U.S. Department of Health and Human Services

Genetics and Biochemistry Branch

Rafael Daniel Camerini-Otero, M.D., Ph.D., Chief

​Publications

A selection of recent and significant publications can be viewed below.

Publications
Moktan H, Guiraldelli MF, Eyster CA, Zhao W, Lee CY, Mather T, Camerini-Otero RD, Sung P, Zhou DH, Pezza RJ. Solution Structure and DNA-binding Properties of the Winged Helix Domain of the Meiotic Recombination HOP2 Protein.J Biol Chem. 2014 Apr 6 (2014 Apr 6) . [Full Text/Abstract]
Pezza RJ, Voloshin ON, Volodin AA, Boateng KA, Bellani MA, Mazin AV, Camerini-Otero RD. The dual role of HOP2 in mammalian meiotic homologous recombination.Nucleic Acids Res. 2014 Feb; 42 (42; 4; 2014 Feb) :2346-57. [Full Text/Abstract]
Margolin G, Khil PP, Kim J, Bellani MA, Camerini-Otero RD. Integrated transcriptome analysis of mouse spermatogenesis.BMC Genomics. 2014 Jan 18; 15 (15; 2014 Jan 18) :39. [Full Text/Abstract]
Zhao W, Saro D, Hammel M, Kwon Y, Xu Y, Rambo RP, Williams GJ, Chi P, Lu L, Pezza RJ, Camerini-Otero RD, Tainer JA, Wang HW, Sung P. Mechanistic insights into the role of Hop2-Mnd1 in meiotic homologous DNA pairing.Nucleic Acids Res. 2014 Jan; 42 (2; 2014 Jan; 42) :906-17. [Full Text/Abstract]
Smagulova F, Brick K, Pu Y, Sengupta U, Camerini-Otero RD, Petukhova GV. Suppression of genetic recombination in the pseudoautosomal region and at subtelomeres in mice with a hypomorphic Spo11 allele.BMC Genomics. 2013 Jul 22; 14 (14; 2013 Jul 22) :493. [Full Text/Abstract]
Pavlova O, Peterson JH, Ieva R, Bernstein HD. Mechanistic link between β barrel assembly and the initiation of autotransporter secretion.Proc Natl Acad Sci U S A. 2013 Mar 5; 110 (110; 10; 2013 Mar 5) :E938-47. [Full Text/Abstract]
Boateng KA, Bellani MA, Gregoretti IV, Pratto F, Camerini-Otero RD. Homologous pairing preceding SPO11-mediated double-strand breaks in mice.Dev Cell. 2013 Jan 28; 24 (2; 24; 2013 Jan 28) :196-205. [Full Text/Abstract]
Bernstein HD. Cell biology: All clear for ribosome landing.Nature. 2012 Dec 13; 492 (492; 2012 Dec 13; 7428) :189-91. [Full Text/Abstract]
Grant J, Mahadevaiah SK, Khil P, Sangrithi MN, Royo H, Duckworth J, McCarrey JR, VandeBerg JL, Renfree MB, Taylor W, Elgar G, Camerini-Otero RD, Gilchrist MJ, Turner JM. Rsx is a metatherian RNA with Xist-like properties in X-chromosome inactivation.Nature. 2012 Jul 12; 487 (7406; 487; 2012 Jul 12) :254-8. [Full Text/Abstract]
Brick K, Smagulova F, Khil P, Camerini-Otero RD, Petukhova GV. Genetic recombination is directed away from functional genomic elements in mice.Nature. 2012 May 13; 485 (2012 May 13; 485; 7400) :642-5. [Full Text/Abstract]
Khil PP, Smagulova F, Brick KM, Camerini-Otero RD, Petukhova GV. Sensitive mapping of recombination hotspots using sequencing-based detection of ssDNA.Genome Res. 2012 May; 22 (2012 May; 5; 22) :957-65. [Full Text/Abstract]
Geng H, Sakato M, DeRocco V, Yamane K, Du C, Erie DA, Hingorani M, Hsieh P. Biochemical analysis of the human mismatch repair proteins hMutSα MSH2(G674A)-MSH6 and MSH2-MSH6(T1219D).J Biol Chem. 2012 Mar 23; 287 (287; 13; 2012 Mar 23) :9777-91. [Full Text/Abstract]
Gowher H, Brick K, Camerini-Otero RD, Felsenfeld G. Vezf1 protein binding sites genome-wide are associated with pausing of elongating RNA polymerase II.Proc Natl Acad Sci U S A. 2012 Feb 14; 109 (109; 7; 2012 Feb 14) :2370-5. [Full Text/Abstract]
Fukuda T, Pratto F, Schimenti JC, Turner JM, Camerini-Otero RD, Höög C. Phosphorylation of chromosome core components may serve as axis marks for the status of chromosomal events during mammalian meiosis.PLoS Genet. 2012 Feb; 8 (2012 Feb; 8; 2) :e1002485. [Full Text/Abstract]
Diouf B, Cheng Q, Krynetskaia NF, Yang W, Cheok M, Pei D, Fan Y, Cheng C, Krynetskiy EY, Geng H, Chen S, Thierfelder WE, Mullighan CG, Downing JR, Hsieh P, Pui CH, Relling MV, Evans WE. Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells.Nat Med. 2011 Sep 25; 17 (17; 2011 Sep 25; 10) :1298-303. [Full Text/Abstract]
