U.S. Department of Health and Human Services

Genetics and Biochemistry Branch

Rafael Daniel Camerini-Otero, M.D., Ph.D., Chief


A selection of recent and significant publications can be viewed below.

Roman-Hernandez G, Peterson JH, Bernstein HD. Reconstitution of bacterial autotransporter assembly using purified components. Elife. 2014 Sep 2; 3 (2014 Sep 2; 3). [Full Text/Abstract]
Hsieh PW, Wen CJ, Yu HP, Aljuffali IA, Huang YH, Fang JY. Nanostructured lipid carriers containing a high percentage of a Pluronic copolymer increase the biodistribution of novel PDE4 inhibitors for the treatment of traumatic hemorrhage. J Biomed Nanotechnol. 10 (8; 10):1520-35. [Full Text/Abstract]
Hsieh PL, Chen ML, Huang CM, Chen WC, Li CH, Chang LC. Physical activity, body mass index, and cardiorespiratory fitness among school children in Taiwan: a cross-sectional study. Int J Environ Res Public Health. 11 (7; 11):7275-7285. [Full Text/Abstract]
Lin TL, Hsieh PF, Huang YT, Lee WC, Tsai YT, Su PA, Pan YJ, Hsu CR, Wu MC, Wang JT. Isolation of a bacteriophage and its depolymerase specific for K1 capsule of Klebsiella pneumoniae: implication in typing and treatment. J Infect Dis. [Full Text/Abstract]
Chuang HW, Liao JB, Chang HC, Wang JS, Lin SL, Hsieh PP. Ciliated muconodular papillary tumor of the lung: A newly defined peripheral pulmonary tumor with conspicuous mucin pool mimicking colloid adenocarcinoma: A case report and review of literature. Pathol Int. 64 (7; 64):352-7. [Full Text/Abstract]
Chiang JM, Hsieh PS, Chen JS, Tang R, You JF, Yeh CY. Rectal cancer level significantly affects rates and patterns of distant metastases among rectal cancer patients post curative-intent surgery without neoadjuvant therapy. World J Surg Oncol. 12 (12; 1):197. [Full Text/Abstract]
Tiong KL, Chang KC, Yeh KT, Liu TY, Wu JH, Hsieh PH, Lin SH, Lai WY, Hsu YC, Chen JY, Chang JG, Shieh GS. CSNK1E/CTNNB1 Are Synthetic Lethal To TP53 in Colorectal Cancer and Are Markers for Prognosis. Neoplasia. [Full Text/Abstract]
Molina CA, Ames CP, Chou D, Rhines LD, Hsieh PC, Zadnik PL, Wolinsky JP, Gokaslan ZL, Sciubba DM. Outcomes following attempted en bloc resection of cervical chordomas in the C-1 and C-2 region versus the subaxial region: a multiinstitutional experience. J Neurosurg Spine. 1-9. [Full Text/Abstract]
Broering TJ, Alavattam KG, Sadreyev RI, Ichijima Y, Kato Y, Hasegawa K, Camerini-Otero RD, Lee JT, Andreassen PR, Namekawa SH. BRCA1 establishes DNA damage signaling and pericentric heterochromatin of the X chromosome in male meiosis. J Cell Biol. 2014 Jun 9; 205 (205; 2014 Jun 9; 5):663-75. [Full Text/Abstract]
Acosta FL Jr, Ames C, Hsieh PC, McCarthy IM. Introduction: Costs and benefits of modern-day spine care. Neurosurg Focus. 36 (6; 36):Introduction. [Full Text/Abstract]
Moktan H, Guiraldelli MF, Eyster CA, Zhao W, Lee CY, Mather T, Camerini-Otero RD, Sung P, Zhou DH, Pezza RJ. Solution structure and DNA-binding properties of the winged helix domain of the meiotic recombination HOP2 protein. J Biol Chem. 2014 May 23; 289 (2014 May 23; 289; 21):14682-91. [Full Text/Abstract]
