Fgfr1 LoxP Mouse
Mutant Mouse: Fgfr1 (Fibroblast Growth Factor Receptor 1)
FGFR1 conditional knockouts. Inactivation of FGFR1 LoxP in limb mesenchyme early in embryogenesis shows that FGFR1 is indispensable for normal limb development.
Fibroblast Growth Factor Receptor 1 (FGFR1) is primarily expressed in the mesenchyme of developing limb buds, and mutant FGFR1 genes in human patients are associated with abnormalities in distal limb structures. Since traditional knockout of FGFR1 is lethal soon after implantation, conditional knockout of the FGFR1 gene in limb mesenchyme at early stages of embryonic development using the Cre-LoxP approach was used to study the role of FGFR1 in limb development. FGFR1 is dispensable for limb initiation, but plays an indispensable role in the very early stages of proximal-distal development of the limb. Expression of several signaling candidate genes that may be involved in digit patterning is altered.