Stat1LoxP (Stat1 tm1Mam) Mouse

Acronym: Mutant Mouse: Stat1 NIDDK Contact: Principal Investigator(s): Lothar Hennighausen


Selective inactivation of Stat 1 in mammary cells indicates that its effect as a tumor suppressor in breast is direct.

STAT1 is considered a tumor suppressor, but it is not known if this effect occurs directly in mammary cells or secondarily by disrupting interferon signaling through the JAK/STAT1 pathway to induce immune responses.  ERBB2/neu-induced breast cancer appeared sooner in mice lacking STAT1 only in mammary cells than in wild-type mice, indicating that STAT1 tumor suppression was intrinsic to mammary cells and not secondary to an induced immune response.

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