Synthesis and purification of hepatitis C virus-like particles (U.S. Patent Number 6,387,662)

Acronym: Not Available NIDDK Contact: Principal Investigator(s): T. Jake Liang


Production of enveloped RNA virus-like particles intracellularly in vitro in insect cells using a recombinant baculovirus vector containing a cDNA coding for viral structural proteins is disclosed. In vitro production and purification of hepatitis C virus (HCV)-like particles containing HCV core protein, E1 protein and E2 protein is disclosed. Production of antibodies in vivo to the purified HCV-like particles is disclosed.

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