Ieva R, Tian P, Peterson JH, Bernstein HD. Sequential and spatially restricted interactions of assembly factors with an autotransporter beta domain.Proc Natl Acad Sci U S A. 2011 Aug 2; 108 (108; 2011 Aug 2; 31) :E383-91. [Full Text/Abstract]
Geng H, Du C, Chen S, Salerno V, Manfredi C, Hsieh P. In vitro studies of DNA mismatch repair proteins.Anal Biochem. 2011 Jun 15; 413 (2; 413; 2011 Jun 15) :179-84. [Full Text/Abstract]
Ichijima Y, Ichijima M, Lou Z, Nussenzweig A, Camerini-Otero RD, Chen J, Andreassen PR, Namekawa SH. MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells.Genes Dev. 2011 May 1; 25 (25; 9; 2011 May 1) :959-71. [Full Text/Abstract]
Smagulova F, Gregoretti IV, Brick K, Khil P, Camerini-Otero RD, Petukhova GV. Genome-wide analysis reveals novel molecular features of mouse recombination hotspots.Nature. 2011 Apr 21; 472 (2011 Apr 21; 472; 7343) :375-8. [Full Text/Abstract]
Bugreev DV, Pezza RJ, Mazina OM, Voloshin ON, Camerini-Otero RD, Mazin AV. The resistance of DMC1 D-loops to dissociation may account for the DMC1 requirement in meiosis.Nat Struct Mol Biol. 2011 Jan; 18 (2011 Jan; 1; 18) :56-60. [Full Text/Abstract]
Pezza RJ, Camerini-Otero RD, Bianco PR. Hop2-Mnd1 condenses DNA to stimulate the synapsis phase of DNA strand exchange.Biophys J. 2010 Dec 1; 99 (99; 2010 Dec 1; 11) :3763-72. [Full Text/Abstract]
Yao H, Brick K, Evrard Y, Xiao T, Camerini-Otero RD, Felsenfeld G. Mediation of CTCF transcriptional insulation by DEAD-box RNA-binding protein p68 and steroid receptor RNA activator SRA.Genes Dev. 2010 Nov 15; 24 (2010 Nov 15; 24; 22) :2543-55. [Full Text/Abstract]
Peterson JH, Tian P, Ieva R, Dautin N, Bernstein HD. Secretion of a bacterial virulence factor is driven by the folding of a C-terminal segment.Proc Natl Acad Sci U S A. 2010 Oct 12; 107 (107; 2010 Oct 12; 41) :17739-44. [Full Text/Abstract]
Peterson JH, Woolhead CA, Bernstein HD. The conformation of a nascent polypeptide inside the ribosome tunnel affects protein targeting and protein folding.Mol Microbiol. 2010 Oct; 78 (2010 Oct; 78; 1) :203-17. [Full Text/Abstract]
Bellani MA, Boateng KA, McLeod D, Camerini-Otero RD. The expression profile of the major mouse SPO11 isoforms indicates that SPO11beta introduces double strand breaks and suggests that SPO11alpha has an additional role in prophase in both spermatocytes and oocytes.Mol Cell Biol. 2010 Sep; 30 (30; 2010 Sep; 18) :4391-403. [Full Text/Abstract]
Khil PP, Camerini-Otero RD. Genetic crossovers are predicted accurately by the computed human recombination map.PLoS Genet. 2010 Jan 29; 6 (2010 Jan 29; 6; 1) :e1000831. [Full Text/Abstract]
Ieva R, Bernstein HD. Interaction of an autotransporter passenger domain with BamA during its translocation across the bacterial outer membrane.Proc Natl Acad Sci U S A. 2009 Nov 10; 106 (106; 2009 Nov 10; 45) :19120-5. [Full Text/Abstract]
Kouznetsova A, Wang H, Bellani M, Camerini-Otero RD, Jessberger R, Höög C. BRCA1-mediated chromatin silencing is limited to oocytes with a small number of asynapsed chromosomes.J Cell Sci. 2009 Jul 15; 122 (Pt 14; 2009 Jul 15; 122) :2446-52. [Full Text/Abstract]
Suhasini AN, Sommers JA, Mason AC, Voloshin ON, Camerini-Otero RD, Wold MS, Brosh RM Jr. FANCJ helicase uniquely senses oxidative base damage in either strand of duplex DNA and is stimulated by replication protein A to unwind the damaged DNA substrate in a strand-specific manner.J Biol Chem. 2009 Jul 3; 284 (2009 Jul 3; 284; 27) :18458-70. [Full Text/Abstract]
Yap MN, Bernstein HD. The plasticity of a translation arrest motif yields insights into nascent polypeptide recognition inside the ribosome tunnel.Mol Cell. 2009 Apr 24; 34 (2; 2009 Apr 24; 34) :201-11. [Full Text/Abstract]