Resource

Receptors that regulate cell signaling relating to chemokines (U.S. Patent Number 6,365,356)

Acronym: Not Available NIDDK Contact: Marvin Gershengorn Principal Investigator(s): Not Available

Description:

A method for discovering molecules that regulate cell signaling specific to the dual presence of Duffy antigen receptor for chemokines (DARC) and a chemokine receptor selected from the group consisting of a CXC receptor, a CC receptor and a CXXXC receptor, the method comprising providing a cell that co-expresses DARC and the chemokine receptor; incubating the molecules with the cell; measuring the cell signaling in the cell specific to the dual presence of DARC and the chemokine receptor; and determining whether the cell signaling specific to the dual presence of DARC and the chemokine receptor is regulated by the molecules.

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