Wang HH, Chung UL, Tsay SL, Hsieh PC, Su HF, Lin KC. Development and preliminary testing of an instrument to measure healthiness of lifestyle among breast cancer survivors. Int J Nurs Pract. [Full Text/Abstract]
Ting YC, Ko HH, Wang HC, Peng CF, Chang HS, Hsieh PC, Chen IS. Biological evaluation of secondary metabolites from the roots of Myrica adenophora. Phytochemistry. [Full Text/Abstract]
Tuchman A, Hsieh PC. Editorial: Comparing minimally invasive, hybrid, and open surgical techniques for adult spinal deformity. Neurosurg Focus. 36 (36; 5):E16. [Full Text/Abstract]
Wang WC, Liu SF, Chang WT, Shiue YL, Hsieh PF, Hung TJ, Hung CY, Hung YJ, Chen MF, Yang YL. The effects of diosgenin in the Regulation of renal proximal tubular fibrosis. Exp Cell Res. 323 (323; 2):255-62. [Full Text/Abstract]
Chen YW, Tzeng JI, Lin MF, Hung CH, Hsieh PL, Wang JJ. High-Frequency Transcutaneous Electrical Nerve Stimulation Attenuates Postsurgical Pain and Inhibits Excess Substance P in Rat Dorsal Root Ganglion. Reg Anesth Pain Med. [Full Text/Abstract]
Hsieh PH, Xu Y, Keire DA, Liu J. Chemoenzymatic synthesis and structural characterization of 2-O-sulfated glucuronic acid containing heparan sulfate hexasaccharides. Glycobiology. [Full Text/Abstract]
Kuo CT, Chiang RH, Wang CY, Hsieh PH, Lin YT, Lin CH, Huang CY. Electrically switchable cholesteric gratings based on slit electrodes. Opt Express. 22 (8; 22):9759-9763. [Full Text/Abstract]
Hsu SC, Lai YC, Hsieh PH, Cheng PJ, Wong SS, Hung CH. Successful enrichment of a rarely found Candidatus Anammoxoglobus propionicus from leachate sludge. J Microbiol Biotechnol. [Full Text/Abstract]
Chen CH, Chang MY, Wang SS, Hsieh PC. Injection of autologous bone marrow cells in hyaluronan hydrogel improves cardiac performance after infarction in pigs. Am J Physiol Heart Circ Physiol. 306 (7; 306):H1078-86. [Full Text/Abstract]
Xu Y, Cai C, Chandarajoti K, Hsieh PH, Li L, Pham TQ, Sparkenbaugh EM, Sheng J, Key NS, Pawlinski R, Harris EN, Linhardt RJ, Liu J. Homogeneous low-molecular-weight heparins with reversible anticoagulant activity. Nat Chem Biol. 10 (4; 10):248-50. [Full Text/Abstract]
Hsueh YC, Wu JM, Yu CK, Wu KK, Hsieh PC. Prostaglandin E2 promotes post-infarction cardiomyocyte replenishment by endogenous stem cells. EMBO Mol Med. 6 (6; 4):496-503. [Full Text/Abstract]
Liu C, Sheng J, Krahn JM, Perera L, Xu Y, Hsieh PH, Dou W, Liu J, Pedersen LC. Molecular mechanism of substrate specificity for heparan sulfate 2-O-sulfotransferase. J Biol Chem. [Full Text/Abstract]
Jang WL, Lu YM, Chen CL, Lu YR, Dong CL, Hsieh PH, Hwang WS, Chen JL, Chen JM, Chan TS, Lee JF, Chou WC. Local geometric and electronic structures of gasochromic VO(x) films. Phys Chem Chem Phys. 16 (16; 10):4699-708. [Full Text/Abstract]
