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Citations of notable research funded by the NIDDK. ​​
NIDDK Grantee News

Aug 28, 2013

[Wright State University] In adults with chronic kidney disease (CKD), cigarette smoking is associated with an increased risk for CKD progression and transplant failure. In children, secondhand smoke (SHS) exposure has been associated with elevated blood pressure. There are no studies on the prevalence and effect of SHS exposure in CKD.

NIDDK Grantee News

Jul 23, 2013

[Harvard Medical School] Classic brown fat and inducible beige fat both dissipate chemical energy in the form of heat through the actions of mitochondrial uncoupling protein 1. This nonshivering thermogenesis is crucial for mammals as a defense against cold and obesity/diabetes.

NIDDK Grantee News

Jul 8, 2013

[McGill University] To better understand the difficulty of looking for a cure, or even effective treatment, one must understand the large and complex nature of the CFTR protein. It is made up of 1,480 amino acids strung together in five three-dimensional strands (called domains) that spin together and fold to act as building blocks for the CFTR protein.

NIDDK Grantee News

Jun 6, 2013

[Harvard Medical School] Shwachman-Diamond syndrome (SDS), a rare autosomal-recessive disorder characterized by exocrine pancreatic insufficiency and hematopoietic dysfunction, is caused by mutations in the Shwachman-Bodian-Diamond syndrome (SBDS) gene.

NIDDK Grantee News

May 8, 2013

[Washington University in St. Louis] Urinary tract infections (UTIs) are common in women, and recurrence is a major clinical problem. Most UTIs are caused by uropathogenic Escherichia coli (UPEC). UPEC are generally thought to migrate from the gut to the bladder to cause UTI. UPEC form specialized intracellular bacterial communities in the bladder urothelium as part of a pathogenic mechanism to establish a foothold during acute stages of infection. Evolutionarily, such a specific adaptation to the bladder environment would be predicted to result in decreased fitness in other habitats, such as the gut. To examine this prediction, we characterized 45 E. coli strains isolated from the feces and urine of four otherwise healthy women with recurrent UTI.

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