the loosely regulated supplement industry in the US.

NIDDK News Item

Nov 21, 2013

Even with more prescriptions for growth hormone, children and adolescents with chronic kidney disease were less likely to grow to normal height ranges if they came from lower-income families, according to research funded by the National Institutes of Health. Results from the Chronic Kidney Disease in Children (CKiD) Study are published in the December issue of the American Journal of Kidney Diseases and online today at http://www.ajkd.org.

NIDDK News Item

Nov 14, 2013

Diabetes does not strike a person alone. It strikes families and communities. It strikes our nation and the world. During today’s World Diabetes Day and National Diabetes Month this November, we at the National Institute of Diabetes and Digestive and Kidney Diseases, part of the National Institutes of Health, renew our efforts to prevent, manage and one day cure diabetes. As well, we encourage families to take steps to improve their health and work together to fight diabetes and its serious and sometimes fatal consequences.

NIDDK News Item

Nov 12, 2013

A gene variant common in African-Americans predicts that people with that gene who also have chronic kidney disease (CKD) are twice as likely to progress to kidney failure as African-Americans without the high-risk gene and white people with CKD. People with the high-risk gene also tend to lose kidney function at twice the rate of those without the gene, according to the research, which was funded by the National Institutes of Health.

NIDDK News Item

Nov 4, 2013

National Institutes of Health-funded researchers found that adults had significant weight loss three years after bariatric surgery, with the majority losing the most weight during the first year. A separate study in teens found few incidences of complications in the first 30 days after bariatric surgery. These studies are part of the Longitudinal Assessment of Bariatric Surgery (LABS) and Teen-LABS. More than one-third of U.S. adults are obese, defined as having a body mass index or BMI of 30 or higher, and almost 17 percent of youth are also obese. Severe obesity is a BMI of 35 or more in adults and teens. BMI measures weight in relation to height.

NIDDK News Item

Oct 21, 2013

Researchers have begun the first definitive, large-scale clinical trial to investigate if a vitamin D supplement helps prevent or delay type 2 diabetes in adults who have pre-diabetes andwho are at high risk for developing type 2. Funded by the NIH, the study is taking place at about 20 study sites across the United States.

NIDDK News Item

Oct 20, 2013

Features news and information on activities, materials, and publications of the National Kidney Disease Education Program and other kidney groups.

NIDDK News Item

Sep 9, 2013

People are host to trillions of microbes living on their skin and in the gut, vagina, mouth, nose, lungs, and penis. These microbes live as communities in and on the human body and are known as the human microbiome. For the most part, we peacefully co-exist with these microbes. But sometimes some of these microorganisms such as, bacteria, can trigger responses that may cause people to develop a disease. To better understand how and why alteration of the normal microbiome at various body sites promotes diseases, the National Institutes of Health will fund three innovative research projects for the next 3 years.

NIDDK News Item

Aug 1, 2013

Deletion of a protein in white blood cells improves their ability to fight the bacteria staphylococcus aureus and possibly other infections in mice with chronic granulomatous disease (CGD), according to a NIH study. CGD, a genetic disorder also found in people, is marked by recurrent, life-threatening infections. The study’s findings appear online in The Journal of Clinical Investigation.

NIDDK News Item

Jul 29, 2013

Researchers at the NIH have created and confirmed the accuracy of a mathematical model that predicts how weight and body fat in children respond to adjustments in diet and physical activity. The results will appear online July 30 in Lancet Diabetes and Endocrinology.

NIDDK News Item

Jul 29, 2013

Researchers from the Chronic Renal Insufficiency Cohort (CRIC) study are embarking on another five years of work to identify risk factors for progression of early stage chronic kidney disease (CKD), better understand the importance of reduced kidney function in older persons, and learn what role CKD may play in other illnesses that require hospitalization. CRIC is supported by the National Institutes of Health.

NIDDK News Item

Jun 3, 2013

The NIH is looking for volunteers to take part in a study to compare the long-term benefits and risks of four widely used diabetes drugs in combination with metformin, the most common first-line medication for treating type 2 diabetes. Beginning recruitment in June, the project is called the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) Study.

NIDDK News Item

May 22, 2013

The NIH is looking for volunteers to take part in one of three clinical trials to improve and preserve the production of insulin in people with pre-diabetes or recently diagnosed type 2 diabetes. The project is called the Restoring Insulin Secretion study (RISE).

NIDDK News Item

May 7, 2013

People with a family history of type 1 diabetes can now conveniently participate in free screening to help find ways to delay or prevent the disease, even if they live far from a study site. This alternative to site-based initial screening comes as modern technology enables more secure online registration for medical research.

NIDDK News Item

Mar 13, 2013

In observance of World Kidney Day on March 14, the NIH is raising awareness of the long term effects of acute kidney injury (AKI) — a sudden loss of kidney function. Research funded by the NIH’s NIDDK suggests survivors of AKI have a lifelong increased risk for developing permanent kidney damage, resulting in decreased kidney function.

NIDDK News Item

Feb 20, 2013

Researchers funded by the NIH plan to determine whether elevated blood sugar during pregnancy, a less–severe condition than gestational diabetes, influences later levels of body fat in children and development of diabetes in mothers after giving birth.

NIDDK News Item

Feb 15, 2013

More people are meeting recommended goals in the three key markers of diabetes control, according to a study conducted and funded by the NIH and the Centers for Disease Control and Prevention.

NIDDK News Item

Nov 2, 2012

In observance of National Diabetes Month, including World Diabetes Day on Nov. 14, the NIH urges people to take action and make simple but important lifestyle changes to achieve their health goals — whether they have diabetes or are at risk for the disease.