Hsieh IC, Kuan TS, Hsieh PC, Chen SM, Yen WJ, Chang WC, Lin IL, Lin YC. Detection of Early Cognitive Impairment Using AD8 in a Young Patient With Stroke With Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Syndrome: A Case Report. Am J Alzheimers Dis Other Demen. 29 (2; 29):133-7. [Full Text/Abstract]
Liu KS, Hsieh PW, Aljuffali IA, Lin YK, Chang SH, Wang JJ, Fang JY. Impact of ester promoieties on transdermal delivery of ketorolac. J Pharm Sci. 103 (3; 103):974-86. [Full Text/Abstract]
Hsieh PC, Lee ST, Chen JF. Lower thoracic degenerative spondylithesis with concomitant lumbar spondylosis. Clin Neurol Neurosurg. 118 (118):21-5. [Full Text/Abstract]
Tsai MT, Wu HY, Roan JN, Tsai YS, Hsieh PC, Yang YJ, Luo CY. Effect of false lumen partial thrombosis on repaired acute type A aortic dissection. J Thorac Cardiovasc Surg. [Full Text/Abstract]
Lai CY, Wu PJ, Roffler SR, Lee ST, Hwang SM, Wang SS, Wang K, Hsieh PC. Clearance kinetics of biomaterials affects stem cell retention and therapeutic efficacy. Biomacromolecules. 15 (2; 15):564-73. [Full Text/Abstract]
Pezza RJ, Voloshin ON, Volodin AA, Boateng KA, Bellani MA, Mazin AV, Camerini-Otero RD. The dual role of HOP2 in mammalian meiotic homologous recombination. Nucleic Acids Res. 2014 Feb; 42 (42; 4; 2014 Feb):2346-57. [Full Text/Abstract]
Chiu YW, Chen WP, Su CC, Lee YC, Hsieh PH, Ho YL. The arrhythmogenic effect of self-assembling nanopeptide hydrogel scaffolds on neonatal mouse cardiomyocytes. Nanomedicine. [Full Text/Abstract]
Margolin G, Khil PP, Kim J, Bellani MA, Camerini-Otero RD. Integrated transcriptome analysis of mouse spermatogenesis. BMC Genomics. 2014 Jan 18; 15 (15; 2014 Jan 18):39. [Full Text/Abstract]
Hsieh PC, Chen KC, Yeh TL, Lee IH, Chen PS, Yao WJ, Chiu NT, Chen CC, Liao MH, Yang YK. Lower availability of midbrain serotonin transporter between healthy subjects with and without a family history of major depressive disorder - a preliminary two-ligand SPECT study. Eur Psychiatry. [Full Text/Abstract]
Zhao W, Saro D, Hammel M, Kwon Y, Xu Y, Rambo RP, Williams GJ, Chi P, Lu L, Pezza RJ, Camerini-Otero RD, Tainer JA, Wang HW, Sung P. Mechanistic insights into the role of Hop2-Mnd1 in meiotic homologous DNA pairing. Nucleic Acids Res. 2014 Jan; 42 (2; 2014 Jan; 42):906-17. [Full Text/Abstract]
Chen DW, Hu CC, Chang YH, Lee MS, Chang CJ, Hsieh PH. Intra-Articular Bupivacaine Reduces Postoperative Pain and Meperidine Use After Total Hip Arthroplasty: A Randomized, Double-Blind Study. J Arthroplasty. [Full Text/Abstract]
Kang'ethe W, Bernstein HD. Charge-dependent secretion of an intrinsically disordered protein via the autotransporter pathway. Proc Natl Acad Sci U S A. 2013 Nov 5; 110 (110; 2013 Nov 5; 45):E4246-55. [Full Text/Abstract]
Smagulova F, Brick K, Pu Y, Sengupta U, Camerini-Otero RD, Petukhova GV. Suppression of genetic recombination in the pseudoautosomal region and at subtelomeres in mice with a hypomorphic Spo11 allele. BMC Genomics. 2013 Jul 22; 14 (14; 2013 Jul 22):493. [Full Text/Abstract]
Pavlova O, Peterson JH, Ieva R, Bernstein HD. Mechanistic link between β barrel assembly and the initiation of autotransporter secretion. Proc Natl Acad Sci U S A. 2013 Mar 5; 110 (110; 10; 2013 Mar 5):E938-47. [Full Text/Abstract]
Boateng KA, Bellani MA, Gregoretti IV, Pratto F, Camerini-Otero RD. Homologous pairing preceding SPO11-mediated double-strand breaks in mice. Dev Cell. 2013 Jan 28; 24 (2; 24; 2013 Jan 28):196-205. [Full Text/Abstract]
Naumova AK, Fayer S, Leung J, Boateng KA, Camerini-Otero RD, Taketo T. Dynamics of response to asynapsis and meiotic silencing in spermatocytes from Robertsonian translocation carriers. PLoS One. 2013; 8 (8; 9; 2013):e75970. [Full Text/Abstract]
Bernstein HD. Cell biology: All clear for ribosome landing. Nature. 2012 Dec 13; 492 (492; 2012 Dec 13; 7428):189-91. [Full Text/Abstract]
Grant J, Mahadevaiah SK, Khil P, Sangrithi MN, Royo H, Duckworth J, McCarrey JR, VandeBerg JL, Renfree MB, Taylor W, Elgar G, Camerini-Otero RD, Gilchrist MJ, Turner JM. Rsx is a metatherian RNA with Xist-like properties in X-chromosome inactivation. Nature. 2012 Jul 12; 487 (7406; 487; 2012 Jul 12):254-8. [Full Text/Abstract]
Brick K, Smagulova F, Khil P, Camerini-Otero RD, Petukhova GV. Genetic recombination is directed away from functional genomic elements in mice. Nature. 2012 May 13; 485 (2012 May 13; 485; 7400):642-5. [Full Text/Abstract]
Khil PP, Smagulova F, Brick KM, Camerini-Otero RD, Petukhova GV. Sensitive mapping of recombination hotspots using sequencing-based detection of ssDNA. Genome Res. 2012 May; 22 (2012 May; 5; 22):957-65. [Full Text/Abstract]
Geng H, Sakato M, DeRocco V, Yamane K, Du C, Erie DA, Hingorani M, Hsieh P. Biochemical analysis of the human mismatch repair proteins hMutSα MSH2(G674A)-MSH6 and MSH2-MSH6(T1219D). J Biol Chem. 2012 Mar 23; 287 (287; 13; 2012 Mar 23):9777-91. [Full Text/Abstract]
Gowher H, Brick K, Camerini-Otero RD, Felsenfeld G. Vezf1 protein binding sites genome-wide are associated with pausing of elongating RNA polymerase II. Proc Natl Acad Sci U S A. 2012 Feb 14; 109 (109; 7; 2012 Feb 14):2370-5. [Full Text/Abstract]
Fukuda T, Pratto F, Schimenti JC, Turner JM, Camerini-Otero RD, Höög C. Phosphorylation of chromosome core components may serve as axis marks for the status of chromosomal events during mammalian meiosis. PLoS Genet. 2012 Feb; 8 (2012 Feb; 8; 2):e1002485. [Full Text/Abstract]
Diouf B, Cheng Q, Krynetskaia NF, Yang W, Cheok M, Pei D, Fan Y, Cheng C, Krynetskiy EY, Geng H, Chen S, Thierfelder WE, Mullighan CG, Downing JR, Hsieh P, Pui CH, Relling MV, Evans WE. Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells. Nat Med. 2011 Sep 25; 17 (17; 2011 Sep 25; 10):1298-303. [Full Text/Abstract]
Ieva R, Tian P, Peterson JH, Bernstein HD. Sequential and spatially restricted interactions of assembly factors with an autotransporter beta domain. Proc Natl Acad Sci U S A. 2011 Aug 2; 108 (108; 2011 Aug 2; 31):E383-91. [Full Text/Abstract]
Geng H, Du C, Chen S, Salerno V, Manfredi C, Hsieh P. In vitro studies of DNA mismatch repair proteins. Anal Biochem. 2011 Jun 15; 413 (2; 413; 2011 Jun 15):179-84. [Full Text/Abstract]