NIDDK News Item

Nov 1, 2012

Researchers have found 71 new human genes associated with Crohn's disease and ulcerative colitis, two chronic inflammatory bowel diseases (IBD) that affect the small and large (colon) intestines of nearly 2.5 million people worldwide. This study brings the total number of known genes associated with IBD to 163.

NIDDK News Item

Oct 19, 2012

An intensive diet and exercise program resulting in weight loss does not reduce cardiovascular events such as heart attack and stroke in people with longstanding type 2 diabetes, according to a study supported by the NIH.

NIDDK News Item

Oct 15, 2012

Exercise and healthy eating reduce body fat and preserve muscle in adults better than diet alone, according to a study funded and conducted by NIDDK, part of the NIH. The study was recently published online in Obesity and will be in a future print edition.

NIDDK News Item

Oct 12, 2012

A free source of evidence-based information for health care professionals and for researchers studying liver injury associated with prescription and over-the-counter drugs, herbals, and dietary supplements is now available from the NIH. Researchers and health care professionals can use the LiverTox database to identify basic and clinical research questions to be answered and to chart optimal ways to diagnose and control drug-induced liver injury.

NIDDK News Item

Oct 9, 2012

By sticking to a healthy diet in the years after pregnancy, women who develop diabetes during pregnancy can greatly reduce their risk of developing type 2 diabetes, a study supported by the NIH has found.

NIDDK News Item

Sep 7, 2012

A clinic-based program for adolescents with type 1 diabetes and their families helped the teens develop the healthy behaviors needed to control their blood sugar levels, researchers at the NIH have found.

NIDDK News Item

Jul 5, 2012

Measuring creatinine and cystatin C — two markers for chronic kidney disease (CKD) — more precisely estimates kidney function than either marker alone, according to a study funded by the NIH. Results appear in the July 5 issue of the New England Journal of Medicine.

NIDDK News Item

Jun 18, 2012

Adults who had a common bariatric surgery to lose weight had a significantly higher risk of alcohol use disorders (AUD)2 years after surgery, according to a study by a NIH research consortium.

NIDDK News Item

May 22, 2012

Death rates for people with diabetes dropped substantially from 1997 to 2006, especially deaths related to heart disease and stroke, according to researchers at the Centers for Disease Control and Prevention and the NIH.

NIDDK News Item

May 2, 2012

An invasive and costly test commonly done in women before surgery for stress urinary incontinence may not be necessary, according to a study funded by the NIH. The study compared results after both a pre-operative check-up in a doctor's office and bladder function tests to results after only the office check-up. Women who had only the office check-up had equally successful outcomes after surgery.

NIDDK News Item

Apr 30, 2012

The Weight of the Nation documentary series and public awareness campaign by the cable network HBO, launching this week, features NIH research showing how obesity affects the country's health and how interventions can turn the tide against obesity and its complications.

NIDDK News Item

Apr 29, 2012

A combination of two diabetes drugs, metformin and rosiglitazone, was more effective in treating youth with recent-onset type 2 diabetes than metformin alone, a study funded by the NIH has found. Adding an intensive lifestyle intervention to metformin provided no more benefit than metformin therapy alone.

NIDDK News Item

Mar 28, 2012

Weight loss and increased physical fitness nearly halved the risk of losing mobility in overweight or obese adults with type 2 diabetes, according to4 year results from the Look AHEAD (Action for Health in Diabetes) trial funded by the NIH. The results are published in the March 29, 2012, issue of the New England Journal of Medicine.

NIDDK News Item

Mar 22, 2012

Programs to prevent or delay type 2 diabetes in high-risk adults would result in fewer people developing diabetes and lower health care costs over time, researchers conclude in a new study funded by the NIH.

NIDDK News Item

Mar 8, 2012

In recognition of World Kidney Day on March 8, the NIH is promoting efforts to reduce disparities in organ transplantation. This is particularly important among African-Americans, Hispanics, and American Indians, all of whom are disproportionately affected by kidney failure — yet are less likely to receive organ transplants.

NIDDK News Item

Feb 6, 2012

The National Institutes of Health has created a new website, NIH Clinical Research Trials and You, to help people learn more about clinical trials, why they matter, and how to participate. From the first cure of a solid tumor with chemotherapy to the use of nitroglycerin in response to heart attacks, clinical research trials — or research studies involving people — have played a vital role in improving health and quality of life for people around the globe.

NIDDK News Item

Jan 26, 2012

A new fact sheet from the NIH explains the A1C test, a widely used and important test to diagnose type 2 diabetes and pre-diabetes, and to monitor blood glucose levels of people with type 1 and type 2 diabetes.

NIDDK News Item

Jan 12, 2012

A new type of lab has been created to utilize near-atomic resolution microscopy and other structural biology technologies to help accelerate important medical discoveries relating to global health challenges, such as cancer and HIV/AIDS. The Living Lab Structural Biology Center was formed through a cooperative research and development agreement between the NIH and FEI, Hillsboro, Ore., a scientific instruments company.

NIDDK News Item

Jan 11, 2012

With the launch of a new clinical trial supported by the National Institutes of Health, researchers are working to determine whether treating children diagnosed with the most severe form of fatty liver disease with a drug called cysteamine will help improve the liver.

NIDDK News Item

Dec 30, 2011

John Buse, M.D., Ph.D., of the University of North Carolina at Chapel Hill School of Medicine, has been named the new chair of the National Diabetes Education Program (NDEP), a joint program of the NIH and the Centers for Disease Control and Prevention, NDEP announced today. The appointment, for a 2-year term, is effective Jan. 1, 2012.